1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
1KHLA 5L0KA 1AJAA 4NWJA 3TG0A 3SZZA 4CXSA 3MK2A 3NKPA 5KXAA 5TJ3A 2QZUA 4KM4A 5LQQA 1KH5A 2G9YA 1K7HA 1ELXA 1KH9A 3Q3QA 1Y7AA 4LR7A 1ANJA 4GTXA 1KHJA 3UN2A 3T01A 1ALKA 4ZG7A 1FSUA 1ZEBA 1ALHA 1EQJA 1E3CP 1AJDA 4LR9A 1ZEDA 4LRAA 3WBHA 3M7VA 2ANHA 1ELYA 5EGEA 3UO0A 1HQAA 4KJDA 4MY4A 1HJKA 4UOPA 5INHA 2D1GA 4UPKA 3NKQA 3BDGA 4CYRA 1SHNA 4ZG6A 3DPCA 3T00A 2RH6A 5K4PA 1KHKA 4LRDA 4LQYA 1SHQA 3NKMA 2W5SA 1EW9A 1EW8A 4UPLA 4LREA 2W5VA 3KD8A 3WAYA 4UORA 1ED9A 5L0EA 4QAXA 1E33P 3BDHA 3BDGB 4FDIA 4UPHA 1EI6A 5L0BA 3WAXA 4CYSA 3ED4A 5HRTA 1ANIA 1N2LA 3MK0A 5C66A 4MIVA 2W5XA 5DLTA 3UN5A 3UNYA 3TWZA 3NKOA 3NKNA 2IFYA 4ZG9A 1ELZA 2GSNA 2W8SA 5IJSA 3TX0A 3WAWA 1P49A 3T02A 4LR2A 4UOOA 4YR1A 5LRMA 3B5QA 1B8JA 3A52A 1EJJA 1ALJA 2XR9A 2W5TA 4LRFA 4LRBA 3OT9A 1URBA 2XRGA 1AUKA 3M8WA 4GTWA 4KJGA 1ED8A 5LRNA 3M8YA 4TN0A 3IDDA 1AJCA 1EW2A 2GA3A 3E2DA 4B56A 4KAYA 1E2SP 3IGZB 2W5QA 3CMRA 3NKRA 1KHNA 2W8DA 4LRCA 2W5RA 5AJ9A 1O99A 2GLQA 1KH7A 2IUCA 4CXUA 5EGHA 4KAVA 3SZYA 1HDHA 1ZEFA 4LR8A 1N2KA 2X98A 4FDJA 3M8ZA 1URAA 1E1ZP 2VQRA 4GTYA 4N7TA 5DLVA 5IJQA 5GRRA 3WAVA 4ZGAA 2GSOA 1AJBA 3BDFA 5LIAA 4NWXA 2GSUA 2IUCB 3DYCA 2W5WA 3MK1A 4CXKA 1Y6VA 4MHXA 5GOVA 1KH4A 4GTZA 4UPIA 5DLWA 3UN3A 1ALIA 3LXQA 2ZKTA 3IGYB 3NVLA 1O98A
chains in the Genus database with same CATH superfamily
1KHLA 5L0KA 1AJAA 4NWJA 3TG0A 3SZZA 4CXSA 3MK2A 3NKPA 5KXAA 5TJ3A 2QZUA 4KM4A 5LQQA 1KH5A 2G9YA 1K7HA 1ELXA 1KH9A 3Q3QA 1Y7AA 4LR7A 1ANJA 4GTXA 1KHJA 3UN2A 3T01A 1ALKA 4ZG7A 1FSUA 1ZEBA 1ALHA 1EQJA 1E3CP 1AJDA 4LR9A 1ZEDA 4LRAA 3WBHA 3M7VA 2ANHA 1ELYA 5EGEA 3UO0A 1HQAA 4KJDA 4MY4A 1HJKA 4UOPA 5INHA 2D1GA 4UPKA 3NKQA 3BDGA 4CYRA 1SHNA 4ZG6A 3DPCA 3T00A 2RH6A 5K4PA 1KHKA 4LRDA 4LQYA 1SHQA 3NKMA 2W5SA 1EW9A 1EW8A 4UPLA 4LREA 2W5VA 3KD8A 3WAYA 4UORA 1ED9A 5L0EA 4QAXA 1E33P 3BDHA 3BDGB 4FDIA 4UPHA 1EI6A 5L0BA 3WAXA 4CYSA 3ED4A 5HRTA 1ANIA 1N2LA 3MK0A 5C66A 4MIVA 2W5XA 5DLTA 3UN5A 3UNYA 3TWZA 3NKOA 3NKNA 2IFYA 4ZG9A 1ELZA 2GSNA 2W8SA 5IJSA 3TX0A 3WAWA 1P49A 3T02A 4LR2A 4UOOA 4YR1A 5LRMA 3B5QA 1B8JA 3A52A 1EJJA 1ALJA 2XR9A 2W5TA 4LRFA 4LRBA 3OT9A 1URBA 2XRGA 1AUKA 3M8WA 4GTWA 4KJGA 1ED8A 5LRNA 3M8YA 4TN0A 3IDDA 1AJCA 1EW2A 2GA3A 3E2DA 4B56A 4KAYA 1E2SP 3IGZB 2W5QA 3CMRA 3NKRA 1KHNA 2W8DA 4LRCA 2W5RA 5AJ9A 1O99A 2GLQA 1KH7A 2IUCA 4CXUA 5EGHA 4KAVA 3SZYA 1HDHA 1ZEFA 4LR8A 1N2KA 2X98A 4FDJA 3M8ZA 1URAA 1E1ZP 2VQRA 4GTYA 4N7TA 5DLVA 5IJQA 5GRRA 3WAVA 4ZGAA 2GSOA 1AJBA 3BDFA 5LIAA 4NWXA 2GSUA 2IUCB 3DYCA 2W5WA 3MK1A 4CXKA 1Y6VA 4MHXA 5GOVA 1KH4A 4GTZA 4UPIA 5DLWA 3UN3A 1ALIA 3LXQA 2ZKTA 3IGYB 3NVLA 1O98A
chains in the Genus database with same CATH topology
1KHLA 5L0KA 1AJAA 4NWJA 3TG0A 3SZZA 4CXSA 3MK2A 3NKPA 5KXAA 5TJ3A 2QZUA 4KM4A 5LQQA 1KH5A 2G9YA 1K7HA 1ELXA 1KH9A 3Q3QA 1Y7AA 4LR7A 1ANJA 4GTXA 1KHJA 3UN2A 3T01A 1ALKA 4ZG7A 1FSUA 1ZEBA 1ALHA 1EQJA 1E3CP 1AJDA 4LR9A 1ZEDA 4LRAA 3WBHA 3M7VA 2ANHA 1ELYA 5EGEA 3UO0A 1HQAA 4KJDA 4MY4A 1HJKA 4UOPA 5INHA 2D1GA 4UPKA 3NKQA 3BDGA 4CYRA 1SHNA 4ZG6A 3DPCA 3T00A 2RH6A 5K4PA 1KHKA 4LRDA 4LQYA 1SHQA 3NKMA 2W5SA 1EW9A 1EW8A 4UPLA 4LREA 2W5VA 3KD8A 3WAYA 4UORA 1ED9A 5L0EA 4QAXA 1E33P 3BDHA 3BDGB 4FDIA 4UPHA 1EI6A 5L0BA 3WAXA 4CYSA 3ED4A 5HRTA 1ANIA 1N2LA 3MK0A 5C66A 4MIVA 2W5XA 5DLTA 3UN5A 3UNYA 3TWZA 3NKOA 3NKNA 2IFYA 4ZG9A 1ELZA 2GSNA 2W8SA 5IJSA 3TX0A 3WAWA 1P49A 3T02A 4LR2A 4UOOA 4YR1A 5LRMA 3B5QA 1B8JA 3A52A 1EJJA 1ALJA 2XR9A 2W5TA 4LRFA 4LRBA 3OT9A 1URBA 2XRGA 1AUKA 3M8WA 4GTWA 4KJGA 1ED8A 5LRNA 3M8YA 4TN0A 3IDDA 1AJCA 1EW2A 2GA3A 3E2DA 4B56A 4KAYA 1E2SP 3IGZB 2W5QA 3CMRA 3NKRA 1KHNA 2W8DA 4LRCA 2W5RA 5AJ9A 1O99A 2GLQA 1KH7A 2IUCA 4CXUA 5EGHA 4KAVA 3SZYA 1HDHA 1ZEFA 4LR8A 1N2KA 2X98A 4FDJA 3M8ZA 1URAA 1E1ZP 2VQRA 4GTYA 4N7TA 5DLVA 5IJQA 5GRRA 3WAVA 4ZGAA 2GSOA 1AJBA 3BDFA 5LIAA 4NWXA 2GSUA 2IUCB 3DYCA 2W5WA 3MK1A 4CXKA 1Y6VA 4MHXA 5GOVA 1KH4A 4GTZA 4UPIA 5DLWA 3UN3A 1ALIA 3LXQA 2ZKTA 3IGYB 3NVLA 1O98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KHL A;  5L0K A;  1AJA A;  4NWJ A;  3TG0 A;  3SZZ A;  4CXS A;  3MK2 A;  3NKP A;  5KXA A;  5TJ3 A;  2QZU A;  4KM4 A;  5LQQ A;  1KH5 A;  2G9Y A;  1K7H A;  1ELX A;  1KH9 A;  3Q3Q A;  1Y7A A;  4LR7 A;  1ANJ A;  4GTX A;  1KHJ A;  3UN2 A;  3T01 A;  1ALK A;  4ZG7 A;  1FSU A;  1ZEB A;  1ALH A;  1EQJ A;  1E3C P;  1AJD A;  4LR9 A;  1ZED A;  4LRA A;  3WBH A;  3M7V A;  2ANH A;  1ELY A;  5EGE A;  3UO0 A;  1HQA A;  4KJD A;  4MY4 A;  1HJK A;  4UOP A;  5INH A;  2D1G A;  4UPK A;  3NKQ A;  3BDG A;  4CYR A;  1SHN A;  4ZG6 A;  3DPC A;  3T00 A;  2RH6 A;  5K4P A;  1KHK A;  4LRD A;  4LQY A;  1SHQ A;  3NKM A;  2W5S A;  1EW9 A;  1EW8 A;  4UPL A;  4LRE A;  2W5V A;  3KD8 A;  3WAY A;  4UOR A;  1ED9 A;  5L0E A;  4QAX A;  1E33 P;  3BDH A;  3BDG B;  4FDI A;  4UPH A;  1EI6 A;  5L0B A;  3WAX A;  4CYS A;  3ED4 A;  5HRT A;  1ANI A;  1N2L A;  3MK0 A;  5C66 A;  4MIV A;  2W5X A;  5DLT A;  3UN5 A;  3UNY A;  3TWZ A;  3NKO A;  3NKN A;  2IFY A;  4ZG9 A;  1ELZ A;  2GSN A;  2W8S A;  5IJS A;  3TX0 A;  3WAW A;  1P49 A;  3T02 A;  4LR2 A;  4UOO A;  4YR1 A;  5LRM A;  3B5Q A;  1B8J A;  3A52 A;  1EJJ A;  1ALJ A;  2XR9 A;  2W5T A;  4LRF A;  4LRB A;  3OT9 A;  1URB A;  2XRG A;  1AUK A;  3M8W A;  4GTW A;  4KJG A;  1ED8 A;  5LRN A;  3M8Y A;  4TN0 A;  3IDD A;  1AJC A;  1EW2 A;  2GA3 A;  3E2D A;  4B56 A;  4KAY A;  1E2S P;  3IGZ B;  2W5Q A;  3CMR A;  3NKR A;  1KHN A;  2W8D A;  4LRC A;  2W5R A;  5AJ9 A;  1O99 A;  2GLQ A;  1KH7 A;  2IUC A;  4CXU A;  5EGH A;  4KAV A;  3SZY A;  1HDH A;  1ZEF A;  4LR8 A;  1N2K A;  2X98 A;  4FDJ A;  3M8Z A;  1URA A;  1E1Z P;  2VQR A;  4GTY A;  4N7T A;  5DLV A;  5IJQ A;  5GRR A;  3WAV A;  4ZGA A;  2GSO A;  1AJB A;  3BDF A;  5LIA A;  4NWX A;  2GSU A;  2IUC B;  3DYC A;  2W5W A;  3MK1 A;  4CXK A;  1Y6V A;  4MHX A;  5GOV A;  1KH4 A;  4GTZ A;  4UPI A;  5DLW A;  3UN3 A;  1ALI A;  3LXQ A;  2ZKT A;  3IGY B;  3NVL A;  1O98 A; 
#chains in the Genus database with same CATH topology
 1KHL A;  5L0K A;  1AJA A;  4NWJ A;  3TG0 A;  3SZZ A;  4CXS A;  3MK2 A;  3NKP A;  5KXA A;  5TJ3 A;  2QZU A;  4KM4 A;  5LQQ A;  1KH5 A;  2G9Y A;  1K7H A;  1ELX A;  1KH9 A;  3Q3Q A;  1Y7A A;  4LR7 A;  1ANJ A;  4GTX A;  1KHJ A;  3UN2 A;  3T01 A;  1ALK A;  4ZG7 A;  1FSU A;  1ZEB A;  1ALH A;  1EQJ A;  1E3C P;  1AJD A;  4LR9 A;  1ZED A;  4LRA A;  3WBH A;  3M7V A;  2ANH A;  1ELY A;  5EGE A;  3UO0 A;  1HQA A;  4KJD A;  4MY4 A;  1HJK A;  4UOP A;  5INH A;  2D1G A;  4UPK A;  3NKQ A;  3BDG A;  4CYR A;  1SHN A;  4ZG6 A;  3DPC A;  3T00 A;  2RH6 A;  5K4P A;  1KHK A;  4LRD A;  4LQY A;  1SHQ A;  3NKM A;  2W5S A;  1EW9 A;  1EW8 A;  4UPL A;  4LRE A;  2W5V A;  3KD8 A;  3WAY A;  4UOR A;  1ED9 A;  5L0E A;  4QAX A;  1E33 P;  3BDH A;  3BDG B;  4FDI A;  4UPH A;  1EI6 A;  5L0B A;  3WAX A;  4CYS A;  3ED4 A;  5HRT A;  1ANI A;  1N2L A;  3MK0 A;  5C66 A;  4MIV A;  2W5X A;  5DLT A;  3UN5 A;  3UNY A;  3TWZ A;  3NKO A;  3NKN A;  2IFY A;  4ZG9 A;  1ELZ A;  2GSN A;  2W8S A;  5IJS A;  3TX0 A;  3WAW A;  1P49 A;  3T02 A;  4LR2 A;  4UOO A;  4YR1 A;  5LRM A;  3B5Q A;  1B8J A;  3A52 A;  1EJJ A;  1ALJ A;  2XR9 A;  2W5T A;  4LRF A;  4LRB A;  3OT9 A;  1URB A;  2XRG A;  1AUK A;  3M8W A;  4GTW A;  4KJG A;  1ED8 A;  5LRN A;  3M8Y A;  4TN0 A;  3IDD A;  1AJC A;  1EW2 A;  2GA3 A;  3E2D A;  4B56 A;  4KAY A;  1E2S P;  3IGZ B;  2W5Q A;  3CMR A;  3NKR A;  1KHN A;  2W8D A;  4LRC A;  2W5R A;  5AJ9 A;  1O99 A;  2GLQ A;  1KH7 A;  2IUC A;  4CXU A;  5EGH A;  4KAV A;  3SZY A;  1HDH A;  1ZEF A;  4LR8 A;  1N2K A;  2X98 A;  4FDJ A;  3M8Z A;  1URA A;  1E1Z P;  2VQR A;  4GTY A;  4N7T A;  5DLV A;  5IJQ A;  5GRR A;  3WAV A;  4ZGA A;  2GSO A;  1AJB A;  3BDF A;  5LIA A;  4NWX A;  2GSU A;  2IUC B;  3DYC A;  2W5W A;  3MK1 A;  4CXK A;  1Y6V A;  4MHX A;  5GOV A;  1KH4 A;  4GTZ A;  4UPI A;  5DLW A;  3UN3 A;  1ALI A;  3LXQ A;  2ZKT A;  3IGY B;  3NVL A;  1O98 A; 
#chains in the Genus database with same CATH homology
 1KHL A;  5L0K A;  1AJA A;  4NWJ A;  3TG0 A;  3SZZ A;  4CXS A;  3MK2 A;  3NKP A;  5KXA A;  5TJ3 A;  2QZU A;  4KM4 A;  5LQQ A;  1KH5 A;  2G9Y A;  1K7H A;  1ELX A;  1KH9 A;  3Q3Q A;  1Y7A A;  4LR7 A;  1ANJ A;  4GTX A;  1KHJ A;  3UN2 A;  3T01 A;  1ALK A;  4ZG7 A;  1FSU A;  1ZEB A;  1ALH A;  1EQJ A;  1E3C P;  1AJD A;  4LR9 A;  1ZED A;  4LRA A;  3WBH A;  3M7V A;  2ANH A;  1ELY A;  5EGE A;  3UO0 A;  1HQA A;  4KJD A;  4MY4 A;  1HJK A;  4UOP A;  5INH A;  2D1G A;  4UPK A;  3NKQ A;  3BDG A;  4CYR A;  1SHN A;  4ZG6 A;  3DPC A;  3T00 A;  2RH6 A;  5K4P A;  1KHK A;  4LRD A;  4LQY A;  1SHQ A;  3NKM A;  2W5S A;  1EW9 A;  1EW8 A;  4UPL A;  4LRE A;  2W5V A;  3KD8 A;  3WAY A;  4UOR A;  1ED9 A;  5L0E A;  4QAX A;  1E33 P;  3BDH A;  3BDG B;  4FDI A;  4UPH A;  1EI6 A;  5L0B A;  3WAX A;  4CYS A;  3ED4 A;  5HRT A;  1ANI A;  1N2L A;  3MK0 A;  5C66 A;  4MIV A;  2W5X A;  5DLT A;  3UN5 A;  3UNY A;  3TWZ A;  3NKO A;  3NKN A;  2IFY A;  4ZG9 A;  1ELZ A;  2GSN A;  2W8S A;  5IJS A;  3TX0 A;  3WAW A;  1P49 A;  3T02 A;  4LR2 A;  4UOO A;  4YR1 A;  5LRM A;  3B5Q A;  1B8J A;  3A52 A;  1EJJ A;  1ALJ A;  2XR9 A;  2W5T A;  4LRF A;  4LRB A;  3OT9 A;  1URB A;  2XRG A;  1AUK A;  3M8W A;  4GTW A;  4KJG A;  1ED8 A;  5LRN A;  3M8Y A;  4TN0 A;  3IDD A;  1AJC A;  1EW2 A;  2GA3 A;  3E2D A;  4B56 A;  4KAY A;  1E2S P;  3IGZ B;  2W5Q A;  3CMR A;  3NKR A;  1KHN A;  2W8D A;  4LRC A;  2W5R A;  5AJ9 A;  1O99 A;  2GLQ A;  1KH7 A;  2IUC A;  4CXU A;  5EGH A;  4KAV A;  3SZY A;  1HDH A;  1ZEF A;  4LR8 A;  1N2K A;  2X98 A;  4FDJ A;  3M8Z A;  1URA A;  1E1Z P;  2VQR A;  4GTY A;  4N7T A;  5DLV A;  5IJQ A;  5GRR A;  3WAV A;  4ZGA A;  2GSO A;  1AJB A;  3BDF A;  5LIA A;  4NWX A;  2GSU A;  2IUC B;  3DYC A;  2W5W A;  3MK1 A;  4CXK A;  1Y6V A;  4MHX A;  5GOV A;  1KH4 A;  4GTZ A;  4UPI A;  5DLW A;  3UN3 A;  1ALI A;  3LXQ A;  2ZKT A;  3IGY B;  3NVL A;  1O98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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