1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 144
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
4FDJA 1ELXA 4LRDA 3WBHA 4KAYA 3DPCA 4LR2A 1KHLA 4LREA 3IDDA 5L0EA 5IJQA 1HJKA 4NWXA 5TJ3A 4UPLA 4LR8A 3BDFA 5C66A 5INHA 1ELYA 1EW2A 1HDHA 4B56A 1Y7AA 4LR9A 1E33P 1AJBA 1SHQA 3SZYA 1K7HA 2W5WA 3UN2A 3NKOA 1ED8A 1EW8A 4GTYA 2IFYA 4N7TA 3WAVA 4NWJA 1ZEFA 3M8WA 5LRNA 1ALHA 5K4PA 1AUKA 3TG0A 4UPIA 4CYRA 4CXSA 2ANHA 4CYSA 3T02A 4UORA 4YR1A 4LRCA 3UO0A 5LQQA 1E2SP 4LRBA 3MK2A 4TN0A 5IJSA 1ZEDA 4KM4A 5DLVA 2XRGA 1KH5A 1AJDA 3IGZB 5EGHA 4KAVA 4FDIA 3OT9A 3SZZA 1SHNA 3NKMA 4ZG6A 2W5TA 5DLTA 1E3CP 4GTXA 4LR7A 3MK1A 4LRAA 2GA3A 1P49A 2D1GA 3M8ZA 1ED9A 2X98A 2QZUA 4UPKA 1ALJA 3TWZA 3E2DA 4KJGA 4UOOA 1AJAA 1ANIA 3NKQA 4CXKA 3IGYB 3Q3QA 5GOVA 1EI6A 1FSUA 2RH6A 4KJDA 4ZG7A 1ELZA 1EJJA 1URBA 1ALKA 2VQRA 2W5RA 5AJ9A 3NVLA 3A52A 2W5SA 1N2LA 2W8DA 3TX0A 4ZG9A 1KHNA 1B8JA 4MHXA 4UOPA 5L0BA 1E1ZP 3UNYA 3KD8A 5DLWA 4ZGAA 4GTZA 5LRMA 5L0KA 3BDHA 2W5VA 3M7VA 3T00A 1HQAA 1KHKA 3T01A 3WAYA 4CXUA 1KH7A 4GTWA 4QAXA 1ALIA 2GSNA 2IUCB 1AJCA 1ZEBA 2GSOA 5LIAA 4UPHA 1EW9A 3WAXA 3ED4A 1KH9A 3UN3A 2XR9A 4MIVA 2ZKTA 1ANJA 3NKPA 1Y6VA 5EGEA 3UN5A 1URAA 1EQJA 1O98A 3M8YA 3WAWA 1KH4A 5KXAA 2W5XA 1O99A 2W8SA 3NKNA 3MK0A 3BDGA 4LQYA 3DYCA 2GSUA 3BDGB 1N2KA 2GLQA 4MY4A 5GRRA 5HRTA 3CMRA 3NKRA 2G9YA 1KHJA 2W5QA 4LRFA 3LXQA 2IUCA 3B5QA
chains in the Genus database with same CATH superfamily
4FDJA 1ELXA 4LRDA 3WBHA 4KAYA 3DPCA 4LR2A 1KHLA 4LREA 3IDDA 5L0EA 5IJQA 1HJKA 4NWXA 5TJ3A 4UPLA 4LR8A 3BDFA 5C66A 5INHA 1ELYA 1EW2A 1HDHA 4B56A 1Y7AA 4LR9A 1E33P 1AJBA 1SHQA 3SZYA 1K7HA 2W5WA 3UN2A 3NKOA 1ED8A 1EW8A 4GTYA 2IFYA 4N7TA 3WAVA 4NWJA 1ZEFA 3M8WA 5LRNA 1ALHA 5K4PA 1AUKA 3TG0A 4UPIA 4CYRA 4CXSA 2ANHA 4CYSA 3T02A 4UORA 4YR1A 4LRCA 3UO0A 5LQQA 1E2SP 4LRBA 3MK2A 4TN0A 5IJSA 1ZEDA 4KM4A 5DLVA 2XRGA 1KH5A 1AJDA 3IGZB 5EGHA 4KAVA 4FDIA 3OT9A 3SZZA 1SHNA 3NKMA 4ZG6A 2W5TA 5DLTA 1E3CP 4GTXA 4LR7A 3MK1A 4LRAA 2GA3A 1P49A 2D1GA 3M8ZA 1ED9A 2X98A 2QZUA 4UPKA 1ALJA 3TWZA 3E2DA 4KJGA 4UOOA 1AJAA 1ANIA 3NKQA 4CXKA 3IGYB 3Q3QA 5GOVA 1EI6A 1FSUA 2RH6A 4KJDA 4ZG7A 1ELZA 1EJJA 1URBA 1ALKA 2VQRA 2W5RA 5AJ9A 3NVLA 3A52A 2W5SA 1N2LA 2W8DA 3TX0A 4ZG9A 1KHNA 1B8JA 4MHXA 4UOPA 5L0BA 1E1ZP 3UNYA 3KD8A 5DLWA 4ZGAA 4GTZA 5LRMA 5L0KA 3BDHA 2W5VA 3M7VA 3T00A 1HQAA 1KHKA 3T01A 3WAYA 4CXUA 1KH7A 4GTWA 4QAXA 1ALIA 2GSNA 2IUCB 1AJCA 1ZEBA 2GSOA 5LIAA 4UPHA 1EW9A 3WAXA 3ED4A 1KH9A 3UN3A 2XR9A 4MIVA 2ZKTA 1ANJA 3NKPA 1Y6VA 5EGEA 3UN5A 1URAA 1EQJA 1O98A 3M8YA 3WAWA 1KH4A 5KXAA 2W5XA 1O99A 2W8SA 3NKNA 3MK0A 3BDGA 4LQYA 3DYCA 2GSUA 3BDGB 1N2KA 2GLQA 4MY4A 5GRRA 5HRTA 3CMRA 3NKRA 2G9YA 1KHJA 2W5QA 4LRFA 3LXQA 2IUCA 3B5QA
chains in the Genus database with same CATH topology
4FDJA 1ELXA 4LRDA 3WBHA 4KAYA 3DPCA 4LR2A 1KHLA 4LREA 3IDDA 5L0EA 5IJQA 1HJKA 4NWXA 5TJ3A 4UPLA 4LR8A 3BDFA 5C66A 5INHA 1ELYA 1EW2A 1HDHA 4B56A 1Y7AA 4LR9A 1E33P 1AJBA 1SHQA 3SZYA 1K7HA 2W5WA 3UN2A 3NKOA 1ED8A 1EW8A 4GTYA 2IFYA 4N7TA 3WAVA 4NWJA 1ZEFA 3M8WA 5LRNA 1ALHA 5K4PA 1AUKA 3TG0A 4UPIA 4CYRA 4CXSA 2ANHA 4CYSA 3T02A 4UORA 4YR1A 4LRCA 3UO0A 5LQQA 1E2SP 4LRBA 3MK2A 4TN0A 5IJSA 1ZEDA 4KM4A 5DLVA 2XRGA 1KH5A 1AJDA 3IGZB 5EGHA 4KAVA 4FDIA 3OT9A 3SZZA 1SHNA 3NKMA 4ZG6A 2W5TA 5DLTA 1E3CP 4GTXA 4LR7A 3MK1A 4LRAA 2GA3A 1P49A 2D1GA 3M8ZA 1ED9A 2X98A 2QZUA 4UPKA 1ALJA 3TWZA 3E2DA 4KJGA 4UOOA 1AJAA 1ANIA 3NKQA 4CXKA 3IGYB 3Q3QA 5GOVA 1EI6A 1FSUA 2RH6A 4KJDA 4ZG7A 1ELZA 1EJJA 1URBA 1ALKA 2VQRA 2W5RA 5AJ9A 3NVLA 3A52A 2W5SA 1N2LA 2W8DA 3TX0A 4ZG9A 1KHNA 1B8JA 4MHXA 4UOPA 5L0BA 1E1ZP 3UNYA 3KD8A 5DLWA 4ZGAA 4GTZA 5LRMA 5L0KA 3BDHA 2W5VA 3M7VA 3T00A 1HQAA 1KHKA 3T01A 3WAYA 4CXUA 1KH7A 4GTWA 4QAXA 1ALIA 2GSNA 2IUCB 1AJCA 1ZEBA 2GSOA 5LIAA 4UPHA 1EW9A 3WAXA 3ED4A 1KH9A 3UN3A 2XR9A 4MIVA 2ZKTA 1ANJA 3NKPA 1Y6VA 5EGEA 3UN5A 1URAA 1EQJA 1O98A 3M8YA 3WAWA 1KH4A 5KXAA 2W5XA 1O99A 2W8SA 3NKNA 3MK0A 3BDGA 4LQYA 3DYCA 2GSUA 3BDGB 1N2KA 2GLQA 4MY4A 5GRRA 5HRTA 3CMRA 3NKRA 2G9YA 1KHJA 2W5QA 4LRFA 3LXQA 2IUCA 3B5QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FDJ A;  1ELX A;  4LRD A;  3WBH A;  4KAY A;  3DPC A;  4LR2 A;  1KHL A;  4LRE A;  3IDD A;  5L0E A;  5IJQ A;  1HJK A;  4NWX A;  5TJ3 A;  4UPL A;  4LR8 A;  3BDF A;  5C66 A;  5INH A;  1ELY A;  1EW2 A;  1HDH A;  4B56 A;  1Y7A A;  4LR9 A;  1E33 P;  1AJB A;  1SHQ A;  3SZY A;  1K7H A;  2W5W A;  3UN2 A;  3NKO A;  1ED8 A;  1EW8 A;  4GTY A;  2IFY A;  4N7T A;  3WAV A;  4NWJ A;  1ZEF A;  3M8W A;  5LRN A;  1ALH A;  5K4P A;  1AUK A;  3TG0 A;  4UPI A;  4CYR A;  4CXS A;  2ANH A;  4CYS A;  3T02 A;  4UOR A;  4YR1 A;  4LRC A;  3UO0 A;  5LQQ A;  1E2S P;  4LRB A;  3MK2 A;  4TN0 A;  5IJS A;  1ZED A;  4KM4 A;  5DLV A;  2XRG A;  1KH5 A;  1AJD A;  3IGZ B;  5EGH A;  4KAV A;  4FDI A;  3OT9 A;  3SZZ A;  1SHN A;  3NKM A;  4ZG6 A;  2W5T A;  5DLT A;  1E3C P;  4GTX A;  4LR7 A;  3MK1 A;  4LRA A;  2GA3 A;  1P49 A;  2D1G A;  3M8Z A;  1ED9 A;  2X98 A;  2QZU A;  4UPK A;  1ALJ A;  3TWZ A;  3E2D A;  4KJG A;  4UOO A;  1AJA A;  1ANI A;  3NKQ A;  4CXK A;  3IGY B;  3Q3Q A;  5GOV A;  1EI6 A;  1FSU A;  2RH6 A;  4KJD A;  4ZG7 A;  1ELZ A;  1EJJ A;  1URB A;  1ALK A;  2VQR A;  2W5R A;  5AJ9 A;  3NVL A;  3A52 A;  2W5S A;  1N2L A;  2W8D A;  3TX0 A;  4ZG9 A;  1KHN A;  1B8J A;  4MHX A;  4UOP A;  5L0B A;  1E1Z P;  3UNY A;  3KD8 A;  5DLW A;  4ZGA A;  4GTZ A;  5LRM A;  5L0K A;  3BDH A;  2W5V A;  3M7V A;  3T00 A;  1HQA A;  1KHK A;  3T01 A;  3WAY A;  4CXU A;  1KH7 A;  4GTW A;  4QAX A;  1ALI A;  2GSN A;  2IUC B;  1AJC A;  1ZEB A;  2GSO A;  5LIA A;  4UPH A;  1EW9 A;  3WAX A;  3ED4 A;  1KH9 A;  3UN3 A;  2XR9 A;  4MIV A;  2ZKT A;  1ANJ A;  3NKP A;  1Y6V A;  5EGE A;  3UN5 A;  1URA A;  1EQJ A;  1O98 A;  3M8Y A;  3WAW A;  1KH4 A;  5KXA A;  2W5X A;  1O99 A;  2W8S A;  3NKN A;  3MK0 A;  3BDG A;  4LQY A;  3DYC A;  2GSU A;  3BDG B;  1N2K A;  2GLQ A;  4MY4 A;  5GRR A;  5HRT A;  3CMR A;  3NKR A;  2G9Y A;  1KHJ A;  2W5Q A;  4LRF A;  3LXQ A;  2IUC A;  3B5Q A; 
#chains in the Genus database with same CATH topology
 4FDJ A;  1ELX A;  4LRD A;  3WBH A;  4KAY A;  3DPC A;  4LR2 A;  1KHL A;  4LRE A;  3IDD A;  5L0E A;  5IJQ A;  1HJK A;  4NWX A;  5TJ3 A;  4UPL A;  4LR8 A;  3BDF A;  5C66 A;  5INH A;  1ELY A;  1EW2 A;  1HDH A;  4B56 A;  1Y7A A;  4LR9 A;  1E33 P;  1AJB A;  1SHQ A;  3SZY A;  1K7H A;  2W5W A;  3UN2 A;  3NKO A;  1ED8 A;  1EW8 A;  4GTY A;  2IFY A;  4N7T A;  3WAV A;  4NWJ A;  1ZEF A;  3M8W A;  5LRN A;  1ALH A;  5K4P A;  1AUK A;  3TG0 A;  4UPI A;  4CYR A;  4CXS A;  2ANH A;  4CYS A;  3T02 A;  4UOR A;  4YR1 A;  4LRC A;  3UO0 A;  5LQQ A;  1E2S P;  4LRB A;  3MK2 A;  4TN0 A;  5IJS A;  1ZED A;  4KM4 A;  5DLV A;  2XRG A;  1KH5 A;  1AJD A;  3IGZ B;  5EGH A;  4KAV A;  4FDI A;  3OT9 A;  3SZZ A;  1SHN A;  3NKM A;  4ZG6 A;  2W5T A;  5DLT A;  1E3C P;  4GTX A;  4LR7 A;  3MK1 A;  4LRA A;  2GA3 A;  1P49 A;  2D1G A;  3M8Z A;  1ED9 A;  2X98 A;  2QZU A;  4UPK A;  1ALJ A;  3TWZ A;  3E2D A;  4KJG A;  4UOO A;  1AJA A;  1ANI A;  3NKQ A;  4CXK A;  3IGY B;  3Q3Q A;  5GOV A;  1EI6 A;  1FSU A;  2RH6 A;  4KJD A;  4ZG7 A;  1ELZ A;  1EJJ A;  1URB A;  1ALK A;  2VQR A;  2W5R A;  5AJ9 A;  3NVL A;  3A52 A;  2W5S A;  1N2L A;  2W8D A;  3TX0 A;  4ZG9 A;  1KHN A;  1B8J A;  4MHX A;  4UOP A;  5L0B A;  1E1Z P;  3UNY A;  3KD8 A;  5DLW A;  4ZGA A;  4GTZ A;  5LRM A;  5L0K A;  3BDH A;  2W5V A;  3M7V A;  3T00 A;  1HQA A;  1KHK A;  3T01 A;  3WAY A;  4CXU A;  1KH7 A;  4GTW A;  4QAX A;  1ALI A;  2GSN A;  2IUC B;  1AJC A;  1ZEB A;  2GSO A;  5LIA A;  4UPH A;  1EW9 A;  3WAX A;  3ED4 A;  1KH9 A;  3UN3 A;  2XR9 A;  4MIV A;  2ZKT A;  1ANJ A;  3NKP A;  1Y6V A;  5EGE A;  3UN5 A;  1URA A;  1EQJ A;  1O98 A;  3M8Y A;  3WAW A;  1KH4 A;  5KXA A;  2W5X A;  1O99 A;  2W8S A;  3NKN A;  3MK0 A;  3BDG A;  4LQY A;  3DYC A;  2GSU A;  3BDG B;  1N2K A;  2GLQ A;  4MY4 A;  5GRR A;  5HRT A;  3CMR A;  3NKR A;  2G9Y A;  1KHJ A;  2W5Q A;  4LRF A;  3LXQ A;  2IUC A;  3B5Q A; 
#chains in the Genus database with same CATH homology
 4FDJ A;  1ELX A;  4LRD A;  3WBH A;  4KAY A;  3DPC A;  4LR2 A;  1KHL A;  4LRE A;  3IDD A;  5L0E A;  5IJQ A;  1HJK A;  4NWX A;  5TJ3 A;  4UPL A;  4LR8 A;  3BDF A;  5C66 A;  5INH A;  1ELY A;  1EW2 A;  1HDH A;  4B56 A;  1Y7A A;  4LR9 A;  1E33 P;  1AJB A;  1SHQ A;  3SZY A;  1K7H A;  2W5W A;  3UN2 A;  3NKO A;  1ED8 A;  1EW8 A;  4GTY A;  2IFY A;  4N7T A;  3WAV A;  4NWJ A;  1ZEF A;  3M8W A;  5LRN A;  1ALH A;  5K4P A;  1AUK A;  3TG0 A;  4UPI A;  4CYR A;  4CXS A;  2ANH A;  4CYS A;  3T02 A;  4UOR A;  4YR1 A;  4LRC A;  3UO0 A;  5LQQ A;  1E2S P;  4LRB A;  3MK2 A;  4TN0 A;  5IJS A;  1ZED A;  4KM4 A;  5DLV A;  2XRG A;  1KH5 A;  1AJD A;  3IGZ B;  5EGH A;  4KAV A;  4FDI A;  3OT9 A;  3SZZ A;  1SHN A;  3NKM A;  4ZG6 A;  2W5T A;  5DLT A;  1E3C P;  4GTX A;  4LR7 A;  3MK1 A;  4LRA A;  2GA3 A;  1P49 A;  2D1G A;  3M8Z A;  1ED9 A;  2X98 A;  2QZU A;  4UPK A;  1ALJ A;  3TWZ A;  3E2D A;  4KJG A;  4UOO A;  1AJA A;  1ANI A;  3NKQ A;  4CXK A;  3IGY B;  3Q3Q A;  5GOV A;  1EI6 A;  1FSU A;  2RH6 A;  4KJD A;  4ZG7 A;  1ELZ A;  1EJJ A;  1URB A;  1ALK A;  2VQR A;  2W5R A;  5AJ9 A;  3NVL A;  3A52 A;  2W5S A;  1N2L A;  2W8D A;  3TX0 A;  4ZG9 A;  1KHN A;  1B8J A;  4MHX A;  4UOP A;  5L0B A;  1E1Z P;  3UNY A;  3KD8 A;  5DLW A;  4ZGA A;  4GTZ A;  5LRM A;  5L0K A;  3BDH A;  2W5V A;  3M7V A;  3T00 A;  1HQA A;  1KHK A;  3T01 A;  3WAY A;  4CXU A;  1KH7 A;  4GTW A;  4QAX A;  1ALI A;  2GSN A;  2IUC B;  1AJC A;  1ZEB A;  2GSO A;  5LIA A;  4UPH A;  1EW9 A;  3WAX A;  3ED4 A;  1KH9 A;  3UN3 A;  2XR9 A;  4MIV A;  2ZKT A;  1ANJ A;  3NKP A;  1Y6V A;  5EGE A;  3UN5 A;  1URA A;  1EQJ A;  1O98 A;  3M8Y A;  3WAW A;  1KH4 A;  5KXA A;  2W5X A;  1O99 A;  2W8S A;  3NKN A;  3MK0 A;  3BDG A;  4LQY A;  3DYC A;  2GSU A;  3BDG B;  1N2K A;  2GLQ A;  4MY4 A;  5GRR A;  5HRT A;  3CMR A;  3NKR A;  2G9Y A;  1KHJ A;  2W5Q A;  4LRF A;  3LXQ A;  2IUC A;  3B5Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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