1URAA

Alkaline phosphatase (d51zn)
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGNGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Alkaline phosphatase
source organism Escherichia coli
publication title Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
total genus 160
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1996-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1uraA00
5K4PA 1ANIA 5AJ9A 4KM4A 1EW2A 2RH6A 4LR8A 5DLVA 3B5QA 3OT9A 1ALHA 1E1ZP 1KHLA 1SHQA 4GTWA 4TN0A 3IGZB 2XRGA 4ZG7A 3DYCA 4KJDA 2W5VA 4CYRA 3UNYA 5IJQA 2W5RA 4NWJA 1FSUA 3UN3A 1ALJA 1ZEFA 4FDIA 4LRFA 1ZEDA 3NKRA 4CXKA 1AJCA 1KH9A 3NKPA 1KHNA 3Q3QA 3UN2A 3NKOA 2GSNA 5DLTA 4ZG9A 4MHXA 5L0EA 1ZEBA 4ZGAA 4LRDA 3MK1A 1KH5A 2ZKTA 1ELXA 1AJDA 1EQJA 1HQAA 1B8JA 4LRCA 5HRTA 3WAVA 2GLQA 1N2LA 4B56A 1AJAA 1KHKA 2VQRA 2IFYA 5LQQA 2W5SA 2GSOA 4N7TA 1E33P 3NKMA 4FDJA 5INHA 4LR7A 1ED9A 1EW9A 2IUCB 3KD8A 4GTYA 3BDGB 3DPCA 2W5QA 5KXAA 4CXUA 3BDFA 1K7HA 3T01A 1Y6VA 3M8YA 5DLWA 1ED8A 3T00A 1EW8A 5L0BA 2D1GA 5LRNA 1ELYA 3A52A 3SZZA 5C66A 4LR9A 3BDHA 5L0KA 1EI6A 3NKNA 1KH7A 1O99A 5EGHA 4KAYA 5IJSA 3WAYA 2QZUA 1ANJA 1N2KA 1URBA 4LQYA 4LRAA 3SZYA 3MK2A 3M7VA 2W8DA 2W8SA 3CMRA 2X98A 3ED4A 4MIVA 4CXSA 2IUCA 3TWZA 1SHNA 4UPHA 3WBHA 1ALKA 1HDHA 3BDGA 3WAXA 1AJBA 5LRMA 2W5TA 3TG0A 1ALIA 1AUKA 1P49A 2GSUA 2ANHA 2W5WA 3LXQA 4QAXA 4LR2A 4MY4A 4UOPA 4GTZA 4ZG6A 4KJGA 5GOVA 3UN5A 3UO0A 1KH4A 2XR9A 2G9YA 3TX0A 1HJKA 3WAWA 3IGYB 4UPIA 1O98A 1Y7AA 2GA3A 4UOOA 1E3CP 4LRBA 3M8ZA 5TJ3A 3E2DA 3NKQA 3NVLA 4LREA 4KAVA 1URAA 1EJJA 1KHJA 4NWXA 4UORA 5GRRA 4GTXA 3M8WA 3MK0A 4CYSA 5EGEA 2W5XA 4YR1A 5LIAA 1ELZA 4UPLA 3T02A 3IDDA 1E2SP 4UPKA
chains in the Genus database with same CATH superfamily
5K4PA 1ANIA 5AJ9A 4KM4A 1EW2A 2RH6A 4LR8A 5DLVA 3B5QA 3OT9A 1ALHA 1E1ZP 1KHLA 1SHQA 4GTWA 4TN0A 3IGZB 2XRGA 4ZG7A 3DYCA 4KJDA 2W5VA 4CYRA 3UNYA 5IJQA 2W5RA 4NWJA 1FSUA 3UN3A 1ALJA 1ZEFA 4FDIA 4LRFA 1ZEDA 3NKRA 4CXKA 1AJCA 1KH9A 3NKPA 1KHNA 3Q3QA 3UN2A 3NKOA 2GSNA 5DLTA 4ZG9A 4MHXA 5L0EA 1ZEBA 4ZGAA 4LRDA 3MK1A 1KH5A 2ZKTA 1ELXA 1AJDA 1EQJA 1HQAA 1B8JA 4LRCA 5HRTA 3WAVA 2GLQA 1N2LA 4B56A 1AJAA 1KHKA 2VQRA 2IFYA 5LQQA 2W5SA 2GSOA 4N7TA 1E33P 3NKMA 4FDJA 5INHA 4LR7A 1ED9A 1EW9A 2IUCB 3KD8A 4GTYA 3BDGB 3DPCA 2W5QA 5KXAA 4CXUA 3BDFA 1K7HA 3T01A 1Y6VA 3M8YA 5DLWA 1ED8A 3T00A 1EW8A 5L0BA 2D1GA 5LRNA 1ELYA 3A52A 3SZZA 5C66A 4LR9A 3BDHA 5L0KA 1EI6A 3NKNA 1KH7A 1O99A 5EGHA 4KAYA 5IJSA 3WAYA 2QZUA 1ANJA 1N2KA 1URBA 4LQYA 4LRAA 3SZYA 3MK2A 3M7VA 2W8DA 2W8SA 3CMRA 2X98A 3ED4A 4MIVA 4CXSA 2IUCA 3TWZA 1SHNA 4UPHA 3WBHA 1ALKA 1HDHA 3BDGA 3WAXA 1AJBA 5LRMA 2W5TA 3TG0A 1ALIA 1AUKA 1P49A 2GSUA 2ANHA 2W5WA 3LXQA 4QAXA 4LR2A 4MY4A 4UOPA 4GTZA 4ZG6A 4KJGA 5GOVA 3UN5A 3UO0A 1KH4A 2XR9A 2G9YA 3TX0A 1HJKA 3WAWA 3IGYB 4UPIA 1O98A 1Y7AA 2GA3A 4UOOA 1E3CP 4LRBA 3M8ZA 5TJ3A 3E2DA 3NKQA 3NVLA 4LREA 4KAVA 1URAA 1EJJA 1KHJA 4NWXA 4UORA 5GRRA 4GTXA 3M8WA 3MK0A 4CYSA 5EGEA 2W5XA 4YR1A 5LIAA 1ELZA 4UPLA 3T02A 3IDDA 1E2SP 4UPKA
chains in the Genus database with same CATH topology
5K4PA 1ANIA 5AJ9A 4KM4A 1EW2A 2RH6A 4LR8A 5DLVA 3B5QA 3OT9A 1ALHA 1E1ZP 1KHLA 1SHQA 4GTWA 4TN0A 3IGZB 2XRGA 4ZG7A 3DYCA 4KJDA 2W5VA 4CYRA 3UNYA 5IJQA 2W5RA 4NWJA 1FSUA 3UN3A 1ALJA 1ZEFA 4FDIA 4LRFA 1ZEDA 3NKRA 4CXKA 1AJCA 1KH9A 3NKPA 1KHNA 3Q3QA 3UN2A 3NKOA 2GSNA 5DLTA 4ZG9A 4MHXA 5L0EA 1ZEBA 4ZGAA 4LRDA 3MK1A 1KH5A 2ZKTA 1ELXA 1AJDA 1EQJA 1HQAA 1B8JA 4LRCA 5HRTA 3WAVA 2GLQA 1N2LA 4B56A 1AJAA 1KHKA 2VQRA 2IFYA 5LQQA 2W5SA 2GSOA 4N7TA 1E33P 3NKMA 4FDJA 5INHA 4LR7A 1ED9A 1EW9A 2IUCB 3KD8A 4GTYA 3BDGB 3DPCA 2W5QA 5KXAA 4CXUA 3BDFA 1K7HA 3T01A 1Y6VA 3M8YA 5DLWA 1ED8A 3T00A 1EW8A 5L0BA 2D1GA 5LRNA 1ELYA 3A52A 3SZZA 5C66A 4LR9A 3BDHA 5L0KA 1EI6A 3NKNA 1KH7A 1O99A 5EGHA 4KAYA 5IJSA 3WAYA 2QZUA 1ANJA 1N2KA 1URBA 4LQYA 4LRAA 3SZYA 3MK2A 3M7VA 2W8DA 2W8SA 3CMRA 2X98A 3ED4A 4MIVA 4CXSA 2IUCA 3TWZA 1SHNA 4UPHA 3WBHA 1ALKA 1HDHA 3BDGA 3WAXA 1AJBA 5LRMA 2W5TA 3TG0A 1ALIA 1AUKA 1P49A 2GSUA 2ANHA 2W5WA 3LXQA 4QAXA 4LR2A 4MY4A 4UOPA 4GTZA 4ZG6A 4KJGA 5GOVA 3UN5A 3UO0A 1KH4A 2XR9A 2G9YA 3TX0A 1HJKA 3WAWA 3IGYB 4UPIA 1O98A 1Y7AA 2GA3A 4UOOA 1E3CP 4LRBA 3M8ZA 5TJ3A 3E2DA 3NKQA 3NVLA 4LREA 4KAVA 1URAA 1EJJA 1KHJA 4NWXA 4UORA 5GRRA 4GTXA 3M8WA 3MK0A 4CYSA 5EGEA 2W5XA 4YR1A 5LIAA 1ELZA 4UPLA 3T02A 3IDDA 1E2SP 4UPKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5K4P A;  1ANI A;  5AJ9 A;  4KM4 A;  1EW2 A;  2RH6 A;  4LR8 A;  5DLV A;  3B5Q A;  3OT9 A;  1ALH A;  1E1Z P;  1KHL A;  1SHQ A;  4GTW A;  4TN0 A;  3IGZ B;  2XRG A;  4ZG7 A;  3DYC A;  4KJD A;  2W5V A;  4CYR A;  3UNY A;  5IJQ A;  2W5R A;  4NWJ A;  1FSU A;  3UN3 A;  1ALJ A;  1ZEF A;  4FDI A;  4LRF A;  1ZED A;  3NKR A;  4CXK A;  1AJC A;  1KH9 A;  3NKP A;  1KHN A;  3Q3Q A;  3UN2 A;  3NKO A;  2GSN A;  5DLT A;  4ZG9 A;  4MHX A;  5L0E A;  1ZEB A;  4ZGA A;  4LRD A;  3MK1 A;  1KH5 A;  2ZKT A;  1ELX A;  1AJD A;  1EQJ A;  1HQA A;  1B8J A;  4LRC A;  5HRT A;  3WAV A;  2GLQ A;  1N2L A;  4B56 A;  1AJA A;  1KHK A;  2VQR A;  2IFY A;  5LQQ A;  2W5S A;  2GSO A;  4N7T A;  1E33 P;  3NKM A;  4FDJ A;  5INH A;  4LR7 A;  1ED9 A;  1EW9 A;  2IUC B;  3KD8 A;  4GTY A;  3BDG B;  3DPC A;  2W5Q A;  5KXA A;  4CXU A;  3BDF A;  1K7H A;  3T01 A;  1Y6V A;  3M8Y A;  5DLW A;  1ED8 A;  3T00 A;  1EW8 A;  5L0B A;  2D1G A;  5LRN A;  1ELY A;  3A52 A;  3SZZ A;  5C66 A;  4LR9 A;  3BDH A;  5L0K A;  1EI6 A;  3NKN A;  1KH7 A;  1O99 A;  5EGH A;  4KAY A;  5IJS A;  3WAY A;  2QZU A;  1ANJ A;  1N2K A;  1URB A;  4LQY A;  4LRA A;  3SZY A;  3MK2 A;  3M7V A;  2W8D A;  2W8S A;  3CMR A;  2X98 A;  3ED4 A;  4MIV A;  4CXS A;  2IUC A;  3TWZ A;  1SHN A;  4UPH A;  3WBH A;  1ALK A;  1HDH A;  3BDG A;  3WAX A;  1AJB A;  5LRM A;  2W5T A;  3TG0 A;  1ALI A;  1AUK A;  1P49 A;  2GSU A;  2ANH A;  2W5W A;  3LXQ A;  4QAX A;  4LR2 A;  4MY4 A;  4UOP A;  4GTZ A;  4ZG6 A;  4KJG A;  5GOV A;  3UN5 A;  3UO0 A;  1KH4 A;  2XR9 A;  2G9Y A;  3TX0 A;  1HJK A;  3WAW A;  3IGY B;  4UPI A;  1O98 A;  1Y7A A;  2GA3 A;  4UOO A;  1E3C P;  4LRB A;  3M8Z A;  5TJ3 A;  3E2D A;  3NKQ A;  3NVL A;  4LRE A;  4KAV A;  1URA A;  1EJJ A;  1KHJ A;  4NWX A;  4UOR A;  5GRR A;  4GTX A;  3M8W A;  3MK0 A;  4CYS A;  5EGE A;  2W5X A;  4YR1 A;  5LIA A;  1ELZ A;  4UPL A;  3T02 A;  3IDD A;  1E2S P;  4UPK A; 
#chains in the Genus database with same CATH topology
 5K4P A;  1ANI A;  5AJ9 A;  4KM4 A;  1EW2 A;  2RH6 A;  4LR8 A;  5DLV A;  3B5Q A;  3OT9 A;  1ALH A;  1E1Z P;  1KHL A;  1SHQ A;  4GTW A;  4TN0 A;  3IGZ B;  2XRG A;  4ZG7 A;  3DYC A;  4KJD A;  2W5V A;  4CYR A;  3UNY A;  5IJQ A;  2W5R A;  4NWJ A;  1FSU A;  3UN3 A;  1ALJ A;  1ZEF A;  4FDI A;  4LRF A;  1ZED A;  3NKR A;  4CXK A;  1AJC A;  1KH9 A;  3NKP A;  1KHN A;  3Q3Q A;  3UN2 A;  3NKO A;  2GSN A;  5DLT A;  4ZG9 A;  4MHX A;  5L0E A;  1ZEB A;  4ZGA A;  4LRD A;  3MK1 A;  1KH5 A;  2ZKT A;  1ELX A;  1AJD A;  1EQJ A;  1HQA A;  1B8J A;  4LRC A;  5HRT A;  3WAV A;  2GLQ A;  1N2L A;  4B56 A;  1AJA A;  1KHK A;  2VQR A;  2IFY A;  5LQQ A;  2W5S A;  2GSO A;  4N7T A;  1E33 P;  3NKM A;  4FDJ A;  5INH A;  4LR7 A;  1ED9 A;  1EW9 A;  2IUC B;  3KD8 A;  4GTY A;  3BDG B;  3DPC A;  2W5Q A;  5KXA A;  4CXU A;  3BDF A;  1K7H A;  3T01 A;  1Y6V A;  3M8Y A;  5DLW A;  1ED8 A;  3T00 A;  1EW8 A;  5L0B A;  2D1G A;  5LRN A;  1ELY A;  3A52 A;  3SZZ A;  5C66 A;  4LR9 A;  3BDH A;  5L0K A;  1EI6 A;  3NKN A;  1KH7 A;  1O99 A;  5EGH A;  4KAY A;  5IJS A;  3WAY A;  2QZU A;  1ANJ A;  1N2K A;  1URB A;  4LQY A;  4LRA A;  3SZY A;  3MK2 A;  3M7V A;  2W8D A;  2W8S A;  3CMR A;  2X98 A;  3ED4 A;  4MIV A;  4CXS A;  2IUC A;  3TWZ A;  1SHN A;  4UPH A;  3WBH A;  1ALK A;  1HDH A;  3BDG A;  3WAX A;  1AJB A;  5LRM A;  2W5T A;  3TG0 A;  1ALI A;  1AUK A;  1P49 A;  2GSU A;  2ANH A;  2W5W A;  3LXQ A;  4QAX A;  4LR2 A;  4MY4 A;  4UOP A;  4GTZ A;  4ZG6 A;  4KJG A;  5GOV A;  3UN5 A;  3UO0 A;  1KH4 A;  2XR9 A;  2G9Y A;  3TX0 A;  1HJK A;  3WAW A;  3IGY B;  4UPI A;  1O98 A;  1Y7A A;  2GA3 A;  4UOO A;  1E3C P;  4LRB A;  3M8Z A;  5TJ3 A;  3E2D A;  3NKQ A;  3NVL A;  4LRE A;  4KAV A;  1URA A;  1EJJ A;  1KHJ A;  4NWX A;  4UOR A;  5GRR A;  4GTX A;  3M8W A;  3MK0 A;  4CYS A;  5EGE A;  2W5X A;  4YR1 A;  5LIA A;  1ELZ A;  4UPL A;  3T02 A;  3IDD A;  1E2S P;  4UPK A; 
#chains in the Genus database with same CATH homology
 5K4P A;  1ANI A;  5AJ9 A;  4KM4 A;  1EW2 A;  2RH6 A;  4LR8 A;  5DLV A;  3B5Q A;  3OT9 A;  1ALH A;  1E1Z P;  1KHL A;  1SHQ A;  4GTW A;  4TN0 A;  3IGZ B;  2XRG A;  4ZG7 A;  3DYC A;  4KJD A;  2W5V A;  4CYR A;  3UNY A;  5IJQ A;  2W5R A;  4NWJ A;  1FSU A;  3UN3 A;  1ALJ A;  1ZEF A;  4FDI A;  4LRF A;  1ZED A;  3NKR A;  4CXK A;  1AJC A;  1KH9 A;  3NKP A;  1KHN A;  3Q3Q A;  3UN2 A;  3NKO A;  2GSN A;  5DLT A;  4ZG9 A;  4MHX A;  5L0E A;  1ZEB A;  4ZGA A;  4LRD A;  3MK1 A;  1KH5 A;  2ZKT A;  1ELX A;  1AJD A;  1EQJ A;  1HQA A;  1B8J A;  4LRC A;  5HRT A;  3WAV A;  2GLQ A;  1N2L A;  4B56 A;  1AJA A;  1KHK A;  2VQR A;  2IFY A;  5LQQ A;  2W5S A;  2GSO A;  4N7T A;  1E33 P;  3NKM A;  4FDJ A;  5INH A;  4LR7 A;  1ED9 A;  1EW9 A;  2IUC B;  3KD8 A;  4GTY A;  3BDG B;  3DPC A;  2W5Q A;  5KXA A;  4CXU A;  3BDF A;  1K7H A;  3T01 A;  1Y6V A;  3M8Y A;  5DLW A;  1ED8 A;  3T00 A;  1EW8 A;  5L0B A;  2D1G A;  5LRN A;  1ELY A;  3A52 A;  3SZZ A;  5C66 A;  4LR9 A;  3BDH A;  5L0K A;  1EI6 A;  3NKN A;  1KH7 A;  1O99 A;  5EGH A;  4KAY A;  5IJS A;  3WAY A;  2QZU A;  1ANJ A;  1N2K A;  1URB A;  4LQY A;  4LRA A;  3SZY A;  3MK2 A;  3M7V A;  2W8D A;  2W8S A;  3CMR A;  2X98 A;  3ED4 A;  4MIV A;  4CXS A;  2IUC A;  3TWZ A;  1SHN A;  4UPH A;  3WBH A;  1ALK A;  1HDH A;  3BDG A;  3WAX A;  1AJB A;  5LRM A;  2W5T A;  3TG0 A;  1ALI A;  1AUK A;  1P49 A;  2GSU A;  2ANH A;  2W5W A;  3LXQ A;  4QAX A;  4LR2 A;  4MY4 A;  4UOP A;  4GTZ A;  4ZG6 A;  4KJG A;  5GOV A;  3UN5 A;  3UO0 A;  1KH4 A;  2XR9 A;  2G9Y A;  3TX0 A;  1HJK A;  3WAW A;  3IGY B;  4UPI A;  1O98 A;  1Y7A A;  2GA3 A;  4UOO A;  1E3C P;  4LRB A;  3M8Z A;  5TJ3 A;  3E2D A;  3NKQ A;  3NVL A;  4LRE A;  4KAV A;  1URA A;  1EJJ A;  1KHJ A;  4NWX A;  4UOR A;  5GRR A;  4GTX A;  3M8W A;  3MK0 A;  4CYS A;  5EGE A;  2W5X A;  4YR1 A;  5LIA A;  1ELZ A;  4UPL A;  3T02 A;  3IDD A;  1E2S P;  4UPK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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