2W5VA

Structure of tab5 alkaline phosphatase mutant his 135 asp with mg bound in the m3 site.
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 128
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5vA00
3NKRA 2XR9A 1AJBA 1SHQA 1HJKA 1KHNA 4NWJA 5L0KA 3TX0A 5DLVA 3UNYA 1EQJA 2W8DA 2W5XA 2G9YA 4LREA 4YR1A 4KAYA 2GSUA 1KHKA 3MK2A 4QAXA 1AJAA 1KH9A 4CXKA 5LRMA 1KH7A 2IUCA 3NKOA 3Q3QA 1EJJA 1EW9A 3ED4A 3T00A 4GTXA 5IJSA 1P49A 4UPLA 3M7VA 3UN2A 1ELZA 5LRNA 1EW8A 2W8SA 3E2DA 3IDDA 2IUCB 4GTYA 4MY4A 1ZEBA 2W5VA 4UOOA 4UPHA 1E33P 3SZYA 4ZGAA 4LR2A 4KJDA 4B56A 3TG0A 3IGYB 3NKMA 1HDHA 4LRDA 2QZUA 2GLQA 4KAVA 4CYRA 5LIAA 3DPCA 1ELYA 4N7TA 2ANHA 4GTWA 3IGZB 4LRCA 1ALJA 3UN3A 1E3CP 1B8JA 4GTZA 1HQAA 1E2SP 1Y7AA 3MK1A 4LQYA 1O99A 4MHXA 3NKNA 1ED9A 3MK0A 1ZEDA 5IJQA 5L0EA 4LRBA 1N2LA 1KH5A 3BDFA 3WBHA 3UO0A 5C66A 2W5TA 3CMRA 5DLTA 5TJ3A 4ZG6A 3BDHA 4LR9A 5GOVA 1FSUA 2W5RA 3LXQA 3TWZA 4LRFA 1ALHA 3WAXA 3M8YA 1ED8A 4KM4A 5HRTA 4UPIA 1SHNA 3M8ZA 1N2KA 4UPKA 4UOPA 2D1GA 2GSNA 1ANIA 2W5SA 1E1ZP 1KHLA 5K4PA 3UN5A 1ALIA 1Y6VA 4LR8A 3WAYA 5LQQA 4TN0A 4FDIA 4MIVA 5INHA 1AJDA 2W5QA 1URBA 4LRAA 2GA3A 5EGEA 4FDJA 2RH6A 2W5WA 2X98A 3M8WA 3NKPA 3WAWA 3WAVA 1EW2A 2ZKTA 3SZZA 5DLWA 3DYCA 1KH4A 2VQRA 4ZG9A 1AUKA 3OT9A 1URAA 3BDGA 1AJCA 3KD8A 4KJGA 1EI6A 5AJ9A 3T02A 4CYSA 5KXAA 3T01A 4CXSA 5GRRA 1ALKA 4LR7A 4CXUA 3A52A 4UORA 1ANJA 3B5QA 2XRGA 5L0BA 3BDGB 1KHJA 1ZEFA 1O98A 3NVLA 4ZG7A 5EGHA 1ELXA 2IFYA 1K7HA 3NKQA 4NWXA 2GSOA
chains in the Genus database with same CATH superfamily
3NKRA 2XR9A 1AJBA 1SHQA 1HJKA 1KHNA 4NWJA 5L0KA 3TX0A 5DLVA 3UNYA 1EQJA 2W8DA 2W5XA 2G9YA 4LREA 4YR1A 4KAYA 2GSUA 1KHKA 3MK2A 4QAXA 1AJAA 1KH9A 4CXKA 5LRMA 1KH7A 2IUCA 3NKOA 3Q3QA 1EJJA 1EW9A 3ED4A 3T00A 4GTXA 5IJSA 1P49A 4UPLA 3M7VA 3UN2A 1ELZA 5LRNA 1EW8A 2W8SA 3E2DA 3IDDA 2IUCB 4GTYA 4MY4A 1ZEBA 2W5VA 4UOOA 4UPHA 1E33P 3SZYA 4ZGAA 4LR2A 4KJDA 4B56A 3TG0A 3IGYB 3NKMA 1HDHA 4LRDA 2QZUA 2GLQA 4KAVA 4CYRA 5LIAA 3DPCA 1ELYA 4N7TA 2ANHA 4GTWA 3IGZB 4LRCA 1ALJA 3UN3A 1E3CP 1B8JA 4GTZA 1HQAA 1E2SP 1Y7AA 3MK1A 4LQYA 1O99A 4MHXA 3NKNA 1ED9A 3MK0A 1ZEDA 5IJQA 5L0EA 4LRBA 1N2LA 1KH5A 3BDFA 3WBHA 3UO0A 5C66A 2W5TA 3CMRA 5DLTA 5TJ3A 4ZG6A 3BDHA 4LR9A 5GOVA 1FSUA 2W5RA 3LXQA 3TWZA 4LRFA 1ALHA 3WAXA 3M8YA 1ED8A 4KM4A 5HRTA 4UPIA 1SHNA 3M8ZA 1N2KA 4UPKA 4UOPA 2D1GA 2GSNA 1ANIA 2W5SA 1E1ZP 1KHLA 5K4PA 3UN5A 1ALIA 1Y6VA 4LR8A 3WAYA 5LQQA 4TN0A 4FDIA 4MIVA 5INHA 1AJDA 2W5QA 1URBA 4LRAA 2GA3A 5EGEA 4FDJA 2RH6A 2W5WA 2X98A 3M8WA 3NKPA 3WAWA 3WAVA 1EW2A 2ZKTA 3SZZA 5DLWA 3DYCA 1KH4A 2VQRA 4ZG9A 1AUKA 3OT9A 1URAA 3BDGA 1AJCA 3KD8A 4KJGA 1EI6A 5AJ9A 3T02A 4CYSA 5KXAA 3T01A 4CXSA 5GRRA 1ALKA 4LR7A 4CXUA 3A52A 4UORA 1ANJA 3B5QA 2XRGA 5L0BA 3BDGB 1KHJA 1ZEFA 1O98A 3NVLA 4ZG7A 5EGHA 1ELXA 2IFYA 1K7HA 3NKQA 4NWXA 2GSOA
chains in the Genus database with same CATH topology
3NKRA 2XR9A 1AJBA 1SHQA 1HJKA 1KHNA 4NWJA 5L0KA 3TX0A 5DLVA 3UNYA 1EQJA 2W8DA 2W5XA 2G9YA 4LREA 4YR1A 4KAYA 2GSUA 1KHKA 3MK2A 4QAXA 1AJAA 1KH9A 4CXKA 5LRMA 1KH7A 2IUCA 3NKOA 3Q3QA 1EJJA 1EW9A 3ED4A 3T00A 4GTXA 5IJSA 1P49A 4UPLA 3M7VA 3UN2A 1ELZA 5LRNA 1EW8A 2W8SA 3E2DA 3IDDA 2IUCB 4GTYA 4MY4A 1ZEBA 2W5VA 4UOOA 4UPHA 1E33P 3SZYA 4ZGAA 4LR2A 4KJDA 4B56A 3TG0A 3IGYB 3NKMA 1HDHA 4LRDA 2QZUA 2GLQA 4KAVA 4CYRA 5LIAA 3DPCA 1ELYA 4N7TA 2ANHA 4GTWA 3IGZB 4LRCA 1ALJA 3UN3A 1E3CP 1B8JA 4GTZA 1HQAA 1E2SP 1Y7AA 3MK1A 4LQYA 1O99A 4MHXA 3NKNA 1ED9A 3MK0A 1ZEDA 5IJQA 5L0EA 4LRBA 1N2LA 1KH5A 3BDFA 3WBHA 3UO0A 5C66A 2W5TA 3CMRA 5DLTA 5TJ3A 4ZG6A 3BDHA 4LR9A 5GOVA 1FSUA 2W5RA 3LXQA 3TWZA 4LRFA 1ALHA 3WAXA 3M8YA 1ED8A 4KM4A 5HRTA 4UPIA 1SHNA 3M8ZA 1N2KA 4UPKA 4UOPA 2D1GA 2GSNA 1ANIA 2W5SA 1E1ZP 1KHLA 5K4PA 3UN5A 1ALIA 1Y6VA 4LR8A 3WAYA 5LQQA 4TN0A 4FDIA 4MIVA 5INHA 1AJDA 2W5QA 1URBA 4LRAA 2GA3A 5EGEA 4FDJA 2RH6A 2W5WA 2X98A 3M8WA 3NKPA 3WAWA 3WAVA 1EW2A 2ZKTA 3SZZA 5DLWA 3DYCA 1KH4A 2VQRA 4ZG9A 1AUKA 3OT9A 1URAA 3BDGA 1AJCA 3KD8A 4KJGA 1EI6A 5AJ9A 3T02A 4CYSA 5KXAA 3T01A 4CXSA 5GRRA 1ALKA 4LR7A 4CXUA 3A52A 4UORA 1ANJA 3B5QA 2XRGA 5L0BA 3BDGB 1KHJA 1ZEFA 1O98A 3NVLA 4ZG7A 5EGHA 1ELXA 2IFYA 1K7HA 3NKQA 4NWXA 2GSOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NKR A;  2XR9 A;  1AJB A;  1SHQ A;  1HJK A;  1KHN A;  4NWJ A;  5L0K A;  3TX0 A;  5DLV A;  3UNY A;  1EQJ A;  2W8D A;  2W5X A;  2G9Y A;  4LRE A;  4YR1 A;  4KAY A;  2GSU A;  1KHK A;  3MK2 A;  4QAX A;  1AJA A;  1KH9 A;  4CXK A;  5LRM A;  1KH7 A;  2IUC A;  3NKO A;  3Q3Q A;  1EJJ A;  1EW9 A;  3ED4 A;  3T00 A;  4GTX A;  5IJS A;  1P49 A;  4UPL A;  3M7V A;  3UN2 A;  1ELZ A;  5LRN A;  1EW8 A;  2W8S A;  3E2D A;  3IDD A;  2IUC B;  4GTY A;  4MY4 A;  1ZEB A;  2W5V A;  4UOO A;  4UPH A;  1E33 P;  3SZY A;  4ZGA A;  4LR2 A;  4KJD A;  4B56 A;  3TG0 A;  3IGY B;  3NKM A;  1HDH A;  4LRD A;  2QZU A;  2GLQ A;  4KAV A;  4CYR A;  5LIA A;  3DPC A;  1ELY A;  4N7T A;  2ANH A;  4GTW A;  3IGZ B;  4LRC A;  1ALJ A;  3UN3 A;  1E3C P;  1B8J A;  4GTZ A;  1HQA A;  1E2S P;  1Y7A A;  3MK1 A;  4LQY A;  1O99 A;  4MHX A;  3NKN A;  1ED9 A;  3MK0 A;  1ZED A;  5IJQ A;  5L0E A;  4LRB A;  1N2L A;  1KH5 A;  3BDF A;  3WBH A;  3UO0 A;  5C66 A;  2W5T A;  3CMR A;  5DLT A;  5TJ3 A;  4ZG6 A;  3BDH A;  4LR9 A;  5GOV A;  1FSU A;  2W5R A;  3LXQ A;  3TWZ A;  4LRF A;  1ALH A;  3WAX A;  3M8Y A;  1ED8 A;  4KM4 A;  5HRT A;  4UPI A;  1SHN A;  3M8Z A;  1N2K A;  4UPK A;  4UOP A;  2D1G A;  2GSN A;  1ANI A;  2W5S A;  1E1Z P;  1KHL A;  5K4P A;  3UN5 A;  1ALI A;  1Y6V A;  4LR8 A;  3WAY A;  5LQQ A;  4TN0 A;  4FDI A;  4MIV A;  5INH A;  1AJD A;  2W5Q A;  1URB A;  4LRA A;  2GA3 A;  5EGE A;  4FDJ A;  2RH6 A;  2W5W A;  2X98 A;  3M8W A;  3NKP A;  3WAW A;  3WAV A;  1EW2 A;  2ZKT A;  3SZZ A;  5DLW A;  3DYC A;  1KH4 A;  2VQR A;  4ZG9 A;  1AUK A;  3OT9 A;  1URA A;  3BDG A;  1AJC A;  3KD8 A;  4KJG A;  1EI6 A;  5AJ9 A;  3T02 A;  4CYS A;  5KXA A;  3T01 A;  4CXS A;  5GRR A;  1ALK A;  4LR7 A;  4CXU A;  3A52 A;  4UOR A;  1ANJ A;  3B5Q A;  2XRG A;  5L0B A;  3BDG B;  1KHJ A;  1ZEF A;  1O98 A;  3NVL A;  4ZG7 A;  5EGH A;  1ELX A;  2IFY A;  1K7H A;  3NKQ A;  4NWX A;  2GSO A; 
#chains in the Genus database with same CATH topology
 3NKR A;  2XR9 A;  1AJB A;  1SHQ A;  1HJK A;  1KHN A;  4NWJ A;  5L0K A;  3TX0 A;  5DLV A;  3UNY A;  1EQJ A;  2W8D A;  2W5X A;  2G9Y A;  4LRE A;  4YR1 A;  4KAY A;  2GSU A;  1KHK A;  3MK2 A;  4QAX A;  1AJA A;  1KH9 A;  4CXK A;  5LRM A;  1KH7 A;  2IUC A;  3NKO A;  3Q3Q A;  1EJJ A;  1EW9 A;  3ED4 A;  3T00 A;  4GTX A;  5IJS A;  1P49 A;  4UPL A;  3M7V A;  3UN2 A;  1ELZ A;  5LRN A;  1EW8 A;  2W8S A;  3E2D A;  3IDD A;  2IUC B;  4GTY A;  4MY4 A;  1ZEB A;  2W5V A;  4UOO A;  4UPH A;  1E33 P;  3SZY A;  4ZGA A;  4LR2 A;  4KJD A;  4B56 A;  3TG0 A;  3IGY B;  3NKM A;  1HDH A;  4LRD A;  2QZU A;  2GLQ A;  4KAV A;  4CYR A;  5LIA A;  3DPC A;  1ELY A;  4N7T A;  2ANH A;  4GTW A;  3IGZ B;  4LRC A;  1ALJ A;  3UN3 A;  1E3C P;  1B8J A;  4GTZ A;  1HQA A;  1E2S P;  1Y7A A;  3MK1 A;  4LQY A;  1O99 A;  4MHX A;  3NKN A;  1ED9 A;  3MK0 A;  1ZED A;  5IJQ A;  5L0E A;  4LRB A;  1N2L A;  1KH5 A;  3BDF A;  3WBH A;  3UO0 A;  5C66 A;  2W5T A;  3CMR A;  5DLT A;  5TJ3 A;  4ZG6 A;  3BDH A;  4LR9 A;  5GOV A;  1FSU A;  2W5R A;  3LXQ A;  3TWZ A;  4LRF A;  1ALH A;  3WAX A;  3M8Y A;  1ED8 A;  4KM4 A;  5HRT A;  4UPI A;  1SHN A;  3M8Z A;  1N2K A;  4UPK A;  4UOP A;  2D1G A;  2GSN A;  1ANI A;  2W5S A;  1E1Z P;  1KHL A;  5K4P A;  3UN5 A;  1ALI A;  1Y6V A;  4LR8 A;  3WAY A;  5LQQ A;  4TN0 A;  4FDI A;  4MIV A;  5INH A;  1AJD A;  2W5Q A;  1URB A;  4LRA A;  2GA3 A;  5EGE A;  4FDJ A;  2RH6 A;  2W5W A;  2X98 A;  3M8W A;  3NKP A;  3WAW A;  3WAV A;  1EW2 A;  2ZKT A;  3SZZ A;  5DLW A;  3DYC A;  1KH4 A;  2VQR A;  4ZG9 A;  1AUK A;  3OT9 A;  1URA A;  3BDG A;  1AJC A;  3KD8 A;  4KJG A;  1EI6 A;  5AJ9 A;  3T02 A;  4CYS A;  5KXA A;  3T01 A;  4CXS A;  5GRR A;  1ALK A;  4LR7 A;  4CXU A;  3A52 A;  4UOR A;  1ANJ A;  3B5Q A;  2XRG A;  5L0B A;  3BDG B;  1KHJ A;  1ZEF A;  1O98 A;  3NVL A;  4ZG7 A;  5EGH A;  1ELX A;  2IFY A;  1K7H A;  3NKQ A;  4NWX A;  2GSO A; 
#chains in the Genus database with same CATH homology
 3NKR A;  2XR9 A;  1AJB A;  1SHQ A;  1HJK A;  1KHN A;  4NWJ A;  5L0K A;  3TX0 A;  5DLV A;  3UNY A;  1EQJ A;  2W8D A;  2W5X A;  2G9Y A;  4LRE A;  4YR1 A;  4KAY A;  2GSU A;  1KHK A;  3MK2 A;  4QAX A;  1AJA A;  1KH9 A;  4CXK A;  5LRM A;  1KH7 A;  2IUC A;  3NKO A;  3Q3Q A;  1EJJ A;  1EW9 A;  3ED4 A;  3T00 A;  4GTX A;  5IJS A;  1P49 A;  4UPL A;  3M7V A;  3UN2 A;  1ELZ A;  5LRN A;  1EW8 A;  2W8S A;  3E2D A;  3IDD A;  2IUC B;  4GTY A;  4MY4 A;  1ZEB A;  2W5V A;  4UOO A;  4UPH A;  1E33 P;  3SZY A;  4ZGA A;  4LR2 A;  4KJD A;  4B56 A;  3TG0 A;  3IGY B;  3NKM A;  1HDH A;  4LRD A;  2QZU A;  2GLQ A;  4KAV A;  4CYR A;  5LIA A;  3DPC A;  1ELY A;  4N7T A;  2ANH A;  4GTW A;  3IGZ B;  4LRC A;  1ALJ A;  3UN3 A;  1E3C P;  1B8J A;  4GTZ A;  1HQA A;  1E2S P;  1Y7A A;  3MK1 A;  4LQY A;  1O99 A;  4MHX A;  3NKN A;  1ED9 A;  3MK0 A;  1ZED A;  5IJQ A;  5L0E A;  4LRB A;  1N2L A;  1KH5 A;  3BDF A;  3WBH A;  3UO0 A;  5C66 A;  2W5T A;  3CMR A;  5DLT A;  5TJ3 A;  4ZG6 A;  3BDH A;  4LR9 A;  5GOV A;  1FSU A;  2W5R A;  3LXQ A;  3TWZ A;  4LRF A;  1ALH A;  3WAX A;  3M8Y A;  1ED8 A;  4KM4 A;  5HRT A;  4UPI A;  1SHN A;  3M8Z A;  1N2K A;  4UPK A;  4UOP A;  2D1G A;  2GSN A;  1ANI A;  2W5S A;  1E1Z P;  1KHL A;  5K4P A;  3UN5 A;  1ALI A;  1Y6V A;  4LR8 A;  3WAY A;  5LQQ A;  4TN0 A;  4FDI A;  4MIV A;  5INH A;  1AJD A;  2W5Q A;  1URB A;  4LRA A;  2GA3 A;  5EGE A;  4FDJ A;  2RH6 A;  2W5W A;  2X98 A;  3M8W A;  3NKP A;  3WAW A;  3WAV A;  1EW2 A;  2ZKT A;  3SZZ A;  5DLW A;  3DYC A;  1KH4 A;  2VQR A;  4ZG9 A;  1AUK A;  3OT9 A;  1URA A;  3BDG A;  1AJC A;  3KD8 A;  4KJG A;  1EI6 A;  5AJ9 A;  3T02 A;  4CYS A;  5KXA A;  3T01 A;  4CXS A;  5GRR A;  1ALK A;  4LR7 A;  4CXU A;  3A52 A;  4UOR A;  1ANJ A;  3B5Q A;  2XRG A;  5L0B A;  3BDG B;  1KHJ A;  1ZEF A;  1O98 A;  3NVL A;  4ZG7 A;  5EGH A;  1ELX A;  2IFY A;  1K7H A;  3NKQ A;  4NWX A;  2GSO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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