3CMR | Genus

Total Genus 164

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	164
Knots found	KnotProt 2.0: S +3₁
sequence length	445
structure length	445
Chain Sequence	MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Escherichia coli
publication title	Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase pubmed doi rcsb
molecule keywords	Alkaline phosphatase
total genus	164
structure length	445
sequence length	445
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2008-03-24

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	3cmrA00

5LIAA 2RH6A 4ZGAA 3BDFA 4UPLA 4LR2A 1HDHA 3BDGA 3OT9A 5GOVA 1Y7AA 4TN0A 1AUKA 1EW9A 2ANHA 2W5RA 1AJBA 4CYRA 4MHXA 2D1GA 1EI6A 5TJ3A 1EJJA 3T02A 3UN3A 4ZG9A 1AJCA 1HJKA 5DLTA 4KAVA 1ALKA 4LRAA 5L0BA 5LRNA 3WAWA 2X98A 4YR1A 1ALHA 1E33P 1EW8A 4CYSA 1N2LA 5DLVA 3NKNA 5GRRA 3LXQA 4LREA 5INHA 3ED4A 5DLWA 4LRFA 4GTXA 1KHJA 3M8ZA 3WAYA 4LR9A 2W5XA 3TG0A 2GA3A 4UPHA 2ZKTA 4LRDA 5K4PA 3WAVA 5IJSA 1ELXA 2GSUA 4FDJA 2W5SA 2W8SA 1SHNA 4UORA 2XR9A 1ALIA 2QZUA 3SZYA 4B56A 5AJ9A 2IUCA 1K7HA 5L0EA 3UN5A 1AJDA 2W5VA 2IUCB 3NKRA 1O99A 3NKOA 1ZEFA 4LRBA 4LR8A 4MY4A 3NKQA 4ZG6A 4UOOA 1KH7A 3NKPA 3TX0A 5LRMA 1URAA 3A52A 3E2DA 4GTWA 3WBHA 1ALJA 1KH4A 5EGEA 1AJAA 1ANJA 2IFYA 3KD8A 3BDHA 3WAXA 4CXUA 1HQAA 3DYCA 3T00A 3M8WA 4LQYA 1SHQA 4NWXA 3UNYA 1E1ZP 1N2KA 2W5QA 1KHNA 4GTYA 4KJGA 5EGHA 1E2SP 5KXAA 1KHLA 3MK0A 4UOPA 1E3CP 2G9YA 3NVLA 1ED8A 3Q3QA 1P49A 1ELZA 3UO0A 4MIVA 2VQRA 4NWJA 3CMRA 4LR7A 4ZG7A 2W5WA 2GSOA 2GLQA 3T01A 3TWZA 1ED9A 1EW2A 3M8YA 4CXKA 4CXSA 1B8JA 5L0KA 2W5TA 4UPKA 1FSUA 2XRGA 4KM4A 3UN2A 1URBA 3BDGB 3DPCA 1Y6VA 4FDIA 3SZZA 1EQJA 3IDDA 3M7VA 5C66A 4UPIA 4QAXA 4KAYA 1ZEDA 3MK1A 1ZEBA 1O98A 4N7TA 5IJQA 1KHKA 3IGYB 2W8DA 1KH9A 3NKMA 3IGZB 1KH5A 1ANIA 4GTZA 2GSNA 3B5QA 5LQQA 5HRTA 4LRCA 3MK2A 1ELYA 4KJDA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 5LIA A;  2RH6 A;  4ZGA A;  3BDF A;  4UPL A;  4LR2 A;  1HDH A;  3BDG A;  3OT9 A;  5GOV A;  1Y7A A;  4TN0 A;  1AUK A;  1EW9 A;  2ANH A;  2W5R A;  1AJB A;  4CYR A;  4MHX A;  2D1G A;  1EI6 A;  5TJ3 A;  1EJJ A;  3T02 A;  3UN3 A;  4ZG9 A;  1AJC A;  1HJK A;  5DLT A;  4KAV A;  1ALK A;  4LRA A;  5L0B A;  5LRN A;  3WAW A;  2X98 A;  4YR1 A;  1ALH A;  1E33 P;  1EW8 A;  4CYS A;  1N2L A;  5DLV A;  3NKN A;  5GRR A;  3LXQ A;  4LRE A;  5INH A;  3ED4 A;  5DLW A;  4LRF A;  4GTX A;  1KHJ A;  3M8Z A;  3WAY A;  4LR9 A;  2W5X A;  3TG0 A;  2GA3 A;  4UPH A;  2ZKT A;  4LRD A;  5K4P A;  3WAV A;  5IJS A;  1ELX A;  2GSU A;  4FDJ A;  2W5S A;  2W8S A;  1SHN A;  4UOR A;  2XR9 A;  1ALI A;  2QZU A;  3SZY A;  4B56 A;  5AJ9 A;  2IUC A;  1K7H A;  5L0E A;  3UN5 A;  1AJD A;  2W5V A;  2IUC B;  3NKR A;  1O99 A;  3NKO A;  1ZEF A;  4LRB A;  4LR8 A;  4MY4 A;  3NKQ A;  4ZG6 A;  4UOO A;  1KH7 A;  3NKP A;  3TX0 A;  5LRM A;  1URA A;  3A52 A;  3E2D A;  4GTW A;  3WBH A;  1ALJ A;  1KH4 A;  5EGE A;  1AJA A;  1ANJ A;  2IFY A;  3KD8 A;  3BDH A;  3WAX A;  4CXU A;  1HQA A;  3DYC A;  3T00 A;  3M8W A;  4LQY A;  1SHQ A;  4NWX A;  3UNY A;  1E1Z P;  1N2K A;  2W5Q A;  1KHN A;  4GTY A;  4KJG A;  5EGH A;  1E2S P;  5KXA A;  1KHL A;  3MK0 A;  4UOP A;  1E3C P;  2G9Y A;  3NVL A;  1ED8 A;  3Q3Q A;  1P49 A;  1ELZ A;  3UO0 A;  4MIV A;  2VQR A;  4NWJ A;  3CMR A;  4LR7 A;  4ZG7 A;  2W5W A;  2GSO A;  2GLQ A;  3T01 A;  3TWZ A;  1ED9 A;  1EW2 A;  3M8Y A;  4CXK A;  4CXS A;  1B8J A;  5L0K A;  2W5T A;  4UPK A;  1FSU A;  2XRG A;  4KM4 A;  3UN2 A;  1URB A;  3BDG B;  3DPC A;  1Y6V A;  4FDI A;  3SZZ A;  1EQJ A;  3IDD A;  3M7V A;  5C66 A;  4UPI A;  4QAX A;  4KAY A;  1ZED A;  3MK1 A;  1ZEB A;  1O98 A;  4N7T A;  5IJQ A;  1KHK A;  3IGY B;  2W8D A;  1KH9 A;  3NKM A;  3IGZ B;  1KH5 A;  1ANI A;  4GTZ A;  2GSN A;  3B5Q A;  5LQQ A;  5HRT A;  4LRC A;  3MK2 A;  1ELY A;  4KJD A; 
#chains in the Genus database with same CATH topology
 5LIA A;  2RH6 A;  4ZGA A;  3BDF A;  4UPL A;  4LR2 A;  1HDH A;  3BDG A;  3OT9 A;  5GOV A;  1Y7A A;  4TN0 A;  1AUK A;  1EW9 A;  2ANH A;  2W5R A;  1AJB A;  4CYR A;  4MHX A;  2D1G A;  1EI6 A;  5TJ3 A;  1EJJ A;  3T02 A;  3UN3 A;  4ZG9 A;  1AJC A;  1HJK A;  5DLT A;  4KAV A;  1ALK A;  4LRA A;  5L0B A;  5LRN A;  3WAW A;  2X98 A;  4YR1 A;  1ALH A;  1E33 P;  1EW8 A;  4CYS A;  1N2L A;  5DLV A;  3NKN A;  5GRR A;  3LXQ A;  4LRE A;  5INH A;  3ED4 A;  5DLW A;  4LRF A;  4GTX A;  1KHJ A;  3M8Z A;  3WAY A;  4LR9 A;  2W5X A;  3TG0 A;  2GA3 A;  4UPH A;  2ZKT A;  4LRD A;  5K4P A;  3WAV A;  5IJS A;  1ELX A;  2GSU A;  4FDJ A;  2W5S A;  2W8S A;  1SHN A;  4UOR A;  2XR9 A;  1ALI A;  2QZU A;  3SZY A;  4B56 A;  5AJ9 A;  2IUC A;  1K7H A;  5L0E A;  3UN5 A;  1AJD A;  2W5V A;  2IUC B;  3NKR A;  1O99 A;  3NKO A;  1ZEF A;  4LRB A;  4LR8 A;  4MY4 A;  3NKQ A;  4ZG6 A;  4UOO A;  1KH7 A;  3NKP A;  3TX0 A;  5LRM A;  1URA A;  3A52 A;  3E2D A;  4GTW A;  3WBH A;  1ALJ A;  1KH4 A;  5EGE A;  1AJA A;  1ANJ A;  2IFY A;  3KD8 A;  3BDH A;  3WAX A;  4CXU A;  1HQA A;  3DYC A;  3T00 A;  3M8W A;  4LQY A;  1SHQ A;  4NWX A;  3UNY A;  1E1Z P;  1N2K A;  2W5Q A;  1KHN A;  4GTY A;  4KJG A;  5EGH A;  1E2S P;  5KXA A;  1KHL A;  3MK0 A;  4UOP A;  1E3C P;  2G9Y A;  3NVL A;  1ED8 A;  3Q3Q A;  1P49 A;  1ELZ A;  3UO0 A;  4MIV A;  2VQR A;  4NWJ A;  3CMR A;  4LR7 A;  4ZG7 A;  2W5W A;  2GSO A;  2GLQ A;  3T01 A;  3TWZ A;  1ED9 A;  1EW2 A;  3M8Y A;  4CXK A;  4CXS A;  1B8J A;  5L0K A;  2W5T A;  4UPK A;  1FSU A;  2XRG A;  4KM4 A;  3UN2 A;  1URB A;  3BDG B;  3DPC A;  1Y6V A;  4FDI A;  3SZZ A;  1EQJ A;  3IDD A;  3M7V A;  5C66 A;  4UPI A;  4QAX A;  4KAY A;  1ZED A;  3MK1 A;  1ZEB A;  1O98 A;  4N7T A;  5IJQ A;  1KHK A;  3IGY B;  2W8D A;  1KH9 A;  3NKM A;  3IGZ B;  1KH5 A;  1ANI A;  4GTZ A;  2GSN A;  3B5Q A;  5LQQ A;  5HRT A;  4LRC A;  3MK2 A;  1ELY A;  4KJD A; 
#chains in the Genus database with same CATH homology
 5LIA A;  2RH6 A;  4ZGA A;  3BDF A;  4UPL A;  4LR2 A;  1HDH A;  3BDG A;  3OT9 A;  5GOV A;  1Y7A A;  4TN0 A;  1AUK A;  1EW9 A;  2ANH A;  2W5R A;  1AJB A;  4CYR A;  4MHX A;  2D1G A;  1EI6 A;  5TJ3 A;  1EJJ A;  3T02 A;  3UN3 A;  4ZG9 A;  1AJC A;  1HJK A;  5DLT A;  4KAV A;  1ALK A;  4LRA A;  5L0B A;  5LRN A;  3WAW A;  2X98 A;  4YR1 A;  1ALH A;  1E33 P;  1EW8 A;  4CYS A;  1N2L A;  5DLV A;  3NKN A;  5GRR A;  3LXQ A;  4LRE A;  5INH A;  3ED4 A;  5DLW A;  4LRF A;  4GTX A;  1KHJ A;  3M8Z A;  3WAY A;  4LR9 A;  2W5X A;  3TG0 A;  2GA3 A;  4UPH A;  2ZKT A;  4LRD A;  5K4P A;  3WAV A;  5IJS A;  1ELX A;  2GSU A;  4FDJ A;  2W5S A;  2W8S A;  1SHN A;  4UOR A;  2XR9 A;  1ALI A;  2QZU A;  3SZY A;  4B56 A;  5AJ9 A;  2IUC A;  1K7H A;  5L0E A;  3UN5 A;  1AJD A;  2W5V A;  2IUC B;  3NKR A;  1O99 A;  3NKO A;  1ZEF A;  4LRB A;  4LR8 A;  4MY4 A;  3NKQ A;  4ZG6 A;  4UOO A;  1KH7 A;  3NKP A;  3TX0 A;  5LRM A;  1URA A;  3A52 A;  3E2D A;  4GTW A;  3WBH A;  1ALJ A;  1KH4 A;  5EGE A;  1AJA A;  1ANJ A;  2IFY A;  3KD8 A;  3BDH A;  3WAX A;  4CXU A;  1HQA A;  3DYC A;  3T00 A;  3M8W A;  4LQY A;  1SHQ A;  4NWX A;  3UNY A;  1E1Z P;  1N2K A;  2W5Q A;  1KHN A;  4GTY A;  4KJG A;  5EGH A;  1E2S P;  5KXA A;  1KHL A;  3MK0 A;  4UOP A;  1E3C P;  2G9Y A;  3NVL A;  1ED8 A;  3Q3Q A;  1P49 A;  1ELZ A;  3UO0 A;  4MIV A;  2VQR A;  4NWJ A;  3CMR A;  4LR7 A;  4ZG7 A;  2W5W A;  2GSO A;  2GLQ A;  3T01 A;  3TWZ A;  1ED9 A;  1EW2 A;  3M8Y A;  4CXK A;  4CXS A;  1B8J A;  5L0K A;  2W5T A;  4UPK A;  1FSU A;  2XRG A;  4KM4 A;  3UN2 A;  1URB A;  3BDG B;  3DPC A;  1Y6V A;  4FDI A;  3SZZ A;  1EQJ A;  3IDD A;  3M7V A;  5C66 A;  4UPI A;  4QAX A;  4KAY A;  1ZED A;  3MK1 A;  1ZEB A;  1O98 A;  4N7T A;  5IJQ A;  1KHK A;  3IGY B;  2W8D A;  1KH9 A;  3NKM A;  3IGZ B;  1KH5 A;  1ANI A;  4GTZ A;  2GSN A;  3B5Q A;  5LQQ A;  5HRT A;  4LRC A;  3MK2 A;  1ELY A;  4KJD A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3CMRA

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations