2W5XA

Structure of tab5 alkaline phosphatase mutant his 135 glu with mg bound in the m3 site.
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITEATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 131
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5xA00
4MIVA 1ALJA 4B56A 5DLTA 1SHQA 2QZUA 4FDIA 5K4PA 1Y7AA 4KJGA 4UOPA 3T02A 1KH9A 4LR9A 2X98A 3UO0A 3ED4A 3TG0A 1EJJA 3WAWA 1E2SP 3UN3A 4LR2A 4ZG7A 1EW8A 2G9YA 2ZKTA 3BDHA 4LRDA 3BDFA 4UPHA 4GTZA 1ALKA 1KHLA 1ED9A 1ALHA 1E33P 4MHXA 5GOVA 2XRGA 1AJDA 1HDHA 1P49A 1URAA 5DLVA 4LREA 1AUKA 4LR8A 4UPIA 1E1ZP 1ED8A 5DLWA 4LRAA 3M8ZA 5LIAA 1O99A 2W5RA 3NVLA 5TJ3A 1AJAA 2W5TA 3CMRA 5LRMA 1ALIA 3NKQA 4UORA 3WAYA 4QAXA 4CXSA 3MK2A 1E3CP 1KH4A 3M8YA 4LRBA 1AJCA 1EQJA 3IGZB 1ELXA 2W5SA 3UN5A 2W8DA 3Q3QA 3BDGA 1ZEFA 2GSUA 4LR7A 5IJSA 1ELZA 3BDGB 3SZZA 2W5XA 5C66A 5LRNA 1N2KA 3M7VA 1HJKA 2W5QA 3B5QA 4KM4A 1KH5A 3TWZA 5LQQA 4ZGAA 1ZEDA 1KH7A 3MK1A 5L0KA 3DPCA 5L0EA 1ELYA 2D1GA 4CXKA 4KAVA 3E2DA 3NKMA 4KJDA 5EGEA 1EW2A 5GRRA 4LRFA 4N7TA 2GSOA 5KXAA 1Y6VA 3MK0A 2GLQA 4GTWA 5INHA 1ANJA 4KAYA 2IUCA 4CYRA 1AJBA 1ZEBA 2ANHA 2RH6A 3NKOA 5L0BA 2W8SA 1KHNA 2IUCB 3UNYA 4LRCA 3LXQA 4FDJA 4ZG6A 1EW9A 2XR9A 3SZYA 1ANIA 4ZG9A 2GSNA 3TX0A 5AJ9A 3NKRA 4UPKA 3KD8A 1SHNA 4UPLA 4YR1A 4GTYA 3T00A 3UN2A 3WBHA 4TN0A 3NKNA 4NWXA 1URBA 5IJQA 3WAVA 5HRTA 1EI6A 4GTXA 2W5VA 3T01A 2W5WA 3IDDA 3M8WA 2VQRA 2IFYA 2GA3A 3IGYB 1HQAA 5EGHA 3DYCA 4CYSA 1N2LA 4MY4A 3NKPA 1O98A 1K7HA 3A52A 3OT9A 1KHKA 4LQYA 4CXUA 1KHJA 1FSUA 1B8JA 3WAXA 4UOOA 4NWJA
chains in the Genus database with same CATH superfamily
4MIVA 1ALJA 4B56A 5DLTA 1SHQA 2QZUA 4FDIA 5K4PA 1Y7AA 4KJGA 4UOPA 3T02A 1KH9A 4LR9A 2X98A 3UO0A 3ED4A 3TG0A 1EJJA 3WAWA 1E2SP 3UN3A 4LR2A 4ZG7A 1EW8A 2G9YA 2ZKTA 3BDHA 4LRDA 3BDFA 4UPHA 4GTZA 1ALKA 1KHLA 1ED9A 1ALHA 1E33P 4MHXA 5GOVA 2XRGA 1AJDA 1HDHA 1P49A 1URAA 5DLVA 4LREA 1AUKA 4LR8A 4UPIA 1E1ZP 1ED8A 5DLWA 4LRAA 3M8ZA 5LIAA 1O99A 2W5RA 3NVLA 5TJ3A 1AJAA 2W5TA 3CMRA 5LRMA 1ALIA 3NKQA 4UORA 3WAYA 4QAXA 4CXSA 3MK2A 1E3CP 1KH4A 3M8YA 4LRBA 1AJCA 1EQJA 3IGZB 1ELXA 2W5SA 3UN5A 2W8DA 3Q3QA 3BDGA 1ZEFA 2GSUA 4LR7A 5IJSA 1ELZA 3BDGB 3SZZA 2W5XA 5C66A 5LRNA 1N2KA 3M7VA 1HJKA 2W5QA 3B5QA 4KM4A 1KH5A 3TWZA 5LQQA 4ZGAA 1ZEDA 1KH7A 3MK1A 5L0KA 3DPCA 5L0EA 1ELYA 2D1GA 4CXKA 4KAVA 3E2DA 3NKMA 4KJDA 5EGEA 1EW2A 5GRRA 4LRFA 4N7TA 2GSOA 5KXAA 1Y6VA 3MK0A 2GLQA 4GTWA 5INHA 1ANJA 4KAYA 2IUCA 4CYRA 1AJBA 1ZEBA 2ANHA 2RH6A 3NKOA 5L0BA 2W8SA 1KHNA 2IUCB 3UNYA 4LRCA 3LXQA 4FDJA 4ZG6A 1EW9A 2XR9A 3SZYA 1ANIA 4ZG9A 2GSNA 3TX0A 5AJ9A 3NKRA 4UPKA 3KD8A 1SHNA 4UPLA 4YR1A 4GTYA 3T00A 3UN2A 3WBHA 4TN0A 3NKNA 4NWXA 1URBA 5IJQA 3WAVA 5HRTA 1EI6A 4GTXA 2W5VA 3T01A 2W5WA 3IDDA 3M8WA 2VQRA 2IFYA 2GA3A 3IGYB 1HQAA 5EGHA 3DYCA 4CYSA 1N2LA 4MY4A 3NKPA 1O98A 1K7HA 3A52A 3OT9A 1KHKA 4LQYA 4CXUA 1KHJA 1FSUA 1B8JA 3WAXA 4UOOA 4NWJA
chains in the Genus database with same CATH topology
4MIVA 1ALJA 4B56A 5DLTA 1SHQA 2QZUA 4FDIA 5K4PA 1Y7AA 4KJGA 4UOPA 3T02A 1KH9A 4LR9A 2X98A 3UO0A 3ED4A 3TG0A 1EJJA 3WAWA 1E2SP 3UN3A 4LR2A 4ZG7A 1EW8A 2G9YA 2ZKTA 3BDHA 4LRDA 3BDFA 4UPHA 4GTZA 1ALKA 1KHLA 1ED9A 1ALHA 1E33P 4MHXA 5GOVA 2XRGA 1AJDA 1HDHA 1P49A 1URAA 5DLVA 4LREA 1AUKA 4LR8A 4UPIA 1E1ZP 1ED8A 5DLWA 4LRAA 3M8ZA 5LIAA 1O99A 2W5RA 3NVLA 5TJ3A 1AJAA 2W5TA 3CMRA 5LRMA 1ALIA 3NKQA 4UORA 3WAYA 4QAXA 4CXSA 3MK2A 1E3CP 1KH4A 3M8YA 4LRBA 1AJCA 1EQJA 3IGZB 1ELXA 2W5SA 3UN5A 2W8DA 3Q3QA 3BDGA 1ZEFA 2GSUA 4LR7A 5IJSA 1ELZA 3BDGB 3SZZA 2W5XA 5C66A 5LRNA 1N2KA 3M7VA 1HJKA 2W5QA 3B5QA 4KM4A 1KH5A 3TWZA 5LQQA 4ZGAA 1ZEDA 1KH7A 3MK1A 5L0KA 3DPCA 5L0EA 1ELYA 2D1GA 4CXKA 4KAVA 3E2DA 3NKMA 4KJDA 5EGEA 1EW2A 5GRRA 4LRFA 4N7TA 2GSOA 5KXAA 1Y6VA 3MK0A 2GLQA 4GTWA 5INHA 1ANJA 4KAYA 2IUCA 4CYRA 1AJBA 1ZEBA 2ANHA 2RH6A 3NKOA 5L0BA 2W8SA 1KHNA 2IUCB 3UNYA 4LRCA 3LXQA 4FDJA 4ZG6A 1EW9A 2XR9A 3SZYA 1ANIA 4ZG9A 2GSNA 3TX0A 5AJ9A 3NKRA 4UPKA 3KD8A 1SHNA 4UPLA 4YR1A 4GTYA 3T00A 3UN2A 3WBHA 4TN0A 3NKNA 4NWXA 1URBA 5IJQA 3WAVA 5HRTA 1EI6A 4GTXA 2W5VA 3T01A 2W5WA 3IDDA 3M8WA 2VQRA 2IFYA 2GA3A 3IGYB 1HQAA 5EGHA 3DYCA 4CYSA 1N2LA 4MY4A 3NKPA 1O98A 1K7HA 3A52A 3OT9A 1KHKA 4LQYA 4CXUA 1KHJA 1FSUA 1B8JA 3WAXA 4UOOA 4NWJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MIV A;  1ALJ A;  4B56 A;  5DLT A;  1SHQ A;  2QZU A;  4FDI A;  5K4P A;  1Y7A A;  4KJG A;  4UOP A;  3T02 A;  1KH9 A;  4LR9 A;  2X98 A;  3UO0 A;  3ED4 A;  3TG0 A;  1EJJ A;  3WAW A;  1E2S P;  3UN3 A;  4LR2 A;  4ZG7 A;  1EW8 A;  2G9Y A;  2ZKT A;  3BDH A;  4LRD A;  3BDF A;  4UPH A;  4GTZ A;  1ALK A;  1KHL A;  1ED9 A;  1ALH A;  1E33 P;  4MHX A;  5GOV A;  2XRG A;  1AJD A;  1HDH A;  1P49 A;  1URA A;  5DLV A;  4LRE A;  1AUK A;  4LR8 A;  4UPI A;  1E1Z P;  1ED8 A;  5DLW A;  4LRA A;  3M8Z A;  5LIA A;  1O99 A;  2W5R A;  3NVL A;  5TJ3 A;  1AJA A;  2W5T A;  3CMR A;  5LRM A;  1ALI A;  3NKQ A;  4UOR A;  3WAY A;  4QAX A;  4CXS A;  3MK2 A;  1E3C P;  1KH4 A;  3M8Y A;  4LRB A;  1AJC A;  1EQJ A;  3IGZ B;  1ELX A;  2W5S A;  3UN5 A;  2W8D A;  3Q3Q A;  3BDG A;  1ZEF A;  2GSU A;  4LR7 A;  5IJS A;  1ELZ A;  3BDG B;  3SZZ A;  2W5X A;  5C66 A;  5LRN A;  1N2K A;  3M7V A;  1HJK A;  2W5Q A;  3B5Q A;  4KM4 A;  1KH5 A;  3TWZ A;  5LQQ A;  4ZGA A;  1ZED A;  1KH7 A;  3MK1 A;  5L0K A;  3DPC A;  5L0E A;  1ELY A;  2D1G A;  4CXK A;  4KAV A;  3E2D A;  3NKM A;  4KJD A;  5EGE A;  1EW2 A;  5GRR A;  4LRF A;  4N7T A;  2GSO A;  5KXA A;  1Y6V A;  3MK0 A;  2GLQ A;  4GTW A;  5INH A;  1ANJ A;  4KAY A;  2IUC A;  4CYR A;  1AJB A;  1ZEB A;  2ANH A;  2RH6 A;  3NKO A;  5L0B A;  2W8S A;  1KHN A;  2IUC B;  3UNY A;  4LRC A;  3LXQ A;  4FDJ A;  4ZG6 A;  1EW9 A;  2XR9 A;  3SZY A;  1ANI A;  4ZG9 A;  2GSN A;  3TX0 A;  5AJ9 A;  3NKR A;  4UPK A;  3KD8 A;  1SHN A;  4UPL A;  4YR1 A;  4GTY A;  3T00 A;  3UN2 A;  3WBH A;  4TN0 A;  3NKN A;  4NWX A;  1URB A;  5IJQ A;  3WAV A;  5HRT A;  1EI6 A;  4GTX A;  2W5V A;  3T01 A;  2W5W A;  3IDD A;  3M8W A;  2VQR A;  2IFY A;  2GA3 A;  3IGY B;  1HQA A;  5EGH A;  3DYC A;  4CYS A;  1N2L A;  4MY4 A;  3NKP A;  1O98 A;  1K7H A;  3A52 A;  3OT9 A;  1KHK A;  4LQY A;  4CXU A;  1KHJ A;  1FSU A;  1B8J A;  3WAX A;  4UOO A;  4NWJ A; 
#chains in the Genus database with same CATH topology
 4MIV A;  1ALJ A;  4B56 A;  5DLT A;  1SHQ A;  2QZU A;  4FDI A;  5K4P A;  1Y7A A;  4KJG A;  4UOP A;  3T02 A;  1KH9 A;  4LR9 A;  2X98 A;  3UO0 A;  3ED4 A;  3TG0 A;  1EJJ A;  3WAW A;  1E2S P;  3UN3 A;  4LR2 A;  4ZG7 A;  1EW8 A;  2G9Y A;  2ZKT A;  3BDH A;  4LRD A;  3BDF A;  4UPH A;  4GTZ A;  1ALK A;  1KHL A;  1ED9 A;  1ALH A;  1E33 P;  4MHX A;  5GOV A;  2XRG A;  1AJD A;  1HDH A;  1P49 A;  1URA A;  5DLV A;  4LRE A;  1AUK A;  4LR8 A;  4UPI A;  1E1Z P;  1ED8 A;  5DLW A;  4LRA A;  3M8Z A;  5LIA A;  1O99 A;  2W5R A;  3NVL A;  5TJ3 A;  1AJA A;  2W5T A;  3CMR A;  5LRM A;  1ALI A;  3NKQ A;  4UOR A;  3WAY A;  4QAX A;  4CXS A;  3MK2 A;  1E3C P;  1KH4 A;  3M8Y A;  4LRB A;  1AJC A;  1EQJ A;  3IGZ B;  1ELX A;  2W5S A;  3UN5 A;  2W8D A;  3Q3Q A;  3BDG A;  1ZEF A;  2GSU A;  4LR7 A;  5IJS A;  1ELZ A;  3BDG B;  3SZZ A;  2W5X A;  5C66 A;  5LRN A;  1N2K A;  3M7V A;  1HJK A;  2W5Q A;  3B5Q A;  4KM4 A;  1KH5 A;  3TWZ A;  5LQQ A;  4ZGA A;  1ZED A;  1KH7 A;  3MK1 A;  5L0K A;  3DPC A;  5L0E A;  1ELY A;  2D1G A;  4CXK A;  4KAV A;  3E2D A;  3NKM A;  4KJD A;  5EGE A;  1EW2 A;  5GRR A;  4LRF A;  4N7T A;  2GSO A;  5KXA A;  1Y6V A;  3MK0 A;  2GLQ A;  4GTW A;  5INH A;  1ANJ A;  4KAY A;  2IUC A;  4CYR A;  1AJB A;  1ZEB A;  2ANH A;  2RH6 A;  3NKO A;  5L0B A;  2W8S A;  1KHN A;  2IUC B;  3UNY A;  4LRC A;  3LXQ A;  4FDJ A;  4ZG6 A;  1EW9 A;  2XR9 A;  3SZY A;  1ANI A;  4ZG9 A;  2GSN A;  3TX0 A;  5AJ9 A;  3NKR A;  4UPK A;  3KD8 A;  1SHN A;  4UPL A;  4YR1 A;  4GTY A;  3T00 A;  3UN2 A;  3WBH A;  4TN0 A;  3NKN A;  4NWX A;  1URB A;  5IJQ A;  3WAV A;  5HRT A;  1EI6 A;  4GTX A;  2W5V A;  3T01 A;  2W5W A;  3IDD A;  3M8W A;  2VQR A;  2IFY A;  2GA3 A;  3IGY B;  1HQA A;  5EGH A;  3DYC A;  4CYS A;  1N2L A;  4MY4 A;  3NKP A;  1O98 A;  1K7H A;  3A52 A;  3OT9 A;  1KHK A;  4LQY A;  4CXU A;  1KHJ A;  1FSU A;  1B8J A;  3WAX A;  4UOO A;  4NWJ A; 
#chains in the Genus database with same CATH homology
 4MIV A;  1ALJ A;  4B56 A;  5DLT A;  1SHQ A;  2QZU A;  4FDI A;  5K4P A;  1Y7A A;  4KJG A;  4UOP A;  3T02 A;  1KH9 A;  4LR9 A;  2X98 A;  3UO0 A;  3ED4 A;  3TG0 A;  1EJJ A;  3WAW A;  1E2S P;  3UN3 A;  4LR2 A;  4ZG7 A;  1EW8 A;  2G9Y A;  2ZKT A;  3BDH A;  4LRD A;  3BDF A;  4UPH A;  4GTZ A;  1ALK A;  1KHL A;  1ED9 A;  1ALH A;  1E33 P;  4MHX A;  5GOV A;  2XRG A;  1AJD A;  1HDH A;  1P49 A;  1URA A;  5DLV A;  4LRE A;  1AUK A;  4LR8 A;  4UPI A;  1E1Z P;  1ED8 A;  5DLW A;  4LRA A;  3M8Z A;  5LIA A;  1O99 A;  2W5R A;  3NVL A;  5TJ3 A;  1AJA A;  2W5T A;  3CMR A;  5LRM A;  1ALI A;  3NKQ A;  4UOR A;  3WAY A;  4QAX A;  4CXS A;  3MK2 A;  1E3C P;  1KH4 A;  3M8Y A;  4LRB A;  1AJC A;  1EQJ A;  3IGZ B;  1ELX A;  2W5S A;  3UN5 A;  2W8D A;  3Q3Q A;  3BDG A;  1ZEF A;  2GSU A;  4LR7 A;  5IJS A;  1ELZ A;  3BDG B;  3SZZ A;  2W5X A;  5C66 A;  5LRN A;  1N2K A;  3M7V A;  1HJK A;  2W5Q A;  3B5Q A;  4KM4 A;  1KH5 A;  3TWZ A;  5LQQ A;  4ZGA A;  1ZED A;  1KH7 A;  3MK1 A;  5L0K A;  3DPC A;  5L0E A;  1ELY A;  2D1G A;  4CXK A;  4KAV A;  3E2D A;  3NKM A;  4KJD A;  5EGE A;  1EW2 A;  5GRR A;  4LRF A;  4N7T A;  2GSO A;  5KXA A;  1Y6V A;  3MK0 A;  2GLQ A;  4GTW A;  5INH A;  1ANJ A;  4KAY A;  2IUC A;  4CYR A;  1AJB A;  1ZEB A;  2ANH A;  2RH6 A;  3NKO A;  5L0B A;  2W8S A;  1KHN A;  2IUC B;  3UNY A;  4LRC A;  3LXQ A;  4FDJ A;  4ZG6 A;  1EW9 A;  2XR9 A;  3SZY A;  1ANI A;  4ZG9 A;  2GSN A;  3TX0 A;  5AJ9 A;  3NKR A;  4UPK A;  3KD8 A;  1SHN A;  4UPL A;  4YR1 A;  4GTY A;  3T00 A;  3UN2 A;  3WBH A;  4TN0 A;  3NKN A;  4NWX A;  1URB A;  5IJQ A;  3WAV A;  5HRT A;  1EI6 A;  4GTX A;  2W5V A;  3T01 A;  2W5W A;  3IDD A;  3M8W A;  2VQR A;  2IFY A;  2GA3 A;  3IGY B;  1HQA A;  5EGH A;  3DYC A;  4CYS A;  1N2L A;  4MY4 A;  3NKP A;  1O98 A;  1K7H A;  3A52 A;  3OT9 A;  1KHK A;  4LQY A;  4CXU A;  1KHJ A;  1FSU A;  1B8J A;  3WAX A;  4UOO A;  4NWJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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