1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
5GRRA 1K7HA 5DLTA 4FDJA 3WBHA 2GLQA 1ELZA 4GTZA 5LQQA 3T00A 3B5QA 3OT9A 3UNYA 1ZEBA 3WAVA 4ZG7A 4KAVA 3E2DA 1AUKA 2QZUA 5INHA 1EW2A 2IUCA 1ELYA 4KAYA 3BDFA 4KM4A 5DLWA 2GSOA 1HJKA 3SZZA 1E33P 1Y6VA 3IGZB 1E2SP 1ALKA 1AJBA 1URAA 4NWJA 5KXAA 1KH9A 4YR1A 1ZEDA 1ELXA 1ALIA 1Y7AA 3MK1A 5L0BA 4FDIA 5IJQA 5LRMA 1SHNA 4UOPA 3NKMA 4LRAA 1E3CP 5EGHA 2X98A 1B8JA 1P49A 3DYCA 5K4PA 2W5VA 5L0EA 4CXSA 4N7TA 3NKOA 3TX0A 3M8YA 4LRCA 4ZGAA 3BDHA 3LXQA 3Q3QA 3TWZA 5L0KA 2W8DA 3NKQA 1AJAA 1AJCA 4GTXA 4LR9A 2IFYA 3M7VA 4LR8A 3UO0A 3BDGA 3CMRA 3TG0A 4B56A 3NKNA 2GSNA 4UPLA 5GOVA 3T01A 4MY4A 1ALJA 2XR9A 3WAXA 1E1ZP 1KH4A 1ED9A 2W5SA 2ANHA 4KJGA 2W8SA 1KH7A 1AJDA 1URBA 1FSUA 1EW9A 1KHLA 3MK0A 5C66A 4UORA 4UOOA 3NKPA 2W5XA 1EJJA 5IJSA 4CYSA 3IDDA 5DLVA 3KD8A 4UPKA 3UN2A 5HRTA 4QAXA 3M8WA 1KHKA 1ZEFA 3NKRA 4GTYA 1SHQA 4LR2A 3M8ZA 5LIAA 3SZYA 1O99A 4GTWA 2VQRA 4TN0A 5LRNA 4LREA 2W5WA 3ED4A 3DPCA 3UN3A 4MIVA 1EQJA 4ZG9A 2IUCB 2GA3A 5AJ9A 1KHJA 1HDHA 4MHXA 3T02A 2ZKTA 3BDGB 2RH6A 1ANJA 5EGEA 1O98A 3WAWA 4LRFA 4NWXA 1ALHA 4ZG6A 1ED8A 1HQAA 1N2LA 2D1GA 1KH5A 4LRBA 2XRGA 1KHNA 5TJ3A 4LR7A 3NVLA 4KJDA 2G9YA 2GSUA 2W5RA 4UPIA 4CXKA 1EI6A 3WAYA 4CXUA 3IGYB 3MK2A 3UN5A 3A52A 1ANIA 2W5TA 1N2KA 4UPHA 1EW8A 4LQYA 4LRDA 2W5QA 4CYRA
chains in the Genus database with same CATH superfamily
5GRRA 1K7HA 5DLTA 4FDJA 3WBHA 2GLQA 1ELZA 4GTZA 5LQQA 3T00A 3B5QA 3OT9A 3UNYA 1ZEBA 3WAVA 4ZG7A 4KAVA 3E2DA 1AUKA 2QZUA 5INHA 1EW2A 2IUCA 1ELYA 4KAYA 3BDFA 4KM4A 5DLWA 2GSOA 1HJKA 3SZZA 1E33P 1Y6VA 3IGZB 1E2SP 1ALKA 1AJBA 1URAA 4NWJA 5KXAA 1KH9A 4YR1A 1ZEDA 1ELXA 1ALIA 1Y7AA 3MK1A 5L0BA 4FDIA 5IJQA 5LRMA 1SHNA 4UOPA 3NKMA 4LRAA 1E3CP 5EGHA 2X98A 1B8JA 1P49A 3DYCA 5K4PA 2W5VA 5L0EA 4CXSA 4N7TA 3NKOA 3TX0A 3M8YA 4LRCA 4ZGAA 3BDHA 3LXQA 3Q3QA 3TWZA 5L0KA 2W8DA 3NKQA 1AJAA 1AJCA 4GTXA 4LR9A 2IFYA 3M7VA 4LR8A 3UO0A 3BDGA 3CMRA 3TG0A 4B56A 3NKNA 2GSNA 4UPLA 5GOVA 3T01A 4MY4A 1ALJA 2XR9A 3WAXA 1E1ZP 1KH4A 1ED9A 2W5SA 2ANHA 4KJGA 2W8SA 1KH7A 1AJDA 1URBA 1FSUA 1EW9A 1KHLA 3MK0A 5C66A 4UORA 4UOOA 3NKPA 2W5XA 1EJJA 5IJSA 4CYSA 3IDDA 5DLVA 3KD8A 4UPKA 3UN2A 5HRTA 4QAXA 3M8WA 1KHKA 1ZEFA 3NKRA 4GTYA 1SHQA 4LR2A 3M8ZA 5LIAA 3SZYA 1O99A 4GTWA 2VQRA 4TN0A 5LRNA 4LREA 2W5WA 3ED4A 3DPCA 3UN3A 4MIVA 1EQJA 4ZG9A 2IUCB 2GA3A 5AJ9A 1KHJA 1HDHA 4MHXA 3T02A 2ZKTA 3BDGB 2RH6A 1ANJA 5EGEA 1O98A 3WAWA 4LRFA 4NWXA 1ALHA 4ZG6A 1ED8A 1HQAA 1N2LA 2D1GA 1KH5A 4LRBA 2XRGA 1KHNA 5TJ3A 4LR7A 3NVLA 4KJDA 2G9YA 2GSUA 2W5RA 4UPIA 4CXKA 1EI6A 3WAYA 4CXUA 3IGYB 3MK2A 3UN5A 3A52A 1ANIA 2W5TA 1N2KA 4UPHA 1EW8A 4LQYA 4LRDA 2W5QA 4CYRA
chains in the Genus database with same CATH topology
5GRRA 1K7HA 5DLTA 4FDJA 3WBHA 2GLQA 1ELZA 4GTZA 5LQQA 3T00A 3B5QA 3OT9A 3UNYA 1ZEBA 3WAVA 4ZG7A 4KAVA 3E2DA 1AUKA 2QZUA 5INHA 1EW2A 2IUCA 1ELYA 4KAYA 3BDFA 4KM4A 5DLWA 2GSOA 1HJKA 3SZZA 1E33P 1Y6VA 3IGZB 1E2SP 1ALKA 1AJBA 1URAA 4NWJA 5KXAA 1KH9A 4YR1A 1ZEDA 1ELXA 1ALIA 1Y7AA 3MK1A 5L0BA 4FDIA 5IJQA 5LRMA 1SHNA 4UOPA 3NKMA 4LRAA 1E3CP 5EGHA 2X98A 1B8JA 1P49A 3DYCA 5K4PA 2W5VA 5L0EA 4CXSA 4N7TA 3NKOA 3TX0A 3M8YA 4LRCA 4ZGAA 3BDHA 3LXQA 3Q3QA 3TWZA 5L0KA 2W8DA 3NKQA 1AJAA 1AJCA 4GTXA 4LR9A 2IFYA 3M7VA 4LR8A 3UO0A 3BDGA 3CMRA 3TG0A 4B56A 3NKNA 2GSNA 4UPLA 5GOVA 3T01A 4MY4A 1ALJA 2XR9A 3WAXA 1E1ZP 1KH4A 1ED9A 2W5SA 2ANHA 4KJGA 2W8SA 1KH7A 1AJDA 1URBA 1FSUA 1EW9A 1KHLA 3MK0A 5C66A 4UORA 4UOOA 3NKPA 2W5XA 1EJJA 5IJSA 4CYSA 3IDDA 5DLVA 3KD8A 4UPKA 3UN2A 5HRTA 4QAXA 3M8WA 1KHKA 1ZEFA 3NKRA 4GTYA 1SHQA 4LR2A 3M8ZA 5LIAA 3SZYA 1O99A 4GTWA 2VQRA 4TN0A 5LRNA 4LREA 2W5WA 3ED4A 3DPCA 3UN3A 4MIVA 1EQJA 4ZG9A 2IUCB 2GA3A 5AJ9A 1KHJA 1HDHA 4MHXA 3T02A 2ZKTA 3BDGB 2RH6A 1ANJA 5EGEA 1O98A 3WAWA 4LRFA 4NWXA 1ALHA 4ZG6A 1ED8A 1HQAA 1N2LA 2D1GA 1KH5A 4LRBA 2XRGA 1KHNA 5TJ3A 4LR7A 3NVLA 4KJDA 2G9YA 2GSUA 2W5RA 4UPIA 4CXKA 1EI6A 3WAYA 4CXUA 3IGYB 3MK2A 3UN5A 3A52A 1ANIA 2W5TA 1N2KA 4UPHA 1EW8A 4LQYA 4LRDA 2W5QA 4CYRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GRR A;  1K7H A;  5DLT A;  4FDJ A;  3WBH A;  2GLQ A;  1ELZ A;  4GTZ A;  5LQQ A;  3T00 A;  3B5Q A;  3OT9 A;  3UNY A;  1ZEB A;  3WAV A;  4ZG7 A;  4KAV A;  3E2D A;  1AUK A;  2QZU A;  5INH A;  1EW2 A;  2IUC A;  1ELY A;  4KAY A;  3BDF A;  4KM4 A;  5DLW A;  2GSO A;  1HJK A;  3SZZ A;  1E33 P;  1Y6V A;  3IGZ B;  1E2S P;  1ALK A;  1AJB A;  1URA A;  4NWJ A;  5KXA A;  1KH9 A;  4YR1 A;  1ZED A;  1ELX A;  1ALI A;  1Y7A A;  3MK1 A;  5L0B A;  4FDI A;  5IJQ A;  5LRM A;  1SHN A;  4UOP A;  3NKM A;  4LRA A;  1E3C P;  5EGH A;  2X98 A;  1B8J A;  1P49 A;  3DYC A;  5K4P A;  2W5V A;  5L0E A;  4CXS A;  4N7T A;  3NKO A;  3TX0 A;  3M8Y A;  4LRC A;  4ZGA A;  3BDH A;  3LXQ A;  3Q3Q A;  3TWZ A;  5L0K A;  2W8D A;  3NKQ A;  1AJA A;  1AJC A;  4GTX A;  4LR9 A;  2IFY A;  3M7V A;  4LR8 A;  3UO0 A;  3BDG A;  3CMR A;  3TG0 A;  4B56 A;  3NKN A;  2GSN A;  4UPL A;  5GOV A;  3T01 A;  4MY4 A;  1ALJ A;  2XR9 A;  3WAX A;  1E1Z P;  1KH4 A;  1ED9 A;  2W5S A;  2ANH A;  4KJG A;  2W8S A;  1KH7 A;  1AJD A;  1URB A;  1FSU A;  1EW9 A;  1KHL A;  3MK0 A;  5C66 A;  4UOR A;  4UOO A;  3NKP A;  2W5X A;  1EJJ A;  5IJS A;  4CYS A;  3IDD A;  5DLV A;  3KD8 A;  4UPK A;  3UN2 A;  5HRT A;  4QAX A;  3M8W A;  1KHK A;  1ZEF A;  3NKR A;  4GTY A;  1SHQ A;  4LR2 A;  3M8Z A;  5LIA A;  3SZY A;  1O99 A;  4GTW A;  2VQR A;  4TN0 A;  5LRN A;  4LRE A;  2W5W A;  3ED4 A;  3DPC A;  3UN3 A;  4MIV A;  1EQJ A;  4ZG9 A;  2IUC B;  2GA3 A;  5AJ9 A;  1KHJ A;  1HDH A;  4MHX A;  3T02 A;  2ZKT A;  3BDG B;  2RH6 A;  1ANJ A;  5EGE A;  1O98 A;  3WAW A;  4LRF A;  4NWX A;  1ALH A;  4ZG6 A;  1ED8 A;  1HQA A;  1N2L A;  2D1G A;  1KH5 A;  4LRB A;  2XRG A;  1KHN A;  5TJ3 A;  4LR7 A;  3NVL A;  4KJD A;  2G9Y A;  2GSU A;  2W5R A;  4UPI A;  4CXK A;  1EI6 A;  3WAY A;  4CXU A;  3IGY B;  3MK2 A;  3UN5 A;  3A52 A;  1ANI A;  2W5T A;  1N2K A;  4UPH A;  1EW8 A;  4LQY A;  4LRD A;  2W5Q A;  4CYR A; 
#chains in the Genus database with same CATH topology
 5GRR A;  1K7H A;  5DLT A;  4FDJ A;  3WBH A;  2GLQ A;  1ELZ A;  4GTZ A;  5LQQ A;  3T00 A;  3B5Q A;  3OT9 A;  3UNY A;  1ZEB A;  3WAV A;  4ZG7 A;  4KAV A;  3E2D A;  1AUK A;  2QZU A;  5INH A;  1EW2 A;  2IUC A;  1ELY A;  4KAY A;  3BDF A;  4KM4 A;  5DLW A;  2GSO A;  1HJK A;  3SZZ A;  1E33 P;  1Y6V A;  3IGZ B;  1E2S P;  1ALK A;  1AJB A;  1URA A;  4NWJ A;  5KXA A;  1KH9 A;  4YR1 A;  1ZED A;  1ELX A;  1ALI A;  1Y7A A;  3MK1 A;  5L0B A;  4FDI A;  5IJQ A;  5LRM A;  1SHN A;  4UOP A;  3NKM A;  4LRA A;  1E3C P;  5EGH A;  2X98 A;  1B8J A;  1P49 A;  3DYC A;  5K4P A;  2W5V A;  5L0E A;  4CXS A;  4N7T A;  3NKO A;  3TX0 A;  3M8Y A;  4LRC A;  4ZGA A;  3BDH A;  3LXQ A;  3Q3Q A;  3TWZ A;  5L0K A;  2W8D A;  3NKQ A;  1AJA A;  1AJC A;  4GTX A;  4LR9 A;  2IFY A;  3M7V A;  4LR8 A;  3UO0 A;  3BDG A;  3CMR A;  3TG0 A;  4B56 A;  3NKN A;  2GSN A;  4UPL A;  5GOV A;  3T01 A;  4MY4 A;  1ALJ A;  2XR9 A;  3WAX A;  1E1Z P;  1KH4 A;  1ED9 A;  2W5S A;  2ANH A;  4KJG A;  2W8S A;  1KH7 A;  1AJD A;  1URB A;  1FSU A;  1EW9 A;  1KHL A;  3MK0 A;  5C66 A;  4UOR A;  4UOO A;  3NKP A;  2W5X A;  1EJJ A;  5IJS A;  4CYS A;  3IDD A;  5DLV A;  3KD8 A;  4UPK A;  3UN2 A;  5HRT A;  4QAX A;  3M8W A;  1KHK A;  1ZEF A;  3NKR A;  4GTY A;  1SHQ A;  4LR2 A;  3M8Z A;  5LIA A;  3SZY A;  1O99 A;  4GTW A;  2VQR A;  4TN0 A;  5LRN A;  4LRE A;  2W5W A;  3ED4 A;  3DPC A;  3UN3 A;  4MIV A;  1EQJ A;  4ZG9 A;  2IUC B;  2GA3 A;  5AJ9 A;  1KHJ A;  1HDH A;  4MHX A;  3T02 A;  2ZKT A;  3BDG B;  2RH6 A;  1ANJ A;  5EGE A;  1O98 A;  3WAW A;  4LRF A;  4NWX A;  1ALH A;  4ZG6 A;  1ED8 A;  1HQA A;  1N2L A;  2D1G A;  1KH5 A;  4LRB A;  2XRG A;  1KHN A;  5TJ3 A;  4LR7 A;  3NVL A;  4KJD A;  2G9Y A;  2GSU A;  2W5R A;  4UPI A;  4CXK A;  1EI6 A;  3WAY A;  4CXU A;  3IGY B;  3MK2 A;  3UN5 A;  3A52 A;  1ANI A;  2W5T A;  1N2K A;  4UPH A;  1EW8 A;  4LQY A;  4LRD A;  2W5Q A;  4CYR A; 
#chains in the Genus database with same CATH homology
 5GRR A;  1K7H A;  5DLT A;  4FDJ A;  3WBH A;  2GLQ A;  1ELZ A;  4GTZ A;  5LQQ A;  3T00 A;  3B5Q A;  3OT9 A;  3UNY A;  1ZEB A;  3WAV A;  4ZG7 A;  4KAV A;  3E2D A;  1AUK A;  2QZU A;  5INH A;  1EW2 A;  2IUC A;  1ELY A;  4KAY A;  3BDF A;  4KM4 A;  5DLW A;  2GSO A;  1HJK A;  3SZZ A;  1E33 P;  1Y6V A;  3IGZ B;  1E2S P;  1ALK A;  1AJB A;  1URA A;  4NWJ A;  5KXA A;  1KH9 A;  4YR1 A;  1ZED A;  1ELX A;  1ALI A;  1Y7A A;  3MK1 A;  5L0B A;  4FDI A;  5IJQ A;  5LRM A;  1SHN A;  4UOP A;  3NKM A;  4LRA A;  1E3C P;  5EGH A;  2X98 A;  1B8J A;  1P49 A;  3DYC A;  5K4P A;  2W5V A;  5L0E A;  4CXS A;  4N7T A;  3NKO A;  3TX0 A;  3M8Y A;  4LRC A;  4ZGA A;  3BDH A;  3LXQ A;  3Q3Q A;  3TWZ A;  5L0K A;  2W8D A;  3NKQ A;  1AJA A;  1AJC A;  4GTX A;  4LR9 A;  2IFY A;  3M7V A;  4LR8 A;  3UO0 A;  3BDG A;  3CMR A;  3TG0 A;  4B56 A;  3NKN A;  2GSN A;  4UPL A;  5GOV A;  3T01 A;  4MY4 A;  1ALJ A;  2XR9 A;  3WAX A;  1E1Z P;  1KH4 A;  1ED9 A;  2W5S A;  2ANH A;  4KJG A;  2W8S A;  1KH7 A;  1AJD A;  1URB A;  1FSU A;  1EW9 A;  1KHL A;  3MK0 A;  5C66 A;  4UOR A;  4UOO A;  3NKP A;  2W5X A;  1EJJ A;  5IJS A;  4CYS A;  3IDD A;  5DLV A;  3KD8 A;  4UPK A;  3UN2 A;  5HRT A;  4QAX A;  3M8W A;  1KHK A;  1ZEF A;  3NKR A;  4GTY A;  1SHQ A;  4LR2 A;  3M8Z A;  5LIA A;  3SZY A;  1O99 A;  4GTW A;  2VQR A;  4TN0 A;  5LRN A;  4LRE A;  2W5W A;  3ED4 A;  3DPC A;  3UN3 A;  4MIV A;  1EQJ A;  4ZG9 A;  2IUC B;  2GA3 A;  5AJ9 A;  1KHJ A;  1HDH A;  4MHX A;  3T02 A;  2ZKT A;  3BDG B;  2RH6 A;  1ANJ A;  5EGE A;  1O98 A;  3WAW A;  4LRF A;  4NWX A;  1ALH A;  4ZG6 A;  1ED8 A;  1HQA A;  1N2L A;  2D1G A;  1KH5 A;  4LRB A;  2XRG A;  1KHN A;  5TJ3 A;  4LR7 A;  3NVL A;  4KJD A;  2G9Y A;  2GSU A;  2W5R A;  4UPI A;  4CXK A;  1EI6 A;  3WAY A;  4CXU A;  3IGY B;  3MK2 A;  3UN5 A;  3A52 A;  1ANI A;  2W5T A;  1N2K A;  4UPH A;  1EW8 A;  4LQY A;  4LRD A;  2W5Q A;  4CYR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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