1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
3NKPA 3WBHA 2X98A 2D1GA 4LR7A 5AJ9A 4ZG6A 1E33P 5INHA 3SZYA 4CYRA 4KJDA 4CXUA 4UPHA 2W5VA 3WAWA 4UOOA 4LRCA 4KAVA 1EW2A 3LXQA 5EGEA 3M8YA 4LRFA 1KH4A 1URAA 2W5QA 4LR8A 1KHNA 2G9YA 4QAXA 4LRAA 1O98A 2W8SA 3E2DA 1EW8A 4ZG9A 3DYCA 3UO0A 3NKNA 1Y7AA 2ZKTA 5DLWA 5DLTA 1HQAA 3KD8A 4CYSA 4YR1A 4KM4A 5LRMA 2W5SA 1KHLA 1AJBA 1KH7A 5L0EA 5DLVA 1ED9A 5C66A 4GTWA 1HDHA 4KAYA 2W5RA 3BDGB 4ZG7A 3IGYB 2W5WA 5GRRA 1E3CP 1AJCA 1ZEFA 2IUCA 1ANJA 5L0KA 1ANIA 3DPCA 4LR9A 3T02A 4ZGAA 5L0BA 3M8WA 4GTXA 4GTZA 4LREA 4UORA 5KXAA 3NKQA 1EI6A 3Q3QA 1N2LA 1ALJA 4LQYA 1N2KA 3MK0A 2ANHA 4UPLA 4NWXA 3BDHA 4N7TA 2GA3A 4CXKA 4LRBA 2W5XA 3NKMA 2GSNA 1EW9A 1B8JA 1FSUA 3IDDA 1ED8A 2IFYA 3A52A 5HRTA 3NKOA 4FDIA 1ELXA 2XRGA 3WAYA 5LRNA 4MY4A 1AUKA 3ED4A 1KHJA 4CXSA 5EGHA 3TX0A 3IGZB 3M7VA 5IJQA 5LQQA 3TG0A 1HJKA 4MIVA 3B5QA 3WAVA 3T01A 4TN0A 1EJJA 1ELYA 1ALHA 5K4PA 2GSOA 1ELZA 1ZEDA 5TJ3A 4NWJA 2VQRA 1P49A 3M8ZA 4LRDA 1Y6VA 2XR9A 4MHXA 3CMRA 1ZEBA 3OT9A 4LR2A 3UN3A 3SZZA 1URBA 2QZUA 2IUCB 1K7HA 3MK1A 2GSUA 5IJSA 5LIAA 3NKRA 1E1ZP 4KJGA 1SHNA 3MK2A 4UPKA 3BDGA 1SHQA 2RH6A 2GLQA 1EQJA 5GOVA 3BDFA 1AJAA 1KHKA 4UPIA 4UOPA 1E2SP 3UN5A 1KH5A 2W5TA 1ALKA 1ALIA 4FDJA 4GTYA 3WAXA 3UN2A 3T00A 1AJDA 3UNYA 1O99A 3NVLA 4B56A 2W8DA 3TWZA 1KH9A
chains in the Genus database with same CATH superfamily
3NKPA 3WBHA 2X98A 2D1GA 4LR7A 5AJ9A 4ZG6A 1E33P 5INHA 3SZYA 4CYRA 4KJDA 4CXUA 4UPHA 2W5VA 3WAWA 4UOOA 4LRCA 4KAVA 1EW2A 3LXQA 5EGEA 3M8YA 4LRFA 1KH4A 1URAA 2W5QA 4LR8A 1KHNA 2G9YA 4QAXA 4LRAA 1O98A 2W8SA 3E2DA 1EW8A 4ZG9A 3DYCA 3UO0A 3NKNA 1Y7AA 2ZKTA 5DLWA 5DLTA 1HQAA 3KD8A 4CYSA 4YR1A 4KM4A 5LRMA 2W5SA 1KHLA 1AJBA 1KH7A 5L0EA 5DLVA 1ED9A 5C66A 4GTWA 1HDHA 4KAYA 2W5RA 3BDGB 4ZG7A 3IGYB 2W5WA 5GRRA 1E3CP 1AJCA 1ZEFA 2IUCA 1ANJA 5L0KA 1ANIA 3DPCA 4LR9A 3T02A 4ZGAA 5L0BA 3M8WA 4GTXA 4GTZA 4LREA 4UORA 5KXAA 3NKQA 1EI6A 3Q3QA 1N2LA 1ALJA 4LQYA 1N2KA 3MK0A 2ANHA 4UPLA 4NWXA 3BDHA 4N7TA 2GA3A 4CXKA 4LRBA 2W5XA 3NKMA 2GSNA 1EW9A 1B8JA 1FSUA 3IDDA 1ED8A 2IFYA 3A52A 5HRTA 3NKOA 4FDIA 1ELXA 2XRGA 3WAYA 5LRNA 4MY4A 1AUKA 3ED4A 1KHJA 4CXSA 5EGHA 3TX0A 3IGZB 3M7VA 5IJQA 5LQQA 3TG0A 1HJKA 4MIVA 3B5QA 3WAVA 3T01A 4TN0A 1EJJA 1ELYA 1ALHA 5K4PA 2GSOA 1ELZA 1ZEDA 5TJ3A 4NWJA 2VQRA 1P49A 3M8ZA 4LRDA 1Y6VA 2XR9A 4MHXA 3CMRA 1ZEBA 3OT9A 4LR2A 3UN3A 3SZZA 1URBA 2QZUA 2IUCB 1K7HA 3MK1A 2GSUA 5IJSA 5LIAA 3NKRA 1E1ZP 4KJGA 1SHNA 3MK2A 4UPKA 3BDGA 1SHQA 2RH6A 2GLQA 1EQJA 5GOVA 3BDFA 1AJAA 1KHKA 4UPIA 4UOPA 1E2SP 3UN5A 1KH5A 2W5TA 1ALKA 1ALIA 4FDJA 4GTYA 3WAXA 3UN2A 3T00A 1AJDA 3UNYA 1O99A 3NVLA 4B56A 2W8DA 3TWZA 1KH9A
chains in the Genus database with same CATH topology
3NKPA 3WBHA 2X98A 2D1GA 4LR7A 5AJ9A 4ZG6A 1E33P 5INHA 3SZYA 4CYRA 4KJDA 4CXUA 4UPHA 2W5VA 3WAWA 4UOOA 4LRCA 4KAVA 1EW2A 3LXQA 5EGEA 3M8YA 4LRFA 1KH4A 1URAA 2W5QA 4LR8A 1KHNA 2G9YA 4QAXA 4LRAA 1O98A 2W8SA 3E2DA 1EW8A 4ZG9A 3DYCA 3UO0A 3NKNA 1Y7AA 2ZKTA 5DLWA 5DLTA 1HQAA 3KD8A 4CYSA 4YR1A 4KM4A 5LRMA 2W5SA 1KHLA 1AJBA 1KH7A 5L0EA 5DLVA 1ED9A 5C66A 4GTWA 1HDHA 4KAYA 2W5RA 3BDGB 4ZG7A 3IGYB 2W5WA 5GRRA 1E3CP 1AJCA 1ZEFA 2IUCA 1ANJA 5L0KA 1ANIA 3DPCA 4LR9A 3T02A 4ZGAA 5L0BA 3M8WA 4GTXA 4GTZA 4LREA 4UORA 5KXAA 3NKQA 1EI6A 3Q3QA 1N2LA 1ALJA 4LQYA 1N2KA 3MK0A 2ANHA 4UPLA 4NWXA 3BDHA 4N7TA 2GA3A 4CXKA 4LRBA 2W5XA 3NKMA 2GSNA 1EW9A 1B8JA 1FSUA 3IDDA 1ED8A 2IFYA 3A52A 5HRTA 3NKOA 4FDIA 1ELXA 2XRGA 3WAYA 5LRNA 4MY4A 1AUKA 3ED4A 1KHJA 4CXSA 5EGHA 3TX0A 3IGZB 3M7VA 5IJQA 5LQQA 3TG0A 1HJKA 4MIVA 3B5QA 3WAVA 3T01A 4TN0A 1EJJA 1ELYA 1ALHA 5K4PA 2GSOA 1ELZA 1ZEDA 5TJ3A 4NWJA 2VQRA 1P49A 3M8ZA 4LRDA 1Y6VA 2XR9A 4MHXA 3CMRA 1ZEBA 3OT9A 4LR2A 3UN3A 3SZZA 1URBA 2QZUA 2IUCB 1K7HA 3MK1A 2GSUA 5IJSA 5LIAA 3NKRA 1E1ZP 4KJGA 1SHNA 3MK2A 4UPKA 3BDGA 1SHQA 2RH6A 2GLQA 1EQJA 5GOVA 3BDFA 1AJAA 1KHKA 4UPIA 4UOPA 1E2SP 3UN5A 1KH5A 2W5TA 1ALKA 1ALIA 4FDJA 4GTYA 3WAXA 3UN2A 3T00A 1AJDA 3UNYA 1O99A 3NVLA 4B56A 2W8DA 3TWZA 1KH9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NKP A;  3WBH A;  2X98 A;  2D1G A;  4LR7 A;  5AJ9 A;  4ZG6 A;  1E33 P;  5INH A;  3SZY A;  4CYR A;  4KJD A;  4CXU A;  4UPH A;  2W5V A;  3WAW A;  4UOO A;  4LRC A;  4KAV A;  1EW2 A;  3LXQ A;  5EGE A;  3M8Y A;  4LRF A;  1KH4 A;  1URA A;  2W5Q A;  4LR8 A;  1KHN A;  2G9Y A;  4QAX A;  4LRA A;  1O98 A;  2W8S A;  3E2D A;  1EW8 A;  4ZG9 A;  3DYC A;  3UO0 A;  3NKN A;  1Y7A A;  2ZKT A;  5DLW A;  5DLT A;  1HQA A;  3KD8 A;  4CYS A;  4YR1 A;  4KM4 A;  5LRM A;  2W5S A;  1KHL A;  1AJB A;  1KH7 A;  5L0E A;  5DLV A;  1ED9 A;  5C66 A;  4GTW A;  1HDH A;  4KAY A;  2W5R A;  3BDG B;  4ZG7 A;  3IGY B;  2W5W A;  5GRR A;  1E3C P;  1AJC A;  1ZEF A;  2IUC A;  1ANJ A;  5L0K A;  1ANI A;  3DPC A;  4LR9 A;  3T02 A;  4ZGA A;  5L0B A;  3M8W A;  4GTX A;  4GTZ A;  4LRE A;  4UOR A;  5KXA A;  3NKQ A;  1EI6 A;  3Q3Q A;  1N2L A;  1ALJ A;  4LQY A;  1N2K A;  3MK0 A;  2ANH A;  4UPL A;  4NWX A;  3BDH A;  4N7T A;  2GA3 A;  4CXK A;  4LRB A;  2W5X A;  3NKM A;  2GSN A;  1EW9 A;  1B8J A;  1FSU A;  3IDD A;  1ED8 A;  2IFY A;  3A52 A;  5HRT A;  3NKO A;  4FDI A;  1ELX A;  2XRG A;  3WAY A;  5LRN A;  4MY4 A;  1AUK A;  3ED4 A;  1KHJ A;  4CXS A;  5EGH A;  3TX0 A;  3IGZ B;  3M7V A;  5IJQ A;  5LQQ A;  3TG0 A;  1HJK A;  4MIV A;  3B5Q A;  3WAV A;  3T01 A;  4TN0 A;  1EJJ A;  1ELY A;  1ALH A;  5K4P A;  2GSO A;  1ELZ A;  1ZED A;  5TJ3 A;  4NWJ A;  2VQR A;  1P49 A;  3M8Z A;  4LRD A;  1Y6V A;  2XR9 A;  4MHX A;  3CMR A;  1ZEB A;  3OT9 A;  4LR2 A;  3UN3 A;  3SZZ A;  1URB A;  2QZU A;  2IUC B;  1K7H A;  3MK1 A;  2GSU A;  5IJS A;  5LIA A;  3NKR A;  1E1Z P;  4KJG A;  1SHN A;  3MK2 A;  4UPK A;  3BDG A;  1SHQ A;  2RH6 A;  2GLQ A;  1EQJ A;  5GOV A;  3BDF A;  1AJA A;  1KHK A;  4UPI A;  4UOP A;  1E2S P;  3UN5 A;  1KH5 A;  2W5T A;  1ALK A;  1ALI A;  4FDJ A;  4GTY A;  3WAX A;  3UN2 A;  3T00 A;  1AJD A;  3UNY A;  1O99 A;  3NVL A;  4B56 A;  2W8D A;  3TWZ A;  1KH9 A; 
#chains in the Genus database with same CATH topology
 3NKP A;  3WBH A;  2X98 A;  2D1G A;  4LR7 A;  5AJ9 A;  4ZG6 A;  1E33 P;  5INH A;  3SZY A;  4CYR A;  4KJD A;  4CXU A;  4UPH A;  2W5V A;  3WAW A;  4UOO A;  4LRC A;  4KAV A;  1EW2 A;  3LXQ A;  5EGE A;  3M8Y A;  4LRF A;  1KH4 A;  1URA A;  2W5Q A;  4LR8 A;  1KHN A;  2G9Y A;  4QAX A;  4LRA A;  1O98 A;  2W8S A;  3E2D A;  1EW8 A;  4ZG9 A;  3DYC A;  3UO0 A;  3NKN A;  1Y7A A;  2ZKT A;  5DLW A;  5DLT A;  1HQA A;  3KD8 A;  4CYS A;  4YR1 A;  4KM4 A;  5LRM A;  2W5S A;  1KHL A;  1AJB A;  1KH7 A;  5L0E A;  5DLV A;  1ED9 A;  5C66 A;  4GTW A;  1HDH A;  4KAY A;  2W5R A;  3BDG B;  4ZG7 A;  3IGY B;  2W5W A;  5GRR A;  1E3C P;  1AJC A;  1ZEF A;  2IUC A;  1ANJ A;  5L0K A;  1ANI A;  3DPC A;  4LR9 A;  3T02 A;  4ZGA A;  5L0B A;  3M8W A;  4GTX A;  4GTZ A;  4LRE A;  4UOR A;  5KXA A;  3NKQ A;  1EI6 A;  3Q3Q A;  1N2L A;  1ALJ A;  4LQY A;  1N2K A;  3MK0 A;  2ANH A;  4UPL A;  4NWX A;  3BDH A;  4N7T A;  2GA3 A;  4CXK A;  4LRB A;  2W5X A;  3NKM A;  2GSN A;  1EW9 A;  1B8J A;  1FSU A;  3IDD A;  1ED8 A;  2IFY A;  3A52 A;  5HRT A;  3NKO A;  4FDI A;  1ELX A;  2XRG A;  3WAY A;  5LRN A;  4MY4 A;  1AUK A;  3ED4 A;  1KHJ A;  4CXS A;  5EGH A;  3TX0 A;  3IGZ B;  3M7V A;  5IJQ A;  5LQQ A;  3TG0 A;  1HJK A;  4MIV A;  3B5Q A;  3WAV A;  3T01 A;  4TN0 A;  1EJJ A;  1ELY A;  1ALH A;  5K4P A;  2GSO A;  1ELZ A;  1ZED A;  5TJ3 A;  4NWJ A;  2VQR A;  1P49 A;  3M8Z A;  4LRD A;  1Y6V A;  2XR9 A;  4MHX A;  3CMR A;  1ZEB A;  3OT9 A;  4LR2 A;  3UN3 A;  3SZZ A;  1URB A;  2QZU A;  2IUC B;  1K7H A;  3MK1 A;  2GSU A;  5IJS A;  5LIA A;  3NKR A;  1E1Z P;  4KJG A;  1SHN A;  3MK2 A;  4UPK A;  3BDG A;  1SHQ A;  2RH6 A;  2GLQ A;  1EQJ A;  5GOV A;  3BDF A;  1AJA A;  1KHK A;  4UPI A;  4UOP A;  1E2S P;  3UN5 A;  1KH5 A;  2W5T A;  1ALK A;  1ALI A;  4FDJ A;  4GTY A;  3WAX A;  3UN2 A;  3T00 A;  1AJD A;  3UNY A;  1O99 A;  3NVL A;  4B56 A;  2W8D A;  3TWZ A;  1KH9 A; 
#chains in the Genus database with same CATH homology
 3NKP A;  3WBH A;  2X98 A;  2D1G A;  4LR7 A;  5AJ9 A;  4ZG6 A;  1E33 P;  5INH A;  3SZY A;  4CYR A;  4KJD A;  4CXU A;  4UPH A;  2W5V A;  3WAW A;  4UOO A;  4LRC A;  4KAV A;  1EW2 A;  3LXQ A;  5EGE A;  3M8Y A;  4LRF A;  1KH4 A;  1URA A;  2W5Q A;  4LR8 A;  1KHN A;  2G9Y A;  4QAX A;  4LRA A;  1O98 A;  2W8S A;  3E2D A;  1EW8 A;  4ZG9 A;  3DYC A;  3UO0 A;  3NKN A;  1Y7A A;  2ZKT A;  5DLW A;  5DLT A;  1HQA A;  3KD8 A;  4CYS A;  4YR1 A;  4KM4 A;  5LRM A;  2W5S A;  1KHL A;  1AJB A;  1KH7 A;  5L0E A;  5DLV A;  1ED9 A;  5C66 A;  4GTW A;  1HDH A;  4KAY A;  2W5R A;  3BDG B;  4ZG7 A;  3IGY B;  2W5W A;  5GRR A;  1E3C P;  1AJC A;  1ZEF A;  2IUC A;  1ANJ A;  5L0K A;  1ANI A;  3DPC A;  4LR9 A;  3T02 A;  4ZGA A;  5L0B A;  3M8W A;  4GTX A;  4GTZ A;  4LRE A;  4UOR A;  5KXA A;  3NKQ A;  1EI6 A;  3Q3Q A;  1N2L A;  1ALJ A;  4LQY A;  1N2K A;  3MK0 A;  2ANH A;  4UPL A;  4NWX A;  3BDH A;  4N7T A;  2GA3 A;  4CXK A;  4LRB A;  2W5X A;  3NKM A;  2GSN A;  1EW9 A;  1B8J A;  1FSU A;  3IDD A;  1ED8 A;  2IFY A;  3A52 A;  5HRT A;  3NKO A;  4FDI A;  1ELX A;  2XRG A;  3WAY A;  5LRN A;  4MY4 A;  1AUK A;  3ED4 A;  1KHJ A;  4CXS A;  5EGH A;  3TX0 A;  3IGZ B;  3M7V A;  5IJQ A;  5LQQ A;  3TG0 A;  1HJK A;  4MIV A;  3B5Q A;  3WAV A;  3T01 A;  4TN0 A;  1EJJ A;  1ELY A;  1ALH A;  5K4P A;  2GSO A;  1ELZ A;  1ZED A;  5TJ3 A;  4NWJ A;  2VQR A;  1P49 A;  3M8Z A;  4LRD A;  1Y6V A;  2XR9 A;  4MHX A;  3CMR A;  1ZEB A;  3OT9 A;  4LR2 A;  3UN3 A;  3SZZ A;  1URB A;  2QZU A;  2IUC B;  1K7H A;  3MK1 A;  2GSU A;  5IJS A;  5LIA A;  3NKR A;  1E1Z P;  4KJG A;  1SHN A;  3MK2 A;  4UPK A;  3BDG A;  1SHQ A;  2RH6 A;  2GLQ A;  1EQJ A;  5GOV A;  3BDF A;  1AJA A;  1KHK A;  4UPI A;  4UOP A;  1E2S P;  3UN5 A;  1KH5 A;  2W5T A;  1ALK A;  1ALI A;  4FDJ A;  4GTY A;  3WAX A;  3UN2 A;  3T00 A;  1AJD A;  3UNY A;  1O99 A;  3NVL A;  4B56 A;  2W8D A;  3TWZ A;  1KH9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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