1KHJ | Genus

Total Genus 156

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	156
Knots found	KnotProt 2.0: S +3₁
sequence length	444
structure length	444
Chain Sequence	VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Escherichia coli
publication title	Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. pubmed doi rcsb
molecule keywords	Alkaline phosphatase
total genus	156
structure length	444
sequence length	444
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2001-11-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1khjA00

4FDJA 2W5RA 2ANHA 1KH4A 5LIAA 4KM4A 1E1ZP 1URBA 3M8WA 3NKOA 5LRMA 1HJKA 3DPCA 3UN2A 3WAYA 4LR9A 1URAA 1N2KA 4QAXA 2GLQA 4CXSA 1E3CP 4MIVA 1KHLA 5AJ9A 3UN3A 3TX0A 4UPHA 1E2SP 1AJDA 5GRRA 1KH9A 5IJQA 4LQYA 2IFYA 2W5SA 4CYSA 4LRAA 3B5QA 5EGHA 5DLVA 2GSOA 4LRFA 1K7HA 2W8SA 3WBHA 1AJBA 2IUCA 1ELXA 3LXQA 3M8YA 3SZZA 1ED9A 3A52A 4KAYA 3NKNA 3T00A 3BDFA 4KJGA 5DLTA 3BDGB 1FSUA 3NVLA 2G9YA 1EW2A 2XR9A 4N7TA 4GTZA 4ZG6A 1EJJA 3MK2A 1KH7A 1KHKA 1KH5A 2W5QA 2W8DA 2IUCB 3CMRA 4CYRA 3NKQA 1SHNA 3E2DA 1ALJA 1AUKA 1ED8A 4KJDA 1ELZA 1P49A 4LR2A 4YR1A 5TJ3A 4MHXA 1ALKA 1AJCA 4FDIA 1O98A 3OT9A 4ZG9A 4ZG7A 4UOPA 3KD8A 1KHNA 3NKRA 3SZYA 4LR7A 5INHA 2QZUA 1ZEBA 4CXKA 3IGZB 1SHQA 1ALIA 3NKMA 2XRGA 4GTWA 2VQRA 2ZKTA 4TN0A 3ED4A 2RH6A 4B56A 3IGYB 3T01A 4NWJA 4LREA 1Y7AA 3MK0A 5EGEA 3Q3QA 4LRDA 1EW9A 1ZEFA 5DLWA 3BDHA 4UPIA 1ELYA 5L0KA 1O99A 5IJSA 1EI6A 1HQAA 1AJAA 3TWZA 3UO0A 2W5VA 3DYCA 5KXAA 3TG0A 4UPKA 2W5TA 4GTXA 4LRCA 2GA3A 5C66A 1ALHA 3T02A 3WAVA 3NKPA 3MK1A 3IDDA 1B8JA 2W5XA 1Y6VA 4LRBA 5K4PA 5HRTA 5LRNA 2D1GA 1HDHA 1ANJA 2GSUA 4GTYA 3UN5A 1ZEDA 4UPLA 4LR8A 1KHJA 1E33P 4CXUA 3WAWA 4ZGAA 3WAXA 3BDGA 4UOOA 2W5WA 3UNYA 5L0EA 5LQQA 3M8ZA 2GSNA 2X98A 4NWXA 4UORA 1ANIA 1N2LA 3M7VA 5GOVA 1EQJA 5L0BA 1EW8A 4KAVA 4MY4A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4FDJ A;  2W5R A;  2ANH A;  1KH4 A;  5LIA A;  4KM4 A;  1E1Z P;  1URB A;  3M8W A;  3NKO A;  5LRM A;  1HJK A;  3DPC A;  3UN2 A;  3WAY A;  4LR9 A;  1URA A;  1N2K A;  4QAX A;  2GLQ A;  4CXS A;  1E3C P;  4MIV A;  1KHL A;  5AJ9 A;  3UN3 A;  3TX0 A;  4UPH A;  1E2S P;  1AJD A;  5GRR A;  1KH9 A;  5IJQ A;  4LQY A;  2IFY A;  2W5S A;  4CYS A;  4LRA A;  3B5Q A;  5EGH A;  5DLV A;  2GSO A;  4LRF A;  1K7H A;  2W8S A;  3WBH A;  1AJB A;  2IUC A;  1ELX A;  3LXQ A;  3M8Y A;  3SZZ A;  1ED9 A;  3A52 A;  4KAY A;  3NKN A;  3T00 A;  3BDF A;  4KJG A;  5DLT A;  3BDG B;  1FSU A;  3NVL A;  2G9Y A;  1EW2 A;  2XR9 A;  4N7T A;  4GTZ A;  4ZG6 A;  1EJJ A;  3MK2 A;  1KH7 A;  1KHK A;  1KH5 A;  2W5Q A;  2W8D A;  2IUC B;  3CMR A;  4CYR A;  3NKQ A;  1SHN A;  3E2D A;  1ALJ A;  1AUK A;  1ED8 A;  4KJD A;  1ELZ A;  1P49 A;  4LR2 A;  4YR1 A;  5TJ3 A;  4MHX A;  1ALK A;  1AJC A;  4FDI A;  1O98 A;  3OT9 A;  4ZG9 A;  4ZG7 A;  4UOP A;  3KD8 A;  1KHN A;  3NKR A;  3SZY A;  4LR7 A;  5INH A;  2QZU A;  1ZEB A;  4CXK A;  3IGZ B;  1SHQ A;  1ALI A;  3NKM A;  2XRG A;  4GTW A;  2VQR A;  2ZKT A;  4TN0 A;  3ED4 A;  2RH6 A;  4B56 A;  3IGY B;  3T01 A;  4NWJ A;  4LRE A;  1Y7A A;  3MK0 A;  5EGE A;  3Q3Q A;  4LRD A;  1EW9 A;  1ZEF A;  5DLW A;  3BDH A;  4UPI A;  1ELY A;  5L0K A;  1O99 A;  5IJS A;  1EI6 A;  1HQA A;  1AJA A;  3TWZ A;  3UO0 A;  2W5V A;  3DYC A;  5KXA A;  3TG0 A;  4UPK A;  2W5T A;  4GTX A;  4LRC A;  2GA3 A;  5C66 A;  1ALH A;  3T02 A;  3WAV A;  3NKP A;  3MK1 A;  3IDD A;  1B8J A;  2W5X A;  1Y6V A;  4LRB A;  5K4P A;  5HRT A;  5LRN A;  2D1G A;  1HDH A;  1ANJ A;  2GSU A;  4GTY A;  3UN5 A;  1ZED A;  4UPL A;  4LR8 A;  1KHJ A;  1E33 P;  4CXU A;  3WAW A;  4ZGA A;  3WAX A;  3BDG A;  4UOO A;  2W5W A;  3UNY A;  5L0E A;  5LQQ A;  3M8Z A;  2GSN A;  2X98 A;  4NWX A;  4UOR A;  1ANI A;  1N2L A;  3M7V A;  5GOV A;  1EQJ A;  5L0B A;  1EW8 A;  4KAV A;  4MY4 A; 
#chains in the Genus database with same CATH topology
 4FDJ A;  2W5R A;  2ANH A;  1KH4 A;  5LIA A;  4KM4 A;  1E1Z P;  1URB A;  3M8W A;  3NKO A;  5LRM A;  1HJK A;  3DPC A;  3UN2 A;  3WAY A;  4LR9 A;  1URA A;  1N2K A;  4QAX A;  2GLQ A;  4CXS A;  1E3C P;  4MIV A;  1KHL A;  5AJ9 A;  3UN3 A;  3TX0 A;  4UPH A;  1E2S P;  1AJD A;  5GRR A;  1KH9 A;  5IJQ A;  4LQY A;  2IFY A;  2W5S A;  4CYS A;  4LRA A;  3B5Q A;  5EGH A;  5DLV A;  2GSO A;  4LRF A;  1K7H A;  2W8S A;  3WBH A;  1AJB A;  2IUC A;  1ELX A;  3LXQ A;  3M8Y A;  3SZZ A;  1ED9 A;  3A52 A;  4KAY A;  3NKN A;  3T00 A;  3BDF A;  4KJG A;  5DLT A;  3BDG B;  1FSU A;  3NVL A;  2G9Y A;  1EW2 A;  2XR9 A;  4N7T A;  4GTZ A;  4ZG6 A;  1EJJ A;  3MK2 A;  1KH7 A;  1KHK A;  1KH5 A;  2W5Q A;  2W8D A;  2IUC B;  3CMR A;  4CYR A;  3NKQ A;  1SHN A;  3E2D A;  1ALJ A;  1AUK A;  1ED8 A;  4KJD A;  1ELZ A;  1P49 A;  4LR2 A;  4YR1 A;  5TJ3 A;  4MHX A;  1ALK A;  1AJC A;  4FDI A;  1O98 A;  3OT9 A;  4ZG9 A;  4ZG7 A;  4UOP A;  3KD8 A;  1KHN A;  3NKR A;  3SZY A;  4LR7 A;  5INH A;  2QZU A;  1ZEB A;  4CXK A;  3IGZ B;  1SHQ A;  1ALI A;  3NKM A;  2XRG A;  4GTW A;  2VQR A;  2ZKT A;  4TN0 A;  3ED4 A;  2RH6 A;  4B56 A;  3IGY B;  3T01 A;  4NWJ A;  4LRE A;  1Y7A A;  3MK0 A;  5EGE A;  3Q3Q A;  4LRD A;  1EW9 A;  1ZEF A;  5DLW A;  3BDH A;  4UPI A;  1ELY A;  5L0K A;  1O99 A;  5IJS A;  1EI6 A;  1HQA A;  1AJA A;  3TWZ A;  3UO0 A;  2W5V A;  3DYC A;  5KXA A;  3TG0 A;  4UPK A;  2W5T A;  4GTX A;  4LRC A;  2GA3 A;  5C66 A;  1ALH A;  3T02 A;  3WAV A;  3NKP A;  3MK1 A;  3IDD A;  1B8J A;  2W5X A;  1Y6V A;  4LRB A;  5K4P A;  5HRT A;  5LRN A;  2D1G A;  1HDH A;  1ANJ A;  2GSU A;  4GTY A;  3UN5 A;  1ZED A;  4UPL A;  4LR8 A;  1KHJ A;  1E33 P;  4CXU A;  3WAW A;  4ZGA A;  3WAX A;  3BDG A;  4UOO A;  2W5W A;  3UNY A;  5L0E A;  5LQQ A;  3M8Z A;  2GSN A;  2X98 A;  4NWX A;  4UOR A;  1ANI A;  1N2L A;  3M7V A;  5GOV A;  1EQJ A;  5L0B A;  1EW8 A;  4KAV A;  4MY4 A; 
#chains in the Genus database with same CATH homology
 4FDJ A;  2W5R A;  2ANH A;  1KH4 A;  5LIA A;  4KM4 A;  1E1Z P;  1URB A;  3M8W A;  3NKO A;  5LRM A;  1HJK A;  3DPC A;  3UN2 A;  3WAY A;  4LR9 A;  1URA A;  1N2K A;  4QAX A;  2GLQ A;  4CXS A;  1E3C P;  4MIV A;  1KHL A;  5AJ9 A;  3UN3 A;  3TX0 A;  4UPH A;  1E2S P;  1AJD A;  5GRR A;  1KH9 A;  5IJQ A;  4LQY A;  2IFY A;  2W5S A;  4CYS A;  4LRA A;  3B5Q A;  5EGH A;  5DLV A;  2GSO A;  4LRF A;  1K7H A;  2W8S A;  3WBH A;  1AJB A;  2IUC A;  1ELX A;  3LXQ A;  3M8Y A;  3SZZ A;  1ED9 A;  3A52 A;  4KAY A;  3NKN A;  3T00 A;  3BDF A;  4KJG A;  5DLT A;  3BDG B;  1FSU A;  3NVL A;  2G9Y A;  1EW2 A;  2XR9 A;  4N7T A;  4GTZ A;  4ZG6 A;  1EJJ A;  3MK2 A;  1KH7 A;  1KHK A;  1KH5 A;  2W5Q A;  2W8D A;  2IUC B;  3CMR A;  4CYR A;  3NKQ A;  1SHN A;  3E2D A;  1ALJ A;  1AUK A;  1ED8 A;  4KJD A;  1ELZ A;  1P49 A;  4LR2 A;  4YR1 A;  5TJ3 A;  4MHX A;  1ALK A;  1AJC A;  4FDI A;  1O98 A;  3OT9 A;  4ZG9 A;  4ZG7 A;  4UOP A;  3KD8 A;  1KHN A;  3NKR A;  3SZY A;  4LR7 A;  5INH A;  2QZU A;  1ZEB A;  4CXK A;  3IGZ B;  1SHQ A;  1ALI A;  3NKM A;  2XRG A;  4GTW A;  2VQR A;  2ZKT A;  4TN0 A;  3ED4 A;  2RH6 A;  4B56 A;  3IGY B;  3T01 A;  4NWJ A;  4LRE A;  1Y7A A;  3MK0 A;  5EGE A;  3Q3Q A;  4LRD A;  1EW9 A;  1ZEF A;  5DLW A;  3BDH A;  4UPI A;  1ELY A;  5L0K A;  1O99 A;  5IJS A;  1EI6 A;  1HQA A;  1AJA A;  3TWZ A;  3UO0 A;  2W5V A;  3DYC A;  5KXA A;  3TG0 A;  4UPK A;  2W5T A;  4GTX A;  4LRC A;  2GA3 A;  5C66 A;  1ALH A;  3T02 A;  3WAV A;  3NKP A;  3MK1 A;  3IDD A;  1B8J A;  2W5X A;  1Y6V A;  4LRB A;  5K4P A;  5HRT A;  5LRN A;  2D1G A;  1HDH A;  1ANJ A;  2GSU A;  4GTY A;  3UN5 A;  1ZED A;  4UPL A;  4LR8 A;  1KHJ A;  1E33 P;  4CXU A;  3WAW A;  4ZGA A;  3WAX A;  3BDG A;  4UOO A;  2W5W A;  3UNY A;  5L0E A;  5LQQ A;  3M8Z A;  2GSN A;  2X98 A;  4NWX A;  4UOR A;  1ANI A;  1N2L A;  3M7V A;  5GOV A;  1EQJ A;  5L0B A;  1EW8 A;  4KAV A;  4MY4 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1KHJA

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations