2W5WA

Structure of tab5 alkaline phosphatase mutant his 135 asp with zn bound in the m3 site.
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 130
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5wA00
3Q3QA 4ZGAA 1AJAA 1EI6A 4QAXA 4LRFA 1KH7A 3BDHA 3DPCA 4LRCA 3UO0A 3M8ZA 4UOOA 5DLTA 1ALJA 2W8DA 1ANJA 1KH5A 1AUKA 3TX0A 4YR1A 1SHNA 4FDJA 3T00A 5TJ3A 1E1ZP 4KAVA 4LRAA 5IJQA 3WBHA 4LR2A 3KD8A 3NVLA 4N7TA 5EGHA 1SHQA 2RH6A 5DLWA 5GOVA 2D1GA 5LQQA 4MY4A 3A52A 4UOPA 3NKRA 2XR9A 4UPLA 1ALIA 2XRGA 1E33P 3SZZA 1ALHA 4MHXA 4GTWA 4KM4A 5K4PA 4KJGA 3WAXA 4UPHA 3IGZB 1URBA 3NKPA 2GSOA 2W5SA 1EJJA 4CYRA 1EW8A 1O99A 3E2DA 3UN3A 3NKMA 4FDIA 1HQAA 5C66A 5LIAA 1ANIA 1ALKA 2GLQA 3NKQA 2GSNA 1FSUA 3CMRA 3DYCA 1URAA 1AJBA 2W5VA 2IUCA 4KJDA 4CXKA 4ZG6A 5LRMA 3IDDA 2IUCB 3M8WA 5L0EA 1O98A 3BDGA 1B8JA 3BDGB 4LRDA 5LRNA 1KHJA 4UORA 3WAYA 4LR9A 2G9YA 2IFYA 5INHA 1ELZA 3IGYB 3OT9A 4TN0A 2W5WA 2ZKTA 5DLVA 5GRRA 4GTYA 3BDFA 1ELYA 1N2LA 3B5QA 3WAVA 4CYSA 1KH9A 1Y6VA 4CXUA 1P49A 3M8YA 4CXSA 1EQJA 1Y7AA 4LR7A 2ANHA 5L0BA 1ZEFA 3UN5A 1KHNA 4LREA 3T01A 2W5RA 3UN2A 4LQYA 1EW2A 1ZEBA 3MK2A 1E3CP 4ZG9A 2GA3A 3MK1A 4B56A 1ZEDA 3UNYA 2W5TA 3NKNA 4UPIA 1AJDA 1HJKA 3M7VA 5AJ9A 4UPKA 5L0KA 1E2SP 1AJCA 5KXAA 3TWZA 4LRBA 5IJSA 2X98A 4ZG7A 4MIVA 3SZYA 2W5QA 3LXQA 3TG0A 5EGEA 2QZUA 1KH4A 4GTZA 4KAYA 4NWJA 3NKOA 1ELXA 2W5XA 3ED4A 1HDHA 2VQRA 5HRTA 1ED9A 2GSUA 1N2KA 1K7HA 3T02A 3MK0A 1EW9A 1ED8A 3WAWA 4GTXA 2W8SA 4LR8A 1KHLA 1KHKA 4NWXA
chains in the Genus database with same CATH superfamily
3Q3QA 4ZGAA 1AJAA 1EI6A 4QAXA 4LRFA 1KH7A 3BDHA 3DPCA 4LRCA 3UO0A 3M8ZA 4UOOA 5DLTA 1ALJA 2W8DA 1ANJA 1KH5A 1AUKA 3TX0A 4YR1A 1SHNA 4FDJA 3T00A 5TJ3A 1E1ZP 4KAVA 4LRAA 5IJQA 3WBHA 4LR2A 3KD8A 3NVLA 4N7TA 5EGHA 1SHQA 2RH6A 5DLWA 5GOVA 2D1GA 5LQQA 4MY4A 3A52A 4UOPA 3NKRA 2XR9A 4UPLA 1ALIA 2XRGA 1E33P 3SZZA 1ALHA 4MHXA 4GTWA 4KM4A 5K4PA 4KJGA 3WAXA 4UPHA 3IGZB 1URBA 3NKPA 2GSOA 2W5SA 1EJJA 4CYRA 1EW8A 1O99A 3E2DA 3UN3A 3NKMA 4FDIA 1HQAA 5C66A 5LIAA 1ANIA 1ALKA 2GLQA 3NKQA 2GSNA 1FSUA 3CMRA 3DYCA 1URAA 1AJBA 2W5VA 2IUCA 4KJDA 4CXKA 4ZG6A 5LRMA 3IDDA 2IUCB 3M8WA 5L0EA 1O98A 3BDGA 1B8JA 3BDGB 4LRDA 5LRNA 1KHJA 4UORA 3WAYA 4LR9A 2G9YA 2IFYA 5INHA 1ELZA 3IGYB 3OT9A 4TN0A 2W5WA 2ZKTA 5DLVA 5GRRA 4GTYA 3BDFA 1ELYA 1N2LA 3B5QA 3WAVA 4CYSA 1KH9A 1Y6VA 4CXUA 1P49A 3M8YA 4CXSA 1EQJA 1Y7AA 4LR7A 2ANHA 5L0BA 1ZEFA 3UN5A 1KHNA 4LREA 3T01A 2W5RA 3UN2A 4LQYA 1EW2A 1ZEBA 3MK2A 1E3CP 4ZG9A 2GA3A 3MK1A 4B56A 1ZEDA 3UNYA 2W5TA 3NKNA 4UPIA 1AJDA 1HJKA 3M7VA 5AJ9A 4UPKA 5L0KA 1E2SP 1AJCA 5KXAA 3TWZA 4LRBA 5IJSA 2X98A 4ZG7A 4MIVA 3SZYA 2W5QA 3LXQA 3TG0A 5EGEA 2QZUA 1KH4A 4GTZA 4KAYA 4NWJA 3NKOA 1ELXA 2W5XA 3ED4A 1HDHA 2VQRA 5HRTA 1ED9A 2GSUA 1N2KA 1K7HA 3T02A 3MK0A 1EW9A 1ED8A 3WAWA 4GTXA 2W8SA 4LR8A 1KHLA 1KHKA 4NWXA
chains in the Genus database with same CATH topology
3Q3QA 4ZGAA 1AJAA 1EI6A 4QAXA 4LRFA 1KH7A 3BDHA 3DPCA 4LRCA 3UO0A 3M8ZA 4UOOA 5DLTA 1ALJA 2W8DA 1ANJA 1KH5A 1AUKA 3TX0A 4YR1A 1SHNA 4FDJA 3T00A 5TJ3A 1E1ZP 4KAVA 4LRAA 5IJQA 3WBHA 4LR2A 3KD8A 3NVLA 4N7TA 5EGHA 1SHQA 2RH6A 5DLWA 5GOVA 2D1GA 5LQQA 4MY4A 3A52A 4UOPA 3NKRA 2XR9A 4UPLA 1ALIA 2XRGA 1E33P 3SZZA 1ALHA 4MHXA 4GTWA 4KM4A 5K4PA 4KJGA 3WAXA 4UPHA 3IGZB 1URBA 3NKPA 2GSOA 2W5SA 1EJJA 4CYRA 1EW8A 1O99A 3E2DA 3UN3A 3NKMA 4FDIA 1HQAA 5C66A 5LIAA 1ANIA 1ALKA 2GLQA 3NKQA 2GSNA 1FSUA 3CMRA 3DYCA 1URAA 1AJBA 2W5VA 2IUCA 4KJDA 4CXKA 4ZG6A 5LRMA 3IDDA 2IUCB 3M8WA 5L0EA 1O98A 3BDGA 1B8JA 3BDGB 4LRDA 5LRNA 1KHJA 4UORA 3WAYA 4LR9A 2G9YA 2IFYA 5INHA 1ELZA 3IGYB 3OT9A 4TN0A 2W5WA 2ZKTA 5DLVA 5GRRA 4GTYA 3BDFA 1ELYA 1N2LA 3B5QA 3WAVA 4CYSA 1KH9A 1Y6VA 4CXUA 1P49A 3M8YA 4CXSA 1EQJA 1Y7AA 4LR7A 2ANHA 5L0BA 1ZEFA 3UN5A 1KHNA 4LREA 3T01A 2W5RA 3UN2A 4LQYA 1EW2A 1ZEBA 3MK2A 1E3CP 4ZG9A 2GA3A 3MK1A 4B56A 1ZEDA 3UNYA 2W5TA 3NKNA 4UPIA 1AJDA 1HJKA 3M7VA 5AJ9A 4UPKA 5L0KA 1E2SP 1AJCA 5KXAA 3TWZA 4LRBA 5IJSA 2X98A 4ZG7A 4MIVA 3SZYA 2W5QA 3LXQA 3TG0A 5EGEA 2QZUA 1KH4A 4GTZA 4KAYA 4NWJA 3NKOA 1ELXA 2W5XA 3ED4A 1HDHA 2VQRA 5HRTA 1ED9A 2GSUA 1N2KA 1K7HA 3T02A 3MK0A 1EW9A 1ED8A 3WAWA 4GTXA 2W8SA 4LR8A 1KHLA 1KHKA 4NWXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q3Q A;  4ZGA A;  1AJA A;  1EI6 A;  4QAX A;  4LRF A;  1KH7 A;  3BDH A;  3DPC A;  4LRC A;  3UO0 A;  3M8Z A;  4UOO A;  5DLT A;  1ALJ A;  2W8D A;  1ANJ A;  1KH5 A;  1AUK A;  3TX0 A;  4YR1 A;  1SHN A;  4FDJ A;  3T00 A;  5TJ3 A;  1E1Z P;  4KAV A;  4LRA A;  5IJQ A;  3WBH A;  4LR2 A;  3KD8 A;  3NVL A;  4N7T A;  5EGH A;  1SHQ A;  2RH6 A;  5DLW A;  5GOV A;  2D1G A;  5LQQ A;  4MY4 A;  3A52 A;  4UOP A;  3NKR A;  2XR9 A;  4UPL A;  1ALI A;  2XRG A;  1E33 P;  3SZZ A;  1ALH A;  4MHX A;  4GTW A;  4KM4 A;  5K4P A;  4KJG A;  3WAX A;  4UPH A;  3IGZ B;  1URB A;  3NKP A;  2GSO A;  2W5S A;  1EJJ A;  4CYR A;  1EW8 A;  1O99 A;  3E2D A;  3UN3 A;  3NKM A;  4FDI A;  1HQA A;  5C66 A;  5LIA A;  1ANI A;  1ALK A;  2GLQ A;  3NKQ A;  2GSN A;  1FSU A;  3CMR A;  3DYC A;  1URA A;  1AJB A;  2W5V A;  2IUC A;  4KJD A;  4CXK A;  4ZG6 A;  5LRM A;  3IDD A;  2IUC B;  3M8W A;  5L0E A;  1O98 A;  3BDG A;  1B8J A;  3BDG B;  4LRD A;  5LRN A;  1KHJ A;  4UOR A;  3WAY A;  4LR9 A;  2G9Y A;  2IFY A;  5INH A;  1ELZ A;  3IGY B;  3OT9 A;  4TN0 A;  2W5W A;  2ZKT A;  5DLV A;  5GRR A;  4GTY A;  3BDF A;  1ELY A;  1N2L A;  3B5Q A;  3WAV A;  4CYS A;  1KH9 A;  1Y6V A;  4CXU A;  1P49 A;  3M8Y A;  4CXS A;  1EQJ A;  1Y7A A;  4LR7 A;  2ANH A;  5L0B A;  1ZEF A;  3UN5 A;  1KHN A;  4LRE A;  3T01 A;  2W5R A;  3UN2 A;  4LQY A;  1EW2 A;  1ZEB A;  3MK2 A;  1E3C P;  4ZG9 A;  2GA3 A;  3MK1 A;  4B56 A;  1ZED A;  3UNY A;  2W5T A;  3NKN A;  4UPI A;  1AJD A;  1HJK A;  3M7V A;  5AJ9 A;  4UPK A;  5L0K A;  1E2S P;  1AJC A;  5KXA A;  3TWZ A;  4LRB A;  5IJS A;  2X98 A;  4ZG7 A;  4MIV A;  3SZY A;  2W5Q A;  3LXQ A;  3TG0 A;  5EGE A;  2QZU A;  1KH4 A;  4GTZ A;  4KAY A;  4NWJ A;  3NKO A;  1ELX A;  2W5X A;  3ED4 A;  1HDH A;  2VQR A;  5HRT A;  1ED9 A;  2GSU A;  1N2K A;  1K7H A;  3T02 A;  3MK0 A;  1EW9 A;  1ED8 A;  3WAW A;  4GTX A;  2W8S A;  4LR8 A;  1KHL A;  1KHK A;  4NWX A; 
#chains in the Genus database with same CATH topology
 3Q3Q A;  4ZGA A;  1AJA A;  1EI6 A;  4QAX A;  4LRF A;  1KH7 A;  3BDH A;  3DPC A;  4LRC A;  3UO0 A;  3M8Z A;  4UOO A;  5DLT A;  1ALJ A;  2W8D A;  1ANJ A;  1KH5 A;  1AUK A;  3TX0 A;  4YR1 A;  1SHN A;  4FDJ A;  3T00 A;  5TJ3 A;  1E1Z P;  4KAV A;  4LRA A;  5IJQ A;  3WBH A;  4LR2 A;  3KD8 A;  3NVL A;  4N7T A;  5EGH A;  1SHQ A;  2RH6 A;  5DLW A;  5GOV A;  2D1G A;  5LQQ A;  4MY4 A;  3A52 A;  4UOP A;  3NKR A;  2XR9 A;  4UPL A;  1ALI A;  2XRG A;  1E33 P;  3SZZ A;  1ALH A;  4MHX A;  4GTW A;  4KM4 A;  5K4P A;  4KJG A;  3WAX A;  4UPH A;  3IGZ B;  1URB A;  3NKP A;  2GSO A;  2W5S A;  1EJJ A;  4CYR A;  1EW8 A;  1O99 A;  3E2D A;  3UN3 A;  3NKM A;  4FDI A;  1HQA A;  5C66 A;  5LIA A;  1ANI A;  1ALK A;  2GLQ A;  3NKQ A;  2GSN A;  1FSU A;  3CMR A;  3DYC A;  1URA A;  1AJB A;  2W5V A;  2IUC A;  4KJD A;  4CXK A;  4ZG6 A;  5LRM A;  3IDD A;  2IUC B;  3M8W A;  5L0E A;  1O98 A;  3BDG A;  1B8J A;  3BDG B;  4LRD A;  5LRN A;  1KHJ A;  4UOR A;  3WAY A;  4LR9 A;  2G9Y A;  2IFY A;  5INH A;  1ELZ A;  3IGY B;  3OT9 A;  4TN0 A;  2W5W A;  2ZKT A;  5DLV A;  5GRR A;  4GTY A;  3BDF A;  1ELY A;  1N2L A;  3B5Q A;  3WAV A;  4CYS A;  1KH9 A;  1Y6V A;  4CXU A;  1P49 A;  3M8Y A;  4CXS A;  1EQJ A;  1Y7A A;  4LR7 A;  2ANH A;  5L0B A;  1ZEF A;  3UN5 A;  1KHN A;  4LRE A;  3T01 A;  2W5R A;  3UN2 A;  4LQY A;  1EW2 A;  1ZEB A;  3MK2 A;  1E3C P;  4ZG9 A;  2GA3 A;  3MK1 A;  4B56 A;  1ZED A;  3UNY A;  2W5T A;  3NKN A;  4UPI A;  1AJD A;  1HJK A;  3M7V A;  5AJ9 A;  4UPK A;  5L0K A;  1E2S P;  1AJC A;  5KXA A;  3TWZ A;  4LRB A;  5IJS A;  2X98 A;  4ZG7 A;  4MIV A;  3SZY A;  2W5Q A;  3LXQ A;  3TG0 A;  5EGE A;  2QZU A;  1KH4 A;  4GTZ A;  4KAY A;  4NWJ A;  3NKO A;  1ELX A;  2W5X A;  3ED4 A;  1HDH A;  2VQR A;  5HRT A;  1ED9 A;  2GSU A;  1N2K A;  1K7H A;  3T02 A;  3MK0 A;  1EW9 A;  1ED8 A;  3WAW A;  4GTX A;  2W8S A;  4LR8 A;  1KHL A;  1KHK A;  4NWX A; 
#chains in the Genus database with same CATH homology
 3Q3Q A;  4ZGA A;  1AJA A;  1EI6 A;  4QAX A;  4LRF A;  1KH7 A;  3BDH A;  3DPC A;  4LRC A;  3UO0 A;  3M8Z A;  4UOO A;  5DLT A;  1ALJ A;  2W8D A;  1ANJ A;  1KH5 A;  1AUK A;  3TX0 A;  4YR1 A;  1SHN A;  4FDJ A;  3T00 A;  5TJ3 A;  1E1Z P;  4KAV A;  4LRA A;  5IJQ A;  3WBH A;  4LR2 A;  3KD8 A;  3NVL A;  4N7T A;  5EGH A;  1SHQ A;  2RH6 A;  5DLW A;  5GOV A;  2D1G A;  5LQQ A;  4MY4 A;  3A52 A;  4UOP A;  3NKR A;  2XR9 A;  4UPL A;  1ALI A;  2XRG A;  1E33 P;  3SZZ A;  1ALH A;  4MHX A;  4GTW A;  4KM4 A;  5K4P A;  4KJG A;  3WAX A;  4UPH A;  3IGZ B;  1URB A;  3NKP A;  2GSO A;  2W5S A;  1EJJ A;  4CYR A;  1EW8 A;  1O99 A;  3E2D A;  3UN3 A;  3NKM A;  4FDI A;  1HQA A;  5C66 A;  5LIA A;  1ANI A;  1ALK A;  2GLQ A;  3NKQ A;  2GSN A;  1FSU A;  3CMR A;  3DYC A;  1URA A;  1AJB A;  2W5V A;  2IUC A;  4KJD A;  4CXK A;  4ZG6 A;  5LRM A;  3IDD A;  2IUC B;  3M8W A;  5L0E A;  1O98 A;  3BDG A;  1B8J A;  3BDG B;  4LRD A;  5LRN A;  1KHJ A;  4UOR A;  3WAY A;  4LR9 A;  2G9Y A;  2IFY A;  5INH A;  1ELZ A;  3IGY B;  3OT9 A;  4TN0 A;  2W5W A;  2ZKT A;  5DLV A;  5GRR A;  4GTY A;  3BDF A;  1ELY A;  1N2L A;  3B5Q A;  3WAV A;  4CYS A;  1KH9 A;  1Y6V A;  4CXU A;  1P49 A;  3M8Y A;  4CXS A;  1EQJ A;  1Y7A A;  4LR7 A;  2ANH A;  5L0B A;  1ZEF A;  3UN5 A;  1KHN A;  4LRE A;  3T01 A;  2W5R A;  3UN2 A;  4LQY A;  1EW2 A;  1ZEB A;  3MK2 A;  1E3C P;  4ZG9 A;  2GA3 A;  3MK1 A;  4B56 A;  1ZED A;  3UNY A;  2W5T A;  3NKN A;  4UPI A;  1AJD A;  1HJK A;  3M7V A;  5AJ9 A;  4UPK A;  5L0K A;  1E2S P;  1AJC A;  5KXA A;  3TWZ A;  4LRB A;  5IJS A;  2X98 A;  4ZG7 A;  4MIV A;  3SZY A;  2W5Q A;  3LXQ A;  3TG0 A;  5EGE A;  2QZU A;  1KH4 A;  4GTZ A;  4KAY A;  4NWJ A;  3NKO A;  1ELX A;  2W5X A;  3ED4 A;  1HDH A;  2VQR A;  5HRT A;  1ED9 A;  2GSU A;  1N2K A;  1K7H A;  3T02 A;  3MK0 A;  1EW9 A;  1ED8 A;  3WAW A;  4GTX A;  2W8S A;  4LR8 A;  1KHL A;  1KHK A;  4NWX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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