2W5WA

Structure of tab5 alkaline phosphatase mutant his 135 asp with zn bound in the m3 site.
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 130
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5wA00
2X98A 1HDHA 1EJJA 3NKQA 4MY4A 4LR2A 2W5WA 3UN3A 3NKRA 4MHXA 2W5XA 2W8DA 5K4PA 4TN0A 1ED8A 2QZUA 4KAVA 3LXQA 4B56A 1AJBA 5EGHA 1URAA 3B5QA 4LRDA 2XR9A 4GTZA 4NWJA 5DLTA 5EGEA 1E33P 3NKOA 4CYRA 1O99A 4ZG7A 2W5RA 1ALKA 4GTWA 1EI6A 1ANJA 3M7VA 4UOOA 1KH7A 1URBA 1ALJA 1EW2A 4LR7A 3MK2A 1ZEBA 5IJSA 4MIVA 4CYSA 1KHNA 1KHKA 1ELYA 1E3CP 4LRCA 4ZGAA 4GTYA 4LRFA 1KHJA 2GSOA 4FDIA 3MK0A 3T01A 1ALHA 1AJCA 1HQAA 2W5VA 4QAXA 4ZG9A 5LIAA 3SZYA 2RH6A 4LR9A 1Y7AA 4GTXA 3T02A 1ANIA 1O98A 2W5QA 4CXUA 4UPIA 2G9YA 5DLVA 3ED4A 5LRNA 2W5SA 2IUCB 4FDJA 3M8ZA 2GA3A 1EW8A 3UO0A 1KH4A 4CXKA 3NKPA 1E2SP 3NVLA 1ALIA 4CXSA 4LREA 2W5TA 3KD8A 1AJAA 5GOVA 2W8SA 1ED9A 5KXAA 2XRGA 3MK1A 3TWZA 3CMRA 4LR8A 3TX0A 5AJ9A 5C66A 4UPLA 5L0BA 1ELXA 4UORA 2IUCA 3UN2A 4YR1A 3SZZA 1E1ZP 1KH5A 2IFYA 5LQQA 1HJKA 4KJGA 4LQYA 1N2LA 3M8WA 1N2KA 3Q3QA 1P49A 5INHA 5IJQA 2GLQA 3NKMA 4KAYA 4KM4A 4KJDA 1FSUA 3BDFA 5DLWA 3DYCA 5L0KA 4LRAA 1ELZA 3BDHA 3IGZB 3WBHA 5TJ3A 3WAXA 5GRRA 1AUKA 4LRBA 1ZEDA 4UOPA 3NKNA 1B8JA 3BDGB 1K7HA 3UN5A 3WAVA 5LRMA 3WAYA 5L0EA 2ANHA 2GSNA 2ZKTA 4UPHA 1SHNA 3T00A 1Y6VA 1EQJA 3A52A 3IGYB 2D1GA 4UPKA 3WAWA 1KHLA 3DPCA 3TG0A 3BDGA 5HRTA 4NWXA 3M8YA 3UNYA 1ZEFA 1KH9A 2GSUA 2VQRA 1AJDA 1SHQA 3E2DA 4ZG6A 1EW9A 3IDDA 4N7TA 3OT9A
chains in the Genus database with same CATH superfamily
2X98A 1HDHA 1EJJA 3NKQA 4MY4A 4LR2A 2W5WA 3UN3A 3NKRA 4MHXA 2W5XA 2W8DA 5K4PA 4TN0A 1ED8A 2QZUA 4KAVA 3LXQA 4B56A 1AJBA 5EGHA 1URAA 3B5QA 4LRDA 2XR9A 4GTZA 4NWJA 5DLTA 5EGEA 1E33P 3NKOA 4CYRA 1O99A 4ZG7A 2W5RA 1ALKA 4GTWA 1EI6A 1ANJA 3M7VA 4UOOA 1KH7A 1URBA 1ALJA 1EW2A 4LR7A 3MK2A 1ZEBA 5IJSA 4MIVA 4CYSA 1KHNA 1KHKA 1ELYA 1E3CP 4LRCA 4ZGAA 4GTYA 4LRFA 1KHJA 2GSOA 4FDIA 3MK0A 3T01A 1ALHA 1AJCA 1HQAA 2W5VA 4QAXA 4ZG9A 5LIAA 3SZYA 2RH6A 4LR9A 1Y7AA 4GTXA 3T02A 1ANIA 1O98A 2W5QA 4CXUA 4UPIA 2G9YA 5DLVA 3ED4A 5LRNA 2W5SA 2IUCB 4FDJA 3M8ZA 2GA3A 1EW8A 3UO0A 1KH4A 4CXKA 3NKPA 1E2SP 3NVLA 1ALIA 4CXSA 4LREA 2W5TA 3KD8A 1AJAA 5GOVA 2W8SA 1ED9A 5KXAA 2XRGA 3MK1A 3TWZA 3CMRA 4LR8A 3TX0A 5AJ9A 5C66A 4UPLA 5L0BA 1ELXA 4UORA 2IUCA 3UN2A 4YR1A 3SZZA 1E1ZP 1KH5A 2IFYA 5LQQA 1HJKA 4KJGA 4LQYA 1N2LA 3M8WA 1N2KA 3Q3QA 1P49A 5INHA 5IJQA 2GLQA 3NKMA 4KAYA 4KM4A 4KJDA 1FSUA 3BDFA 5DLWA 3DYCA 5L0KA 4LRAA 1ELZA 3BDHA 3IGZB 3WBHA 5TJ3A 3WAXA 5GRRA 1AUKA 4LRBA 1ZEDA 4UOPA 3NKNA 1B8JA 3BDGB 1K7HA 3UN5A 3WAVA 5LRMA 3WAYA 5L0EA 2ANHA 2GSNA 2ZKTA 4UPHA 1SHNA 3T00A 1Y6VA 1EQJA 3A52A 3IGYB 2D1GA 4UPKA 3WAWA 1KHLA 3DPCA 3TG0A 3BDGA 5HRTA 4NWXA 3M8YA 3UNYA 1ZEFA 1KH9A 2GSUA 2VQRA 1AJDA 1SHQA 3E2DA 4ZG6A 1EW9A 3IDDA 4N7TA 3OT9A
chains in the Genus database with same CATH topology
2X98A 1HDHA 1EJJA 3NKQA 4MY4A 4LR2A 2W5WA 3UN3A 3NKRA 4MHXA 2W5XA 2W8DA 5K4PA 4TN0A 1ED8A 2QZUA 4KAVA 3LXQA 4B56A 1AJBA 5EGHA 1URAA 3B5QA 4LRDA 2XR9A 4GTZA 4NWJA 5DLTA 5EGEA 1E33P 3NKOA 4CYRA 1O99A 4ZG7A 2W5RA 1ALKA 4GTWA 1EI6A 1ANJA 3M7VA 4UOOA 1KH7A 1URBA 1ALJA 1EW2A 4LR7A 3MK2A 1ZEBA 5IJSA 4MIVA 4CYSA 1KHNA 1KHKA 1ELYA 1E3CP 4LRCA 4ZGAA 4GTYA 4LRFA 1KHJA 2GSOA 4FDIA 3MK0A 3T01A 1ALHA 1AJCA 1HQAA 2W5VA 4QAXA 4ZG9A 5LIAA 3SZYA 2RH6A 4LR9A 1Y7AA 4GTXA 3T02A 1ANIA 1O98A 2W5QA 4CXUA 4UPIA 2G9YA 5DLVA 3ED4A 5LRNA 2W5SA 2IUCB 4FDJA 3M8ZA 2GA3A 1EW8A 3UO0A 1KH4A 4CXKA 3NKPA 1E2SP 3NVLA 1ALIA 4CXSA 4LREA 2W5TA 3KD8A 1AJAA 5GOVA 2W8SA 1ED9A 5KXAA 2XRGA 3MK1A 3TWZA 3CMRA 4LR8A 3TX0A 5AJ9A 5C66A 4UPLA 5L0BA 1ELXA 4UORA 2IUCA 3UN2A 4YR1A 3SZZA 1E1ZP 1KH5A 2IFYA 5LQQA 1HJKA 4KJGA 4LQYA 1N2LA 3M8WA 1N2KA 3Q3QA 1P49A 5INHA 5IJQA 2GLQA 3NKMA 4KAYA 4KM4A 4KJDA 1FSUA 3BDFA 5DLWA 3DYCA 5L0KA 4LRAA 1ELZA 3BDHA 3IGZB 3WBHA 5TJ3A 3WAXA 5GRRA 1AUKA 4LRBA 1ZEDA 4UOPA 3NKNA 1B8JA 3BDGB 1K7HA 3UN5A 3WAVA 5LRMA 3WAYA 5L0EA 2ANHA 2GSNA 2ZKTA 4UPHA 1SHNA 3T00A 1Y6VA 1EQJA 3A52A 3IGYB 2D1GA 4UPKA 3WAWA 1KHLA 3DPCA 3TG0A 3BDGA 5HRTA 4NWXA 3M8YA 3UNYA 1ZEFA 1KH9A 2GSUA 2VQRA 1AJDA 1SHQA 3E2DA 4ZG6A 1EW9A 3IDDA 4N7TA 3OT9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X98 A;  1HDH A;  1EJJ A;  3NKQ A;  4MY4 A;  4LR2 A;  2W5W A;  3UN3 A;  3NKR A;  4MHX A;  2W5X A;  2W8D A;  5K4P A;  4TN0 A;  1ED8 A;  2QZU A;  4KAV A;  3LXQ A;  4B56 A;  1AJB A;  5EGH A;  1URA A;  3B5Q A;  4LRD A;  2XR9 A;  4GTZ A;  4NWJ A;  5DLT A;  5EGE A;  1E33 P;  3NKO A;  4CYR A;  1O99 A;  4ZG7 A;  2W5R A;  1ALK A;  4GTW A;  1EI6 A;  1ANJ A;  3M7V A;  4UOO A;  1KH7 A;  1URB A;  1ALJ A;  1EW2 A;  4LR7 A;  3MK2 A;  1ZEB A;  5IJS A;  4MIV A;  4CYS A;  1KHN A;  1KHK A;  1ELY A;  1E3C P;  4LRC A;  4ZGA A;  4GTY A;  4LRF A;  1KHJ A;  2GSO A;  4FDI A;  3MK0 A;  3T01 A;  1ALH A;  1AJC A;  1HQA A;  2W5V A;  4QAX A;  4ZG9 A;  5LIA A;  3SZY A;  2RH6 A;  4LR9 A;  1Y7A A;  4GTX A;  3T02 A;  1ANI A;  1O98 A;  2W5Q A;  4CXU A;  4UPI A;  2G9Y A;  5DLV A;  3ED4 A;  5LRN A;  2W5S A;  2IUC B;  4FDJ A;  3M8Z A;  2GA3 A;  1EW8 A;  3UO0 A;  1KH4 A;  4CXK A;  3NKP A;  1E2S P;  3NVL A;  1ALI A;  4CXS A;  4LRE A;  2W5T A;  3KD8 A;  1AJA A;  5GOV A;  2W8S A;  1ED9 A;  5KXA A;  2XRG A;  3MK1 A;  3TWZ A;  3CMR A;  4LR8 A;  3TX0 A;  5AJ9 A;  5C66 A;  4UPL A;  5L0B A;  1ELX A;  4UOR A;  2IUC A;  3UN2 A;  4YR1 A;  3SZZ A;  1E1Z P;  1KH5 A;  2IFY A;  5LQQ A;  1HJK A;  4KJG A;  4LQY A;  1N2L A;  3M8W A;  1N2K A;  3Q3Q A;  1P49 A;  5INH A;  5IJQ A;  2GLQ A;  3NKM A;  4KAY A;  4KM4 A;  4KJD A;  1FSU A;  3BDF A;  5DLW A;  3DYC A;  5L0K A;  4LRA A;  1ELZ A;  3BDH A;  3IGZ B;  3WBH A;  5TJ3 A;  3WAX A;  5GRR A;  1AUK A;  4LRB A;  1ZED A;  4UOP A;  3NKN A;  1B8J A;  3BDG B;  1K7H A;  3UN5 A;  3WAV A;  5LRM A;  3WAY A;  5L0E A;  2ANH A;  2GSN A;  2ZKT A;  4UPH A;  1SHN A;  3T00 A;  1Y6V A;  1EQJ A;  3A52 A;  3IGY B;  2D1G A;  4UPK A;  3WAW A;  1KHL A;  3DPC A;  3TG0 A;  3BDG A;  5HRT A;  4NWX A;  3M8Y A;  3UNY A;  1ZEF A;  1KH9 A;  2GSU A;  2VQR A;  1AJD A;  1SHQ A;  3E2D A;  4ZG6 A;  1EW9 A;  3IDD A;  4N7T A;  3OT9 A; 
#chains in the Genus database with same CATH topology
 2X98 A;  1HDH A;  1EJJ A;  3NKQ A;  4MY4 A;  4LR2 A;  2W5W A;  3UN3 A;  3NKR A;  4MHX A;  2W5X A;  2W8D A;  5K4P A;  4TN0 A;  1ED8 A;  2QZU A;  4KAV A;  3LXQ A;  4B56 A;  1AJB A;  5EGH A;  1URA A;  3B5Q A;  4LRD A;  2XR9 A;  4GTZ A;  4NWJ A;  5DLT A;  5EGE A;  1E33 P;  3NKO A;  4CYR A;  1O99 A;  4ZG7 A;  2W5R A;  1ALK A;  4GTW A;  1EI6 A;  1ANJ A;  3M7V A;  4UOO A;  1KH7 A;  1URB A;  1ALJ A;  1EW2 A;  4LR7 A;  3MK2 A;  1ZEB A;  5IJS A;  4MIV A;  4CYS A;  1KHN A;  1KHK A;  1ELY A;  1E3C P;  4LRC A;  4ZGA A;  4GTY A;  4LRF A;  1KHJ A;  2GSO A;  4FDI A;  3MK0 A;  3T01 A;  1ALH A;  1AJC A;  1HQA A;  2W5V A;  4QAX A;  4ZG9 A;  5LIA A;  3SZY A;  2RH6 A;  4LR9 A;  1Y7A A;  4GTX A;  3T02 A;  1ANI A;  1O98 A;  2W5Q A;  4CXU A;  4UPI A;  2G9Y A;  5DLV A;  3ED4 A;  5LRN A;  2W5S A;  2IUC B;  4FDJ A;  3M8Z A;  2GA3 A;  1EW8 A;  3UO0 A;  1KH4 A;  4CXK A;  3NKP A;  1E2S P;  3NVL A;  1ALI A;  4CXS A;  4LRE A;  2W5T A;  3KD8 A;  1AJA A;  5GOV A;  2W8S A;  1ED9 A;  5KXA A;  2XRG A;  3MK1 A;  3TWZ A;  3CMR A;  4LR8 A;  3TX0 A;  5AJ9 A;  5C66 A;  4UPL A;  5L0B A;  1ELX A;  4UOR A;  2IUC A;  3UN2 A;  4YR1 A;  3SZZ A;  1E1Z P;  1KH5 A;  2IFY A;  5LQQ A;  1HJK A;  4KJG A;  4LQY A;  1N2L A;  3M8W A;  1N2K A;  3Q3Q A;  1P49 A;  5INH A;  5IJQ A;  2GLQ A;  3NKM A;  4KAY A;  4KM4 A;  4KJD A;  1FSU A;  3BDF A;  5DLW A;  3DYC A;  5L0K A;  4LRA A;  1ELZ A;  3BDH A;  3IGZ B;  3WBH A;  5TJ3 A;  3WAX A;  5GRR A;  1AUK A;  4LRB A;  1ZED A;  4UOP A;  3NKN A;  1B8J A;  3BDG B;  1K7H A;  3UN5 A;  3WAV A;  5LRM A;  3WAY A;  5L0E A;  2ANH A;  2GSN A;  2ZKT A;  4UPH A;  1SHN A;  3T00 A;  1Y6V A;  1EQJ A;  3A52 A;  3IGY B;  2D1G A;  4UPK A;  3WAW A;  1KHL A;  3DPC A;  3TG0 A;  3BDG A;  5HRT A;  4NWX A;  3M8Y A;  3UNY A;  1ZEF A;  1KH9 A;  2GSU A;  2VQR A;  1AJD A;  1SHQ A;  3E2D A;  4ZG6 A;  1EW9 A;  3IDD A;  4N7T A;  3OT9 A; 
#chains in the Genus database with same CATH homology
 2X98 A;  1HDH A;  1EJJ A;  3NKQ A;  4MY4 A;  4LR2 A;  2W5W A;  3UN3 A;  3NKR A;  4MHX A;  2W5X A;  2W8D A;  5K4P A;  4TN0 A;  1ED8 A;  2QZU A;  4KAV A;  3LXQ A;  4B56 A;  1AJB A;  5EGH A;  1URA A;  3B5Q A;  4LRD A;  2XR9 A;  4GTZ A;  4NWJ A;  5DLT A;  5EGE A;  1E33 P;  3NKO A;  4CYR A;  1O99 A;  4ZG7 A;  2W5R A;  1ALK A;  4GTW A;  1EI6 A;  1ANJ A;  3M7V A;  4UOO A;  1KH7 A;  1URB A;  1ALJ A;  1EW2 A;  4LR7 A;  3MK2 A;  1ZEB A;  5IJS A;  4MIV A;  4CYS A;  1KHN A;  1KHK A;  1ELY A;  1E3C P;  4LRC A;  4ZGA A;  4GTY A;  4LRF A;  1KHJ A;  2GSO A;  4FDI A;  3MK0 A;  3T01 A;  1ALH A;  1AJC A;  1HQA A;  2W5V A;  4QAX A;  4ZG9 A;  5LIA A;  3SZY A;  2RH6 A;  4LR9 A;  1Y7A A;  4GTX A;  3T02 A;  1ANI A;  1O98 A;  2W5Q A;  4CXU A;  4UPI A;  2G9Y A;  5DLV A;  3ED4 A;  5LRN A;  2W5S A;  2IUC B;  4FDJ A;  3M8Z A;  2GA3 A;  1EW8 A;  3UO0 A;  1KH4 A;  4CXK A;  3NKP A;  1E2S P;  3NVL A;  1ALI A;  4CXS A;  4LRE A;  2W5T A;  3KD8 A;  1AJA A;  5GOV A;  2W8S A;  1ED9 A;  5KXA A;  2XRG A;  3MK1 A;  3TWZ A;  3CMR A;  4LR8 A;  3TX0 A;  5AJ9 A;  5C66 A;  4UPL A;  5L0B A;  1ELX A;  4UOR A;  2IUC A;  3UN2 A;  4YR1 A;  3SZZ A;  1E1Z P;  1KH5 A;  2IFY A;  5LQQ A;  1HJK A;  4KJG A;  4LQY A;  1N2L A;  3M8W A;  1N2K A;  3Q3Q A;  1P49 A;  5INH A;  5IJQ A;  2GLQ A;  3NKM A;  4KAY A;  4KM4 A;  4KJD A;  1FSU A;  3BDF A;  5DLW A;  3DYC A;  5L0K A;  4LRA A;  1ELZ A;  3BDH A;  3IGZ B;  3WBH A;  5TJ3 A;  3WAX A;  5GRR A;  1AUK A;  4LRB A;  1ZED A;  4UOP A;  3NKN A;  1B8J A;  3BDG B;  1K7H A;  3UN5 A;  3WAV A;  5LRM A;  3WAY A;  5L0E A;  2ANH A;  2GSN A;  2ZKT A;  4UPH A;  1SHN A;  3T00 A;  1Y6V A;  1EQJ A;  3A52 A;  3IGY B;  2D1G A;  4UPK A;  3WAW A;  1KHL A;  3DPC A;  3TG0 A;  3BDG A;  5HRT A;  4NWX A;  3M8Y A;  3UNY A;  1ZEF A;  1KH9 A;  2GSU A;  2VQR A;  1AJD A;  1SHQ A;  3E2D A;  4ZG6 A;  1EW9 A;  3IDD A;  4N7T A;  3OT9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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