1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule keywords Alkaline phosphatase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
3UO0A 4UPLA 3M7VA 2GA3A 4GTXA 4FDIA 1URAA 5L0EA 3NKQA 1KH9A 3WAYA 4ZG7A 1E33P 1ANJA 1Y6VA 4MIVA 1KH7A 5HRTA 4FDJA 2ANHA 1URBA 1ZEDA 2IUCA 1ALJA 3TG0A 4CXUA 1E1ZP 3BDGA 5DLVA 1ALKA 3M8ZA 1EW8A 1SHQA 3UN3A 1HJKA 1EQJA 1ZEFA 4CYRA 1EI6A 5KXAA 4UOPA 4UOOA 2GSUA 4LRAA 4LRBA 5GOVA 5IJSA 3NKNA 1KHLA 3TWZA 3UN2A 3NKMA 4KAYA 4UPKA 4B56A 2VQRA 5EGEA 2W5WA 3NKPA 2W5SA 1SHNA 3T02A 5LIAA 5K4PA 1ANIA 3CMRA 3WBHA 2W5TA 4CYSA 3MK1A 4LQYA 3T00A 3A52A 2XR9A 4LRCA 3NVLA 5LRMA 3LXQA 4KAVA 1ELZA 2X98A 2RH6A 3SZYA 1E2SP 2GSNA 1FSUA 4MHXA 4UPHA 4CXKA 2IUCB 3IGYB 4GTZA 3UN5A 5DLTA 1KH5A 3B5QA 4LR7A 2GLQA 3BDGB 1O99A 2W8SA 1AJAA 4LREA 3ED4A 2IFYA 3TX0A 3IDDA 3UNYA 2W8DA 4LR8A 2W5VA 2W5XA 1ALIA 1EW2A 4GTWA 3OT9A 4KM4A 3BDHA 4LRDA 1ZEBA 3NKRA 5AJ9A 5L0KA 2GSOA 1ELYA 3Q3QA 5EGHA 3IGZB 4NWXA 2G9YA 4YR1A 4MY4A 1O98A 1KH4A 5L0BA 1N2LA 3DYCA 1KHJA 5C66A 1E3CP 4KJGA 5IJQA 3DPCA 3T01A 1EJJA 1N2KA 1KHKA 2D1GA 4GTYA 5INHA 2QZUA 4KJDA 3SZZA 1EW9A 1K7HA 4CXSA 1ED9A 5LQQA 4QAXA 1ELXA 1AJBA 5TJ3A 3E2DA 4ZG9A 3NKOA 4ZGAA 4LR2A 1HQAA 5GRRA 3BDFA 2XRGA 4LRFA 1Y7AA 3WAXA 4N7TA 3MK2A 1AUKA 1AJCA 4LR9A 1B8JA 1ALHA 1AJDA 3MK0A 4NWJA 1HDHA 3M8WA 3WAVA 4TN0A 3M8YA 1ED8A 4UORA 5DLWA 4ZG6A 3KD8A 4UPIA 1P49A 2W5RA 2W5QA 3WAWA 1KHNA 2ZKTA 5LRNA
chains in the Genus database with same CATH superfamily
3UO0A 4UPLA 3M7VA 2GA3A 4GTXA 4FDIA 1URAA 5L0EA 3NKQA 1KH9A 3WAYA 4ZG7A 1E33P 1ANJA 1Y6VA 4MIVA 1KH7A 5HRTA 4FDJA 2ANHA 1URBA 1ZEDA 2IUCA 1ALJA 3TG0A 4CXUA 1E1ZP 3BDGA 5DLVA 1ALKA 3M8ZA 1EW8A 1SHQA 3UN3A 1HJKA 1EQJA 1ZEFA 4CYRA 1EI6A 5KXAA 4UOPA 4UOOA 2GSUA 4LRAA 4LRBA 5GOVA 5IJSA 3NKNA 1KHLA 3TWZA 3UN2A 3NKMA 4KAYA 4UPKA 4B56A 2VQRA 5EGEA 2W5WA 3NKPA 2W5SA 1SHNA 3T02A 5LIAA 5K4PA 1ANIA 3CMRA 3WBHA 2W5TA 4CYSA 3MK1A 4LQYA 3T00A 3A52A 2XR9A 4LRCA 3NVLA 5LRMA 3LXQA 4KAVA 1ELZA 2X98A 2RH6A 3SZYA 1E2SP 2GSNA 1FSUA 4MHXA 4UPHA 4CXKA 2IUCB 3IGYB 4GTZA 3UN5A 5DLTA 1KH5A 3B5QA 4LR7A 2GLQA 3BDGB 1O99A 2W8SA 1AJAA 4LREA 3ED4A 2IFYA 3TX0A 3IDDA 3UNYA 2W8DA 4LR8A 2W5VA 2W5XA 1ALIA 1EW2A 4GTWA 3OT9A 4KM4A 3BDHA 4LRDA 1ZEBA 3NKRA 5AJ9A 5L0KA 2GSOA 1ELYA 3Q3QA 5EGHA 3IGZB 4NWXA 2G9YA 4YR1A 4MY4A 1O98A 1KH4A 5L0BA 1N2LA 3DYCA 1KHJA 5C66A 1E3CP 4KJGA 5IJQA 3DPCA 3T01A 1EJJA 1N2KA 1KHKA 2D1GA 4GTYA 5INHA 2QZUA 4KJDA 3SZZA 1EW9A 1K7HA 4CXSA 1ED9A 5LQQA 4QAXA 1ELXA 1AJBA 5TJ3A 3E2DA 4ZG9A 3NKOA 4ZGAA 4LR2A 1HQAA 5GRRA 3BDFA 2XRGA 4LRFA 1Y7AA 3WAXA 4N7TA 3MK2A 1AUKA 1AJCA 4LR9A 1B8JA 1ALHA 1AJDA 3MK0A 4NWJA 1HDHA 3M8WA 3WAVA 4TN0A 3M8YA 1ED8A 4UORA 5DLWA 4ZG6A 3KD8A 4UPIA 1P49A 2W5RA 2W5QA 3WAWA 1KHNA 2ZKTA 5LRNA
chains in the Genus database with same CATH topology
3UO0A 4UPLA 3M7VA 2GA3A 4GTXA 4FDIA 1URAA 5L0EA 3NKQA 1KH9A 3WAYA 4ZG7A 1E33P 1ANJA 1Y6VA 4MIVA 1KH7A 5HRTA 4FDJA 2ANHA 1URBA 1ZEDA 2IUCA 1ALJA 3TG0A 4CXUA 1E1ZP 3BDGA 5DLVA 1ALKA 3M8ZA 1EW8A 1SHQA 3UN3A 1HJKA 1EQJA 1ZEFA 4CYRA 1EI6A 5KXAA 4UOPA 4UOOA 2GSUA 4LRAA 4LRBA 5GOVA 5IJSA 3NKNA 1KHLA 3TWZA 3UN2A 3NKMA 4KAYA 4UPKA 4B56A 2VQRA 5EGEA 2W5WA 3NKPA 2W5SA 1SHNA 3T02A 5LIAA 5K4PA 1ANIA 3CMRA 3WBHA 2W5TA 4CYSA 3MK1A 4LQYA 3T00A 3A52A 2XR9A 4LRCA 3NVLA 5LRMA 3LXQA 4KAVA 1ELZA 2X98A 2RH6A 3SZYA 1E2SP 2GSNA 1FSUA 4MHXA 4UPHA 4CXKA 2IUCB 3IGYB 4GTZA 3UN5A 5DLTA 1KH5A 3B5QA 4LR7A 2GLQA 3BDGB 1O99A 2W8SA 1AJAA 4LREA 3ED4A 2IFYA 3TX0A 3IDDA 3UNYA 2W8DA 4LR8A 2W5VA 2W5XA 1ALIA 1EW2A 4GTWA 3OT9A 4KM4A 3BDHA 4LRDA 1ZEBA 3NKRA 5AJ9A 5L0KA 2GSOA 1ELYA 3Q3QA 5EGHA 3IGZB 4NWXA 2G9YA 4YR1A 4MY4A 1O98A 1KH4A 5L0BA 1N2LA 3DYCA 1KHJA 5C66A 1E3CP 4KJGA 5IJQA 3DPCA 3T01A 1EJJA 1N2KA 1KHKA 2D1GA 4GTYA 5INHA 2QZUA 4KJDA 3SZZA 1EW9A 1K7HA 4CXSA 1ED9A 5LQQA 4QAXA 1ELXA 1AJBA 5TJ3A 3E2DA 4ZG9A 3NKOA 4ZGAA 4LR2A 1HQAA 5GRRA 3BDFA 2XRGA 4LRFA 1Y7AA 3WAXA 4N7TA 3MK2A 1AUKA 1AJCA 4LR9A 1B8JA 1ALHA 1AJDA 3MK0A 4NWJA 1HDHA 3M8WA 3WAVA 4TN0A 3M8YA 1ED8A 4UORA 5DLWA 4ZG6A 3KD8A 4UPIA 1P49A 2W5RA 2W5QA 3WAWA 1KHNA 2ZKTA 5LRNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UO0 A;  4UPL A;  3M7V A;  2GA3 A;  4GTX A;  4FDI A;  1URA A;  5L0E A;  3NKQ A;  1KH9 A;  3WAY A;  4ZG7 A;  1E33 P;  1ANJ A;  1Y6V A;  4MIV A;  1KH7 A;  5HRT A;  4FDJ A;  2ANH A;  1URB A;  1ZED A;  2IUC A;  1ALJ A;  3TG0 A;  4CXU A;  1E1Z P;  3BDG A;  5DLV A;  1ALK A;  3M8Z A;  1EW8 A;  1SHQ A;  3UN3 A;  1HJK A;  1EQJ A;  1ZEF A;  4CYR A;  1EI6 A;  5KXA A;  4UOP A;  4UOO A;  2GSU A;  4LRA A;  4LRB A;  5GOV A;  5IJS A;  3NKN A;  1KHL A;  3TWZ A;  3UN2 A;  3NKM A;  4KAY A;  4UPK A;  4B56 A;  2VQR A;  5EGE A;  2W5W A;  3NKP A;  2W5S A;  1SHN A;  3T02 A;  5LIA A;  5K4P A;  1ANI A;  3CMR A;  3WBH A;  2W5T A;  4CYS A;  3MK1 A;  4LQY A;  3T00 A;  3A52 A;  2XR9 A;  4LRC A;  3NVL A;  5LRM A;  3LXQ A;  4KAV A;  1ELZ A;  2X98 A;  2RH6 A;  3SZY A;  1E2S P;  2GSN A;  1FSU A;  4MHX A;  4UPH A;  4CXK A;  2IUC B;  3IGY B;  4GTZ A;  3UN5 A;  5DLT A;  1KH5 A;  3B5Q A;  4LR7 A;  2GLQ A;  3BDG B;  1O99 A;  2W8S A;  1AJA A;  4LRE A;  3ED4 A;  2IFY A;  3TX0 A;  3IDD A;  3UNY A;  2W8D A;  4LR8 A;  2W5V A;  2W5X A;  1ALI A;  1EW2 A;  4GTW A;  3OT9 A;  4KM4 A;  3BDH A;  4LRD A;  1ZEB A;  3NKR A;  5AJ9 A;  5L0K A;  2GSO A;  1ELY A;  3Q3Q A;  5EGH A;  3IGZ B;  4NWX A;  2G9Y A;  4YR1 A;  4MY4 A;  1O98 A;  1KH4 A;  5L0B A;  1N2L A;  3DYC A;  1KHJ A;  5C66 A;  1E3C P;  4KJG A;  5IJQ A;  3DPC A;  3T01 A;  1EJJ A;  1N2K A;  1KHK A;  2D1G A;  4GTY A;  5INH A;  2QZU A;  4KJD A;  3SZZ A;  1EW9 A;  1K7H A;  4CXS A;  1ED9 A;  5LQQ A;  4QAX A;  1ELX A;  1AJB A;  5TJ3 A;  3E2D A;  4ZG9 A;  3NKO A;  4ZGA A;  4LR2 A;  1HQA A;  5GRR A;  3BDF A;  2XRG A;  4LRF A;  1Y7A A;  3WAX A;  4N7T A;  3MK2 A;  1AUK A;  1AJC A;  4LR9 A;  1B8J A;  1ALH A;  1AJD A;  3MK0 A;  4NWJ A;  1HDH A;  3M8W A;  3WAV A;  4TN0 A;  3M8Y A;  1ED8 A;  4UOR A;  5DLW A;  4ZG6 A;  3KD8 A;  4UPI A;  1P49 A;  2W5R A;  2W5Q A;  3WAW A;  1KHN A;  2ZKT A;  5LRN A; 
#chains in the Genus database with same CATH topology
 3UO0 A;  4UPL A;  3M7V A;  2GA3 A;  4GTX A;  4FDI A;  1URA A;  5L0E A;  3NKQ A;  1KH9 A;  3WAY A;  4ZG7 A;  1E33 P;  1ANJ A;  1Y6V A;  4MIV A;  1KH7 A;  5HRT A;  4FDJ A;  2ANH A;  1URB A;  1ZED A;  2IUC A;  1ALJ A;  3TG0 A;  4CXU A;  1E1Z P;  3BDG A;  5DLV A;  1ALK A;  3M8Z A;  1EW8 A;  1SHQ A;  3UN3 A;  1HJK A;  1EQJ A;  1ZEF A;  4CYR A;  1EI6 A;  5KXA A;  4UOP A;  4UOO A;  2GSU A;  4LRA A;  4LRB A;  5GOV A;  5IJS A;  3NKN A;  1KHL A;  3TWZ A;  3UN2 A;  3NKM A;  4KAY A;  4UPK A;  4B56 A;  2VQR A;  5EGE A;  2W5W A;  3NKP A;  2W5S A;  1SHN A;  3T02 A;  5LIA A;  5K4P A;  1ANI A;  3CMR A;  3WBH A;  2W5T A;  4CYS A;  3MK1 A;  4LQY A;  3T00 A;  3A52 A;  2XR9 A;  4LRC A;  3NVL A;  5LRM A;  3LXQ A;  4KAV A;  1ELZ A;  2X98 A;  2RH6 A;  3SZY A;  1E2S P;  2GSN A;  1FSU A;  4MHX A;  4UPH A;  4CXK A;  2IUC B;  3IGY B;  4GTZ A;  3UN5 A;  5DLT A;  1KH5 A;  3B5Q A;  4LR7 A;  2GLQ A;  3BDG B;  1O99 A;  2W8S A;  1AJA A;  4LRE A;  3ED4 A;  2IFY A;  3TX0 A;  3IDD A;  3UNY A;  2W8D A;  4LR8 A;  2W5V A;  2W5X A;  1ALI A;  1EW2 A;  4GTW A;  3OT9 A;  4KM4 A;  3BDH A;  4LRD A;  1ZEB A;  3NKR A;  5AJ9 A;  5L0K A;  2GSO A;  1ELY A;  3Q3Q A;  5EGH A;  3IGZ B;  4NWX A;  2G9Y A;  4YR1 A;  4MY4 A;  1O98 A;  1KH4 A;  5L0B A;  1N2L A;  3DYC A;  1KHJ A;  5C66 A;  1E3C P;  4KJG A;  5IJQ A;  3DPC A;  3T01 A;  1EJJ A;  1N2K A;  1KHK A;  2D1G A;  4GTY A;  5INH A;  2QZU A;  4KJD A;  3SZZ A;  1EW9 A;  1K7H A;  4CXS A;  1ED9 A;  5LQQ A;  4QAX A;  1ELX A;  1AJB A;  5TJ3 A;  3E2D A;  4ZG9 A;  3NKO A;  4ZGA A;  4LR2 A;  1HQA A;  5GRR A;  3BDF A;  2XRG A;  4LRF A;  1Y7A A;  3WAX A;  4N7T A;  3MK2 A;  1AUK A;  1AJC A;  4LR9 A;  1B8J A;  1ALH A;  1AJD A;  3MK0 A;  4NWJ A;  1HDH A;  3M8W A;  3WAV A;  4TN0 A;  3M8Y A;  1ED8 A;  4UOR A;  5DLW A;  4ZG6 A;  3KD8 A;  4UPI A;  1P49 A;  2W5R A;  2W5Q A;  3WAW A;  1KHN A;  2ZKT A;  5LRN A; 
#chains in the Genus database with same CATH homology
 3UO0 A;  4UPL A;  3M7V A;  2GA3 A;  4GTX A;  4FDI A;  1URA A;  5L0E A;  3NKQ A;  1KH9 A;  3WAY A;  4ZG7 A;  1E33 P;  1ANJ A;  1Y6V A;  4MIV A;  1KH7 A;  5HRT A;  4FDJ A;  2ANH A;  1URB A;  1ZED A;  2IUC A;  1ALJ A;  3TG0 A;  4CXU A;  1E1Z P;  3BDG A;  5DLV A;  1ALK A;  3M8Z A;  1EW8 A;  1SHQ A;  3UN3 A;  1HJK A;  1EQJ A;  1ZEF A;  4CYR A;  1EI6 A;  5KXA A;  4UOP A;  4UOO A;  2GSU A;  4LRA A;  4LRB A;  5GOV A;  5IJS A;  3NKN A;  1KHL A;  3TWZ A;  3UN2 A;  3NKM A;  4KAY A;  4UPK A;  4B56 A;  2VQR A;  5EGE A;  2W5W A;  3NKP A;  2W5S A;  1SHN A;  3T02 A;  5LIA A;  5K4P A;  1ANI A;  3CMR A;  3WBH A;  2W5T A;  4CYS A;  3MK1 A;  4LQY A;  3T00 A;  3A52 A;  2XR9 A;  4LRC A;  3NVL A;  5LRM A;  3LXQ A;  4KAV A;  1ELZ A;  2X98 A;  2RH6 A;  3SZY A;  1E2S P;  2GSN A;  1FSU A;  4MHX A;  4UPH A;  4CXK A;  2IUC B;  3IGY B;  4GTZ A;  3UN5 A;  5DLT A;  1KH5 A;  3B5Q A;  4LR7 A;  2GLQ A;  3BDG B;  1O99 A;  2W8S A;  1AJA A;  4LRE A;  3ED4 A;  2IFY A;  3TX0 A;  3IDD A;  3UNY A;  2W8D A;  4LR8 A;  2W5V A;  2W5X A;  1ALI A;  1EW2 A;  4GTW A;  3OT9 A;  4KM4 A;  3BDH A;  4LRD A;  1ZEB A;  3NKR A;  5AJ9 A;  5L0K A;  2GSO A;  1ELY A;  3Q3Q A;  5EGH A;  3IGZ B;  4NWX A;  2G9Y A;  4YR1 A;  4MY4 A;  1O98 A;  1KH4 A;  5L0B A;  1N2L A;  3DYC A;  1KHJ A;  5C66 A;  1E3C P;  4KJG A;  5IJQ A;  3DPC A;  3T01 A;  1EJJ A;  1N2K A;  1KHK A;  2D1G A;  4GTY A;  5INH A;  2QZU A;  4KJD A;  3SZZ A;  1EW9 A;  1K7H A;  4CXS A;  1ED9 A;  5LQQ A;  4QAX A;  1ELX A;  1AJB A;  5TJ3 A;  3E2D A;  4ZG9 A;  3NKO A;  4ZGA A;  4LR2 A;  1HQA A;  5GRR A;  3BDF A;  2XRG A;  4LRF A;  1Y7A A;  3WAX A;  4N7T A;  3MK2 A;  1AUK A;  1AJC A;  4LR9 A;  1B8J A;  1ALH A;  1AJD A;  3MK0 A;  4NWJ A;  1HDH A;  3M8W A;  3WAV A;  4TN0 A;  3M8Y A;  1ED8 A;  4UOR A;  5DLW A;  4ZG6 A;  3KD8 A;  4UPI A;  1P49 A;  2W5R A;  2W5Q A;  3WAW A;  1KHN A;  2ZKT A;  5LRN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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