1Y7AA

Structure of d153h/k328w e. coli alkaline phosphatase in presence of cobalt at 1.77 a resolution
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDWQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y7aA00
3MK2A 4YR1A 1AJBA 5GRRA 2GSUA 3WAVA 5LRMA 4ZG7A 1KH5A 4KAVA 1EW2A 1EQJA 1KH7A 1EW9A 2XR9A 3M8YA 4UPLA 4CXSA 4LRCA 5LRNA 2IFYA 3NKMA 5K4PA 1O99A 4ZG6A 1ELXA 4KAYA 4QAXA 1KHNA 3KD8A 3T00A 4TN0A 2G9YA 2GSOA 3LXQA 4MHXA 4UORA 3SZYA 2GSNA 3BDFA 1SHNA 5IJSA 3DYCA 5LQQA 5C66A 3UNYA 3BDGB 1AJAA 1ALKA 1ED9A 4B56A 1KHJA 3ED4A 2W5WA 3OT9A 3MK1A 4GTWA 4LR8A 3M8WA 1ALHA 4CXKA 4GTZA 2IUCA 3T02A 2W5XA 1ANJA 3NKNA 1HQAA 3Q3QA 2RH6A 5DLVA 3B5QA 2ANHA 3NKOA 1URAA 3A52A 2W5VA 4CYSA 1EJJA 5L0BA 1B8JA 5L0KA 4LRBA 1ZEBA 4FDJA 4LRDA 5GOVA 3WAYA 5INHA 1AUKA 5DLTA 3E2DA 3NKPA 4KJGA 4LRFA 1ALJA 3M7VA 5TJ3A 3NKQA 5EGEA 1FSUA 1N2LA 4MY4A 4UPKA 2VQRA 3CMRA 3NKRA 3TX0A 4LQYA 1URBA 5KXAA 3BDHA 2GA3A 2QZUA 1Y7AA 1ZEFA 1HDHA 4LR7A 1ELZA 1KHKA 5DLWA 3T01A 4KM4A 4NWXA 3UO0A 3WAXA 2D1GA 2W5QA 1E2SP 4UOPA 1Y6VA 5EGHA 1E1ZP 5IJQA 4GTYA 4CYRA 4ZG9A 1ED8A 3M8ZA 4N7TA 3BDGA 1EW8A 4UPIA 1AJCA 2W8DA 2XRGA 1KH4A 4LREA 3SZZA 5LIAA 5AJ9A 4LRAA 3TWZA 4KJDA 2IUCB 1P49A 4MIVA 3IGZB 4ZGAA 3MK0A 2X98A 3NVLA 1N2KA 5L0EA 4CXUA 1ANIA 1HJKA 1E33P 1O98A 4UOOA 1ALIA 2GLQA 1K7HA 2W8SA 1KHLA 1EI6A 2W5TA 4FDIA 1KH9A 3TG0A 3WAWA 4GTXA 1E3CP 4LR2A 3UN2A 3UN5A 4UPHA 3WBHA 1ZEDA 2W5SA 5HRTA 2W5RA 3DPCA 3UN3A 3IDDA 2ZKTA 4LR9A 4NWJA 1ELYA 1AJDA 3IGYB 1SHQA
chains in the Genus database with same CATH superfamily
3MK2A 4YR1A 1AJBA 5GRRA 2GSUA 3WAVA 5LRMA 4ZG7A 1KH5A 4KAVA 1EW2A 1EQJA 1KH7A 1EW9A 2XR9A 3M8YA 4UPLA 4CXSA 4LRCA 5LRNA 2IFYA 3NKMA 5K4PA 1O99A 4ZG6A 1ELXA 4KAYA 4QAXA 1KHNA 3KD8A 3T00A 4TN0A 2G9YA 2GSOA 3LXQA 4MHXA 4UORA 3SZYA 2GSNA 3BDFA 1SHNA 5IJSA 3DYCA 5LQQA 5C66A 3UNYA 3BDGB 1AJAA 1ALKA 1ED9A 4B56A 1KHJA 3ED4A 2W5WA 3OT9A 3MK1A 4GTWA 4LR8A 3M8WA 1ALHA 4CXKA 4GTZA 2IUCA 3T02A 2W5XA 1ANJA 3NKNA 1HQAA 3Q3QA 2RH6A 5DLVA 3B5QA 2ANHA 3NKOA 1URAA 3A52A 2W5VA 4CYSA 1EJJA 5L0BA 1B8JA 5L0KA 4LRBA 1ZEBA 4FDJA 4LRDA 5GOVA 3WAYA 5INHA 1AUKA 5DLTA 3E2DA 3NKPA 4KJGA 4LRFA 1ALJA 3M7VA 5TJ3A 3NKQA 5EGEA 1FSUA 1N2LA 4MY4A 4UPKA 2VQRA 3CMRA 3NKRA 3TX0A 4LQYA 1URBA 5KXAA 3BDHA 2GA3A 2QZUA 1Y7AA 1ZEFA 1HDHA 4LR7A 1ELZA 1KHKA 5DLWA 3T01A 4KM4A 4NWXA 3UO0A 3WAXA 2D1GA 2W5QA 1E2SP 4UOPA 1Y6VA 5EGHA 1E1ZP 5IJQA 4GTYA 4CYRA 4ZG9A 1ED8A 3M8ZA 4N7TA 3BDGA 1EW8A 4UPIA 1AJCA 2W8DA 2XRGA 1KH4A 4LREA 3SZZA 5LIAA 5AJ9A 4LRAA 3TWZA 4KJDA 2IUCB 1P49A 4MIVA 3IGZB 4ZGAA 3MK0A 2X98A 3NVLA 1N2KA 5L0EA 4CXUA 1ANIA 1HJKA 1E33P 1O98A 4UOOA 1ALIA 2GLQA 1K7HA 2W8SA 1KHLA 1EI6A 2W5TA 4FDIA 1KH9A 3TG0A 3WAWA 4GTXA 1E3CP 4LR2A 3UN2A 3UN5A 4UPHA 3WBHA 1ZEDA 2W5SA 5HRTA 2W5RA 3DPCA 3UN3A 3IDDA 2ZKTA 4LR9A 4NWJA 1ELYA 1AJDA 3IGYB 1SHQA
chains in the Genus database with same CATH topology
3MK2A 4YR1A 1AJBA 5GRRA 2GSUA 3WAVA 5LRMA 4ZG7A 1KH5A 4KAVA 1EW2A 1EQJA 1KH7A 1EW9A 2XR9A 3M8YA 4UPLA 4CXSA 4LRCA 5LRNA 2IFYA 3NKMA 5K4PA 1O99A 4ZG6A 1ELXA 4KAYA 4QAXA 1KHNA 3KD8A 3T00A 4TN0A 2G9YA 2GSOA 3LXQA 4MHXA 4UORA 3SZYA 2GSNA 3BDFA 1SHNA 5IJSA 3DYCA 5LQQA 5C66A 3UNYA 3BDGB 1AJAA 1ALKA 1ED9A 4B56A 1KHJA 3ED4A 2W5WA 3OT9A 3MK1A 4GTWA 4LR8A 3M8WA 1ALHA 4CXKA 4GTZA 2IUCA 3T02A 2W5XA 1ANJA 3NKNA 1HQAA 3Q3QA 2RH6A 5DLVA 3B5QA 2ANHA 3NKOA 1URAA 3A52A 2W5VA 4CYSA 1EJJA 5L0BA 1B8JA 5L0KA 4LRBA 1ZEBA 4FDJA 4LRDA 5GOVA 3WAYA 5INHA 1AUKA 5DLTA 3E2DA 3NKPA 4KJGA 4LRFA 1ALJA 3M7VA 5TJ3A 3NKQA 5EGEA 1FSUA 1N2LA 4MY4A 4UPKA 2VQRA 3CMRA 3NKRA 3TX0A 4LQYA 1URBA 5KXAA 3BDHA 2GA3A 2QZUA 1Y7AA 1ZEFA 1HDHA 4LR7A 1ELZA 1KHKA 5DLWA 3T01A 4KM4A 4NWXA 3UO0A 3WAXA 2D1GA 2W5QA 1E2SP 4UOPA 1Y6VA 5EGHA 1E1ZP 5IJQA 4GTYA 4CYRA 4ZG9A 1ED8A 3M8ZA 4N7TA 3BDGA 1EW8A 4UPIA 1AJCA 2W8DA 2XRGA 1KH4A 4LREA 3SZZA 5LIAA 5AJ9A 4LRAA 3TWZA 4KJDA 2IUCB 1P49A 4MIVA 3IGZB 4ZGAA 3MK0A 2X98A 3NVLA 1N2KA 5L0EA 4CXUA 1ANIA 1HJKA 1E33P 1O98A 4UOOA 1ALIA 2GLQA 1K7HA 2W8SA 1KHLA 1EI6A 2W5TA 4FDIA 1KH9A 3TG0A 3WAWA 4GTXA 1E3CP 4LR2A 3UN2A 3UN5A 4UPHA 3WBHA 1ZEDA 2W5SA 5HRTA 2W5RA 3DPCA 3UN3A 3IDDA 2ZKTA 4LR9A 4NWJA 1ELYA 1AJDA 3IGYB 1SHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MK2 A;  4YR1 A;  1AJB A;  5GRR A;  2GSU A;  3WAV A;  5LRM A;  4ZG7 A;  1KH5 A;  4KAV A;  1EW2 A;  1EQJ A;  1KH7 A;  1EW9 A;  2XR9 A;  3M8Y A;  4UPL A;  4CXS A;  4LRC A;  5LRN A;  2IFY A;  3NKM A;  5K4P A;  1O99 A;  4ZG6 A;  1ELX A;  4KAY A;  4QAX A;  1KHN A;  3KD8 A;  3T00 A;  4TN0 A;  2G9Y A;  2GSO A;  3LXQ A;  4MHX A;  4UOR A;  3SZY A;  2GSN A;  3BDF A;  1SHN A;  5IJS A;  3DYC A;  5LQQ A;  5C66 A;  3UNY A;  3BDG B;  1AJA A;  1ALK A;  1ED9 A;  4B56 A;  1KHJ A;  3ED4 A;  2W5W A;  3OT9 A;  3MK1 A;  4GTW A;  4LR8 A;  3M8W A;  1ALH A;  4CXK A;  4GTZ A;  2IUC A;  3T02 A;  2W5X A;  1ANJ A;  3NKN A;  1HQA A;  3Q3Q A;  2RH6 A;  5DLV A;  3B5Q A;  2ANH A;  3NKO A;  1URA A;  3A52 A;  2W5V A;  4CYS A;  1EJJ A;  5L0B A;  1B8J A;  5L0K A;  4LRB A;  1ZEB A;  4FDJ A;  4LRD A;  5GOV A;  3WAY A;  5INH A;  1AUK A;  5DLT A;  3E2D A;  3NKP A;  4KJG A;  4LRF A;  1ALJ A;  3M7V A;  5TJ3 A;  3NKQ A;  5EGE A;  1FSU A;  1N2L A;  4MY4 A;  4UPK A;  2VQR A;  3CMR A;  3NKR A;  3TX0 A;  4LQY A;  1URB A;  5KXA A;  3BDH A;  2GA3 A;  2QZU A;  1Y7A A;  1ZEF A;  1HDH A;  4LR7 A;  1ELZ A;  1KHK A;  5DLW A;  3T01 A;  4KM4 A;  4NWX A;  3UO0 A;  3WAX A;  2D1G A;  2W5Q A;  1E2S P;  4UOP A;  1Y6V A;  5EGH A;  1E1Z P;  5IJQ A;  4GTY A;  4CYR A;  4ZG9 A;  1ED8 A;  3M8Z A;  4N7T A;  3BDG A;  1EW8 A;  4UPI A;  1AJC A;  2W8D A;  2XRG A;  1KH4 A;  4LRE A;  3SZZ A;  5LIA A;  5AJ9 A;  4LRA A;  3TWZ A;  4KJD A;  2IUC B;  1P49 A;  4MIV A;  3IGZ B;  4ZGA A;  3MK0 A;  2X98 A;  3NVL A;  1N2K A;  5L0E A;  4CXU A;  1ANI A;  1HJK A;  1E33 P;  1O98 A;  4UOO A;  1ALI A;  2GLQ A;  1K7H A;  2W8S A;  1KHL A;  1EI6 A;  2W5T A;  4FDI A;  1KH9 A;  3TG0 A;  3WAW A;  4GTX A;  1E3C P;  4LR2 A;  3UN2 A;  3UN5 A;  4UPH A;  3WBH A;  1ZED A;  2W5S A;  5HRT A;  2W5R A;  3DPC A;  3UN3 A;  3IDD A;  2ZKT A;  4LR9 A;  4NWJ A;  1ELY A;  1AJD A;  3IGY B;  1SHQ A; 
#chains in the Genus database with same CATH topology
 3MK2 A;  4YR1 A;  1AJB A;  5GRR A;  2GSU A;  3WAV A;  5LRM A;  4ZG7 A;  1KH5 A;  4KAV A;  1EW2 A;  1EQJ A;  1KH7 A;  1EW9 A;  2XR9 A;  3M8Y A;  4UPL A;  4CXS A;  4LRC A;  5LRN A;  2IFY A;  3NKM A;  5K4P A;  1O99 A;  4ZG6 A;  1ELX A;  4KAY A;  4QAX A;  1KHN A;  3KD8 A;  3T00 A;  4TN0 A;  2G9Y A;  2GSO A;  3LXQ A;  4MHX A;  4UOR A;  3SZY A;  2GSN A;  3BDF A;  1SHN A;  5IJS A;  3DYC A;  5LQQ A;  5C66 A;  3UNY A;  3BDG B;  1AJA A;  1ALK A;  1ED9 A;  4B56 A;  1KHJ A;  3ED4 A;  2W5W A;  3OT9 A;  3MK1 A;  4GTW A;  4LR8 A;  3M8W A;  1ALH A;  4CXK A;  4GTZ A;  2IUC A;  3T02 A;  2W5X A;  1ANJ A;  3NKN A;  1HQA A;  3Q3Q A;  2RH6 A;  5DLV A;  3B5Q A;  2ANH A;  3NKO A;  1URA A;  3A52 A;  2W5V A;  4CYS A;  1EJJ A;  5L0B A;  1B8J A;  5L0K A;  4LRB A;  1ZEB A;  4FDJ A;  4LRD A;  5GOV A;  3WAY A;  5INH A;  1AUK A;  5DLT A;  3E2D A;  3NKP A;  4KJG A;  4LRF A;  1ALJ A;  3M7V A;  5TJ3 A;  3NKQ A;  5EGE A;  1FSU A;  1N2L A;  4MY4 A;  4UPK A;  2VQR A;  3CMR A;  3NKR A;  3TX0 A;  4LQY A;  1URB A;  5KXA A;  3BDH A;  2GA3 A;  2QZU A;  1Y7A A;  1ZEF A;  1HDH A;  4LR7 A;  1ELZ A;  1KHK A;  5DLW A;  3T01 A;  4KM4 A;  4NWX A;  3UO0 A;  3WAX A;  2D1G A;  2W5Q A;  1E2S P;  4UOP A;  1Y6V A;  5EGH A;  1E1Z P;  5IJQ A;  4GTY A;  4CYR A;  4ZG9 A;  1ED8 A;  3M8Z A;  4N7T A;  3BDG A;  1EW8 A;  4UPI A;  1AJC A;  2W8D A;  2XRG A;  1KH4 A;  4LRE A;  3SZZ A;  5LIA A;  5AJ9 A;  4LRA A;  3TWZ A;  4KJD A;  2IUC B;  1P49 A;  4MIV A;  3IGZ B;  4ZGA A;  3MK0 A;  2X98 A;  3NVL A;  1N2K A;  5L0E A;  4CXU A;  1ANI A;  1HJK A;  1E33 P;  1O98 A;  4UOO A;  1ALI A;  2GLQ A;  1K7H A;  2W8S A;  1KHL A;  1EI6 A;  2W5T A;  4FDI A;  1KH9 A;  3TG0 A;  3WAW A;  4GTX A;  1E3C P;  4LR2 A;  3UN2 A;  3UN5 A;  4UPH A;  3WBH A;  1ZED A;  2W5S A;  5HRT A;  2W5R A;  3DPC A;  3UN3 A;  3IDD A;  2ZKT A;  4LR9 A;  4NWJ A;  1ELY A;  1AJD A;  3IGY B;  1SHQ A; 
#chains in the Genus database with same CATH homology
 3MK2 A;  4YR1 A;  1AJB A;  5GRR A;  2GSU A;  3WAV A;  5LRM A;  4ZG7 A;  1KH5 A;  4KAV A;  1EW2 A;  1EQJ A;  1KH7 A;  1EW9 A;  2XR9 A;  3M8Y A;  4UPL A;  4CXS A;  4LRC A;  5LRN A;  2IFY A;  3NKM A;  5K4P A;  1O99 A;  4ZG6 A;  1ELX A;  4KAY A;  4QAX A;  1KHN A;  3KD8 A;  3T00 A;  4TN0 A;  2G9Y A;  2GSO A;  3LXQ A;  4MHX A;  4UOR A;  3SZY A;  2GSN A;  3BDF A;  1SHN A;  5IJS A;  3DYC A;  5LQQ A;  5C66 A;  3UNY A;  3BDG B;  1AJA A;  1ALK A;  1ED9 A;  4B56 A;  1KHJ A;  3ED4 A;  2W5W A;  3OT9 A;  3MK1 A;  4GTW A;  4LR8 A;  3M8W A;  1ALH A;  4CXK A;  4GTZ A;  2IUC A;  3T02 A;  2W5X A;  1ANJ A;  3NKN A;  1HQA A;  3Q3Q A;  2RH6 A;  5DLV A;  3B5Q A;  2ANH A;  3NKO A;  1URA A;  3A52 A;  2W5V A;  4CYS A;  1EJJ A;  5L0B A;  1B8J A;  5L0K A;  4LRB A;  1ZEB A;  4FDJ A;  4LRD A;  5GOV A;  3WAY A;  5INH A;  1AUK A;  5DLT A;  3E2D A;  3NKP A;  4KJG A;  4LRF A;  1ALJ A;  3M7V A;  5TJ3 A;  3NKQ A;  5EGE A;  1FSU A;  1N2L A;  4MY4 A;  4UPK A;  2VQR A;  3CMR A;  3NKR A;  3TX0 A;  4LQY A;  1URB A;  5KXA A;  3BDH A;  2GA3 A;  2QZU A;  1Y7A A;  1ZEF A;  1HDH A;  4LR7 A;  1ELZ A;  1KHK A;  5DLW A;  3T01 A;  4KM4 A;  4NWX A;  3UO0 A;  3WAX A;  2D1G A;  2W5Q A;  1E2S P;  4UOP A;  1Y6V A;  5EGH A;  1E1Z P;  5IJQ A;  4GTY A;  4CYR A;  4ZG9 A;  1ED8 A;  3M8Z A;  4N7T A;  3BDG A;  1EW8 A;  4UPI A;  1AJC A;  2W8D A;  2XRG A;  1KH4 A;  4LRE A;  3SZZ A;  5LIA A;  5AJ9 A;  4LRA A;  3TWZ A;  4KJD A;  2IUC B;  1P49 A;  4MIV A;  3IGZ B;  4ZGA A;  3MK0 A;  2X98 A;  3NVL A;  1N2K A;  5L0E A;  4CXU A;  1ANI A;  1HJK A;  1E33 P;  1O98 A;  4UOO A;  1ALI A;  2GLQ A;  1K7H A;  2W8S A;  1KHL A;  1EI6 A;  2W5T A;  4FDI A;  1KH9 A;  3TG0 A;  3WAW A;  4GTX A;  1E3C P;  4LR2 A;  3UN2 A;  3UN5 A;  4UPH A;  3WBH A;  1ZED A;  2W5S A;  5HRT A;  2W5R A;  3DPC A;  3UN3 A;  3IDD A;  2ZKT A;  4LR9 A;  4NWJ A;  1ELY A;  1AJD A;  3IGY B;  1SHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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