1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
1ALKA 3NKPA 5LRMA 5GOVA 3IGZB 5IJQA 1ELXA 3NKRA 2IUCB 1N2LA 1EJJA 4LR8A 1E33P 1ZEBA 1O98A 2RH6A 1URBA 1K7HA 3E2DA 4YR1A 1P49A 3WAYA 1E3CP 5L0BA 1EI6A 4LR7A 4CYRA 5C66A 4N7TA 3BDGA 2GA3A 5TJ3A 3NVLA 3NKNA 1ALJA 5HRTA 2QZUA 4FDIA 3UN3A 3UN5A 2W5XA 2W5RA 2X98A 4KJDA 4UORA 5KXAA 3MK2A 3MK0A 1ELZA 3TG0A 3WAXA 4ZG7A 3OT9A 1HDHA 1AJCA 4CXSA 1KHLA 4UPIA 4UOOA 2W5WA 5INHA 4MY4A 2W5VA 3M8ZA 3T01A 3BDFA 3T02A 1KHKA 4LRDA 4LRAA 3TWZA 5GRRA 4ZG9A 1KH9A 1KH7A 4MHXA 5L0KA 5K4PA 4GTXA 4CYSA 3NKQA 1AJBA 1N2KA 4QAXA 2D1GA 3M8WA 4TN0A 5EGEA 5DLVA 4GTZA 1ALHA 4ZGAA 5LIAA 2W8SA 4LQYA 4CXKA 1EQJA 1KHJA 1E1ZP 4KAVA 5EGHA 3M7VA 3WBHA 4FDJA 4CXUA 3UO0A 3MK1A 1AJAA 1SHNA 1O99A 2W5TA 3A52A 2W5QA 1HJKA 2GLQA 2W8DA 3T00A 1AJDA 1KH4A 2GSNA 3ED4A 4LR2A 5AJ9A 4NWXA 5LRNA 3NKOA 1ANIA 2XR9A 4LRCA 3TX0A 1KHNA 4UPKA 1ED9A 5DLWA 3BDGB 2GSUA 2G9YA 3CMRA 1AUKA 4LRBA 3NKMA 1KH5A 1URAA 1B8JA 2ANHA 4KJGA 5L0EA 4ZG6A 2VQRA 3DPCA 5IJSA 1ELYA 2GSOA 1ZEDA 3IDDA 1ALIA 5DLTA 2IUCA 1EW2A 1HQAA 4NWJA 1FSUA 3SZYA 5LQQA 1SHQA 2IFYA 2XRGA 1ED8A 2W5SA 2ZKTA 3IGYB 3BDHA 4MIVA 3B5QA 3UN2A 4GTWA 3LXQA 4LRFA 3DYCA 4LREA 4UOPA 4LR9A 3KD8A 3SZZA 3M8YA 1ANJA 1Y7AA 4B56A 4KM4A 4UPHA 1Y6VA 3WAVA 3UNYA 1ZEFA 4GTYA 1EW9A 3Q3QA 1EW8A 3WAWA 4KAYA 4UPLA 1E2SP
chains in the Genus database with same CATH superfamily
1ALKA 3NKPA 5LRMA 5GOVA 3IGZB 5IJQA 1ELXA 3NKRA 2IUCB 1N2LA 1EJJA 4LR8A 1E33P 1ZEBA 1O98A 2RH6A 1URBA 1K7HA 3E2DA 4YR1A 1P49A 3WAYA 1E3CP 5L0BA 1EI6A 4LR7A 4CYRA 5C66A 4N7TA 3BDGA 2GA3A 5TJ3A 3NVLA 3NKNA 1ALJA 5HRTA 2QZUA 4FDIA 3UN3A 3UN5A 2W5XA 2W5RA 2X98A 4KJDA 4UORA 5KXAA 3MK2A 3MK0A 1ELZA 3TG0A 3WAXA 4ZG7A 3OT9A 1HDHA 1AJCA 4CXSA 1KHLA 4UPIA 4UOOA 2W5WA 5INHA 4MY4A 2W5VA 3M8ZA 3T01A 3BDFA 3T02A 1KHKA 4LRDA 4LRAA 3TWZA 5GRRA 4ZG9A 1KH9A 1KH7A 4MHXA 5L0KA 5K4PA 4GTXA 4CYSA 3NKQA 1AJBA 1N2KA 4QAXA 2D1GA 3M8WA 4TN0A 5EGEA 5DLVA 4GTZA 1ALHA 4ZGAA 5LIAA 2W8SA 4LQYA 4CXKA 1EQJA 1KHJA 1E1ZP 4KAVA 5EGHA 3M7VA 3WBHA 4FDJA 4CXUA 3UO0A 3MK1A 1AJAA 1SHNA 1O99A 2W5TA 3A52A 2W5QA 1HJKA 2GLQA 2W8DA 3T00A 1AJDA 1KH4A 2GSNA 3ED4A 4LR2A 5AJ9A 4NWXA 5LRNA 3NKOA 1ANIA 2XR9A 4LRCA 3TX0A 1KHNA 4UPKA 1ED9A 5DLWA 3BDGB 2GSUA 2G9YA 3CMRA 1AUKA 4LRBA 3NKMA 1KH5A 1URAA 1B8JA 2ANHA 4KJGA 5L0EA 4ZG6A 2VQRA 3DPCA 5IJSA 1ELYA 2GSOA 1ZEDA 3IDDA 1ALIA 5DLTA 2IUCA 1EW2A 1HQAA 4NWJA 1FSUA 3SZYA 5LQQA 1SHQA 2IFYA 2XRGA 1ED8A 2W5SA 2ZKTA 3IGYB 3BDHA 4MIVA 3B5QA 3UN2A 4GTWA 3LXQA 4LRFA 3DYCA 4LREA 4UOPA 4LR9A 3KD8A 3SZZA 3M8YA 1ANJA 1Y7AA 4B56A 4KM4A 4UPHA 1Y6VA 3WAVA 3UNYA 1ZEFA 4GTYA 1EW9A 3Q3QA 1EW8A 3WAWA 4KAYA 4UPLA 1E2SP
chains in the Genus database with same CATH topology
1ALKA 3NKPA 5LRMA 5GOVA 3IGZB 5IJQA 1ELXA 3NKRA 2IUCB 1N2LA 1EJJA 4LR8A 1E33P 1ZEBA 1O98A 2RH6A 1URBA 1K7HA 3E2DA 4YR1A 1P49A 3WAYA 1E3CP 5L0BA 1EI6A 4LR7A 4CYRA 5C66A 4N7TA 3BDGA 2GA3A 5TJ3A 3NVLA 3NKNA 1ALJA 5HRTA 2QZUA 4FDIA 3UN3A 3UN5A 2W5XA 2W5RA 2X98A 4KJDA 4UORA 5KXAA 3MK2A 3MK0A 1ELZA 3TG0A 3WAXA 4ZG7A 3OT9A 1HDHA 1AJCA 4CXSA 1KHLA 4UPIA 4UOOA 2W5WA 5INHA 4MY4A 2W5VA 3M8ZA 3T01A 3BDFA 3T02A 1KHKA 4LRDA 4LRAA 3TWZA 5GRRA 4ZG9A 1KH9A 1KH7A 4MHXA 5L0KA 5K4PA 4GTXA 4CYSA 3NKQA 1AJBA 1N2KA 4QAXA 2D1GA 3M8WA 4TN0A 5EGEA 5DLVA 4GTZA 1ALHA 4ZGAA 5LIAA 2W8SA 4LQYA 4CXKA 1EQJA 1KHJA 1E1ZP 4KAVA 5EGHA 3M7VA 3WBHA 4FDJA 4CXUA 3UO0A 3MK1A 1AJAA 1SHNA 1O99A 2W5TA 3A52A 2W5QA 1HJKA 2GLQA 2W8DA 3T00A 1AJDA 1KH4A 2GSNA 3ED4A 4LR2A 5AJ9A 4NWXA 5LRNA 3NKOA 1ANIA 2XR9A 4LRCA 3TX0A 1KHNA 4UPKA 1ED9A 5DLWA 3BDGB 2GSUA 2G9YA 3CMRA 1AUKA 4LRBA 3NKMA 1KH5A 1URAA 1B8JA 2ANHA 4KJGA 5L0EA 4ZG6A 2VQRA 3DPCA 5IJSA 1ELYA 2GSOA 1ZEDA 3IDDA 1ALIA 5DLTA 2IUCA 1EW2A 1HQAA 4NWJA 1FSUA 3SZYA 5LQQA 1SHQA 2IFYA 2XRGA 1ED8A 2W5SA 2ZKTA 3IGYB 3BDHA 4MIVA 3B5QA 3UN2A 4GTWA 3LXQA 4LRFA 3DYCA 4LREA 4UOPA 4LR9A 3KD8A 3SZZA 3M8YA 1ANJA 1Y7AA 4B56A 4KM4A 4UPHA 1Y6VA 3WAVA 3UNYA 1ZEFA 4GTYA 1EW9A 3Q3QA 1EW8A 3WAWA 4KAYA 4UPLA 1E2SP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ALK A;  3NKP A;  5LRM A;  5GOV A;  3IGZ B;  5IJQ A;  1ELX A;  3NKR A;  2IUC B;  1N2L A;  1EJJ A;  4LR8 A;  1E33 P;  1ZEB A;  1O98 A;  2RH6 A;  1URB A;  1K7H A;  3E2D A;  4YR1 A;  1P49 A;  3WAY A;  1E3C P;  5L0B A;  1EI6 A;  4LR7 A;  4CYR A;  5C66 A;  4N7T A;  3BDG A;  2GA3 A;  5TJ3 A;  3NVL A;  3NKN A;  1ALJ A;  5HRT A;  2QZU A;  4FDI A;  3UN3 A;  3UN5 A;  2W5X A;  2W5R A;  2X98 A;  4KJD A;  4UOR A;  5KXA A;  3MK2 A;  3MK0 A;  1ELZ A;  3TG0 A;  3WAX A;  4ZG7 A;  3OT9 A;  1HDH A;  1AJC A;  4CXS A;  1KHL A;  4UPI A;  4UOO A;  2W5W A;  5INH A;  4MY4 A;  2W5V A;  3M8Z A;  3T01 A;  3BDF A;  3T02 A;  1KHK A;  4LRD A;  4LRA A;  3TWZ A;  5GRR A;  4ZG9 A;  1KH9 A;  1KH7 A;  4MHX A;  5L0K A;  5K4P A;  4GTX A;  4CYS A;  3NKQ A;  1AJB A;  1N2K A;  4QAX A;  2D1G A;  3M8W A;  4TN0 A;  5EGE A;  5DLV A;  4GTZ A;  1ALH A;  4ZGA A;  5LIA A;  2W8S A;  4LQY A;  4CXK A;  1EQJ A;  1KHJ A;  1E1Z P;  4KAV A;  5EGH A;  3M7V A;  3WBH A;  4FDJ A;  4CXU A;  3UO0 A;  3MK1 A;  1AJA A;  1SHN A;  1O99 A;  2W5T A;  3A52 A;  2W5Q A;  1HJK A;  2GLQ A;  2W8D A;  3T00 A;  1AJD A;  1KH4 A;  2GSN A;  3ED4 A;  4LR2 A;  5AJ9 A;  4NWX A;  5LRN A;  3NKO A;  1ANI A;  2XR9 A;  4LRC A;  3TX0 A;  1KHN A;  4UPK A;  1ED9 A;  5DLW A;  3BDG B;  2GSU A;  2G9Y A;  3CMR A;  1AUK A;  4LRB A;  3NKM A;  1KH5 A;  1URA A;  1B8J A;  2ANH A;  4KJG A;  5L0E A;  4ZG6 A;  2VQR A;  3DPC A;  5IJS A;  1ELY A;  2GSO A;  1ZED A;  3IDD A;  1ALI A;  5DLT A;  2IUC A;  1EW2 A;  1HQA A;  4NWJ A;  1FSU A;  3SZY A;  5LQQ A;  1SHQ A;  2IFY A;  2XRG A;  1ED8 A;  2W5S A;  2ZKT A;  3IGY B;  3BDH A;  4MIV A;  3B5Q A;  3UN2 A;  4GTW A;  3LXQ A;  4LRF A;  3DYC A;  4LRE A;  4UOP A;  4LR9 A;  3KD8 A;  3SZZ A;  3M8Y A;  1ANJ A;  1Y7A A;  4B56 A;  4KM4 A;  4UPH A;  1Y6V A;  3WAV A;  3UNY A;  1ZEF A;  4GTY A;  1EW9 A;  3Q3Q A;  1EW8 A;  3WAW A;  4KAY A;  4UPL A;  1E2S P; 
#chains in the Genus database with same CATH topology
 1ALK A;  3NKP A;  5LRM A;  5GOV A;  3IGZ B;  5IJQ A;  1ELX A;  3NKR A;  2IUC B;  1N2L A;  1EJJ A;  4LR8 A;  1E33 P;  1ZEB A;  1O98 A;  2RH6 A;  1URB A;  1K7H A;  3E2D A;  4YR1 A;  1P49 A;  3WAY A;  1E3C P;  5L0B A;  1EI6 A;  4LR7 A;  4CYR A;  5C66 A;  4N7T A;  3BDG A;  2GA3 A;  5TJ3 A;  3NVL A;  3NKN A;  1ALJ A;  5HRT A;  2QZU A;  4FDI A;  3UN3 A;  3UN5 A;  2W5X A;  2W5R A;  2X98 A;  4KJD A;  4UOR A;  5KXA A;  3MK2 A;  3MK0 A;  1ELZ A;  3TG0 A;  3WAX A;  4ZG7 A;  3OT9 A;  1HDH A;  1AJC A;  4CXS A;  1KHL A;  4UPI A;  4UOO A;  2W5W A;  5INH A;  4MY4 A;  2W5V A;  3M8Z A;  3T01 A;  3BDF A;  3T02 A;  1KHK A;  4LRD A;  4LRA A;  3TWZ A;  5GRR A;  4ZG9 A;  1KH9 A;  1KH7 A;  4MHX A;  5L0K A;  5K4P A;  4GTX A;  4CYS A;  3NKQ A;  1AJB A;  1N2K A;  4QAX A;  2D1G A;  3M8W A;  4TN0 A;  5EGE A;  5DLV A;  4GTZ A;  1ALH A;  4ZGA A;  5LIA A;  2W8S A;  4LQY A;  4CXK A;  1EQJ A;  1KHJ A;  1E1Z P;  4KAV A;  5EGH A;  3M7V A;  3WBH A;  4FDJ A;  4CXU A;  3UO0 A;  3MK1 A;  1AJA A;  1SHN A;  1O99 A;  2W5T A;  3A52 A;  2W5Q A;  1HJK A;  2GLQ A;  2W8D A;  3T00 A;  1AJD A;  1KH4 A;  2GSN A;  3ED4 A;  4LR2 A;  5AJ9 A;  4NWX A;  5LRN A;  3NKO A;  1ANI A;  2XR9 A;  4LRC A;  3TX0 A;  1KHN A;  4UPK A;  1ED9 A;  5DLW A;  3BDG B;  2GSU A;  2G9Y A;  3CMR A;  1AUK A;  4LRB A;  3NKM A;  1KH5 A;  1URA A;  1B8J A;  2ANH A;  4KJG A;  5L0E A;  4ZG6 A;  2VQR A;  3DPC A;  5IJS A;  1ELY A;  2GSO A;  1ZED A;  3IDD A;  1ALI A;  5DLT A;  2IUC A;  1EW2 A;  1HQA A;  4NWJ A;  1FSU A;  3SZY A;  5LQQ A;  1SHQ A;  2IFY A;  2XRG A;  1ED8 A;  2W5S A;  2ZKT A;  3IGY B;  3BDH A;  4MIV A;  3B5Q A;  3UN2 A;  4GTW A;  3LXQ A;  4LRF A;  3DYC A;  4LRE A;  4UOP A;  4LR9 A;  3KD8 A;  3SZZ A;  3M8Y A;  1ANJ A;  1Y7A A;  4B56 A;  4KM4 A;  4UPH A;  1Y6V A;  3WAV A;  3UNY A;  1ZEF A;  4GTY A;  1EW9 A;  3Q3Q A;  1EW8 A;  3WAW A;  4KAY A;  4UPL A;  1E2S P; 
#chains in the Genus database with same CATH homology
 1ALK A;  3NKP A;  5LRM A;  5GOV A;  3IGZ B;  5IJQ A;  1ELX A;  3NKR A;  2IUC B;  1N2L A;  1EJJ A;  4LR8 A;  1E33 P;  1ZEB A;  1O98 A;  2RH6 A;  1URB A;  1K7H A;  3E2D A;  4YR1 A;  1P49 A;  3WAY A;  1E3C P;  5L0B A;  1EI6 A;  4LR7 A;  4CYR A;  5C66 A;  4N7T A;  3BDG A;  2GA3 A;  5TJ3 A;  3NVL A;  3NKN A;  1ALJ A;  5HRT A;  2QZU A;  4FDI A;  3UN3 A;  3UN5 A;  2W5X A;  2W5R A;  2X98 A;  4KJD A;  4UOR A;  5KXA A;  3MK2 A;  3MK0 A;  1ELZ A;  3TG0 A;  3WAX A;  4ZG7 A;  3OT9 A;  1HDH A;  1AJC A;  4CXS A;  1KHL A;  4UPI A;  4UOO A;  2W5W A;  5INH A;  4MY4 A;  2W5V A;  3M8Z A;  3T01 A;  3BDF A;  3T02 A;  1KHK A;  4LRD A;  4LRA A;  3TWZ A;  5GRR A;  4ZG9 A;  1KH9 A;  1KH7 A;  4MHX A;  5L0K A;  5K4P A;  4GTX A;  4CYS A;  3NKQ A;  1AJB A;  1N2K A;  4QAX A;  2D1G A;  3M8W A;  4TN0 A;  5EGE A;  5DLV A;  4GTZ A;  1ALH A;  4ZGA A;  5LIA A;  2W8S A;  4LQY A;  4CXK A;  1EQJ A;  1KHJ A;  1E1Z P;  4KAV A;  5EGH A;  3M7V A;  3WBH A;  4FDJ A;  4CXU A;  3UO0 A;  3MK1 A;  1AJA A;  1SHN A;  1O99 A;  2W5T A;  3A52 A;  2W5Q A;  1HJK A;  2GLQ A;  2W8D A;  3T00 A;  1AJD A;  1KH4 A;  2GSN A;  3ED4 A;  4LR2 A;  5AJ9 A;  4NWX A;  5LRN A;  3NKO A;  1ANI A;  2XR9 A;  4LRC A;  3TX0 A;  1KHN A;  4UPK A;  1ED9 A;  5DLW A;  3BDG B;  2GSU A;  2G9Y A;  3CMR A;  1AUK A;  4LRB A;  3NKM A;  1KH5 A;  1URA A;  1B8J A;  2ANH A;  4KJG A;  5L0E A;  4ZG6 A;  2VQR A;  3DPC A;  5IJS A;  1ELY A;  2GSO A;  1ZED A;  3IDD A;  1ALI A;  5DLT A;  2IUC A;  1EW2 A;  1HQA A;  4NWJ A;  1FSU A;  3SZY A;  5LQQ A;  1SHQ A;  2IFY A;  2XRG A;  1ED8 A;  2W5S A;  2ZKT A;  3IGY B;  3BDH A;  4MIV A;  3B5Q A;  3UN2 A;  4GTW A;  3LXQ A;  4LRF A;  3DYC A;  4LRE A;  4UOP A;  4LR9 A;  3KD8 A;  3SZZ A;  3M8Y A;  1ANJ A;  1Y7A A;  4B56 A;  4KM4 A;  4UPH A;  1Y6V A;  3WAV A;  3UNY A;  1ZEF A;  4GTY A;  1EW9 A;  3Q3Q A;  1EW8 A;  3WAW A;  4KAY A;  4UPL A;  1E2S P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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