1Y6V | Genus

Total Genus 163

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	163
Knots found	KnotProt 2.0: S +3₁
sequence length	449
structure length	449
Chain Sequence	TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Escherichia coli
publication title	Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,). pubmed doi rcsb
molecule keywords	Alkaline phosphatase
total genus	163
structure length	449
sequence length	449
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2004-12-07

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1y6vA00

2XRGA 5KXAA 1KHKA 3IGYB 1ED8A 1KHJA 1E2SP 1ALHA 4LREA 3WBHA 5LQQA 1K7HA 1EW9A 4CXSA 3BDGA 5DLVA 4LR8A 3IDDA 4LRFA 3Q3QA 5EGHA 1ANIA 1ALJA 4CYRA 2RH6A 5K4PA 1ALKA 5IJSA 2IFYA 4MY4A 4NWJA 4ZGAA 3WAXA 4LQYA 5C66A 4LR9A 3BDGB 4B56A 1B8JA 3ED4A 4ZG7A 1O99A 2XR9A 1AJAA 1ED9A 3NKQA 4MIVA 1SHNA 4LR2A 1N2LA 3UN3A 3CMRA 1ELZA 4LRDA 5DLTA 2GSNA 2W5SA 3TX0A 2QZUA 1KH9A 3SZYA 2W5XA 4GTYA 5L0KA 1AJDA 4UOPA 4ZG6A 5LRNA 4KJDA 5L0BA 2W5TA 3IGZB 3M7VA 1ELXA 1URBA 4YR1A 4UPIA 3B5QA 3OT9A 4LRBA 1KH7A 5GOVA 4GTZA 3UN5A 2GA3A 3NKRA 1ANJA 2W8SA 1O98A 5EGEA 1N2KA 5HRTA 3T01A 5L0EA 2IUCB 1HQAA 3WAWA 4CYSA 3BDFA 4ZG9A 1ZEFA 1KH4A 2VQRA 3NVLA 4CXKA 1HDHA 2GLQA 4QAXA 1EW2A 3TG0A 1EI6A 3A52A 4FDIA 3TWZA 3NKPA 4CXUA 2X98A 3WAVA 3NKMA 4UPKA 1ELYA 1FSUA 1KHNA 2IUCA 1EJJA 2ZKTA 2W8DA 4KJGA 5LIAA 3SZZA 4LRAA 4UORA 4KAYA 3M8YA 3WAYA 3UN2A 1AJBA 1Y6VA 1Y7AA 3MK0A 5DLWA 1HJKA 5GRRA 1KH5A 4FDJA 3LXQA 3NKNA 2W5WA 1AJCA 3BDHA 3MK1A 2D1GA 4N7TA 1EQJA 4LR7A 5LRMA 5TJ3A 3UNYA 1AUKA 3T00A 5AJ9A 4LRCA 1E3CP 3DPCA 4UPLA 2GSOA 4UOOA 3DYCA 4MHXA 2GSUA 3E2DA 3NKOA 4TN0A 1ZEBA 2W5QA 1ALIA 1EW8A 2ANHA 3UO0A 1URAA 1P49A 5INHA 1KHLA 3M8ZA 1E33P 2W5VA 4GTWA 3T02A 3KD8A 4GTXA 4NWXA 3MK2A 3M8WA 4KM4A 2G9YA 4KAVA 4UPHA 5IJQA 1E1ZP 1SHQA 2W5RA 1ZEDA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 2XRG A;  5KXA A;  1KHK A;  3IGY B;  1ED8 A;  1KHJ A;  1E2S P;  1ALH A;  4LRE A;  3WBH A;  5LQQ A;  1K7H A;  1EW9 A;  4CXS A;  3BDG A;  5DLV A;  4LR8 A;  3IDD A;  4LRF A;  3Q3Q A;  5EGH A;  1ANI A;  1ALJ A;  4CYR A;  2RH6 A;  5K4P A;  1ALK A;  5IJS A;  2IFY A;  4MY4 A;  4NWJ A;  4ZGA A;  3WAX A;  4LQY A;  5C66 A;  4LR9 A;  3BDG B;  4B56 A;  1B8J A;  3ED4 A;  4ZG7 A;  1O99 A;  2XR9 A;  1AJA A;  1ED9 A;  3NKQ A;  4MIV A;  1SHN A;  4LR2 A;  1N2L A;  3UN3 A;  3CMR A;  1ELZ A;  4LRD A;  5DLT A;  2GSN A;  2W5S A;  3TX0 A;  2QZU A;  1KH9 A;  3SZY A;  2W5X A;  4GTY A;  5L0K A;  1AJD A;  4UOP A;  4ZG6 A;  5LRN A;  4KJD A;  5L0B A;  2W5T A;  3IGZ B;  3M7V A;  1ELX A;  1URB A;  4YR1 A;  4UPI A;  3B5Q A;  3OT9 A;  4LRB A;  1KH7 A;  5GOV A;  4GTZ A;  3UN5 A;  2GA3 A;  3NKR A;  1ANJ A;  2W8S A;  1O98 A;  5EGE A;  1N2K A;  5HRT A;  3T01 A;  5L0E A;  2IUC B;  1HQA A;  3WAW A;  4CYS A;  3BDF A;  4ZG9 A;  1ZEF A;  1KH4 A;  2VQR A;  3NVL A;  4CXK A;  1HDH A;  2GLQ A;  4QAX A;  1EW2 A;  3TG0 A;  1EI6 A;  3A52 A;  4FDI A;  3TWZ A;  3NKP A;  4CXU A;  2X98 A;  3WAV A;  3NKM A;  4UPK A;  1ELY A;  1FSU A;  1KHN A;  2IUC A;  1EJJ A;  2ZKT A;  2W8D A;  4KJG A;  5LIA A;  3SZZ A;  4LRA A;  4UOR A;  4KAY A;  3M8Y A;  3WAY A;  3UN2 A;  1AJB A;  1Y6V A;  1Y7A A;  3MK0 A;  5DLW A;  1HJK A;  5GRR A;  1KH5 A;  4FDJ A;  3LXQ A;  3NKN A;  2W5W A;  1AJC A;  3BDH A;  3MK1 A;  2D1G A;  4N7T A;  1EQJ A;  4LR7 A;  5LRM A;  5TJ3 A;  3UNY A;  1AUK A;  3T00 A;  5AJ9 A;  4LRC A;  1E3C P;  3DPC A;  4UPL A;  2GSO A;  4UOO A;  3DYC A;  4MHX A;  2GSU A;  3E2D A;  3NKO A;  4TN0 A;  1ZEB A;  2W5Q A;  1ALI A;  1EW8 A;  2ANH A;  3UO0 A;  1URA A;  1P49 A;  5INH A;  1KHL A;  3M8Z A;  1E33 P;  2W5V A;  4GTW A;  3T02 A;  3KD8 A;  4GTX A;  4NWX A;  3MK2 A;  3M8W A;  4KM4 A;  2G9Y A;  4KAV A;  4UPH A;  5IJQ A;  1E1Z P;  1SHQ A;  2W5R A;  1ZED A; 
#chains in the Genus database with same CATH topology
 2XRG A;  5KXA A;  1KHK A;  3IGY B;  1ED8 A;  1KHJ A;  1E2S P;  1ALH A;  4LRE A;  3WBH A;  5LQQ A;  1K7H A;  1EW9 A;  4CXS A;  3BDG A;  5DLV A;  4LR8 A;  3IDD A;  4LRF A;  3Q3Q A;  5EGH A;  1ANI A;  1ALJ A;  4CYR A;  2RH6 A;  5K4P A;  1ALK A;  5IJS A;  2IFY A;  4MY4 A;  4NWJ A;  4ZGA A;  3WAX A;  4LQY A;  5C66 A;  4LR9 A;  3BDG B;  4B56 A;  1B8J A;  3ED4 A;  4ZG7 A;  1O99 A;  2XR9 A;  1AJA A;  1ED9 A;  3NKQ A;  4MIV A;  1SHN A;  4LR2 A;  1N2L A;  3UN3 A;  3CMR A;  1ELZ A;  4LRD A;  5DLT A;  2GSN A;  2W5S A;  3TX0 A;  2QZU A;  1KH9 A;  3SZY A;  2W5X A;  4GTY A;  5L0K A;  1AJD A;  4UOP A;  4ZG6 A;  5LRN A;  4KJD A;  5L0B A;  2W5T A;  3IGZ B;  3M7V A;  1ELX A;  1URB A;  4YR1 A;  4UPI A;  3B5Q A;  3OT9 A;  4LRB A;  1KH7 A;  5GOV A;  4GTZ A;  3UN5 A;  2GA3 A;  3NKR A;  1ANJ A;  2W8S A;  1O98 A;  5EGE A;  1N2K A;  5HRT A;  3T01 A;  5L0E A;  2IUC B;  1HQA A;  3WAW A;  4CYS A;  3BDF A;  4ZG9 A;  1ZEF A;  1KH4 A;  2VQR A;  3NVL A;  4CXK A;  1HDH A;  2GLQ A;  4QAX A;  1EW2 A;  3TG0 A;  1EI6 A;  3A52 A;  4FDI A;  3TWZ A;  3NKP A;  4CXU A;  2X98 A;  3WAV A;  3NKM A;  4UPK A;  1ELY A;  1FSU A;  1KHN A;  2IUC A;  1EJJ A;  2ZKT A;  2W8D A;  4KJG A;  5LIA A;  3SZZ A;  4LRA A;  4UOR A;  4KAY A;  3M8Y A;  3WAY A;  3UN2 A;  1AJB A;  1Y6V A;  1Y7A A;  3MK0 A;  5DLW A;  1HJK A;  5GRR A;  1KH5 A;  4FDJ A;  3LXQ A;  3NKN A;  2W5W A;  1AJC A;  3BDH A;  3MK1 A;  2D1G A;  4N7T A;  1EQJ A;  4LR7 A;  5LRM A;  5TJ3 A;  3UNY A;  1AUK A;  3T00 A;  5AJ9 A;  4LRC A;  1E3C P;  3DPC A;  4UPL A;  2GSO A;  4UOO A;  3DYC A;  4MHX A;  2GSU A;  3E2D A;  3NKO A;  4TN0 A;  1ZEB A;  2W5Q A;  1ALI A;  1EW8 A;  2ANH A;  3UO0 A;  1URA A;  1P49 A;  5INH A;  1KHL A;  3M8Z A;  1E33 P;  2W5V A;  4GTW A;  3T02 A;  3KD8 A;  4GTX A;  4NWX A;  3MK2 A;  3M8W A;  4KM4 A;  2G9Y A;  4KAV A;  4UPH A;  5IJQ A;  1E1Z P;  1SHQ A;  2W5R A;  1ZED A; 
#chains in the Genus database with same CATH homology
 2XRG A;  5KXA A;  1KHK A;  3IGY B;  1ED8 A;  1KHJ A;  1E2S P;  1ALH A;  4LRE A;  3WBH A;  5LQQ A;  1K7H A;  1EW9 A;  4CXS A;  3BDG A;  5DLV A;  4LR8 A;  3IDD A;  4LRF A;  3Q3Q A;  5EGH A;  1ANI A;  1ALJ A;  4CYR A;  2RH6 A;  5K4P A;  1ALK A;  5IJS A;  2IFY A;  4MY4 A;  4NWJ A;  4ZGA A;  3WAX A;  4LQY A;  5C66 A;  4LR9 A;  3BDG B;  4B56 A;  1B8J A;  3ED4 A;  4ZG7 A;  1O99 A;  2XR9 A;  1AJA A;  1ED9 A;  3NKQ A;  4MIV A;  1SHN A;  4LR2 A;  1N2L A;  3UN3 A;  3CMR A;  1ELZ A;  4LRD A;  5DLT A;  2GSN A;  2W5S A;  3TX0 A;  2QZU A;  1KH9 A;  3SZY A;  2W5X A;  4GTY A;  5L0K A;  1AJD A;  4UOP A;  4ZG6 A;  5LRN A;  4KJD A;  5L0B A;  2W5T A;  3IGZ B;  3M7V A;  1ELX A;  1URB A;  4YR1 A;  4UPI A;  3B5Q A;  3OT9 A;  4LRB A;  1KH7 A;  5GOV A;  4GTZ A;  3UN5 A;  2GA3 A;  3NKR A;  1ANJ A;  2W8S A;  1O98 A;  5EGE A;  1N2K A;  5HRT A;  3T01 A;  5L0E A;  2IUC B;  1HQA A;  3WAW A;  4CYS A;  3BDF A;  4ZG9 A;  1ZEF A;  1KH4 A;  2VQR A;  3NVL A;  4CXK A;  1HDH A;  2GLQ A;  4QAX A;  1EW2 A;  3TG0 A;  1EI6 A;  3A52 A;  4FDI A;  3TWZ A;  3NKP A;  4CXU A;  2X98 A;  3WAV A;  3NKM A;  4UPK A;  1ELY A;  1FSU A;  1KHN A;  2IUC A;  1EJJ A;  2ZKT A;  2W8D A;  4KJG A;  5LIA A;  3SZZ A;  4LRA A;  4UOR A;  4KAY A;  3M8Y A;  3WAY A;  3UN2 A;  1AJB A;  1Y6V A;  1Y7A A;  3MK0 A;  5DLW A;  1HJK A;  5GRR A;  1KH5 A;  4FDJ A;  3LXQ A;  3NKN A;  2W5W A;  1AJC A;  3BDH A;  3MK1 A;  2D1G A;  4N7T A;  1EQJ A;  4LR7 A;  5LRM A;  5TJ3 A;  3UNY A;  1AUK A;  3T00 A;  5AJ9 A;  4LRC A;  1E3C P;  3DPC A;  4UPL A;  2GSO A;  4UOO A;  3DYC A;  4MHX A;  2GSU A;  3E2D A;  3NKO A;  4TN0 A;  1ZEB A;  2W5Q A;  1ALI A;  1EW8 A;  2ANH A;  3UO0 A;  1URA A;  1P49 A;  5INH A;  1KHL A;  3M8Z A;  1E33 P;  2W5V A;  4GTW A;  3T02 A;  3KD8 A;  4GTX A;  4NWX A;  3MK2 A;  3M8W A;  4KM4 A;  2G9Y A;  4KAV A;  4UPH A;  5IJQ A;  1E1Z P;  1SHQ A;  2W5R A;  1ZED A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1Y6VA

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations