3CMRA

E. coli alkaline phosphatase mutant r166s in complex with phosphate
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Escherichia coli
publication title Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
pubmed doi rcsb
molecule keywords Alkaline phosphatase
total genus 164
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3cmrA00
3A52A 2IFYA 3M8ZA 1ELXA 4KJGA 3MK0A 2X98A 3T00A 4UPLA 2IUCA 1AJBA 2W5XA 4UPHA 4CXUA 4LRCA 1N2KA 3SZZA 3MK1A 4CYSA 4N7TA 1ELZA 3BDGB 2W5VA 2W5TA 3NKQA 1SHQA 5DLVA 4LR2A 4YR1A 3BDHA 3Q3QA 1B8JA 1O99A 1P49A 3M8WA 4QAXA 2QZUA 2GA3A 1SHNA 5EGHA 2W5RA 3WAYA 1E2SP 3IGZB 4LRDA 1ALHA 4MY4A 2RH6A 2D1GA 2W8DA 2GSNA 3IGYB 4MIVA 1ALKA 3T02A 5HRTA 1EW2A 1ELYA 4ZGAA 1ZEBA 4UPIA 4LRBA 1KHNA 2ANHA 1AJCA 5DLWA 3T01A 1ALJA 3WAWA 5L0EA 1AUKA 4LQYA 2W5SA 2W5WA 4GTYA 3IDDA 3WAXA 3SZYA 4MHXA 3M7VA 5LRNA 3ED4A 2VQRA 1KHLA 4KAYA 1KH5A 3UNYA 3CMRA 1URAA 2IUCB 1KHJA 4FDJA 5LQQA 1Y6VA 3NKRA 3NKPA 3UN2A 4CXKA 1EJJA 3NKMA 2W8SA 1E33P 1KHKA 4B56A 1Y7AA 4KM4A 4ZG9A 1HJKA 5LIAA 2XR9A 1N2LA 4FDIA 5GOVA 1KH4A 4NWJA 3TWZA 3UN5A 3B5QA 4CYRA 1KH9A 4LRFA 1AJDA 4LRAA 3UN3A 4UOOA 4LREA 2ZKTA 4LR9A 3TG0A 2GSOA 3NKNA 5TJ3A 5IJQA 2GSUA 3BDFA 5L0BA 5IJSA 1ALIA 3BDGA 3UO0A 3NVLA 4UOPA 4UPKA 4TN0A 5K4PA 5LRMA 1O98A 1FSUA 3NKOA 5DLTA 4LR7A 4GTXA 4GTZA 4GTWA 2XRGA 3TX0A 1E3CP 4LR8A 5GRRA 4CXSA 2W5QA 4ZG7A 5C66A 1ANJA 1URBA 1EW8A 2G9YA 1AJAA 5L0KA 1ANIA 3KD8A 1ED8A 4NWXA 1EI6A 1EW9A 4UORA 1K7HA 3M8YA 4KJDA 5EGEA 5KXAA 1ED9A 3WAVA 1HDHA 3MK2A 3OT9A 5AJ9A 5INHA 1E1ZP 1HQAA 2GLQA 1ZEFA 4KAVA 3WBHA 3DPCA 1KH7A 3DYCA 3E2DA 4ZG6A 3LXQA 1ZEDA 1EQJA
chains in the Genus database with same CATH superfamily
3A52A 2IFYA 3M8ZA 1ELXA 4KJGA 3MK0A 2X98A 3T00A 4UPLA 2IUCA 1AJBA 2W5XA 4UPHA 4CXUA 4LRCA 1N2KA 3SZZA 3MK1A 4CYSA 4N7TA 1ELZA 3BDGB 2W5VA 2W5TA 3NKQA 1SHQA 5DLVA 4LR2A 4YR1A 3BDHA 3Q3QA 1B8JA 1O99A 1P49A 3M8WA 4QAXA 2QZUA 2GA3A 1SHNA 5EGHA 2W5RA 3WAYA 1E2SP 3IGZB 4LRDA 1ALHA 4MY4A 2RH6A 2D1GA 2W8DA 2GSNA 3IGYB 4MIVA 1ALKA 3T02A 5HRTA 1EW2A 1ELYA 4ZGAA 1ZEBA 4UPIA 4LRBA 1KHNA 2ANHA 1AJCA 5DLWA 3T01A 1ALJA 3WAWA 5L0EA 1AUKA 4LQYA 2W5SA 2W5WA 4GTYA 3IDDA 3WAXA 3SZYA 4MHXA 3M7VA 5LRNA 3ED4A 2VQRA 1KHLA 4KAYA 1KH5A 3UNYA 3CMRA 1URAA 2IUCB 1KHJA 4FDJA 5LQQA 1Y6VA 3NKRA 3NKPA 3UN2A 4CXKA 1EJJA 3NKMA 2W8SA 1E33P 1KHKA 4B56A 1Y7AA 4KM4A 4ZG9A 1HJKA 5LIAA 2XR9A 1N2LA 4FDIA 5GOVA 1KH4A 4NWJA 3TWZA 3UN5A 3B5QA 4CYRA 1KH9A 4LRFA 1AJDA 4LRAA 3UN3A 4UOOA 4LREA 2ZKTA 4LR9A 3TG0A 2GSOA 3NKNA 5TJ3A 5IJQA 2GSUA 3BDFA 5L0BA 5IJSA 1ALIA 3BDGA 3UO0A 3NVLA 4UOPA 4UPKA 4TN0A 5K4PA 5LRMA 1O98A 1FSUA 3NKOA 5DLTA 4LR7A 4GTXA 4GTZA 4GTWA 2XRGA 3TX0A 1E3CP 4LR8A 5GRRA 4CXSA 2W5QA 4ZG7A 5C66A 1ANJA 1URBA 1EW8A 2G9YA 1AJAA 5L0KA 1ANIA 3KD8A 1ED8A 4NWXA 1EI6A 1EW9A 4UORA 1K7HA 3M8YA 4KJDA 5EGEA 5KXAA 1ED9A 3WAVA 1HDHA 3MK2A 3OT9A 5AJ9A 5INHA 1E1ZP 1HQAA 2GLQA 1ZEFA 4KAVA 3WBHA 3DPCA 1KH7A 3DYCA 3E2DA 4ZG6A 3LXQA 1ZEDA 1EQJA
chains in the Genus database with same CATH topology
3A52A 2IFYA 3M8ZA 1ELXA 4KJGA 3MK0A 2X98A 3T00A 4UPLA 2IUCA 1AJBA 2W5XA 4UPHA 4CXUA 4LRCA 1N2KA 3SZZA 3MK1A 4CYSA 4N7TA 1ELZA 3BDGB 2W5VA 2W5TA 3NKQA 1SHQA 5DLVA 4LR2A 4YR1A 3BDHA 3Q3QA 1B8JA 1O99A 1P49A 3M8WA 4QAXA 2QZUA 2GA3A 1SHNA 5EGHA 2W5RA 3WAYA 1E2SP 3IGZB 4LRDA 1ALHA 4MY4A 2RH6A 2D1GA 2W8DA 2GSNA 3IGYB 4MIVA 1ALKA 3T02A 5HRTA 1EW2A 1ELYA 4ZGAA 1ZEBA 4UPIA 4LRBA 1KHNA 2ANHA 1AJCA 5DLWA 3T01A 1ALJA 3WAWA 5L0EA 1AUKA 4LQYA 2W5SA 2W5WA 4GTYA 3IDDA 3WAXA 3SZYA 4MHXA 3M7VA 5LRNA 3ED4A 2VQRA 1KHLA 4KAYA 1KH5A 3UNYA 3CMRA 1URAA 2IUCB 1KHJA 4FDJA 5LQQA 1Y6VA 3NKRA 3NKPA 3UN2A 4CXKA 1EJJA 3NKMA 2W8SA 1E33P 1KHKA 4B56A 1Y7AA 4KM4A 4ZG9A 1HJKA 5LIAA 2XR9A 1N2LA 4FDIA 5GOVA 1KH4A 4NWJA 3TWZA 3UN5A 3B5QA 4CYRA 1KH9A 4LRFA 1AJDA 4LRAA 3UN3A 4UOOA 4LREA 2ZKTA 4LR9A 3TG0A 2GSOA 3NKNA 5TJ3A 5IJQA 2GSUA 3BDFA 5L0BA 5IJSA 1ALIA 3BDGA 3UO0A 3NVLA 4UOPA 4UPKA 4TN0A 5K4PA 5LRMA 1O98A 1FSUA 3NKOA 5DLTA 4LR7A 4GTXA 4GTZA 4GTWA 2XRGA 3TX0A 1E3CP 4LR8A 5GRRA 4CXSA 2W5QA 4ZG7A 5C66A 1ANJA 1URBA 1EW8A 2G9YA 1AJAA 5L0KA 1ANIA 3KD8A 1ED8A 4NWXA 1EI6A 1EW9A 4UORA 1K7HA 3M8YA 4KJDA 5EGEA 5KXAA 1ED9A 3WAVA 1HDHA 3MK2A 3OT9A 5AJ9A 5INHA 1E1ZP 1HQAA 2GLQA 1ZEFA 4KAVA 3WBHA 3DPCA 1KH7A 3DYCA 3E2DA 4ZG6A 3LXQA 1ZEDA 1EQJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A52 A;  2IFY A;  3M8Z A;  1ELX A;  4KJG A;  3MK0 A;  2X98 A;  3T00 A;  4UPL A;  2IUC A;  1AJB A;  2W5X A;  4UPH A;  4CXU A;  4LRC A;  1N2K A;  3SZZ A;  3MK1 A;  4CYS A;  4N7T A;  1ELZ A;  3BDG B;  2W5V A;  2W5T A;  3NKQ A;  1SHQ A;  5DLV A;  4LR2 A;  4YR1 A;  3BDH A;  3Q3Q A;  1B8J A;  1O99 A;  1P49 A;  3M8W A;  4QAX A;  2QZU A;  2GA3 A;  1SHN A;  5EGH A;  2W5R A;  3WAY A;  1E2S P;  3IGZ B;  4LRD A;  1ALH A;  4MY4 A;  2RH6 A;  2D1G A;  2W8D A;  2GSN A;  3IGY B;  4MIV A;  1ALK A;  3T02 A;  5HRT A;  1EW2 A;  1ELY A;  4ZGA A;  1ZEB A;  4UPI A;  4LRB A;  1KHN A;  2ANH A;  1AJC A;  5DLW A;  3T01 A;  1ALJ A;  3WAW A;  5L0E A;  1AUK A;  4LQY A;  2W5S A;  2W5W A;  4GTY A;  3IDD A;  3WAX A;  3SZY A;  4MHX A;  3M7V A;  5LRN A;  3ED4 A;  2VQR A;  1KHL A;  4KAY A;  1KH5 A;  3UNY A;  3CMR A;  1URA A;  2IUC B;  1KHJ A;  4FDJ A;  5LQQ A;  1Y6V A;  3NKR A;  3NKP A;  3UN2 A;  4CXK A;  1EJJ A;  3NKM A;  2W8S A;  1E33 P;  1KHK A;  4B56 A;  1Y7A A;  4KM4 A;  4ZG9 A;  1HJK A;  5LIA A;  2XR9 A;  1N2L A;  4FDI A;  5GOV A;  1KH4 A;  4NWJ A;  3TWZ A;  3UN5 A;  3B5Q A;  4CYR A;  1KH9 A;  4LRF A;  1AJD A;  4LRA A;  3UN3 A;  4UOO A;  4LRE A;  2ZKT A;  4LR9 A;  3TG0 A;  2GSO A;  3NKN A;  5TJ3 A;  5IJQ A;  2GSU A;  3BDF A;  5L0B A;  5IJS A;  1ALI A;  3BDG A;  3UO0 A;  3NVL A;  4UOP A;  4UPK A;  4TN0 A;  5K4P A;  5LRM A;  1O98 A;  1FSU A;  3NKO A;  5DLT A;  4LR7 A;  4GTX A;  4GTZ A;  4GTW A;  2XRG A;  3TX0 A;  1E3C P;  4LR8 A;  5GRR A;  4CXS A;  2W5Q A;  4ZG7 A;  5C66 A;  1ANJ A;  1URB A;  1EW8 A;  2G9Y A;  1AJA A;  5L0K A;  1ANI A;  3KD8 A;  1ED8 A;  4NWX A;  1EI6 A;  1EW9 A;  4UOR A;  1K7H A;  3M8Y A;  4KJD A;  5EGE A;  5KXA A;  1ED9 A;  3WAV A;  1HDH A;  3MK2 A;  3OT9 A;  5AJ9 A;  5INH A;  1E1Z P;  1HQA A;  2GLQ A;  1ZEF A;  4KAV A;  3WBH A;  3DPC A;  1KH7 A;  3DYC A;  3E2D A;  4ZG6 A;  3LXQ A;  1ZED A;  1EQJ A; 
#chains in the Genus database with same CATH topology
 3A52 A;  2IFY A;  3M8Z A;  1ELX A;  4KJG A;  3MK0 A;  2X98 A;  3T00 A;  4UPL A;  2IUC A;  1AJB A;  2W5X A;  4UPH A;  4CXU A;  4LRC A;  1N2K A;  3SZZ A;  3MK1 A;  4CYS A;  4N7T A;  1ELZ A;  3BDG B;  2W5V A;  2W5T A;  3NKQ A;  1SHQ A;  5DLV A;  4LR2 A;  4YR1 A;  3BDH A;  3Q3Q A;  1B8J A;  1O99 A;  1P49 A;  3M8W A;  4QAX A;  2QZU A;  2GA3 A;  1SHN A;  5EGH A;  2W5R A;  3WAY A;  1E2S P;  3IGZ B;  4LRD A;  1ALH A;  4MY4 A;  2RH6 A;  2D1G A;  2W8D A;  2GSN A;  3IGY B;  4MIV A;  1ALK A;  3T02 A;  5HRT A;  1EW2 A;  1ELY A;  4ZGA A;  1ZEB A;  4UPI A;  4LRB A;  1KHN A;  2ANH A;  1AJC A;  5DLW A;  3T01 A;  1ALJ A;  3WAW A;  5L0E A;  1AUK A;  4LQY A;  2W5S A;  2W5W A;  4GTY A;  3IDD A;  3WAX A;  3SZY A;  4MHX A;  3M7V A;  5LRN A;  3ED4 A;  2VQR A;  1KHL A;  4KAY A;  1KH5 A;  3UNY A;  3CMR A;  1URA A;  2IUC B;  1KHJ A;  4FDJ A;  5LQQ A;  1Y6V A;  3NKR A;  3NKP A;  3UN2 A;  4CXK A;  1EJJ A;  3NKM A;  2W8S A;  1E33 P;  1KHK A;  4B56 A;  1Y7A A;  4KM4 A;  4ZG9 A;  1HJK A;  5LIA A;  2XR9 A;  1N2L A;  4FDI A;  5GOV A;  1KH4 A;  4NWJ A;  3TWZ A;  3UN5 A;  3B5Q A;  4CYR A;  1KH9 A;  4LRF A;  1AJD A;  4LRA A;  3UN3 A;  4UOO A;  4LRE A;  2ZKT A;  4LR9 A;  3TG0 A;  2GSO A;  3NKN A;  5TJ3 A;  5IJQ A;  2GSU A;  3BDF A;  5L0B A;  5IJS A;  1ALI A;  3BDG A;  3UO0 A;  3NVL A;  4UOP A;  4UPK A;  4TN0 A;  5K4P A;  5LRM A;  1O98 A;  1FSU A;  3NKO A;  5DLT A;  4LR7 A;  4GTX A;  4GTZ A;  4GTW A;  2XRG A;  3TX0 A;  1E3C P;  4LR8 A;  5GRR A;  4CXS A;  2W5Q A;  4ZG7 A;  5C66 A;  1ANJ A;  1URB A;  1EW8 A;  2G9Y A;  1AJA A;  5L0K A;  1ANI A;  3KD8 A;  1ED8 A;  4NWX A;  1EI6 A;  1EW9 A;  4UOR A;  1K7H A;  3M8Y A;  4KJD A;  5EGE A;  5KXA A;  1ED9 A;  3WAV A;  1HDH A;  3MK2 A;  3OT9 A;  5AJ9 A;  5INH A;  1E1Z P;  1HQA A;  2GLQ A;  1ZEF A;  4KAV A;  3WBH A;  3DPC A;  1KH7 A;  3DYC A;  3E2D A;  4ZG6 A;  3LXQ A;  1ZED A;  1EQJ A; 
#chains in the Genus database with same CATH homology
 3A52 A;  2IFY A;  3M8Z A;  1ELX A;  4KJG A;  3MK0 A;  2X98 A;  3T00 A;  4UPL A;  2IUC A;  1AJB A;  2W5X A;  4UPH A;  4CXU A;  4LRC A;  1N2K A;  3SZZ A;  3MK1 A;  4CYS A;  4N7T A;  1ELZ A;  3BDG B;  2W5V A;  2W5T A;  3NKQ A;  1SHQ A;  5DLV A;  4LR2 A;  4YR1 A;  3BDH A;  3Q3Q A;  1B8J A;  1O99 A;  1P49 A;  3M8W A;  4QAX A;  2QZU A;  2GA3 A;  1SHN A;  5EGH A;  2W5R A;  3WAY A;  1E2S P;  3IGZ B;  4LRD A;  1ALH A;  4MY4 A;  2RH6 A;  2D1G A;  2W8D A;  2GSN A;  3IGY B;  4MIV A;  1ALK A;  3T02 A;  5HRT A;  1EW2 A;  1ELY A;  4ZGA A;  1ZEB A;  4UPI A;  4LRB A;  1KHN A;  2ANH A;  1AJC A;  5DLW A;  3T01 A;  1ALJ A;  3WAW A;  5L0E A;  1AUK A;  4LQY A;  2W5S A;  2W5W A;  4GTY A;  3IDD A;  3WAX A;  3SZY A;  4MHX A;  3M7V A;  5LRN A;  3ED4 A;  2VQR A;  1KHL A;  4KAY A;  1KH5 A;  3UNY A;  3CMR A;  1URA A;  2IUC B;  1KHJ A;  4FDJ A;  5LQQ A;  1Y6V A;  3NKR A;  3NKP A;  3UN2 A;  4CXK A;  1EJJ A;  3NKM A;  2W8S A;  1E33 P;  1KHK A;  4B56 A;  1Y7A A;  4KM4 A;  4ZG9 A;  1HJK A;  5LIA A;  2XR9 A;  1N2L A;  4FDI A;  5GOV A;  1KH4 A;  4NWJ A;  3TWZ A;  3UN5 A;  3B5Q A;  4CYR A;  1KH9 A;  4LRF A;  1AJD A;  4LRA A;  3UN3 A;  4UOO A;  4LRE A;  2ZKT A;  4LR9 A;  3TG0 A;  2GSO A;  3NKN A;  5TJ3 A;  5IJQ A;  2GSU A;  3BDF A;  5L0B A;  5IJS A;  1ALI A;  3BDG A;  3UO0 A;  3NVL A;  4UOP A;  4UPK A;  4TN0 A;  5K4P A;  5LRM A;  1O98 A;  1FSU A;  3NKO A;  5DLT A;  4LR7 A;  4GTX A;  4GTZ A;  4GTW A;  2XRG A;  3TX0 A;  1E3C P;  4LR8 A;  5GRR A;  4CXS A;  2W5Q A;  4ZG7 A;  5C66 A;  1ANJ A;  1URB A;  1EW8 A;  2G9Y A;  1AJA A;  5L0K A;  1ANI A;  3KD8 A;  1ED8 A;  4NWX A;  1EI6 A;  1EW9 A;  4UOR A;  1K7H A;  3M8Y A;  4KJD A;  5EGE A;  5KXA A;  1ED9 A;  3WAV A;  1HDH A;  3MK2 A;  3OT9 A;  5AJ9 A;  5INH A;  1E1Z P;  1HQA A;  2GLQ A;  1ZEF A;  4KAV A;  3WBH A;  3DPC A;  1KH7 A;  3DYC A;  3E2D A;  4ZG6 A;  3LXQ A;  1ZED A;  1EQJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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