2GA3 | Genus

Total Genus 165

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	165
Knots found	KnotProt 2.0: S +3₁
sequence length	449
structure length	448
Chain Sequence	TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Escherichia coli
publication title	Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine. pubmed doi rcsb
molecule keywords	Alkaline phosphatase
total genus	165
structure length	448
sequence length	449
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2006-03-07

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	2ga3A00

3MK0A 4GTYA 4KM4A 4CXSA 4QAXA 3T01A 4LR7A 2W5TA 4YR1A 4UPKA 1KH4A 1B8JA 1URBA 3ED4A 1ELYA 3M8ZA 3NKMA 5DLWA 3NKNA 2XRGA 1AJDA 1E2SP 1EW9A 1KHNA 1ZEFA 1ALHA 1KHLA 3DPCA 4LRBA 3NKQA 3UN5A 1EQJA 2IFYA 1EW8A 3NKPA 2RH6A 2IUCA 5GOVA 2W5XA 4UPIA 1EI6A 3BDFA 4LR8A 2GSUA 2W5SA 5K4PA 3UO0A 3WAVA 3TG0A 1P49A 2X98A 4CXKA 4UOPA 5C66A 4UPHA 4LREA 1Y7AA 1KHKA 1ELZA 3IDDA 5L0EA 4ZGAA 1ED9A 2W5QA 2XR9A 3WAWA 2W5RA 4MHXA 4LR2A 3SZYA 5TJ3A 4ZG6A 2ZKTA 3A52A 5GRRA 1K7HA 3MK2A 1FSUA 5L0KA 1AJAA 5EGEA 4CXUA 1ZEBA 5INHA 4GTWA 4NWJA 3UN2A 3KD8A 2W8SA 2GA3A 2GSNA 1KHJA 4KJDA 3IGYB 1KH7A 1E1ZP 1ELXA 2W5WA 5LQQA 1SHNA 4LQYA 2GLQA 1ANJA 3BDHA 1ALIA 3IGZB 3WAYA 5AJ9A 4ZG7A 1ZEDA 3MK1A 5LRNA 3E2DA 3DYCA 1ED8A 4NWXA 4UOOA 5L0BA 2W8DA 5IJSA 1KH5A 1O99A 4ZG9A 1HJKA 2D1GA 1N2LA 1HDHA 3BDGB 1AJCA 4KAYA 4LRCA 1URAA 2IUCB 4FDJA 2ANHA 3LXQA 4MIVA 3WBHA 5DLVA 4MY4A 4FDIA 1ALJA 4KAVA 3NKRA 4LR9A 5HRTA 3M8WA 1Y6VA 4N7TA 4LRAA 4TN0A 1EW2A 5KXAA 1N2KA 5EGHA 4UORA 1HQAA 5LRMA 1ALKA 1EJJA 3M8YA 1AJBA 4CYRA 3UN3A 4GTXA 3CMRA 3SZZA 3UNYA 4CYSA 2GSOA 3T00A 2VQRA 3NVLA 5LIAA 1E3CP 1O98A 2W5VA 5DLTA 5IJQA 4B56A 1ANIA 3OT9A 3WAXA 1E33P 3BDGA 4UPLA 3NKOA 1KH9A 2G9YA 4LRDA 1AUKA 4GTZA 3M7VA 4KJGA 3B5QA 2QZUA 3TX0A 1SHQA 3T02A 4LRFA 3Q3QA 3TWZA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3MK0 A;  4GTY A;  4KM4 A;  4CXS A;  4QAX A;  3T01 A;  4LR7 A;  2W5T A;  4YR1 A;  4UPK A;  1KH4 A;  1B8J A;  1URB A;  3ED4 A;  1ELY A;  3M8Z A;  3NKM A;  5DLW A;  3NKN A;  2XRG A;  1AJD A;  1E2S P;  1EW9 A;  1KHN A;  1ZEF A;  1ALH A;  1KHL A;  3DPC A;  4LRB A;  3NKQ A;  3UN5 A;  1EQJ A;  2IFY A;  1EW8 A;  3NKP A;  2RH6 A;  2IUC A;  5GOV A;  2W5X A;  4UPI A;  1EI6 A;  3BDF A;  4LR8 A;  2GSU A;  2W5S A;  5K4P A;  3UO0 A;  3WAV A;  3TG0 A;  1P49 A;  2X98 A;  4CXK A;  4UOP A;  5C66 A;  4UPH A;  4LRE A;  1Y7A A;  1KHK A;  1ELZ A;  3IDD A;  5L0E A;  4ZGA A;  1ED9 A;  2W5Q A;  2XR9 A;  3WAW A;  2W5R A;  4MHX A;  4LR2 A;  3SZY A;  5TJ3 A;  4ZG6 A;  2ZKT A;  3A52 A;  5GRR A;  1K7H A;  3MK2 A;  1FSU A;  5L0K A;  1AJA A;  5EGE A;  4CXU A;  1ZEB A;  5INH A;  4GTW A;  4NWJ A;  3UN2 A;  3KD8 A;  2W8S A;  2GA3 A;  2GSN A;  1KHJ A;  4KJD A;  3IGY B;  1KH7 A;  1E1Z P;  1ELX A;  2W5W A;  5LQQ A;  1SHN A;  4LQY A;  2GLQ A;  1ANJ A;  3BDH A;  1ALI A;  3IGZ B;  3WAY A;  5AJ9 A;  4ZG7 A;  1ZED A;  3MK1 A;  5LRN A;  3E2D A;  3DYC A;  1ED8 A;  4NWX A;  4UOO A;  5L0B A;  2W8D A;  5IJS A;  1KH5 A;  1O99 A;  4ZG9 A;  1HJK A;  2D1G A;  1N2L A;  1HDH A;  3BDG B;  1AJC A;  4KAY A;  4LRC A;  1URA A;  2IUC B;  4FDJ A;  2ANH A;  3LXQ A;  4MIV A;  3WBH A;  5DLV A;  4MY4 A;  4FDI A;  1ALJ A;  4KAV A;  3NKR A;  4LR9 A;  5HRT A;  3M8W A;  1Y6V A;  4N7T A;  4LRA A;  4TN0 A;  1EW2 A;  5KXA A;  1N2K A;  5EGH A;  4UOR A;  1HQA A;  5LRM A;  1ALK A;  1EJJ A;  3M8Y A;  1AJB A;  4CYR A;  3UN3 A;  4GTX A;  3CMR A;  3SZZ A;  3UNY A;  4CYS A;  2GSO A;  3T00 A;  2VQR A;  3NVL A;  5LIA A;  1E3C P;  1O98 A;  2W5V A;  5DLT A;  5IJQ A;  4B56 A;  1ANI A;  3OT9 A;  3WAX A;  1E33 P;  3BDG A;  4UPL A;  3NKO A;  1KH9 A;  2G9Y A;  4LRD A;  1AUK A;  4GTZ A;  3M7V A;  4KJG A;  3B5Q A;  2QZU A;  3TX0 A;  1SHQ A;  3T02 A;  4LRF A;  3Q3Q A;  3TWZ A; 
#chains in the Genus database with same CATH topology
 3MK0 A;  4GTY A;  4KM4 A;  4CXS A;  4QAX A;  3T01 A;  4LR7 A;  2W5T A;  4YR1 A;  4UPK A;  1KH4 A;  1B8J A;  1URB A;  3ED4 A;  1ELY A;  3M8Z A;  3NKM A;  5DLW A;  3NKN A;  2XRG A;  1AJD A;  1E2S P;  1EW9 A;  1KHN A;  1ZEF A;  1ALH A;  1KHL A;  3DPC A;  4LRB A;  3NKQ A;  3UN5 A;  1EQJ A;  2IFY A;  1EW8 A;  3NKP A;  2RH6 A;  2IUC A;  5GOV A;  2W5X A;  4UPI A;  1EI6 A;  3BDF A;  4LR8 A;  2GSU A;  2W5S A;  5K4P A;  3UO0 A;  3WAV A;  3TG0 A;  1P49 A;  2X98 A;  4CXK A;  4UOP A;  5C66 A;  4UPH A;  4LRE A;  1Y7A A;  1KHK A;  1ELZ A;  3IDD A;  5L0E A;  4ZGA A;  1ED9 A;  2W5Q A;  2XR9 A;  3WAW A;  2W5R A;  4MHX A;  4LR2 A;  3SZY A;  5TJ3 A;  4ZG6 A;  2ZKT A;  3A52 A;  5GRR A;  1K7H A;  3MK2 A;  1FSU A;  5L0K A;  1AJA A;  5EGE A;  4CXU A;  1ZEB A;  5INH A;  4GTW A;  4NWJ A;  3UN2 A;  3KD8 A;  2W8S A;  2GA3 A;  2GSN A;  1KHJ A;  4KJD A;  3IGY B;  1KH7 A;  1E1Z P;  1ELX A;  2W5W A;  5LQQ A;  1SHN A;  4LQY A;  2GLQ A;  1ANJ A;  3BDH A;  1ALI A;  3IGZ B;  3WAY A;  5AJ9 A;  4ZG7 A;  1ZED A;  3MK1 A;  5LRN A;  3E2D A;  3DYC A;  1ED8 A;  4NWX A;  4UOO A;  5L0B A;  2W8D A;  5IJS A;  1KH5 A;  1O99 A;  4ZG9 A;  1HJK A;  2D1G A;  1N2L A;  1HDH A;  3BDG B;  1AJC A;  4KAY A;  4LRC A;  1URA A;  2IUC B;  4FDJ A;  2ANH A;  3LXQ A;  4MIV A;  3WBH A;  5DLV A;  4MY4 A;  4FDI A;  1ALJ A;  4KAV A;  3NKR A;  4LR9 A;  5HRT A;  3M8W A;  1Y6V A;  4N7T A;  4LRA A;  4TN0 A;  1EW2 A;  5KXA A;  1N2K A;  5EGH A;  4UOR A;  1HQA A;  5LRM A;  1ALK A;  1EJJ A;  3M8Y A;  1AJB A;  4CYR A;  3UN3 A;  4GTX A;  3CMR A;  3SZZ A;  3UNY A;  4CYS A;  2GSO A;  3T00 A;  2VQR A;  3NVL A;  5LIA A;  1E3C P;  1O98 A;  2W5V A;  5DLT A;  5IJQ A;  4B56 A;  1ANI A;  3OT9 A;  3WAX A;  1E33 P;  3BDG A;  4UPL A;  3NKO A;  1KH9 A;  2G9Y A;  4LRD A;  1AUK A;  4GTZ A;  3M7V A;  4KJG A;  3B5Q A;  2QZU A;  3TX0 A;  1SHQ A;  3T02 A;  4LRF A;  3Q3Q A;  3TWZ A; 
#chains in the Genus database with same CATH homology
 3MK0 A;  4GTY A;  4KM4 A;  4CXS A;  4QAX A;  3T01 A;  4LR7 A;  2W5T A;  4YR1 A;  4UPK A;  1KH4 A;  1B8J A;  1URB A;  3ED4 A;  1ELY A;  3M8Z A;  3NKM A;  5DLW A;  3NKN A;  2XRG A;  1AJD A;  1E2S P;  1EW9 A;  1KHN A;  1ZEF A;  1ALH A;  1KHL A;  3DPC A;  4LRB A;  3NKQ A;  3UN5 A;  1EQJ A;  2IFY A;  1EW8 A;  3NKP A;  2RH6 A;  2IUC A;  5GOV A;  2W5X A;  4UPI A;  1EI6 A;  3BDF A;  4LR8 A;  2GSU A;  2W5S A;  5K4P A;  3UO0 A;  3WAV A;  3TG0 A;  1P49 A;  2X98 A;  4CXK A;  4UOP A;  5C66 A;  4UPH A;  4LRE A;  1Y7A A;  1KHK A;  1ELZ A;  3IDD A;  5L0E A;  4ZGA A;  1ED9 A;  2W5Q A;  2XR9 A;  3WAW A;  2W5R A;  4MHX A;  4LR2 A;  3SZY A;  5TJ3 A;  4ZG6 A;  2ZKT A;  3A52 A;  5GRR A;  1K7H A;  3MK2 A;  1FSU A;  5L0K A;  1AJA A;  5EGE A;  4CXU A;  1ZEB A;  5INH A;  4GTW A;  4NWJ A;  3UN2 A;  3KD8 A;  2W8S A;  2GA3 A;  2GSN A;  1KHJ A;  4KJD A;  3IGY B;  1KH7 A;  1E1Z P;  1ELX A;  2W5W A;  5LQQ A;  1SHN A;  4LQY A;  2GLQ A;  1ANJ A;  3BDH A;  1ALI A;  3IGZ B;  3WAY A;  5AJ9 A;  4ZG7 A;  1ZED A;  3MK1 A;  5LRN A;  3E2D A;  3DYC A;  1ED8 A;  4NWX A;  4UOO A;  5L0B A;  2W8D A;  5IJS A;  1KH5 A;  1O99 A;  4ZG9 A;  1HJK A;  2D1G A;  1N2L A;  1HDH A;  3BDG B;  1AJC A;  4KAY A;  4LRC A;  1URA A;  2IUC B;  4FDJ A;  2ANH A;  3LXQ A;  4MIV A;  3WBH A;  5DLV A;  4MY4 A;  4FDI A;  1ALJ A;  4KAV A;  3NKR A;  4LR9 A;  5HRT A;  3M8W A;  1Y6V A;  4N7T A;  4LRA A;  4TN0 A;  1EW2 A;  5KXA A;  1N2K A;  5EGH A;  4UOR A;  1HQA A;  5LRM A;  1ALK A;  1EJJ A;  3M8Y A;  1AJB A;  4CYR A;  3UN3 A;  4GTX A;  3CMR A;  3SZZ A;  3UNY A;  4CYS A;  2GSO A;  3T00 A;  2VQR A;  3NVL A;  5LIA A;  1E3C P;  1O98 A;  2W5V A;  5DLT A;  5IJQ A;  4B56 A;  1ANI A;  3OT9 A;  3WAX A;  1E33 P;  3BDG A;  4UPL A;  3NKO A;  1KH9 A;  2G9Y A;  4LRD A;  1AUK A;  4GTZ A;  3M7V A;  4KJG A;  3B5Q A;  2QZU A;  3TX0 A;  1SHQ A;  3T02 A;  4LRF A;  3Q3Q A;  3TWZ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2GA3A

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations