1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
3M8WA 3WAXA 5TJ3A 1AJCA 5EGEA 1ED9A 3M8ZA 5L0KA 1E2SP 4TN0A 1KH5A 1ELYA 1URBA 1K7HA 4UPIA 5IJSA 2X98A 1HQAA 5AJ9A 3NKQA 3MK0A 1KHKA 4LQYA 1ALJA 5EGHA 5DLWA 3OT9A 2IUCA 1SHNA 4KAYA 1AJAA 2GSUA 3UN3A 1URAA 3BDGA 1Y6VA 1N2KA 4B56A 1ED8A 1AJDA 3DYCA 1KHNA 2GSNA 2GA3A 4KAVA 1ZEBA 1E1ZP 5L0BA 3WAVA 4UOPA 1KHJA 4LR2A 4LRFA 1FSUA 4MY4A 1EQJA 3M7VA 4KJDA 3WBHA 5LQQA 4FDIA 5KXAA 1SHQA 4UOOA 3WAWA 2QZUA 3IDDA 1HJKA 4KJGA 5IJQA 3UN2A 4NWJA 3SZZA 1ALHA 2GLQA 1ALKA 3E2DA 3TG0A 4CYRA 4UORA 4MHXA 4LRCA 4UPKA 4GTYA 1EI6A 2VQRA 3DPCA 3UN5A 3MK2A 3UNYA 3ED4A 1KH4A 2W8DA 1EJJA 4LR7A 1EW2A 4FDJA 1ANJA 1O98A 4LREA 4CXUA 2W5VA 5LRMA 1ALIA 3NKNA 3CMRA 2ANHA 2XR9A 1Y7AA 3NKRA 4YR1A 3A52A 4GTZA 4ZG7A 3T02A 2W5XA 5DLTA 1ZEFA 3UO0A 4KM4A 4ZG6A 4CXKA 1KHLA 5HRTA 3WAYA 1N2LA 1ANIA 4LR9A 1AUKA 3T00A 5L0EA 2W5SA 1ELZA 3IGYB 1AJBA 4CXSA 2ZKTA 4MIVA 4UPLA 3M8YA 1ZEDA 3B5QA 5GOVA 3TX0A 5C66A 4LR8A 1P49A 2W5QA 4LRBA 1B8JA 4GTWA 2GSOA 2W8SA 3LXQA 4GTXA 5LIAA 4UPHA 4NWXA 1E33P 2IUCB 1KH9A 1O99A 3BDHA 3IGZB 3Q3QA 2RH6A 3NKMA 4QAXA 4LRAA 3BDGB 2W5TA 1EW9A 3TWZA 3NKPA 5INHA 1ELXA 4N7TA 2W5WA 1HDHA 4CYSA 4LRDA 4ZG9A 1E3CP 4ZGAA 2XRGA 1EW8A 2G9YA 3MK1A 3NKOA 1KH7A 5GRRA 5LRNA 5K4PA 3SZYA 3KD8A 3NVLA 3BDFA 2D1GA 5DLVA 2IFYA 3T01A 2W5RA
chains in the Genus database with same CATH superfamily
3M8WA 3WAXA 5TJ3A 1AJCA 5EGEA 1ED9A 3M8ZA 5L0KA 1E2SP 4TN0A 1KH5A 1ELYA 1URBA 1K7HA 4UPIA 5IJSA 2X98A 1HQAA 5AJ9A 3NKQA 3MK0A 1KHKA 4LQYA 1ALJA 5EGHA 5DLWA 3OT9A 2IUCA 1SHNA 4KAYA 1AJAA 2GSUA 3UN3A 1URAA 3BDGA 1Y6VA 1N2KA 4B56A 1ED8A 1AJDA 3DYCA 1KHNA 2GSNA 2GA3A 4KAVA 1ZEBA 1E1ZP 5L0BA 3WAVA 4UOPA 1KHJA 4LR2A 4LRFA 1FSUA 4MY4A 1EQJA 3M7VA 4KJDA 3WBHA 5LQQA 4FDIA 5KXAA 1SHQA 4UOOA 3WAWA 2QZUA 3IDDA 1HJKA 4KJGA 5IJQA 3UN2A 4NWJA 3SZZA 1ALHA 2GLQA 1ALKA 3E2DA 3TG0A 4CYRA 4UORA 4MHXA 4LRCA 4UPKA 4GTYA 1EI6A 2VQRA 3DPCA 3UN5A 3MK2A 3UNYA 3ED4A 1KH4A 2W8DA 1EJJA 4LR7A 1EW2A 4FDJA 1ANJA 1O98A 4LREA 4CXUA 2W5VA 5LRMA 1ALIA 3NKNA 3CMRA 2ANHA 2XR9A 1Y7AA 3NKRA 4YR1A 3A52A 4GTZA 4ZG7A 3T02A 2W5XA 5DLTA 1ZEFA 3UO0A 4KM4A 4ZG6A 4CXKA 1KHLA 5HRTA 3WAYA 1N2LA 1ANIA 4LR9A 1AUKA 3T00A 5L0EA 2W5SA 1ELZA 3IGYB 1AJBA 4CXSA 2ZKTA 4MIVA 4UPLA 3M8YA 1ZEDA 3B5QA 5GOVA 3TX0A 5C66A 4LR8A 1P49A 2W5QA 4LRBA 1B8JA 4GTWA 2GSOA 2W8SA 3LXQA 4GTXA 5LIAA 4UPHA 4NWXA 1E33P 2IUCB 1KH9A 1O99A 3BDHA 3IGZB 3Q3QA 2RH6A 3NKMA 4QAXA 4LRAA 3BDGB 2W5TA 1EW9A 3TWZA 3NKPA 5INHA 1ELXA 4N7TA 2W5WA 1HDHA 4CYSA 4LRDA 4ZG9A 1E3CP 4ZGAA 2XRGA 1EW8A 2G9YA 3MK1A 3NKOA 1KH7A 5GRRA 5LRNA 5K4PA 3SZYA 3KD8A 3NVLA 3BDFA 2D1GA 5DLVA 2IFYA 3T01A 2W5RA
chains in the Genus database with same CATH topology
3M8WA 3WAXA 5TJ3A 1AJCA 5EGEA 1ED9A 3M8ZA 5L0KA 1E2SP 4TN0A 1KH5A 1ELYA 1URBA 1K7HA 4UPIA 5IJSA 2X98A 1HQAA 5AJ9A 3NKQA 3MK0A 1KHKA 4LQYA 1ALJA 5EGHA 5DLWA 3OT9A 2IUCA 1SHNA 4KAYA 1AJAA 2GSUA 3UN3A 1URAA 3BDGA 1Y6VA 1N2KA 4B56A 1ED8A 1AJDA 3DYCA 1KHNA 2GSNA 2GA3A 4KAVA 1ZEBA 1E1ZP 5L0BA 3WAVA 4UOPA 1KHJA 4LR2A 4LRFA 1FSUA 4MY4A 1EQJA 3M7VA 4KJDA 3WBHA 5LQQA 4FDIA 5KXAA 1SHQA 4UOOA 3WAWA 2QZUA 3IDDA 1HJKA 4KJGA 5IJQA 3UN2A 4NWJA 3SZZA 1ALHA 2GLQA 1ALKA 3E2DA 3TG0A 4CYRA 4UORA 4MHXA 4LRCA 4UPKA 4GTYA 1EI6A 2VQRA 3DPCA 3UN5A 3MK2A 3UNYA 3ED4A 1KH4A 2W8DA 1EJJA 4LR7A 1EW2A 4FDJA 1ANJA 1O98A 4LREA 4CXUA 2W5VA 5LRMA 1ALIA 3NKNA 3CMRA 2ANHA 2XR9A 1Y7AA 3NKRA 4YR1A 3A52A 4GTZA 4ZG7A 3T02A 2W5XA 5DLTA 1ZEFA 3UO0A 4KM4A 4ZG6A 4CXKA 1KHLA 5HRTA 3WAYA 1N2LA 1ANIA 4LR9A 1AUKA 3T00A 5L0EA 2W5SA 1ELZA 3IGYB 1AJBA 4CXSA 2ZKTA 4MIVA 4UPLA 3M8YA 1ZEDA 3B5QA 5GOVA 3TX0A 5C66A 4LR8A 1P49A 2W5QA 4LRBA 1B8JA 4GTWA 2GSOA 2W8SA 3LXQA 4GTXA 5LIAA 4UPHA 4NWXA 1E33P 2IUCB 1KH9A 1O99A 3BDHA 3IGZB 3Q3QA 2RH6A 3NKMA 4QAXA 4LRAA 3BDGB 2W5TA 1EW9A 3TWZA 3NKPA 5INHA 1ELXA 4N7TA 2W5WA 1HDHA 4CYSA 4LRDA 4ZG9A 1E3CP 4ZGAA 2XRGA 1EW8A 2G9YA 3MK1A 3NKOA 1KH7A 5GRRA 5LRNA 5K4PA 3SZYA 3KD8A 3NVLA 3BDFA 2D1GA 5DLVA 2IFYA 3T01A 2W5RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M8W A;  3WAX A;  5TJ3 A;  1AJC A;  5EGE A;  1ED9 A;  3M8Z A;  5L0K A;  1E2S P;  4TN0 A;  1KH5 A;  1ELY A;  1URB A;  1K7H A;  4UPI A;  5IJS A;  2X98 A;  1HQA A;  5AJ9 A;  3NKQ A;  3MK0 A;  1KHK A;  4LQY A;  1ALJ A;  5EGH A;  5DLW A;  3OT9 A;  2IUC A;  1SHN A;  4KAY A;  1AJA A;  2GSU A;  3UN3 A;  1URA A;  3BDG A;  1Y6V A;  1N2K A;  4B56 A;  1ED8 A;  1AJD A;  3DYC A;  1KHN A;  2GSN A;  2GA3 A;  4KAV A;  1ZEB A;  1E1Z P;  5L0B A;  3WAV A;  4UOP A;  1KHJ A;  4LR2 A;  4LRF A;  1FSU A;  4MY4 A;  1EQJ A;  3M7V A;  4KJD A;  3WBH A;  5LQQ A;  4FDI A;  5KXA A;  1SHQ A;  4UOO A;  3WAW A;  2QZU A;  3IDD A;  1HJK A;  4KJG A;  5IJQ A;  3UN2 A;  4NWJ A;  3SZZ A;  1ALH A;  2GLQ A;  1ALK A;  3E2D A;  3TG0 A;  4CYR A;  4UOR A;  4MHX A;  4LRC A;  4UPK A;  4GTY A;  1EI6 A;  2VQR A;  3DPC A;  3UN5 A;  3MK2 A;  3UNY A;  3ED4 A;  1KH4 A;  2W8D A;  1EJJ A;  4LR7 A;  1EW2 A;  4FDJ A;  1ANJ A;  1O98 A;  4LRE A;  4CXU A;  2W5V A;  5LRM A;  1ALI A;  3NKN A;  3CMR A;  2ANH A;  2XR9 A;  1Y7A A;  3NKR A;  4YR1 A;  3A52 A;  4GTZ A;  4ZG7 A;  3T02 A;  2W5X A;  5DLT A;  1ZEF A;  3UO0 A;  4KM4 A;  4ZG6 A;  4CXK A;  1KHL A;  5HRT A;  3WAY A;  1N2L A;  1ANI A;  4LR9 A;  1AUK A;  3T00 A;  5L0E A;  2W5S A;  1ELZ A;  3IGY B;  1AJB A;  4CXS A;  2ZKT A;  4MIV A;  4UPL A;  3M8Y A;  1ZED A;  3B5Q A;  5GOV A;  3TX0 A;  5C66 A;  4LR8 A;  1P49 A;  2W5Q A;  4LRB A;  1B8J A;  4GTW A;  2GSO A;  2W8S A;  3LXQ A;  4GTX A;  5LIA A;  4UPH A;  4NWX A;  1E33 P;  2IUC B;  1KH9 A;  1O99 A;  3BDH A;  3IGZ B;  3Q3Q A;  2RH6 A;  3NKM A;  4QAX A;  4LRA A;  3BDG B;  2W5T A;  1EW9 A;  3TWZ A;  3NKP A;  5INH A;  1ELX A;  4N7T A;  2W5W A;  1HDH A;  4CYS A;  4LRD A;  4ZG9 A;  1E3C P;  4ZGA A;  2XRG A;  1EW8 A;  2G9Y A;  3MK1 A;  3NKO A;  1KH7 A;  5GRR A;  5LRN A;  5K4P A;  3SZY A;  3KD8 A;  3NVL A;  3BDF A;  2D1G A;  5DLV A;  2IFY A;  3T01 A;  2W5R A; 
#chains in the Genus database with same CATH topology
 3M8W A;  3WAX A;  5TJ3 A;  1AJC A;  5EGE A;  1ED9 A;  3M8Z A;  5L0K A;  1E2S P;  4TN0 A;  1KH5 A;  1ELY A;  1URB A;  1K7H A;  4UPI A;  5IJS A;  2X98 A;  1HQA A;  5AJ9 A;  3NKQ A;  3MK0 A;  1KHK A;  4LQY A;  1ALJ A;  5EGH A;  5DLW A;  3OT9 A;  2IUC A;  1SHN A;  4KAY A;  1AJA A;  2GSU A;  3UN3 A;  1URA A;  3BDG A;  1Y6V A;  1N2K A;  4B56 A;  1ED8 A;  1AJD A;  3DYC A;  1KHN A;  2GSN A;  2GA3 A;  4KAV A;  1ZEB A;  1E1Z P;  5L0B A;  3WAV A;  4UOP A;  1KHJ A;  4LR2 A;  4LRF A;  1FSU A;  4MY4 A;  1EQJ A;  3M7V A;  4KJD A;  3WBH A;  5LQQ A;  4FDI A;  5KXA A;  1SHQ A;  4UOO A;  3WAW A;  2QZU A;  3IDD A;  1HJK A;  4KJG A;  5IJQ A;  3UN2 A;  4NWJ A;  3SZZ A;  1ALH A;  2GLQ A;  1ALK A;  3E2D A;  3TG0 A;  4CYR A;  4UOR A;  4MHX A;  4LRC A;  4UPK A;  4GTY A;  1EI6 A;  2VQR A;  3DPC A;  3UN5 A;  3MK2 A;  3UNY A;  3ED4 A;  1KH4 A;  2W8D A;  1EJJ A;  4LR7 A;  1EW2 A;  4FDJ A;  1ANJ A;  1O98 A;  4LRE A;  4CXU A;  2W5V A;  5LRM A;  1ALI A;  3NKN A;  3CMR A;  2ANH A;  2XR9 A;  1Y7A A;  3NKR A;  4YR1 A;  3A52 A;  4GTZ A;  4ZG7 A;  3T02 A;  2W5X A;  5DLT A;  1ZEF A;  3UO0 A;  4KM4 A;  4ZG6 A;  4CXK A;  1KHL A;  5HRT A;  3WAY A;  1N2L A;  1ANI A;  4LR9 A;  1AUK A;  3T00 A;  5L0E A;  2W5S A;  1ELZ A;  3IGY B;  1AJB A;  4CXS A;  2ZKT A;  4MIV A;  4UPL A;  3M8Y A;  1ZED A;  3B5Q A;  5GOV A;  3TX0 A;  5C66 A;  4LR8 A;  1P49 A;  2W5Q A;  4LRB A;  1B8J A;  4GTW A;  2GSO A;  2W8S A;  3LXQ A;  4GTX A;  5LIA A;  4UPH A;  4NWX A;  1E33 P;  2IUC B;  1KH9 A;  1O99 A;  3BDH A;  3IGZ B;  3Q3Q A;  2RH6 A;  3NKM A;  4QAX A;  4LRA A;  3BDG B;  2W5T A;  1EW9 A;  3TWZ A;  3NKP A;  5INH A;  1ELX A;  4N7T A;  2W5W A;  1HDH A;  4CYS A;  4LRD A;  4ZG9 A;  1E3C P;  4ZGA A;  2XRG A;  1EW8 A;  2G9Y A;  3MK1 A;  3NKO A;  1KH7 A;  5GRR A;  5LRN A;  5K4P A;  3SZY A;  3KD8 A;  3NVL A;  3BDF A;  2D1G A;  5DLV A;  2IFY A;  3T01 A;  2W5R A; 
#chains in the Genus database with same CATH homology
 3M8W A;  3WAX A;  5TJ3 A;  1AJC A;  5EGE A;  1ED9 A;  3M8Z A;  5L0K A;  1E2S P;  4TN0 A;  1KH5 A;  1ELY A;  1URB A;  1K7H A;  4UPI A;  5IJS A;  2X98 A;  1HQA A;  5AJ9 A;  3NKQ A;  3MK0 A;  1KHK A;  4LQY A;  1ALJ A;  5EGH A;  5DLW A;  3OT9 A;  2IUC A;  1SHN A;  4KAY A;  1AJA A;  2GSU A;  3UN3 A;  1URA A;  3BDG A;  1Y6V A;  1N2K A;  4B56 A;  1ED8 A;  1AJD A;  3DYC A;  1KHN A;  2GSN A;  2GA3 A;  4KAV A;  1ZEB A;  1E1Z P;  5L0B A;  3WAV A;  4UOP A;  1KHJ A;  4LR2 A;  4LRF A;  1FSU A;  4MY4 A;  1EQJ A;  3M7V A;  4KJD A;  3WBH A;  5LQQ A;  4FDI A;  5KXA A;  1SHQ A;  4UOO A;  3WAW A;  2QZU A;  3IDD A;  1HJK A;  4KJG A;  5IJQ A;  3UN2 A;  4NWJ A;  3SZZ A;  1ALH A;  2GLQ A;  1ALK A;  3E2D A;  3TG0 A;  4CYR A;  4UOR A;  4MHX A;  4LRC A;  4UPK A;  4GTY A;  1EI6 A;  2VQR A;  3DPC A;  3UN5 A;  3MK2 A;  3UNY A;  3ED4 A;  1KH4 A;  2W8D A;  1EJJ A;  4LR7 A;  1EW2 A;  4FDJ A;  1ANJ A;  1O98 A;  4LRE A;  4CXU A;  2W5V A;  5LRM A;  1ALI A;  3NKN A;  3CMR A;  2ANH A;  2XR9 A;  1Y7A A;  3NKR A;  4YR1 A;  3A52 A;  4GTZ A;  4ZG7 A;  3T02 A;  2W5X A;  5DLT A;  1ZEF A;  3UO0 A;  4KM4 A;  4ZG6 A;  4CXK A;  1KHL A;  5HRT A;  3WAY A;  1N2L A;  1ANI A;  4LR9 A;  1AUK A;  3T00 A;  5L0E A;  2W5S A;  1ELZ A;  3IGY B;  1AJB A;  4CXS A;  2ZKT A;  4MIV A;  4UPL A;  3M8Y A;  1ZED A;  3B5Q A;  5GOV A;  3TX0 A;  5C66 A;  4LR8 A;  1P49 A;  2W5Q A;  4LRB A;  1B8J A;  4GTW A;  2GSO A;  2W8S A;  3LXQ A;  4GTX A;  5LIA A;  4UPH A;  4NWX A;  1E33 P;  2IUC B;  1KH9 A;  1O99 A;  3BDH A;  3IGZ B;  3Q3Q A;  2RH6 A;  3NKM A;  4QAX A;  4LRA A;  3BDG B;  2W5T A;  1EW9 A;  3TWZ A;  3NKP A;  5INH A;  1ELX A;  4N7T A;  2W5W A;  1HDH A;  4CYS A;  4LRD A;  4ZG9 A;  1E3C P;  4ZGA A;  2XRG A;  1EW8 A;  2G9Y A;  3MK1 A;  3NKO A;  1KH7 A;  5GRR A;  5LRN A;  5K4P A;  3SZY A;  3KD8 A;  3NVL A;  3BDF A;  2D1G A;  5DLV A;  2IFY A;  3T01 A;  2W5R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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