1ZEBA

X-ray structure of alkaline phosphatase from human placenta in complex with 5'-amp
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
Knots found
sequence length
480
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 173
structure length 479
sequence length 480
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zebA00
5L0BA 3TX0A 3TWZA 2W8DA 5C66A 4TN0A 2GSNA 4KAVA 4GTYA 1KHNA 1KH9A 3E2DA 2IUCB 2W8SA 3BDGB 3NKQA 4MHXA 3T02A 5INHA 1AJCA 4GTWA 4LR8A 5GOVA 2VQRA 1SHNA 3NKMA 4UOPA 1ALIA 4ZGAA 3WBHA 2XRGA 5EGEA 4CXSA 1ELZA 3UN2A 1E33P 5LRNA 4MIVA 3UN3A 4CYRA 5DLTA 1Y6VA 2W5QA 4NWJA 4ZG7A 2ZKTA 3M7VA 3ED4A 4B56A 1ANIA 1EJJA 2W5VA 2GSUA 4LQYA 2GA3A 3Q3QA 1Y7AA 4NWXA 4GTXA 4KAYA 3IGZB 3IDDA 5L0KA 1ELYA 3B5QA 1HQAA 3NVLA 4LR2A 1ZEBA 1E2SP 2W5SA 4UPKA 2GLQA 4ZG6A 5LRMA 1O99A 4UPHA 5GRRA 4LR7A 1K7HA 2RH6A 4LRDA 1P49A 1EW9A 1HDHA 1ZEFA 4LRBA 5IJQA 3MK0A 3TG0A 2G9YA 3IGYB 2ANHA 3CMRA 5AJ9A 1ELXA 1O98A 3LXQA 3MK2A 4CXUA 4QAXA 2GSOA 1AUKA 1EQJA 4FDIA 4LREA 3WAXA 1KHKA 1ALHA 2IFYA 3NKOA 3A52A 4KJDA 4LRFA 1ALJA 5DLVA 4UPLA 4ZG9A 5TJ3A 1E3CP 3WAWA 2QZUA 1KHJA 4KJGA 4LRAA 4GTZA 4N7TA 1AJDA 1EW8A 1ZEDA 3M8YA 1KH5A 3WAYA 5L0EA 1ANJA 2XR9A 3KD8A 4KM4A 1KHLA 1AJAA 2W5RA 3UN5A 5LQQA 5HRTA 1ALKA 3NKNA 1ED9A 3MK1A 2X98A 3M8WA 1N2KA 3T00A 2IUCA 4CXKA 1EI6A 1URBA 3BDGA 3OT9A 3WAVA 3SZZA 2W5WA 1SHQA 1URAA 4LRCA 3NKRA 3UNYA 1ED8A 1KH7A 3T01A 1KH4A 5DLWA 3DYCA 3NKPA 3DPCA 2W5TA 3BDFA 1HJKA 1FSUA 2W5XA 4UOOA 1B8JA 5LIAA 4YR1A 5EGHA 3SZYA 1AJBA 4FDJA 4LR9A 1E1ZP 4UPIA 3UO0A 4CYSA 3M8ZA 1N2LA 2D1GA 4UORA 1EW2A 5K4PA 3BDHA 4MY4A 5IJSA 5KXAA
chains in the Genus database with same CATH superfamily
5L0BA 3TX0A 3TWZA 2W8DA 5C66A 4TN0A 2GSNA 4KAVA 4GTYA 1KHNA 1KH9A 3E2DA 2IUCB 2W8SA 3BDGB 3NKQA 4MHXA 3T02A 5INHA 1AJCA 4GTWA 4LR8A 5GOVA 2VQRA 1SHNA 3NKMA 4UOPA 1ALIA 4ZGAA 3WBHA 2XRGA 5EGEA 4CXSA 1ELZA 3UN2A 1E33P 5LRNA 4MIVA 3UN3A 4CYRA 5DLTA 1Y6VA 2W5QA 4NWJA 4ZG7A 2ZKTA 3M7VA 3ED4A 4B56A 1ANIA 1EJJA 2W5VA 2GSUA 4LQYA 2GA3A 3Q3QA 1Y7AA 4NWXA 4GTXA 4KAYA 3IGZB 3IDDA 5L0KA 1ELYA 3B5QA 1HQAA 3NVLA 4LR2A 1ZEBA 1E2SP 2W5SA 4UPKA 2GLQA 4ZG6A 5LRMA 1O99A 4UPHA 5GRRA 4LR7A 1K7HA 2RH6A 4LRDA 1P49A 1EW9A 1HDHA 1ZEFA 4LRBA 5IJQA 3MK0A 3TG0A 2G9YA 3IGYB 2ANHA 3CMRA 5AJ9A 1ELXA 1O98A 3LXQA 3MK2A 4CXUA 4QAXA 2GSOA 1AUKA 1EQJA 4FDIA 4LREA 3WAXA 1KHKA 1ALHA 2IFYA 3NKOA 3A52A 4KJDA 4LRFA 1ALJA 5DLVA 4UPLA 4ZG9A 5TJ3A 1E3CP 3WAWA 2QZUA 1KHJA 4KJGA 4LRAA 4GTZA 4N7TA 1AJDA 1EW8A 1ZEDA 3M8YA 1KH5A 3WAYA 5L0EA 1ANJA 2XR9A 3KD8A 4KM4A 1KHLA 1AJAA 2W5RA 3UN5A 5LQQA 5HRTA 1ALKA 3NKNA 1ED9A 3MK1A 2X98A 3M8WA 1N2KA 3T00A 2IUCA 4CXKA 1EI6A 1URBA 3BDGA 3OT9A 3WAVA 3SZZA 2W5WA 1SHQA 1URAA 4LRCA 3NKRA 3UNYA 1ED8A 1KH7A 3T01A 1KH4A 5DLWA 3DYCA 3NKPA 3DPCA 2W5TA 3BDFA 1HJKA 1FSUA 2W5XA 4UOOA 1B8JA 5LIAA 4YR1A 5EGHA 3SZYA 1AJBA 4FDJA 4LR9A 1E1ZP 4UPIA 3UO0A 4CYSA 3M8ZA 1N2LA 2D1GA 4UORA 1EW2A 5K4PA 3BDHA 4MY4A 5IJSA 5KXAA
chains in the Genus database with same CATH topology
5L0BA 3TX0A 3TWZA 2W8DA 5C66A 4TN0A 2GSNA 4KAVA 4GTYA 1KHNA 1KH9A 3E2DA 2IUCB 2W8SA 3BDGB 3NKQA 4MHXA 3T02A 5INHA 1AJCA 4GTWA 4LR8A 5GOVA 2VQRA 1SHNA 3NKMA 4UOPA 1ALIA 4ZGAA 3WBHA 2XRGA 5EGEA 4CXSA 1ELZA 3UN2A 1E33P 5LRNA 4MIVA 3UN3A 4CYRA 5DLTA 1Y6VA 2W5QA 4NWJA 4ZG7A 2ZKTA 3M7VA 3ED4A 4B56A 1ANIA 1EJJA 2W5VA 2GSUA 4LQYA 2GA3A 3Q3QA 1Y7AA 4NWXA 4GTXA 4KAYA 3IGZB 3IDDA 5L0KA 1ELYA 3B5QA 1HQAA 3NVLA 4LR2A 1ZEBA 1E2SP 2W5SA 4UPKA 2GLQA 4ZG6A 5LRMA 1O99A 4UPHA 5GRRA 4LR7A 1K7HA 2RH6A 4LRDA 1P49A 1EW9A 1HDHA 1ZEFA 4LRBA 5IJQA 3MK0A 3TG0A 2G9YA 3IGYB 2ANHA 3CMRA 5AJ9A 1ELXA 1O98A 3LXQA 3MK2A 4CXUA 4QAXA 2GSOA 1AUKA 1EQJA 4FDIA 4LREA 3WAXA 1KHKA 1ALHA 2IFYA 3NKOA 3A52A 4KJDA 4LRFA 1ALJA 5DLVA 4UPLA 4ZG9A 5TJ3A 1E3CP 3WAWA 2QZUA 1KHJA 4KJGA 4LRAA 4GTZA 4N7TA 1AJDA 1EW8A 1ZEDA 3M8YA 1KH5A 3WAYA 5L0EA 1ANJA 2XR9A 3KD8A 4KM4A 1KHLA 1AJAA 2W5RA 3UN5A 5LQQA 5HRTA 1ALKA 3NKNA 1ED9A 3MK1A 2X98A 3M8WA 1N2KA 3T00A 2IUCA 4CXKA 1EI6A 1URBA 3BDGA 3OT9A 3WAVA 3SZZA 2W5WA 1SHQA 1URAA 4LRCA 3NKRA 3UNYA 1ED8A 1KH7A 3T01A 1KH4A 5DLWA 3DYCA 3NKPA 3DPCA 2W5TA 3BDFA 1HJKA 1FSUA 2W5XA 4UOOA 1B8JA 5LIAA 4YR1A 5EGHA 3SZYA 1AJBA 4FDJA 4LR9A 1E1ZP 4UPIA 3UO0A 4CYSA 3M8ZA 1N2LA 2D1GA 4UORA 1EW2A 5K4PA 3BDHA 4MY4A 5IJSA 5KXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0B A;  3TX0 A;  3TWZ A;  2W8D A;  5C66 A;  4TN0 A;  2GSN A;  4KAV A;  4GTY A;  1KHN A;  1KH9 A;  3E2D A;  2IUC B;  2W8S A;  3BDG B;  3NKQ A;  4MHX A;  3T02 A;  5INH A;  1AJC A;  4GTW A;  4LR8 A;  5GOV A;  2VQR A;  1SHN A;  3NKM A;  4UOP A;  1ALI A;  4ZGA A;  3WBH A;  2XRG A;  5EGE A;  4CXS A;  1ELZ A;  3UN2 A;  1E33 P;  5LRN A;  4MIV A;  3UN3 A;  4CYR A;  5DLT A;  1Y6V A;  2W5Q A;  4NWJ A;  4ZG7 A;  2ZKT A;  3M7V A;  3ED4 A;  4B56 A;  1ANI A;  1EJJ A;  2W5V A;  2GSU A;  4LQY A;  2GA3 A;  3Q3Q A;  1Y7A A;  4NWX A;  4GTX A;  4KAY A;  3IGZ B;  3IDD A;  5L0K A;  1ELY A;  3B5Q A;  1HQA A;  3NVL A;  4LR2 A;  1ZEB A;  1E2S P;  2W5S A;  4UPK A;  2GLQ A;  4ZG6 A;  5LRM A;  1O99 A;  4UPH A;  5GRR A;  4LR7 A;  1K7H A;  2RH6 A;  4LRD A;  1P49 A;  1EW9 A;  1HDH A;  1ZEF A;  4LRB A;  5IJQ A;  3MK0 A;  3TG0 A;  2G9Y A;  3IGY B;  2ANH A;  3CMR A;  5AJ9 A;  1ELX A;  1O98 A;  3LXQ A;  3MK2 A;  4CXU A;  4QAX A;  2GSO A;  1AUK A;  1EQJ A;  4FDI A;  4LRE A;  3WAX A;  1KHK A;  1ALH A;  2IFY A;  3NKO A;  3A52 A;  4KJD A;  4LRF A;  1ALJ A;  5DLV A;  4UPL A;  4ZG9 A;  5TJ3 A;  1E3C P;  3WAW A;  2QZU A;  1KHJ A;  4KJG A;  4LRA A;  4GTZ A;  4N7T A;  1AJD A;  1EW8 A;  1ZED A;  3M8Y A;  1KH5 A;  3WAY A;  5L0E A;  1ANJ A;  2XR9 A;  3KD8 A;  4KM4 A;  1KHL A;  1AJA A;  2W5R A;  3UN5 A;  5LQQ A;  5HRT A;  1ALK A;  3NKN A;  1ED9 A;  3MK1 A;  2X98 A;  3M8W A;  1N2K A;  3T00 A;  2IUC A;  4CXK A;  1EI6 A;  1URB A;  3BDG A;  3OT9 A;  3WAV A;  3SZZ A;  2W5W A;  1SHQ A;  1URA A;  4LRC A;  3NKR A;  3UNY A;  1ED8 A;  1KH7 A;  3T01 A;  1KH4 A;  5DLW A;  3DYC A;  3NKP A;  3DPC A;  2W5T A;  3BDF A;  1HJK A;  1FSU A;  2W5X A;  4UOO A;  1B8J A;  5LIA A;  4YR1 A;  5EGH A;  3SZY A;  1AJB A;  4FDJ A;  4LR9 A;  1E1Z P;  4UPI A;  3UO0 A;  4CYS A;  3M8Z A;  1N2L A;  2D1G A;  4UOR A;  1EW2 A;  5K4P A;  3BDH A;  4MY4 A;  5IJS A;  5KXA A; 
#chains in the Genus database with same CATH topology
 5L0B A;  3TX0 A;  3TWZ A;  2W8D A;  5C66 A;  4TN0 A;  2GSN A;  4KAV A;  4GTY A;  1KHN A;  1KH9 A;  3E2D A;  2IUC B;  2W8S A;  3BDG B;  3NKQ A;  4MHX A;  3T02 A;  5INH A;  1AJC A;  4GTW A;  4LR8 A;  5GOV A;  2VQR A;  1SHN A;  3NKM A;  4UOP A;  1ALI A;  4ZGA A;  3WBH A;  2XRG A;  5EGE A;  4CXS A;  1ELZ A;  3UN2 A;  1E33 P;  5LRN A;  4MIV A;  3UN3 A;  4CYR A;  5DLT A;  1Y6V A;  2W5Q A;  4NWJ A;  4ZG7 A;  2ZKT A;  3M7V A;  3ED4 A;  4B56 A;  1ANI A;  1EJJ A;  2W5V A;  2GSU A;  4LQY A;  2GA3 A;  3Q3Q A;  1Y7A A;  4NWX A;  4GTX A;  4KAY A;  3IGZ B;  3IDD A;  5L0K A;  1ELY A;  3B5Q A;  1HQA A;  3NVL A;  4LR2 A;  1ZEB A;  1E2S P;  2W5S A;  4UPK A;  2GLQ A;  4ZG6 A;  5LRM A;  1O99 A;  4UPH A;  5GRR A;  4LR7 A;  1K7H A;  2RH6 A;  4LRD A;  1P49 A;  1EW9 A;  1HDH A;  1ZEF A;  4LRB A;  5IJQ A;  3MK0 A;  3TG0 A;  2G9Y A;  3IGY B;  2ANH A;  3CMR A;  5AJ9 A;  1ELX A;  1O98 A;  3LXQ A;  3MK2 A;  4CXU A;  4QAX A;  2GSO A;  1AUK A;  1EQJ A;  4FDI A;  4LRE A;  3WAX A;  1KHK A;  1ALH A;  2IFY A;  3NKO A;  3A52 A;  4KJD A;  4LRF A;  1ALJ A;  5DLV A;  4UPL A;  4ZG9 A;  5TJ3 A;  1E3C P;  3WAW A;  2QZU A;  1KHJ A;  4KJG A;  4LRA A;  4GTZ A;  4N7T A;  1AJD A;  1EW8 A;  1ZED A;  3M8Y A;  1KH5 A;  3WAY A;  5L0E A;  1ANJ A;  2XR9 A;  3KD8 A;  4KM4 A;  1KHL A;  1AJA A;  2W5R A;  3UN5 A;  5LQQ A;  5HRT A;  1ALK A;  3NKN A;  1ED9 A;  3MK1 A;  2X98 A;  3M8W A;  1N2K A;  3T00 A;  2IUC A;  4CXK A;  1EI6 A;  1URB A;  3BDG A;  3OT9 A;  3WAV A;  3SZZ A;  2W5W A;  1SHQ A;  1URA A;  4LRC A;  3NKR A;  3UNY A;  1ED8 A;  1KH7 A;  3T01 A;  1KH4 A;  5DLW A;  3DYC A;  3NKP A;  3DPC A;  2W5T A;  3BDF A;  1HJK A;  1FSU A;  2W5X A;  4UOO A;  1B8J A;  5LIA A;  4YR1 A;  5EGH A;  3SZY A;  1AJB A;  4FDJ A;  4LR9 A;  1E1Z P;  4UPI A;  3UO0 A;  4CYS A;  3M8Z A;  1N2L A;  2D1G A;  4UOR A;  1EW2 A;  5K4P A;  3BDH A;  4MY4 A;  5IJS A;  5KXA A; 
#chains in the Genus database with same CATH homology
 5L0B A;  3TX0 A;  3TWZ A;  2W8D A;  5C66 A;  4TN0 A;  2GSN A;  4KAV A;  4GTY A;  1KHN A;  1KH9 A;  3E2D A;  2IUC B;  2W8S A;  3BDG B;  3NKQ A;  4MHX A;  3T02 A;  5INH A;  1AJC A;  4GTW A;  4LR8 A;  5GOV A;  2VQR A;  1SHN A;  3NKM A;  4UOP A;  1ALI A;  4ZGA A;  3WBH A;  2XRG A;  5EGE A;  4CXS A;  1ELZ A;  3UN2 A;  1E33 P;  5LRN A;  4MIV A;  3UN3 A;  4CYR A;  5DLT A;  1Y6V A;  2W5Q A;  4NWJ A;  4ZG7 A;  2ZKT A;  3M7V A;  3ED4 A;  4B56 A;  1ANI A;  1EJJ A;  2W5V A;  2GSU A;  4LQY A;  2GA3 A;  3Q3Q A;  1Y7A A;  4NWX A;  4GTX A;  4KAY A;  3IGZ B;  3IDD A;  5L0K A;  1ELY A;  3B5Q A;  1HQA A;  3NVL A;  4LR2 A;  1ZEB A;  1E2S P;  2W5S A;  4UPK A;  2GLQ A;  4ZG6 A;  5LRM A;  1O99 A;  4UPH A;  5GRR A;  4LR7 A;  1K7H A;  2RH6 A;  4LRD A;  1P49 A;  1EW9 A;  1HDH A;  1ZEF A;  4LRB A;  5IJQ A;  3MK0 A;  3TG0 A;  2G9Y A;  3IGY B;  2ANH A;  3CMR A;  5AJ9 A;  1ELX A;  1O98 A;  3LXQ A;  3MK2 A;  4CXU A;  4QAX A;  2GSO A;  1AUK A;  1EQJ A;  4FDI A;  4LRE A;  3WAX A;  1KHK A;  1ALH A;  2IFY A;  3NKO A;  3A52 A;  4KJD A;  4LRF A;  1ALJ A;  5DLV A;  4UPL A;  4ZG9 A;  5TJ3 A;  1E3C P;  3WAW A;  2QZU A;  1KHJ A;  4KJG A;  4LRA A;  4GTZ A;  4N7T A;  1AJD A;  1EW8 A;  1ZED A;  3M8Y A;  1KH5 A;  3WAY A;  5L0E A;  1ANJ A;  2XR9 A;  3KD8 A;  4KM4 A;  1KHL A;  1AJA A;  2W5R A;  3UN5 A;  5LQQ A;  5HRT A;  1ALK A;  3NKN A;  1ED9 A;  3MK1 A;  2X98 A;  3M8W A;  1N2K A;  3T00 A;  2IUC A;  4CXK A;  1EI6 A;  1URB A;  3BDG A;  3OT9 A;  3WAV A;  3SZZ A;  2W5W A;  1SHQ A;  1URA A;  4LRC A;  3NKR A;  3UNY A;  1ED8 A;  1KH7 A;  3T01 A;  1KH4 A;  5DLW A;  3DYC A;  3NKP A;  3DPC A;  2W5T A;  3BDF A;  1HJK A;  1FSU A;  2W5X A;  4UOO A;  1B8J A;  5LIA A;  4YR1 A;  5EGH A;  3SZY A;  1AJB A;  4FDJ A;  4LR9 A;  1E1Z P;  4UPI A;  3UO0 A;  4CYS A;  3M8Z A;  1N2L A;  2D1G A;  4UOR A;  1EW2 A;  5K4P A;  3BDH A;  4MY4 A;  5IJS A;  5KXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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