1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
3BDFA 3UN3A 2GSUA 1Y6VA 3MK2A 2G9YA 2X98A 4FDIA 4N7TA 3NKNA 4KJGA 3M8YA 5C66A 2GA3A 1HQAA 1ALIA 1ALKA 4FDJA 3T00A 5L0KA 2W8DA 2W5VA 2IUCA 2GSOA 1SHQA 3MK0A 1KH4A 3E2DA 3BDGA 3T02A 1KHJA 1KHKA 3TG0A 4LR7A 1P49A 3M8WA 3Q3QA 1FSUA 3WAXA 1ELYA 4NWJA 4UPHA 2W5SA 3LXQA 4UPKA 1B8JA 2W5TA 3WBHA 1KHNA 3CMRA 4MHXA 3BDHA 5IJQA 1EI6A 2ZKTA 2QZUA 4KAYA 4UPIA 3SZZA 1ED8A 2GSNA 3TX0A 1ZEBA 2XRGA 4MY4A 1HDHA 3WAVA 5HRTA 1E1ZP 3M7VA 3UNYA 4LR9A 2VQRA 2W5XA 5K4PA 1ANJA 2IUCB 5AJ9A 1AJAA 3IGYB 3SZYA 3A52A 4LRFA 3NKMA 2W5QA 1EJJA 1E3CP 3T01A 2W5WA 4UPLA 5EGHA 1ELXA 1ZEFA 4GTWA 5EGEA 1EW9A 5GRRA 2D1GA 2W5RA 1O98A 4CXUA 4NWXA 1KH9A 3NKRA 4GTYA 1E33P 1K7HA 3NVLA 5LIAA 3UN5A 5DLWA 4ZGAA 1SHNA 3UN2A 3KD8A 3DPCA 2GLQA 1ALJA 5DLTA 4TN0A 3BDGB 3WAYA 3NKPA 4ZG7A 3OT9A 1O99A 3TWZA 5L0BA 3M8ZA 1ED9A 1EW8A 3NKQA 1N2KA 1ANIA 4LRBA 3WAWA 5LQQA 1ZEDA 2XR9A 1KH7A 3MK1A 4QAXA 1HJKA 5INHA 5IJSA 4CXKA 1KH5A 2IFYA 2RH6A 5L0EA 3DYCA 4LR2A 4UORA 4B56A 3NKOA 4LQYA 4YR1A 4LRDA 2W8SA 1AJDA 5LRNA 5LRMA 4CXSA 1EQJA 4KM4A 3IDDA 3UO0A 4ZG6A 1AJCA 1N2LA 4MIVA 4KAVA 5TJ3A 4CYSA 2ANHA 1URBA 1Y7AA 4GTXA 4UOPA 1AJBA 4GTZA 4UOOA 1KHLA 4LREA 5GOVA 4LRAA 4ZG9A 3ED4A 5KXAA 4CYRA 1EW2A 1AUKA 1URAA 3IGZB 1ELZA 1ALHA 1E2SP 3B5QA 4KJDA 4LRCA 5DLVA 4LR8A
chains in the Genus database with same CATH superfamily
3BDFA 3UN3A 2GSUA 1Y6VA 3MK2A 2G9YA 2X98A 4FDIA 4N7TA 3NKNA 4KJGA 3M8YA 5C66A 2GA3A 1HQAA 1ALIA 1ALKA 4FDJA 3T00A 5L0KA 2W8DA 2W5VA 2IUCA 2GSOA 1SHQA 3MK0A 1KH4A 3E2DA 3BDGA 3T02A 1KHJA 1KHKA 3TG0A 4LR7A 1P49A 3M8WA 3Q3QA 1FSUA 3WAXA 1ELYA 4NWJA 4UPHA 2W5SA 3LXQA 4UPKA 1B8JA 2W5TA 3WBHA 1KHNA 3CMRA 4MHXA 3BDHA 5IJQA 1EI6A 2ZKTA 2QZUA 4KAYA 4UPIA 3SZZA 1ED8A 2GSNA 3TX0A 1ZEBA 2XRGA 4MY4A 1HDHA 3WAVA 5HRTA 1E1ZP 3M7VA 3UNYA 4LR9A 2VQRA 2W5XA 5K4PA 1ANJA 2IUCB 5AJ9A 1AJAA 3IGYB 3SZYA 3A52A 4LRFA 3NKMA 2W5QA 1EJJA 1E3CP 3T01A 2W5WA 4UPLA 5EGHA 1ELXA 1ZEFA 4GTWA 5EGEA 1EW9A 5GRRA 2D1GA 2W5RA 1O98A 4CXUA 4NWXA 1KH9A 3NKRA 4GTYA 1E33P 1K7HA 3NVLA 5LIAA 3UN5A 5DLWA 4ZGAA 1SHNA 3UN2A 3KD8A 3DPCA 2GLQA 1ALJA 5DLTA 4TN0A 3BDGB 3WAYA 3NKPA 4ZG7A 3OT9A 1O99A 3TWZA 5L0BA 3M8ZA 1ED9A 1EW8A 3NKQA 1N2KA 1ANIA 4LRBA 3WAWA 5LQQA 1ZEDA 2XR9A 1KH7A 3MK1A 4QAXA 1HJKA 5INHA 5IJSA 4CXKA 1KH5A 2IFYA 2RH6A 5L0EA 3DYCA 4LR2A 4UORA 4B56A 3NKOA 4LQYA 4YR1A 4LRDA 2W8SA 1AJDA 5LRNA 5LRMA 4CXSA 1EQJA 4KM4A 3IDDA 3UO0A 4ZG6A 1AJCA 1N2LA 4MIVA 4KAVA 5TJ3A 4CYSA 2ANHA 1URBA 1Y7AA 4GTXA 4UOPA 1AJBA 4GTZA 4UOOA 1KHLA 4LREA 5GOVA 4LRAA 4ZG9A 3ED4A 5KXAA 4CYRA 1EW2A 1AUKA 1URAA 3IGZB 1ELZA 1ALHA 1E2SP 3B5QA 4KJDA 4LRCA 5DLVA 4LR8A
chains in the Genus database with same CATH topology
3BDFA 3UN3A 2GSUA 1Y6VA 3MK2A 2G9YA 2X98A 4FDIA 4N7TA 3NKNA 4KJGA 3M8YA 5C66A 2GA3A 1HQAA 1ALIA 1ALKA 4FDJA 3T00A 5L0KA 2W8DA 2W5VA 2IUCA 2GSOA 1SHQA 3MK0A 1KH4A 3E2DA 3BDGA 3T02A 1KHJA 1KHKA 3TG0A 4LR7A 1P49A 3M8WA 3Q3QA 1FSUA 3WAXA 1ELYA 4NWJA 4UPHA 2W5SA 3LXQA 4UPKA 1B8JA 2W5TA 3WBHA 1KHNA 3CMRA 4MHXA 3BDHA 5IJQA 1EI6A 2ZKTA 2QZUA 4KAYA 4UPIA 3SZZA 1ED8A 2GSNA 3TX0A 1ZEBA 2XRGA 4MY4A 1HDHA 3WAVA 5HRTA 1E1ZP 3M7VA 3UNYA 4LR9A 2VQRA 2W5XA 5K4PA 1ANJA 2IUCB 5AJ9A 1AJAA 3IGYB 3SZYA 3A52A 4LRFA 3NKMA 2W5QA 1EJJA 1E3CP 3T01A 2W5WA 4UPLA 5EGHA 1ELXA 1ZEFA 4GTWA 5EGEA 1EW9A 5GRRA 2D1GA 2W5RA 1O98A 4CXUA 4NWXA 1KH9A 3NKRA 4GTYA 1E33P 1K7HA 3NVLA 5LIAA 3UN5A 5DLWA 4ZGAA 1SHNA 3UN2A 3KD8A 3DPCA 2GLQA 1ALJA 5DLTA 4TN0A 3BDGB 3WAYA 3NKPA 4ZG7A 3OT9A 1O99A 3TWZA 5L0BA 3M8ZA 1ED9A 1EW8A 3NKQA 1N2KA 1ANIA 4LRBA 3WAWA 5LQQA 1ZEDA 2XR9A 1KH7A 3MK1A 4QAXA 1HJKA 5INHA 5IJSA 4CXKA 1KH5A 2IFYA 2RH6A 5L0EA 3DYCA 4LR2A 4UORA 4B56A 3NKOA 4LQYA 4YR1A 4LRDA 2W8SA 1AJDA 5LRNA 5LRMA 4CXSA 1EQJA 4KM4A 3IDDA 3UO0A 4ZG6A 1AJCA 1N2LA 4MIVA 4KAVA 5TJ3A 4CYSA 2ANHA 1URBA 1Y7AA 4GTXA 4UOPA 1AJBA 4GTZA 4UOOA 1KHLA 4LREA 5GOVA 4LRAA 4ZG9A 3ED4A 5KXAA 4CYRA 1EW2A 1AUKA 1URAA 3IGZB 1ELZA 1ALHA 1E2SP 3B5QA 4KJDA 4LRCA 5DLVA 4LR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDF A;  3UN3 A;  2GSU A;  1Y6V A;  3MK2 A;  2G9Y A;  2X98 A;  4FDI A;  4N7T A;  3NKN A;  4KJG A;  3M8Y A;  5C66 A;  2GA3 A;  1HQA A;  1ALI A;  1ALK A;  4FDJ A;  3T00 A;  5L0K A;  2W8D A;  2W5V A;  2IUC A;  2GSO A;  1SHQ A;  3MK0 A;  1KH4 A;  3E2D A;  3BDG A;  3T02 A;  1KHJ A;  1KHK A;  3TG0 A;  4LR7 A;  1P49 A;  3M8W A;  3Q3Q A;  1FSU A;  3WAX A;  1ELY A;  4NWJ A;  4UPH A;  2W5S A;  3LXQ A;  4UPK A;  1B8J A;  2W5T A;  3WBH A;  1KHN A;  3CMR A;  4MHX A;  3BDH A;  5IJQ A;  1EI6 A;  2ZKT A;  2QZU A;  4KAY A;  4UPI A;  3SZZ A;  1ED8 A;  2GSN A;  3TX0 A;  1ZEB A;  2XRG A;  4MY4 A;  1HDH A;  3WAV A;  5HRT A;  1E1Z P;  3M7V A;  3UNY A;  4LR9 A;  2VQR A;  2W5X A;  5K4P A;  1ANJ A;  2IUC B;  5AJ9 A;  1AJA A;  3IGY B;  3SZY A;  3A52 A;  4LRF A;  3NKM A;  2W5Q A;  1EJJ A;  1E3C P;  3T01 A;  2W5W A;  4UPL A;  5EGH A;  1ELX A;  1ZEF A;  4GTW A;  5EGE A;  1EW9 A;  5GRR A;  2D1G A;  2W5R A;  1O98 A;  4CXU A;  4NWX A;  1KH9 A;  3NKR A;  4GTY A;  1E33 P;  1K7H A;  3NVL A;  5LIA A;  3UN5 A;  5DLW A;  4ZGA A;  1SHN A;  3UN2 A;  3KD8 A;  3DPC A;  2GLQ A;  1ALJ A;  5DLT A;  4TN0 A;  3BDG B;  3WAY A;  3NKP A;  4ZG7 A;  3OT9 A;  1O99 A;  3TWZ A;  5L0B A;  3M8Z A;  1ED9 A;  1EW8 A;  3NKQ A;  1N2K A;  1ANI A;  4LRB A;  3WAW A;  5LQQ A;  1ZED A;  2XR9 A;  1KH7 A;  3MK1 A;  4QAX A;  1HJK A;  5INH A;  5IJS A;  4CXK A;  1KH5 A;  2IFY A;  2RH6 A;  5L0E A;  3DYC A;  4LR2 A;  4UOR A;  4B56 A;  3NKO A;  4LQY A;  4YR1 A;  4LRD A;  2W8S A;  1AJD A;  5LRN A;  5LRM A;  4CXS A;  1EQJ A;  4KM4 A;  3IDD A;  3UO0 A;  4ZG6 A;  1AJC A;  1N2L A;  4MIV A;  4KAV A;  5TJ3 A;  4CYS A;  2ANH A;  1URB A;  1Y7A A;  4GTX A;  4UOP A;  1AJB A;  4GTZ A;  4UOO A;  1KHL A;  4LRE A;  5GOV A;  4LRA A;  4ZG9 A;  3ED4 A;  5KXA A;  4CYR A;  1EW2 A;  1AUK A;  1URA A;  3IGZ B;  1ELZ A;  1ALH A;  1E2S P;  3B5Q A;  4KJD A;  4LRC A;  5DLV A;  4LR8 A; 
#chains in the Genus database with same CATH topology
 3BDF A;  3UN3 A;  2GSU A;  1Y6V A;  3MK2 A;  2G9Y A;  2X98 A;  4FDI A;  4N7T A;  3NKN A;  4KJG A;  3M8Y A;  5C66 A;  2GA3 A;  1HQA A;  1ALI A;  1ALK A;  4FDJ A;  3T00 A;  5L0K A;  2W8D A;  2W5V A;  2IUC A;  2GSO A;  1SHQ A;  3MK0 A;  1KH4 A;  3E2D A;  3BDG A;  3T02 A;  1KHJ A;  1KHK A;  3TG0 A;  4LR7 A;  1P49 A;  3M8W A;  3Q3Q A;  1FSU A;  3WAX A;  1ELY A;  4NWJ A;  4UPH A;  2W5S A;  3LXQ A;  4UPK A;  1B8J A;  2W5T A;  3WBH A;  1KHN A;  3CMR A;  4MHX A;  3BDH A;  5IJQ A;  1EI6 A;  2ZKT A;  2QZU A;  4KAY A;  4UPI A;  3SZZ A;  1ED8 A;  2GSN A;  3TX0 A;  1ZEB A;  2XRG A;  4MY4 A;  1HDH A;  3WAV A;  5HRT A;  1E1Z P;  3M7V A;  3UNY A;  4LR9 A;  2VQR A;  2W5X A;  5K4P A;  1ANJ A;  2IUC B;  5AJ9 A;  1AJA A;  3IGY B;  3SZY A;  3A52 A;  4LRF A;  3NKM A;  2W5Q A;  1EJJ A;  1E3C P;  3T01 A;  2W5W A;  4UPL A;  5EGH A;  1ELX A;  1ZEF A;  4GTW A;  5EGE A;  1EW9 A;  5GRR A;  2D1G A;  2W5R A;  1O98 A;  4CXU A;  4NWX A;  1KH9 A;  3NKR A;  4GTY A;  1E33 P;  1K7H A;  3NVL A;  5LIA A;  3UN5 A;  5DLW A;  4ZGA A;  1SHN A;  3UN2 A;  3KD8 A;  3DPC A;  2GLQ A;  1ALJ A;  5DLT A;  4TN0 A;  3BDG B;  3WAY A;  3NKP A;  4ZG7 A;  3OT9 A;  1O99 A;  3TWZ A;  5L0B A;  3M8Z A;  1ED9 A;  1EW8 A;  3NKQ A;  1N2K A;  1ANI A;  4LRB A;  3WAW A;  5LQQ A;  1ZED A;  2XR9 A;  1KH7 A;  3MK1 A;  4QAX A;  1HJK A;  5INH A;  5IJS A;  4CXK A;  1KH5 A;  2IFY A;  2RH6 A;  5L0E A;  3DYC A;  4LR2 A;  4UOR A;  4B56 A;  3NKO A;  4LQY A;  4YR1 A;  4LRD A;  2W8S A;  1AJD A;  5LRN A;  5LRM A;  4CXS A;  1EQJ A;  4KM4 A;  3IDD A;  3UO0 A;  4ZG6 A;  1AJC A;  1N2L A;  4MIV A;  4KAV A;  5TJ3 A;  4CYS A;  2ANH A;  1URB A;  1Y7A A;  4GTX A;  4UOP A;  1AJB A;  4GTZ A;  4UOO A;  1KHL A;  4LRE A;  5GOV A;  4LRA A;  4ZG9 A;  3ED4 A;  5KXA A;  4CYR A;  1EW2 A;  1AUK A;  1URA A;  3IGZ B;  1ELZ A;  1ALH A;  1E2S P;  3B5Q A;  4KJD A;  4LRC A;  5DLV A;  4LR8 A; 
#chains in the Genus database with same CATH homology
 3BDF A;  3UN3 A;  2GSU A;  1Y6V A;  3MK2 A;  2G9Y A;  2X98 A;  4FDI A;  4N7T A;  3NKN A;  4KJG A;  3M8Y A;  5C66 A;  2GA3 A;  1HQA A;  1ALI A;  1ALK A;  4FDJ A;  3T00 A;  5L0K A;  2W8D A;  2W5V A;  2IUC A;  2GSO A;  1SHQ A;  3MK0 A;  1KH4 A;  3E2D A;  3BDG A;  3T02 A;  1KHJ A;  1KHK A;  3TG0 A;  4LR7 A;  1P49 A;  3M8W A;  3Q3Q A;  1FSU A;  3WAX A;  1ELY A;  4NWJ A;  4UPH A;  2W5S A;  3LXQ A;  4UPK A;  1B8J A;  2W5T A;  3WBH A;  1KHN A;  3CMR A;  4MHX A;  3BDH A;  5IJQ A;  1EI6 A;  2ZKT A;  2QZU A;  4KAY A;  4UPI A;  3SZZ A;  1ED8 A;  2GSN A;  3TX0 A;  1ZEB A;  2XRG A;  4MY4 A;  1HDH A;  3WAV A;  5HRT A;  1E1Z P;  3M7V A;  3UNY A;  4LR9 A;  2VQR A;  2W5X A;  5K4P A;  1ANJ A;  2IUC B;  5AJ9 A;  1AJA A;  3IGY B;  3SZY A;  3A52 A;  4LRF A;  3NKM A;  2W5Q A;  1EJJ A;  1E3C P;  3T01 A;  2W5W A;  4UPL A;  5EGH A;  1ELX A;  1ZEF A;  4GTW A;  5EGE A;  1EW9 A;  5GRR A;  2D1G A;  2W5R A;  1O98 A;  4CXU A;  4NWX A;  1KH9 A;  3NKR A;  4GTY A;  1E33 P;  1K7H A;  3NVL A;  5LIA A;  3UN5 A;  5DLW A;  4ZGA A;  1SHN A;  3UN2 A;  3KD8 A;  3DPC A;  2GLQ A;  1ALJ A;  5DLT A;  4TN0 A;  3BDG B;  3WAY A;  3NKP A;  4ZG7 A;  3OT9 A;  1O99 A;  3TWZ A;  5L0B A;  3M8Z A;  1ED9 A;  1EW8 A;  3NKQ A;  1N2K A;  1ANI A;  4LRB A;  3WAW A;  5LQQ A;  1ZED A;  2XR9 A;  1KH7 A;  3MK1 A;  4QAX A;  1HJK A;  5INH A;  5IJS A;  4CXK A;  1KH5 A;  2IFY A;  2RH6 A;  5L0E A;  3DYC A;  4LR2 A;  4UOR A;  4B56 A;  3NKO A;  4LQY A;  4YR1 A;  4LRD A;  2W8S A;  1AJD A;  5LRN A;  5LRM A;  4CXS A;  1EQJ A;  4KM4 A;  3IDD A;  3UO0 A;  4ZG6 A;  1AJC A;  1N2L A;  4MIV A;  4KAV A;  5TJ3 A;  4CYS A;  2ANH A;  1URB A;  1Y7A A;  4GTX A;  4UOP A;  1AJB A;  4GTZ A;  4UOO A;  1KHL A;  4LRE A;  5GOV A;  4LRA A;  4ZG9 A;  3ED4 A;  5KXA A;  4CYR A;  1EW2 A;  1AUK A;  1URA A;  3IGZ B;  1ELZ A;  1ALH A;  1E2S P;  3B5Q A;  4KJD A;  4LRC A;  5DLV A;  4LR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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