2W5XA

Structure of tab5 alkaline phosphatase mutant his 135 glu with mg bound in the m3 site.
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITEATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 131
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5xA00
4LR7A 3WAYA 1KH9A 1KH4A 4TN0A 4LRDA 3M8YA 1KHKA 5HRTA 3T02A 4CXKA 4UPIA 3M8ZA 4KAVA 1AJBA 1ZEFA 4FDIA 2W5SA 1ALKA 3B5QA 3NKNA 1AJCA 4KAYA 4N7TA 3SZZA 1ED8A 2XRGA 3M7VA 3MK2A 1EI6A 1KHLA 5L0EA 3M8WA 1ALJA 1O98A 4MIVA 4LR8A 1K7HA 1ANJA 2W5QA 5K4PA 5LRMA 1N2KA 2VQRA 3NKPA 5EGHA 2W8DA 5DLTA 4UORA 1AJDA 3DPCA 3WAXA 4GTWA 1ELZA 3T00A 3CMRA 3UN5A 2X98A 2GSNA 2W5WA 4GTYA 3IGZB 3A52A 3BDHA 1HDHA 3ED4A 1E3CP 3BDGB 3IDDA 2GA3A 2W5VA 4GTZA 4MY4A 4CYRA 4ZG7A 5LIAA 2G9YA 3BDFA 5L0BA 4ZG9A 3E2DA 1URBA 4MHXA 2W8SA 1KHNA 2GSUA 3NKRA 1ZEDA 2ZKTA 2IUCA 4LR9A 4NWJA 4NWXA 4B56A 3LXQA 2IUCB 2W5RA 3UO0A 4ZGAA 4CXUA 4FDJA 4YR1A 3MK1A 1ELXA 4CYSA 3UNYA 2W5TA 1FSUA 5C66A 1AUKA 3WAVA 2W5XA 1KH7A 5AJ9A 5DLVA 5TJ3A 2IFYA 3TX0A 5LQQA 3WBHA 1EQJA 1HJKA 5INHA 3WAWA 3NKMA 3OT9A 5DLWA 3BDGA 1AJAA 3MK0A 3TWZA 1ALIA 3KD8A 4UPKA 3T01A 4LRBA 1N2LA 1URAA 2GSOA 3Q3QA 5L0KA 2D1GA 3UN3A 1EJJA 1EW9A 1Y6VA 1HQAA 1E1ZP 1SHNA 4QAXA 5GRRA 5KXAA 4ZG6A 4KJGA 2GLQA 3SZYA 4LRAA 1E33P 5IJQA 1SHQA 4UPLA 1KHJA 5EGEA 1E2SP 2XR9A 4KM4A 1Y7AA 1ELYA 4LREA 4GTXA 4CXSA 1P49A 4KJDA 3IGYB 3TG0A 4UPHA 5LRNA 4UOPA 1ED9A 2QZUA 4LRCA 5GOVA 2ANHA 1EW8A 1KH5A 5IJSA 3NKOA 1ANIA 3UN2A 4UOOA 1EW2A 1B8JA 3NKQA 4LR2A 4LQYA 4LRFA 1ZEBA 3NVLA 2RH6A 1ALHA 1O99A 3DYCA
chains in the Genus database with same CATH superfamily
4LR7A 3WAYA 1KH9A 1KH4A 4TN0A 4LRDA 3M8YA 1KHKA 5HRTA 3T02A 4CXKA 4UPIA 3M8ZA 4KAVA 1AJBA 1ZEFA 4FDIA 2W5SA 1ALKA 3B5QA 3NKNA 1AJCA 4KAYA 4N7TA 3SZZA 1ED8A 2XRGA 3M7VA 3MK2A 1EI6A 1KHLA 5L0EA 3M8WA 1ALJA 1O98A 4MIVA 4LR8A 1K7HA 1ANJA 2W5QA 5K4PA 5LRMA 1N2KA 2VQRA 3NKPA 5EGHA 2W8DA 5DLTA 4UORA 1AJDA 3DPCA 3WAXA 4GTWA 1ELZA 3T00A 3CMRA 3UN5A 2X98A 2GSNA 2W5WA 4GTYA 3IGZB 3A52A 3BDHA 1HDHA 3ED4A 1E3CP 3BDGB 3IDDA 2GA3A 2W5VA 4GTZA 4MY4A 4CYRA 4ZG7A 5LIAA 2G9YA 3BDFA 5L0BA 4ZG9A 3E2DA 1URBA 4MHXA 2W8SA 1KHNA 2GSUA 3NKRA 1ZEDA 2ZKTA 2IUCA 4LR9A 4NWJA 4NWXA 4B56A 3LXQA 2IUCB 2W5RA 3UO0A 4ZGAA 4CXUA 4FDJA 4YR1A 3MK1A 1ELXA 4CYSA 3UNYA 2W5TA 1FSUA 5C66A 1AUKA 3WAVA 2W5XA 1KH7A 5AJ9A 5DLVA 5TJ3A 2IFYA 3TX0A 5LQQA 3WBHA 1EQJA 1HJKA 5INHA 3WAWA 3NKMA 3OT9A 5DLWA 3BDGA 1AJAA 3MK0A 3TWZA 1ALIA 3KD8A 4UPKA 3T01A 4LRBA 1N2LA 1URAA 2GSOA 3Q3QA 5L0KA 2D1GA 3UN3A 1EJJA 1EW9A 1Y6VA 1HQAA 1E1ZP 1SHNA 4QAXA 5GRRA 5KXAA 4ZG6A 4KJGA 2GLQA 3SZYA 4LRAA 1E33P 5IJQA 1SHQA 4UPLA 1KHJA 5EGEA 1E2SP 2XR9A 4KM4A 1Y7AA 1ELYA 4LREA 4GTXA 4CXSA 1P49A 4KJDA 3IGYB 3TG0A 4UPHA 5LRNA 4UOPA 1ED9A 2QZUA 4LRCA 5GOVA 2ANHA 1EW8A 1KH5A 5IJSA 3NKOA 1ANIA 3UN2A 4UOOA 1EW2A 1B8JA 3NKQA 4LR2A 4LQYA 4LRFA 1ZEBA 3NVLA 2RH6A 1ALHA 1O99A 3DYCA
chains in the Genus database with same CATH topology
4LR7A 3WAYA 1KH9A 1KH4A 4TN0A 4LRDA 3M8YA 1KHKA 5HRTA 3T02A 4CXKA 4UPIA 3M8ZA 4KAVA 1AJBA 1ZEFA 4FDIA 2W5SA 1ALKA 3B5QA 3NKNA 1AJCA 4KAYA 4N7TA 3SZZA 1ED8A 2XRGA 3M7VA 3MK2A 1EI6A 1KHLA 5L0EA 3M8WA 1ALJA 1O98A 4MIVA 4LR8A 1K7HA 1ANJA 2W5QA 5K4PA 5LRMA 1N2KA 2VQRA 3NKPA 5EGHA 2W8DA 5DLTA 4UORA 1AJDA 3DPCA 3WAXA 4GTWA 1ELZA 3T00A 3CMRA 3UN5A 2X98A 2GSNA 2W5WA 4GTYA 3IGZB 3A52A 3BDHA 1HDHA 3ED4A 1E3CP 3BDGB 3IDDA 2GA3A 2W5VA 4GTZA 4MY4A 4CYRA 4ZG7A 5LIAA 2G9YA 3BDFA 5L0BA 4ZG9A 3E2DA 1URBA 4MHXA 2W8SA 1KHNA 2GSUA 3NKRA 1ZEDA 2ZKTA 2IUCA 4LR9A 4NWJA 4NWXA 4B56A 3LXQA 2IUCB 2W5RA 3UO0A 4ZGAA 4CXUA 4FDJA 4YR1A 3MK1A 1ELXA 4CYSA 3UNYA 2W5TA 1FSUA 5C66A 1AUKA 3WAVA 2W5XA 1KH7A 5AJ9A 5DLVA 5TJ3A 2IFYA 3TX0A 5LQQA 3WBHA 1EQJA 1HJKA 5INHA 3WAWA 3NKMA 3OT9A 5DLWA 3BDGA 1AJAA 3MK0A 3TWZA 1ALIA 3KD8A 4UPKA 3T01A 4LRBA 1N2LA 1URAA 2GSOA 3Q3QA 5L0KA 2D1GA 3UN3A 1EJJA 1EW9A 1Y6VA 1HQAA 1E1ZP 1SHNA 4QAXA 5GRRA 5KXAA 4ZG6A 4KJGA 2GLQA 3SZYA 4LRAA 1E33P 5IJQA 1SHQA 4UPLA 1KHJA 5EGEA 1E2SP 2XR9A 4KM4A 1Y7AA 1ELYA 4LREA 4GTXA 4CXSA 1P49A 4KJDA 3IGYB 3TG0A 4UPHA 5LRNA 4UOPA 1ED9A 2QZUA 4LRCA 5GOVA 2ANHA 1EW8A 1KH5A 5IJSA 3NKOA 1ANIA 3UN2A 4UOOA 1EW2A 1B8JA 3NKQA 4LR2A 4LQYA 4LRFA 1ZEBA 3NVLA 2RH6A 1ALHA 1O99A 3DYCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR7 A;  3WAY A;  1KH9 A;  1KH4 A;  4TN0 A;  4LRD A;  3M8Y A;  1KHK A;  5HRT A;  3T02 A;  4CXK A;  4UPI A;  3M8Z A;  4KAV A;  1AJB A;  1ZEF A;  4FDI A;  2W5S A;  1ALK A;  3B5Q A;  3NKN A;  1AJC A;  4KAY A;  4N7T A;  3SZZ A;  1ED8 A;  2XRG A;  3M7V A;  3MK2 A;  1EI6 A;  1KHL A;  5L0E A;  3M8W A;  1ALJ A;  1O98 A;  4MIV A;  4LR8 A;  1K7H A;  1ANJ A;  2W5Q A;  5K4P A;  5LRM A;  1N2K A;  2VQR A;  3NKP A;  5EGH A;  2W8D A;  5DLT A;  4UOR A;  1AJD A;  3DPC A;  3WAX A;  4GTW A;  1ELZ A;  3T00 A;  3CMR A;  3UN5 A;  2X98 A;  2GSN A;  2W5W A;  4GTY A;  3IGZ B;  3A52 A;  3BDH A;  1HDH A;  3ED4 A;  1E3C P;  3BDG B;  3IDD A;  2GA3 A;  2W5V A;  4GTZ A;  4MY4 A;  4CYR A;  4ZG7 A;  5LIA A;  2G9Y A;  3BDF A;  5L0B A;  4ZG9 A;  3E2D A;  1URB A;  4MHX A;  2W8S A;  1KHN A;  2GSU A;  3NKR A;  1ZED A;  2ZKT A;  2IUC A;  4LR9 A;  4NWJ A;  4NWX A;  4B56 A;  3LXQ A;  2IUC B;  2W5R A;  3UO0 A;  4ZGA A;  4CXU A;  4FDJ A;  4YR1 A;  3MK1 A;  1ELX A;  4CYS A;  3UNY A;  2W5T A;  1FSU A;  5C66 A;  1AUK A;  3WAV A;  2W5X A;  1KH7 A;  5AJ9 A;  5DLV A;  5TJ3 A;  2IFY A;  3TX0 A;  5LQQ A;  3WBH A;  1EQJ A;  1HJK A;  5INH A;  3WAW A;  3NKM A;  3OT9 A;  5DLW A;  3BDG A;  1AJA A;  3MK0 A;  3TWZ A;  1ALI A;  3KD8 A;  4UPK A;  3T01 A;  4LRB A;  1N2L A;  1URA A;  2GSO A;  3Q3Q A;  5L0K A;  2D1G A;  3UN3 A;  1EJJ A;  1EW9 A;  1Y6V A;  1HQA A;  1E1Z P;  1SHN A;  4QAX A;  5GRR A;  5KXA A;  4ZG6 A;  4KJG A;  2GLQ A;  3SZY A;  4LRA A;  1E33 P;  5IJQ A;  1SHQ A;  4UPL A;  1KHJ A;  5EGE A;  1E2S P;  2XR9 A;  4KM4 A;  1Y7A A;  1ELY A;  4LRE A;  4GTX A;  4CXS A;  1P49 A;  4KJD A;  3IGY B;  3TG0 A;  4UPH A;  5LRN A;  4UOP A;  1ED9 A;  2QZU A;  4LRC A;  5GOV A;  2ANH A;  1EW8 A;  1KH5 A;  5IJS A;  3NKO A;  1ANI A;  3UN2 A;  4UOO A;  1EW2 A;  1B8J A;  3NKQ A;  4LR2 A;  4LQY A;  4LRF A;  1ZEB A;  3NVL A;  2RH6 A;  1ALH A;  1O99 A;  3DYC A; 
#chains in the Genus database with same CATH topology
 4LR7 A;  3WAY A;  1KH9 A;  1KH4 A;  4TN0 A;  4LRD A;  3M8Y A;  1KHK A;  5HRT A;  3T02 A;  4CXK A;  4UPI A;  3M8Z A;  4KAV A;  1AJB A;  1ZEF A;  4FDI A;  2W5S A;  1ALK A;  3B5Q A;  3NKN A;  1AJC A;  4KAY A;  4N7T A;  3SZZ A;  1ED8 A;  2XRG A;  3M7V A;  3MK2 A;  1EI6 A;  1KHL A;  5L0E A;  3M8W A;  1ALJ A;  1O98 A;  4MIV A;  4LR8 A;  1K7H A;  1ANJ A;  2W5Q A;  5K4P A;  5LRM A;  1N2K A;  2VQR A;  3NKP A;  5EGH A;  2W8D A;  5DLT A;  4UOR A;  1AJD A;  3DPC A;  3WAX A;  4GTW A;  1ELZ A;  3T00 A;  3CMR A;  3UN5 A;  2X98 A;  2GSN A;  2W5W A;  4GTY A;  3IGZ B;  3A52 A;  3BDH A;  1HDH A;  3ED4 A;  1E3C P;  3BDG B;  3IDD A;  2GA3 A;  2W5V A;  4GTZ A;  4MY4 A;  4CYR A;  4ZG7 A;  5LIA A;  2G9Y A;  3BDF A;  5L0B A;  4ZG9 A;  3E2D A;  1URB A;  4MHX A;  2W8S A;  1KHN A;  2GSU A;  3NKR A;  1ZED A;  2ZKT A;  2IUC A;  4LR9 A;  4NWJ A;  4NWX A;  4B56 A;  3LXQ A;  2IUC B;  2W5R A;  3UO0 A;  4ZGA A;  4CXU A;  4FDJ A;  4YR1 A;  3MK1 A;  1ELX A;  4CYS A;  3UNY A;  2W5T A;  1FSU A;  5C66 A;  1AUK A;  3WAV A;  2W5X A;  1KH7 A;  5AJ9 A;  5DLV A;  5TJ3 A;  2IFY A;  3TX0 A;  5LQQ A;  3WBH A;  1EQJ A;  1HJK A;  5INH A;  3WAW A;  3NKM A;  3OT9 A;  5DLW A;  3BDG A;  1AJA A;  3MK0 A;  3TWZ A;  1ALI A;  3KD8 A;  4UPK A;  3T01 A;  4LRB A;  1N2L A;  1URA A;  2GSO A;  3Q3Q A;  5L0K A;  2D1G A;  3UN3 A;  1EJJ A;  1EW9 A;  1Y6V A;  1HQA A;  1E1Z P;  1SHN A;  4QAX A;  5GRR A;  5KXA A;  4ZG6 A;  4KJG A;  2GLQ A;  3SZY A;  4LRA A;  1E33 P;  5IJQ A;  1SHQ A;  4UPL A;  1KHJ A;  5EGE A;  1E2S P;  2XR9 A;  4KM4 A;  1Y7A A;  1ELY A;  4LRE A;  4GTX A;  4CXS A;  1P49 A;  4KJD A;  3IGY B;  3TG0 A;  4UPH A;  5LRN A;  4UOP A;  1ED9 A;  2QZU A;  4LRC A;  5GOV A;  2ANH A;  1EW8 A;  1KH5 A;  5IJS A;  3NKO A;  1ANI A;  3UN2 A;  4UOO A;  1EW2 A;  1B8J A;  3NKQ A;  4LR2 A;  4LQY A;  4LRF A;  1ZEB A;  3NVL A;  2RH6 A;  1ALH A;  1O99 A;  3DYC A; 
#chains in the Genus database with same CATH homology
 4LR7 A;  3WAY A;  1KH9 A;  1KH4 A;  4TN0 A;  4LRD A;  3M8Y A;  1KHK A;  5HRT A;  3T02 A;  4CXK A;  4UPI A;  3M8Z A;  4KAV A;  1AJB A;  1ZEF A;  4FDI A;  2W5S A;  1ALK A;  3B5Q A;  3NKN A;  1AJC A;  4KAY A;  4N7T A;  3SZZ A;  1ED8 A;  2XRG A;  3M7V A;  3MK2 A;  1EI6 A;  1KHL A;  5L0E A;  3M8W A;  1ALJ A;  1O98 A;  4MIV A;  4LR8 A;  1K7H A;  1ANJ A;  2W5Q A;  5K4P A;  5LRM A;  1N2K A;  2VQR A;  3NKP A;  5EGH A;  2W8D A;  5DLT A;  4UOR A;  1AJD A;  3DPC A;  3WAX A;  4GTW A;  1ELZ A;  3T00 A;  3CMR A;  3UN5 A;  2X98 A;  2GSN A;  2W5W A;  4GTY A;  3IGZ B;  3A52 A;  3BDH A;  1HDH A;  3ED4 A;  1E3C P;  3BDG B;  3IDD A;  2GA3 A;  2W5V A;  4GTZ A;  4MY4 A;  4CYR A;  4ZG7 A;  5LIA A;  2G9Y A;  3BDF A;  5L0B A;  4ZG9 A;  3E2D A;  1URB A;  4MHX A;  2W8S A;  1KHN A;  2GSU A;  3NKR A;  1ZED A;  2ZKT A;  2IUC A;  4LR9 A;  4NWJ A;  4NWX A;  4B56 A;  3LXQ A;  2IUC B;  2W5R A;  3UO0 A;  4ZGA A;  4CXU A;  4FDJ A;  4YR1 A;  3MK1 A;  1ELX A;  4CYS A;  3UNY A;  2W5T A;  1FSU A;  5C66 A;  1AUK A;  3WAV A;  2W5X A;  1KH7 A;  5AJ9 A;  5DLV A;  5TJ3 A;  2IFY A;  3TX0 A;  5LQQ A;  3WBH A;  1EQJ A;  1HJK A;  5INH A;  3WAW A;  3NKM A;  3OT9 A;  5DLW A;  3BDG A;  1AJA A;  3MK0 A;  3TWZ A;  1ALI A;  3KD8 A;  4UPK A;  3T01 A;  4LRB A;  1N2L A;  1URA A;  2GSO A;  3Q3Q A;  5L0K A;  2D1G A;  3UN3 A;  1EJJ A;  1EW9 A;  1Y6V A;  1HQA A;  1E1Z P;  1SHN A;  4QAX A;  5GRR A;  5KXA A;  4ZG6 A;  4KJG A;  2GLQ A;  3SZY A;  4LRA A;  1E33 P;  5IJQ A;  1SHQ A;  4UPL A;  1KHJ A;  5EGE A;  1E2S P;  2XR9 A;  4KM4 A;  1Y7A A;  1ELY A;  4LRE A;  4GTX A;  4CXS A;  1P49 A;  4KJD A;  3IGY B;  3TG0 A;  4UPH A;  5LRN A;  4UOP A;  1ED9 A;  2QZU A;  4LRC A;  5GOV A;  2ANH A;  1EW8 A;  1KH5 A;  5IJS A;  3NKO A;  1ANI A;  3UN2 A;  4UOO A;  1EW2 A;  1B8J A;  3NKQ A;  4LR2 A;  4LQY A;  4LRF A;  1ZEB A;  3NVL A;  2RH6 A;  1ALH A;  1O99 A;  3DYC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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