1HQAA

Alkaline phosphatase (h412q)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEQTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
pubmed doi rcsb
molecule tags Hydrolase (alkaline phosphatase)
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hqaA00
4YR1A 2W5XA 5INHA 4ZG6A 1URAA 5EGHA 3T00A 2XR9A 5HRTA 1ANJA 5LRMA 3WAYA 1E3CP 1AJDA 1Y7AA 1ALIA 2GSNA 5L0BA 1FSUA 4CYSA 5L0EA 2W5WA 3MK2A 1SHQA 2D1GA 3UN2A 4LREA 2GA3A 5DLTA 1B8JA 1EQJA 3B5QA 2X98A 3WAWA 4ZGAA 3A52A 3UN5A 2W8SA 4B56A 4CXKA 2IUCB 3M8WA 3IGZB 1ELZA 4UPIA 3TG0A 5GOVA 5C66A 4ZG9A 4UOPA 4LQYA 1KHKA 2W5VA 1HJKA 3M7VA 4LR2A 1EW2A 1AJAA 1EI6A 5EGEA 4LRCA 4CXSA 4LR7A 3TX0A 4KAVA 2ANHA 1ANIA 1HDHA 5IJSA 3E2DA 3WAXA 1N2KA 2W8DA 4QAXA 3T02A 5DLWA 4GTYA 5K4PA 2QZUA 2W5SA 1HQAA 5DLVA 2GLQA 1E1ZP 1KH9A 1E2SP 2GSOA 4MIVA 1KHJA 4N7TA 1ALJA 1O99A 1KHNA 3CMRA 3T01A 4KJGA 2W5RA 3WAVA 1N2LA 1P49A 4LRDA 4KAYA 1SHNA 1URBA 1ZEFA 1AJBA 4CYRA 1EW9A 3NKPA 5GRRA 1O98A 4GTXA 3BDGB 4MHXA 3M8ZA 3UNYA 1ZEBA 5AJ9A 4GTWA 2RH6A 1K7HA 3BDHA 3IGYB 4GTZA 4LR9A 2IUCA 4LR8A 3SZZA 4UORA 5KXAA 1KH4A 1ELXA 2W5TA 3KD8A 3BDFA 3IDDA 4KM4A 4UOOA 1EW8A 1ELYA 3NKQA 2IFYA 1ED9A 1AJCA 4ZG7A 5LRNA 1EJJA 1ZEDA 3NKOA 4FDJA 4UPKA 2VQRA 1KH7A 3UN3A 1KHLA 4UPHA 5LIAA 4NWJA 3NKNA 1AUKA 4NWXA 3DYCA 2W5QA 3M8YA 4CXUA 2ZKTA 4UPLA 3ED4A 1ALKA 1ED8A 3MK0A 3NKMA 3OT9A 4KJDA 3Q3QA 3LXQA 3MK1A 3TWZA 4LRAA 4MY4A 3SZYA 1ALHA 2G9YA 5IJQA 3WBHA 2GSUA 5TJ3A 3BDGA 3UO0A 1KH5A 5LQQA 1Y6VA 4FDIA 3NKRA 3NVLA 4TN0A 1E33P 3DPCA 2XRGA 4LRFA 4LRBA 5L0KA
chains in the Genus database with same CATH superfamily
4YR1A 2W5XA 5INHA 4ZG6A 1URAA 5EGHA 3T00A 2XR9A 5HRTA 1ANJA 5LRMA 3WAYA 1E3CP 1AJDA 1Y7AA 1ALIA 2GSNA 5L0BA 1FSUA 4CYSA 5L0EA 2W5WA 3MK2A 1SHQA 2D1GA 3UN2A 4LREA 2GA3A 5DLTA 1B8JA 1EQJA 3B5QA 2X98A 3WAWA 4ZGAA 3A52A 3UN5A 2W8SA 4B56A 4CXKA 2IUCB 3M8WA 3IGZB 1ELZA 4UPIA 3TG0A 5GOVA 5C66A 4ZG9A 4UOPA 4LQYA 1KHKA 2W5VA 1HJKA 3M7VA 4LR2A 1EW2A 1AJAA 1EI6A 5EGEA 4LRCA 4CXSA 4LR7A 3TX0A 4KAVA 2ANHA 1ANIA 1HDHA 5IJSA 3E2DA 3WAXA 1N2KA 2W8DA 4QAXA 3T02A 5DLWA 4GTYA 5K4PA 2QZUA 2W5SA 1HQAA 5DLVA 2GLQA 1E1ZP 1KH9A 1E2SP 2GSOA 4MIVA 1KHJA 4N7TA 1ALJA 1O99A 1KHNA 3CMRA 3T01A 4KJGA 2W5RA 3WAVA 1N2LA 1P49A 4LRDA 4KAYA 1SHNA 1URBA 1ZEFA 1AJBA 4CYRA 1EW9A 3NKPA 5GRRA 1O98A 4GTXA 3BDGB 4MHXA 3M8ZA 3UNYA 1ZEBA 5AJ9A 4GTWA 2RH6A 1K7HA 3BDHA 3IGYB 4GTZA 4LR9A 2IUCA 4LR8A 3SZZA 4UORA 5KXAA 1KH4A 1ELXA 2W5TA 3KD8A 3BDFA 3IDDA 4KM4A 4UOOA 1EW8A 1ELYA 3NKQA 2IFYA 1ED9A 1AJCA 4ZG7A 5LRNA 1EJJA 1ZEDA 3NKOA 4FDJA 4UPKA 2VQRA 1KH7A 3UN3A 1KHLA 4UPHA 5LIAA 4NWJA 3NKNA 1AUKA 4NWXA 3DYCA 2W5QA 3M8YA 4CXUA 2ZKTA 4UPLA 3ED4A 1ALKA 1ED8A 3MK0A 3NKMA 3OT9A 4KJDA 3Q3QA 3LXQA 3MK1A 3TWZA 4LRAA 4MY4A 3SZYA 1ALHA 2G9YA 5IJQA 3WBHA 2GSUA 5TJ3A 3BDGA 3UO0A 1KH5A 5LQQA 1Y6VA 4FDIA 3NKRA 3NVLA 4TN0A 1E33P 3DPCA 2XRGA 4LRFA 4LRBA 5L0KA
chains in the Genus database with same CATH topology
4YR1A 2W5XA 5INHA 4ZG6A 1URAA 5EGHA 3T00A 2XR9A 5HRTA 1ANJA 5LRMA 3WAYA 1E3CP 1AJDA 1Y7AA 1ALIA 2GSNA 5L0BA 1FSUA 4CYSA 5L0EA 2W5WA 3MK2A 1SHQA 2D1GA 3UN2A 4LREA 2GA3A 5DLTA 1B8JA 1EQJA 3B5QA 2X98A 3WAWA 4ZGAA 3A52A 3UN5A 2W8SA 4B56A 4CXKA 2IUCB 3M8WA 3IGZB 1ELZA 4UPIA 3TG0A 5GOVA 5C66A 4ZG9A 4UOPA 4LQYA 1KHKA 2W5VA 1HJKA 3M7VA 4LR2A 1EW2A 1AJAA 1EI6A 5EGEA 4LRCA 4CXSA 4LR7A 3TX0A 4KAVA 2ANHA 1ANIA 1HDHA 5IJSA 3E2DA 3WAXA 1N2KA 2W8DA 4QAXA 3T02A 5DLWA 4GTYA 5K4PA 2QZUA 2W5SA 1HQAA 5DLVA 2GLQA 1E1ZP 1KH9A 1E2SP 2GSOA 4MIVA 1KHJA 4N7TA 1ALJA 1O99A 1KHNA 3CMRA 3T01A 4KJGA 2W5RA 3WAVA 1N2LA 1P49A 4LRDA 4KAYA 1SHNA 1URBA 1ZEFA 1AJBA 4CYRA 1EW9A 3NKPA 5GRRA 1O98A 4GTXA 3BDGB 4MHXA 3M8ZA 3UNYA 1ZEBA 5AJ9A 4GTWA 2RH6A 1K7HA 3BDHA 3IGYB 4GTZA 4LR9A 2IUCA 4LR8A 3SZZA 4UORA 5KXAA 1KH4A 1ELXA 2W5TA 3KD8A 3BDFA 3IDDA 4KM4A 4UOOA 1EW8A 1ELYA 3NKQA 2IFYA 1ED9A 1AJCA 4ZG7A 5LRNA 1EJJA 1ZEDA 3NKOA 4FDJA 4UPKA 2VQRA 1KH7A 3UN3A 1KHLA 4UPHA 5LIAA 4NWJA 3NKNA 1AUKA 4NWXA 3DYCA 2W5QA 3M8YA 4CXUA 2ZKTA 4UPLA 3ED4A 1ALKA 1ED8A 3MK0A 3NKMA 3OT9A 4KJDA 3Q3QA 3LXQA 3MK1A 3TWZA 4LRAA 4MY4A 3SZYA 1ALHA 2G9YA 5IJQA 3WBHA 2GSUA 5TJ3A 3BDGA 3UO0A 1KH5A 5LQQA 1Y6VA 4FDIA 3NKRA 3NVLA 4TN0A 1E33P 3DPCA 2XRGA 4LRFA 4LRBA 5L0KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YR1 A;  2W5X A;  5INH A;  4ZG6 A;  1URA A;  5EGH A;  3T00 A;  2XR9 A;  5HRT A;  1ANJ A;  5LRM A;  3WAY A;  1E3C P;  1AJD A;  1Y7A A;  1ALI A;  2GSN A;  5L0B A;  1FSU A;  4CYS A;  5L0E A;  2W5W A;  3MK2 A;  1SHQ A;  2D1G A;  3UN2 A;  4LRE A;  2GA3 A;  5DLT A;  1B8J A;  1EQJ A;  3B5Q A;  2X98 A;  3WAW A;  4ZGA A;  3A52 A;  3UN5 A;  2W8S A;  4B56 A;  4CXK A;  2IUC B;  3M8W A;  3IGZ B;  1ELZ A;  4UPI A;  3TG0 A;  5GOV A;  5C66 A;  4ZG9 A;  4UOP A;  4LQY A;  1KHK A;  2W5V A;  1HJK A;  3M7V A;  4LR2 A;  1EW2 A;  1AJA A;  1EI6 A;  5EGE A;  4LRC A;  4CXS A;  4LR7 A;  3TX0 A;  4KAV A;  2ANH A;  1ANI A;  1HDH A;  5IJS A;  3E2D A;  3WAX A;  1N2K A;  2W8D A;  4QAX A;  3T02 A;  5DLW A;  4GTY A;  5K4P A;  2QZU A;  2W5S A;  1HQA A;  5DLV A;  2GLQ A;  1E1Z P;  1KH9 A;  1E2S P;  2GSO A;  4MIV A;  1KHJ A;  4N7T A;  1ALJ A;  1O99 A;  1KHN A;  3CMR A;  3T01 A;  4KJG A;  2W5R A;  3WAV A;  1N2L A;  1P49 A;  4LRD A;  4KAY A;  1SHN A;  1URB A;  1ZEF A;  1AJB A;  4CYR A;  1EW9 A;  3NKP A;  5GRR A;  1O98 A;  4GTX A;  3BDG B;  4MHX A;  3M8Z A;  3UNY A;  1ZEB A;  5AJ9 A;  4GTW A;  2RH6 A;  1K7H A;  3BDH A;  3IGY B;  4GTZ A;  4LR9 A;  2IUC A;  4LR8 A;  3SZZ A;  4UOR A;  5KXA A;  1KH4 A;  1ELX A;  2W5T A;  3KD8 A;  3BDF A;  3IDD A;  4KM4 A;  4UOO A;  1EW8 A;  1ELY A;  3NKQ A;  2IFY A;  1ED9 A;  1AJC A;  4ZG7 A;  5LRN A;  1EJJ A;  1ZED A;  3NKO A;  4FDJ A;  4UPK A;  2VQR A;  1KH7 A;  3UN3 A;  1KHL A;  4UPH A;  5LIA A;  4NWJ A;  3NKN A;  1AUK A;  4NWX A;  3DYC A;  2W5Q A;  3M8Y A;  4CXU A;  2ZKT A;  4UPL A;  3ED4 A;  1ALK A;  1ED8 A;  3MK0 A;  3NKM A;  3OT9 A;  4KJD A;  3Q3Q A;  3LXQ A;  3MK1 A;  3TWZ A;  4LRA A;  4MY4 A;  3SZY A;  1ALH A;  2G9Y A;  5IJQ A;  3WBH A;  2GSU A;  5TJ3 A;  3BDG A;  3UO0 A;  1KH5 A;  5LQQ A;  1Y6V A;  4FDI A;  3NKR A;  3NVL A;  4TN0 A;  1E33 P;  3DPC A;  2XRG A;  4LRF A;  4LRB A;  5L0K A; 
#chains in the Genus database with same CATH topology
 4YR1 A;  2W5X A;  5INH A;  4ZG6 A;  1URA A;  5EGH A;  3T00 A;  2XR9 A;  5HRT A;  1ANJ A;  5LRM A;  3WAY A;  1E3C P;  1AJD A;  1Y7A A;  1ALI A;  2GSN A;  5L0B A;  1FSU A;  4CYS A;  5L0E A;  2W5W A;  3MK2 A;  1SHQ A;  2D1G A;  3UN2 A;  4LRE A;  2GA3 A;  5DLT A;  1B8J A;  1EQJ A;  3B5Q A;  2X98 A;  3WAW A;  4ZGA A;  3A52 A;  3UN5 A;  2W8S A;  4B56 A;  4CXK A;  2IUC B;  3M8W A;  3IGZ B;  1ELZ A;  4UPI A;  3TG0 A;  5GOV A;  5C66 A;  4ZG9 A;  4UOP A;  4LQY A;  1KHK A;  2W5V A;  1HJK A;  3M7V A;  4LR2 A;  1EW2 A;  1AJA A;  1EI6 A;  5EGE A;  4LRC A;  4CXS A;  4LR7 A;  3TX0 A;  4KAV A;  2ANH A;  1ANI A;  1HDH A;  5IJS A;  3E2D A;  3WAX A;  1N2K A;  2W8D A;  4QAX A;  3T02 A;  5DLW A;  4GTY A;  5K4P A;  2QZU A;  2W5S A;  1HQA A;  5DLV A;  2GLQ A;  1E1Z P;  1KH9 A;  1E2S P;  2GSO A;  4MIV A;  1KHJ A;  4N7T A;  1ALJ A;  1O99 A;  1KHN A;  3CMR A;  3T01 A;  4KJG A;  2W5R A;  3WAV A;  1N2L A;  1P49 A;  4LRD A;  4KAY A;  1SHN A;  1URB A;  1ZEF A;  1AJB A;  4CYR A;  1EW9 A;  3NKP A;  5GRR A;  1O98 A;  4GTX A;  3BDG B;  4MHX A;  3M8Z A;  3UNY A;  1ZEB A;  5AJ9 A;  4GTW A;  2RH6 A;  1K7H A;  3BDH A;  3IGY B;  4GTZ A;  4LR9 A;  2IUC A;  4LR8 A;  3SZZ A;  4UOR A;  5KXA A;  1KH4 A;  1ELX A;  2W5T A;  3KD8 A;  3BDF A;  3IDD A;  4KM4 A;  4UOO A;  1EW8 A;  1ELY A;  3NKQ A;  2IFY A;  1ED9 A;  1AJC A;  4ZG7 A;  5LRN A;  1EJJ A;  1ZED A;  3NKO A;  4FDJ A;  4UPK A;  2VQR A;  1KH7 A;  3UN3 A;  1KHL A;  4UPH A;  5LIA A;  4NWJ A;  3NKN A;  1AUK A;  4NWX A;  3DYC A;  2W5Q A;  3M8Y A;  4CXU A;  2ZKT A;  4UPL A;  3ED4 A;  1ALK A;  1ED8 A;  3MK0 A;  3NKM A;  3OT9 A;  4KJD A;  3Q3Q A;  3LXQ A;  3MK1 A;  3TWZ A;  4LRA A;  4MY4 A;  3SZY A;  1ALH A;  2G9Y A;  5IJQ A;  3WBH A;  2GSU A;  5TJ3 A;  3BDG A;  3UO0 A;  1KH5 A;  5LQQ A;  1Y6V A;  4FDI A;  3NKR A;  3NVL A;  4TN0 A;  1E33 P;  3DPC A;  2XRG A;  4LRF A;  4LRB A;  5L0K A; 
#chains in the Genus database with same CATH homology
 4YR1 A;  2W5X A;  5INH A;  4ZG6 A;  1URA A;  5EGH A;  3T00 A;  2XR9 A;  5HRT A;  1ANJ A;  5LRM A;  3WAY A;  1E3C P;  1AJD A;  1Y7A A;  1ALI A;  2GSN A;  5L0B A;  1FSU A;  4CYS A;  5L0E A;  2W5W A;  3MK2 A;  1SHQ A;  2D1G A;  3UN2 A;  4LRE A;  2GA3 A;  5DLT A;  1B8J A;  1EQJ A;  3B5Q A;  2X98 A;  3WAW A;  4ZGA A;  3A52 A;  3UN5 A;  2W8S A;  4B56 A;  4CXK A;  2IUC B;  3M8W A;  3IGZ B;  1ELZ A;  4UPI A;  3TG0 A;  5GOV A;  5C66 A;  4ZG9 A;  4UOP A;  4LQY A;  1KHK A;  2W5V A;  1HJK A;  3M7V A;  4LR2 A;  1EW2 A;  1AJA A;  1EI6 A;  5EGE A;  4LRC A;  4CXS A;  4LR7 A;  3TX0 A;  4KAV A;  2ANH A;  1ANI A;  1HDH A;  5IJS A;  3E2D A;  3WAX A;  1N2K A;  2W8D A;  4QAX A;  3T02 A;  5DLW A;  4GTY A;  5K4P A;  2QZU A;  2W5S A;  1HQA A;  5DLV A;  2GLQ A;  1E1Z P;  1KH9 A;  1E2S P;  2GSO A;  4MIV A;  1KHJ A;  4N7T A;  1ALJ A;  1O99 A;  1KHN A;  3CMR A;  3T01 A;  4KJG A;  2W5R A;  3WAV A;  1N2L A;  1P49 A;  4LRD A;  4KAY A;  1SHN A;  1URB A;  1ZEF A;  1AJB A;  4CYR A;  1EW9 A;  3NKP A;  5GRR A;  1O98 A;  4GTX A;  3BDG B;  4MHX A;  3M8Z A;  3UNY A;  1ZEB A;  5AJ9 A;  4GTW A;  2RH6 A;  1K7H A;  3BDH A;  3IGY B;  4GTZ A;  4LR9 A;  2IUC A;  4LR8 A;  3SZZ A;  4UOR A;  5KXA A;  1KH4 A;  1ELX A;  2W5T A;  3KD8 A;  3BDF A;  3IDD A;  4KM4 A;  4UOO A;  1EW8 A;  1ELY A;  3NKQ A;  2IFY A;  1ED9 A;  1AJC A;  4ZG7 A;  5LRN A;  1EJJ A;  1ZED A;  3NKO A;  4FDJ A;  4UPK A;  2VQR A;  1KH7 A;  3UN3 A;  1KHL A;  4UPH A;  5LIA A;  4NWJ A;  3NKN A;  1AUK A;  4NWX A;  3DYC A;  2W5Q A;  3M8Y A;  4CXU A;  2ZKT A;  4UPL A;  3ED4 A;  1ALK A;  1ED8 A;  3MK0 A;  3NKM A;  3OT9 A;  4KJD A;  3Q3Q A;  3LXQ A;  3MK1 A;  3TWZ A;  4LRA A;  4MY4 A;  3SZY A;  1ALH A;  2G9Y A;  5IJQ A;  3WBH A;  2GSU A;  5TJ3 A;  3BDG A;  3UO0 A;  1KH5 A;  5LQQ A;  1Y6V A;  4FDI A;  3NKR A;  3NVL A;  4TN0 A;  1E33 P;  3DPC A;  2XRG A;  4LRF A;  4LRB A;  5L0K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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