3CMRA

E. coli alkaline phosphatase mutant r166s in complex with phosphate
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 164
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3cmrA00
3M7VA 3DYCA 4KAVA 4LR2A 4GTXA 1AJBA 4TN0A 2ZKTA 1Y6VA 1ELYA 3SZYA 3WAXA 5IJSA 1AJDA 4LR7A 4NWXA 4ZG6A 1ALHA 2W5VA 1HDHA 2W5TA 3T02A 3WBHA 4LRFA 3NKQA 2IUCA 3MK1A 1AUKA 3NKOA 4FDIA 2W5WA 1ZEDA 2GSNA 3Q3QA 4GTYA 3BDFA 4YR1A 3T01A 2RH6A 2D1GA 4ZG7A 4CXUA 4LRAA 5EGEA 5C66A 5EGHA 1ED9A 4LRDA 1KHNA 5TJ3A 3WAWA 1EJJA 3M8YA 4LR9A 3UN5A 4CXKA 3UN2A 1ED8A 4GTWA 3M8ZA 4NWJA 1SHQA 1URBA 1EQJA 1KH9A 5K4PA 1EW2A 1N2KA 3MK2A 5LIAA 3WAVA 4ZGAA 1Y7AA 3DPCA 5GRRA 1N2LA 4UPKA 1ELZA 3BDGB 1KHKA 4B56A 3UN3A 1E33P 3OT9A 2GA3A 3IGZB 3M8WA 4UPIA 4CYSA 3WAYA 4LRBA 1O98A 1KHLA 3CMRA 2VQRA 3B5QA 4QAXA 1URAA 4LRCA 2ANHA 5L0EA 3E2DA 2W5SA 4UPHA 1ANJA 1ALKA 5GOVA 1ZEBA 4UOPA 5DLTA 2W5RA 4CYRA 1K7HA 5DLVA 1FSUA 4UPLA 3SZZA 1EW9A 1EW8A 3NKRA 2IUCB 3KD8A 4UOOA 2XR9A 5LRMA 2W5QA 2GLQA 1HJKA 3ED4A 3UO0A 4FDJA 2IFYA 3TWZA 4LREA 4ZG9A 1E1ZP 4MY4A 5LQQA 3TX0A 1ELXA 2W8SA 3TG0A 5L0BA 3NKMA 1E3CP 4MHXA 3LXQA 4LQYA 1AJAA 1KHJA 5DLWA 5LRNA 1ZEFA 2QZUA 1KH7A 4KJGA 4MIVA 1ALIA 1AJCA 2W5XA 5L0KA 4KAYA 1O99A 1ANIA 1B8JA 5IJQA 3BDHA 3UNYA 1KH5A 5AJ9A 3NKPA 5KXAA 4N7TA 4CXSA 3NKNA 3IDDA 2GSUA 3IGYB 1ALJA 2GSOA 3BDGA 5INHA 2XRGA 3MK0A 4LR8A 5HRTA 4UORA 1EI6A 4GTZA 1P49A 4KM4A 1KH4A 3T00A 2X98A 3A52A 4KJDA 1SHNA 1E2SP 1HQAA 3NVLA 2G9YA 2W8DA
chains in the Genus database with same CATH superfamily
3M7VA 3DYCA 4KAVA 4LR2A 4GTXA 1AJBA 4TN0A 2ZKTA 1Y6VA 1ELYA 3SZYA 3WAXA 5IJSA 1AJDA 4LR7A 4NWXA 4ZG6A 1ALHA 2W5VA 1HDHA 2W5TA 3T02A 3WBHA 4LRFA 3NKQA 2IUCA 3MK1A 1AUKA 3NKOA 4FDIA 2W5WA 1ZEDA 2GSNA 3Q3QA 4GTYA 3BDFA 4YR1A 3T01A 2RH6A 2D1GA 4ZG7A 4CXUA 4LRAA 5EGEA 5C66A 5EGHA 1ED9A 4LRDA 1KHNA 5TJ3A 3WAWA 1EJJA 3M8YA 4LR9A 3UN5A 4CXKA 3UN2A 1ED8A 4GTWA 3M8ZA 4NWJA 1SHQA 1URBA 1EQJA 1KH9A 5K4PA 1EW2A 1N2KA 3MK2A 5LIAA 3WAVA 4ZGAA 1Y7AA 3DPCA 5GRRA 1N2LA 4UPKA 1ELZA 3BDGB 1KHKA 4B56A 3UN3A 1E33P 3OT9A 2GA3A 3IGZB 3M8WA 4UPIA 4CYSA 3WAYA 4LRBA 1O98A 1KHLA 3CMRA 2VQRA 3B5QA 4QAXA 1URAA 4LRCA 2ANHA 5L0EA 3E2DA 2W5SA 4UPHA 1ANJA 1ALKA 5GOVA 1ZEBA 4UOPA 5DLTA 2W5RA 4CYRA 1K7HA 5DLVA 1FSUA 4UPLA 3SZZA 1EW9A 1EW8A 3NKRA 2IUCB 3KD8A 4UOOA 2XR9A 5LRMA 2W5QA 2GLQA 1HJKA 3ED4A 3UO0A 4FDJA 2IFYA 3TWZA 4LREA 4ZG9A 1E1ZP 4MY4A 5LQQA 3TX0A 1ELXA 2W8SA 3TG0A 5L0BA 3NKMA 1E3CP 4MHXA 3LXQA 4LQYA 1AJAA 1KHJA 5DLWA 5LRNA 1ZEFA 2QZUA 1KH7A 4KJGA 4MIVA 1ALIA 1AJCA 2W5XA 5L0KA 4KAYA 1O99A 1ANIA 1B8JA 5IJQA 3BDHA 3UNYA 1KH5A 5AJ9A 3NKPA 5KXAA 4N7TA 4CXSA 3NKNA 3IDDA 2GSUA 3IGYB 1ALJA 2GSOA 3BDGA 5INHA 2XRGA 3MK0A 4LR8A 5HRTA 4UORA 1EI6A 4GTZA 1P49A 4KM4A 1KH4A 3T00A 2X98A 3A52A 4KJDA 1SHNA 1E2SP 1HQAA 3NVLA 2G9YA 2W8DA
chains in the Genus database with same CATH topology
3M7VA 3DYCA 4KAVA 4LR2A 4GTXA 1AJBA 4TN0A 2ZKTA 1Y6VA 1ELYA 3SZYA 3WAXA 5IJSA 1AJDA 4LR7A 4NWXA 4ZG6A 1ALHA 2W5VA 1HDHA 2W5TA 3T02A 3WBHA 4LRFA 3NKQA 2IUCA 3MK1A 1AUKA 3NKOA 4FDIA 2W5WA 1ZEDA 2GSNA 3Q3QA 4GTYA 3BDFA 4YR1A 3T01A 2RH6A 2D1GA 4ZG7A 4CXUA 4LRAA 5EGEA 5C66A 5EGHA 1ED9A 4LRDA 1KHNA 5TJ3A 3WAWA 1EJJA 3M8YA 4LR9A 3UN5A 4CXKA 3UN2A 1ED8A 4GTWA 3M8ZA 4NWJA 1SHQA 1URBA 1EQJA 1KH9A 5K4PA 1EW2A 1N2KA 3MK2A 5LIAA 3WAVA 4ZGAA 1Y7AA 3DPCA 5GRRA 1N2LA 4UPKA 1ELZA 3BDGB 1KHKA 4B56A 3UN3A 1E33P 3OT9A 2GA3A 3IGZB 3M8WA 4UPIA 4CYSA 3WAYA 4LRBA 1O98A 1KHLA 3CMRA 2VQRA 3B5QA 4QAXA 1URAA 4LRCA 2ANHA 5L0EA 3E2DA 2W5SA 4UPHA 1ANJA 1ALKA 5GOVA 1ZEBA 4UOPA 5DLTA 2W5RA 4CYRA 1K7HA 5DLVA 1FSUA 4UPLA 3SZZA 1EW9A 1EW8A 3NKRA 2IUCB 3KD8A 4UOOA 2XR9A 5LRMA 2W5QA 2GLQA 1HJKA 3ED4A 3UO0A 4FDJA 2IFYA 3TWZA 4LREA 4ZG9A 1E1ZP 4MY4A 5LQQA 3TX0A 1ELXA 2W8SA 3TG0A 5L0BA 3NKMA 1E3CP 4MHXA 3LXQA 4LQYA 1AJAA 1KHJA 5DLWA 5LRNA 1ZEFA 2QZUA 1KH7A 4KJGA 4MIVA 1ALIA 1AJCA 2W5XA 5L0KA 4KAYA 1O99A 1ANIA 1B8JA 5IJQA 3BDHA 3UNYA 1KH5A 5AJ9A 3NKPA 5KXAA 4N7TA 4CXSA 3NKNA 3IDDA 2GSUA 3IGYB 1ALJA 2GSOA 3BDGA 5INHA 2XRGA 3MK0A 4LR8A 5HRTA 4UORA 1EI6A 4GTZA 1P49A 4KM4A 1KH4A 3T00A 2X98A 3A52A 4KJDA 1SHNA 1E2SP 1HQAA 3NVLA 2G9YA 2W8DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M7V A;  3DYC A;  4KAV A;  4LR2 A;  4GTX A;  1AJB A;  4TN0 A;  2ZKT A;  1Y6V A;  1ELY A;  3SZY A;  3WAX A;  5IJS A;  1AJD A;  4LR7 A;  4NWX A;  4ZG6 A;  1ALH A;  2W5V A;  1HDH A;  2W5T A;  3T02 A;  3WBH A;  4LRF A;  3NKQ A;  2IUC A;  3MK1 A;  1AUK A;  3NKO A;  4FDI A;  2W5W A;  1ZED A;  2GSN A;  3Q3Q A;  4GTY A;  3BDF A;  4YR1 A;  3T01 A;  2RH6 A;  2D1G A;  4ZG7 A;  4CXU A;  4LRA A;  5EGE A;  5C66 A;  5EGH A;  1ED9 A;  4LRD A;  1KHN A;  5TJ3 A;  3WAW A;  1EJJ A;  3M8Y A;  4LR9 A;  3UN5 A;  4CXK A;  3UN2 A;  1ED8 A;  4GTW A;  3M8Z A;  4NWJ A;  1SHQ A;  1URB A;  1EQJ A;  1KH9 A;  5K4P A;  1EW2 A;  1N2K A;  3MK2 A;  5LIA A;  3WAV A;  4ZGA A;  1Y7A A;  3DPC A;  5GRR A;  1N2L A;  4UPK A;  1ELZ A;  3BDG B;  1KHK A;  4B56 A;  3UN3 A;  1E33 P;  3OT9 A;  2GA3 A;  3IGZ B;  3M8W A;  4UPI A;  4CYS A;  3WAY A;  4LRB A;  1O98 A;  1KHL A;  3CMR A;  2VQR A;  3B5Q A;  4QAX A;  1URA A;  4LRC A;  2ANH A;  5L0E A;  3E2D A;  2W5S A;  4UPH A;  1ANJ A;  1ALK A;  5GOV A;  1ZEB A;  4UOP A;  5DLT A;  2W5R A;  4CYR A;  1K7H A;  5DLV A;  1FSU A;  4UPL A;  3SZZ A;  1EW9 A;  1EW8 A;  3NKR A;  2IUC B;  3KD8 A;  4UOO A;  2XR9 A;  5LRM A;  2W5Q A;  2GLQ A;  1HJK A;  3ED4 A;  3UO0 A;  4FDJ A;  2IFY A;  3TWZ A;  4LRE A;  4ZG9 A;  1E1Z P;  4MY4 A;  5LQQ A;  3TX0 A;  1ELX A;  2W8S A;  3TG0 A;  5L0B A;  3NKM A;  1E3C P;  4MHX A;  3LXQ A;  4LQY A;  1AJA A;  1KHJ A;  5DLW A;  5LRN A;  1ZEF A;  2QZU A;  1KH7 A;  4KJG A;  4MIV A;  1ALI A;  1AJC A;  2W5X A;  5L0K A;  4KAY A;  1O99 A;  1ANI A;  1B8J A;  5IJQ A;  3BDH A;  3UNY A;  1KH5 A;  5AJ9 A;  3NKP A;  5KXA A;  4N7T A;  4CXS A;  3NKN A;  3IDD A;  2GSU A;  3IGY B;  1ALJ A;  2GSO A;  3BDG A;  5INH A;  2XRG A;  3MK0 A;  4LR8 A;  5HRT A;  4UOR A;  1EI6 A;  4GTZ A;  1P49 A;  4KM4 A;  1KH4 A;  3T00 A;  2X98 A;  3A52 A;  4KJD A;  1SHN A;  1E2S P;  1HQA A;  3NVL A;  2G9Y A;  2W8D A; 
#chains in the Genus database with same CATH topology
 3M7V A;  3DYC A;  4KAV A;  4LR2 A;  4GTX A;  1AJB A;  4TN0 A;  2ZKT A;  1Y6V A;  1ELY A;  3SZY A;  3WAX A;  5IJS A;  1AJD A;  4LR7 A;  4NWX A;  4ZG6 A;  1ALH A;  2W5V A;  1HDH A;  2W5T A;  3T02 A;  3WBH A;  4LRF A;  3NKQ A;  2IUC A;  3MK1 A;  1AUK A;  3NKO A;  4FDI A;  2W5W A;  1ZED A;  2GSN A;  3Q3Q A;  4GTY A;  3BDF A;  4YR1 A;  3T01 A;  2RH6 A;  2D1G A;  4ZG7 A;  4CXU A;  4LRA A;  5EGE A;  5C66 A;  5EGH A;  1ED9 A;  4LRD A;  1KHN A;  5TJ3 A;  3WAW A;  1EJJ A;  3M8Y A;  4LR9 A;  3UN5 A;  4CXK A;  3UN2 A;  1ED8 A;  4GTW A;  3M8Z A;  4NWJ A;  1SHQ A;  1URB A;  1EQJ A;  1KH9 A;  5K4P A;  1EW2 A;  1N2K A;  3MK2 A;  5LIA A;  3WAV A;  4ZGA A;  1Y7A A;  3DPC A;  5GRR A;  1N2L A;  4UPK A;  1ELZ A;  3BDG B;  1KHK A;  4B56 A;  3UN3 A;  1E33 P;  3OT9 A;  2GA3 A;  3IGZ B;  3M8W A;  4UPI A;  4CYS A;  3WAY A;  4LRB A;  1O98 A;  1KHL A;  3CMR A;  2VQR A;  3B5Q A;  4QAX A;  1URA A;  4LRC A;  2ANH A;  5L0E A;  3E2D A;  2W5S A;  4UPH A;  1ANJ A;  1ALK A;  5GOV A;  1ZEB A;  4UOP A;  5DLT A;  2W5R A;  4CYR A;  1K7H A;  5DLV A;  1FSU A;  4UPL A;  3SZZ A;  1EW9 A;  1EW8 A;  3NKR A;  2IUC B;  3KD8 A;  4UOO A;  2XR9 A;  5LRM A;  2W5Q A;  2GLQ A;  1HJK A;  3ED4 A;  3UO0 A;  4FDJ A;  2IFY A;  3TWZ A;  4LRE A;  4ZG9 A;  1E1Z P;  4MY4 A;  5LQQ A;  3TX0 A;  1ELX A;  2W8S A;  3TG0 A;  5L0B A;  3NKM A;  1E3C P;  4MHX A;  3LXQ A;  4LQY A;  1AJA A;  1KHJ A;  5DLW A;  5LRN A;  1ZEF A;  2QZU A;  1KH7 A;  4KJG A;  4MIV A;  1ALI A;  1AJC A;  2W5X A;  5L0K A;  4KAY A;  1O99 A;  1ANI A;  1B8J A;  5IJQ A;  3BDH A;  3UNY A;  1KH5 A;  5AJ9 A;  3NKP A;  5KXA A;  4N7T A;  4CXS A;  3NKN A;  3IDD A;  2GSU A;  3IGY B;  1ALJ A;  2GSO A;  3BDG A;  5INH A;  2XRG A;  3MK0 A;  4LR8 A;  5HRT A;  4UOR A;  1EI6 A;  4GTZ A;  1P49 A;  4KM4 A;  1KH4 A;  3T00 A;  2X98 A;  3A52 A;  4KJD A;  1SHN A;  1E2S P;  1HQA A;  3NVL A;  2G9Y A;  2W8D A; 
#chains in the Genus database with same CATH homology
 3M7V A;  3DYC A;  4KAV A;  4LR2 A;  4GTX A;  1AJB A;  4TN0 A;  2ZKT A;  1Y6V A;  1ELY A;  3SZY A;  3WAX A;  5IJS A;  1AJD A;  4LR7 A;  4NWX A;  4ZG6 A;  1ALH A;  2W5V A;  1HDH A;  2W5T A;  3T02 A;  3WBH A;  4LRF A;  3NKQ A;  2IUC A;  3MK1 A;  1AUK A;  3NKO A;  4FDI A;  2W5W A;  1ZED A;  2GSN A;  3Q3Q A;  4GTY A;  3BDF A;  4YR1 A;  3T01 A;  2RH6 A;  2D1G A;  4ZG7 A;  4CXU A;  4LRA A;  5EGE A;  5C66 A;  5EGH A;  1ED9 A;  4LRD A;  1KHN A;  5TJ3 A;  3WAW A;  1EJJ A;  3M8Y A;  4LR9 A;  3UN5 A;  4CXK A;  3UN2 A;  1ED8 A;  4GTW A;  3M8Z A;  4NWJ A;  1SHQ A;  1URB A;  1EQJ A;  1KH9 A;  5K4P A;  1EW2 A;  1N2K A;  3MK2 A;  5LIA A;  3WAV A;  4ZGA A;  1Y7A A;  3DPC A;  5GRR A;  1N2L A;  4UPK A;  1ELZ A;  3BDG B;  1KHK A;  4B56 A;  3UN3 A;  1E33 P;  3OT9 A;  2GA3 A;  3IGZ B;  3M8W A;  4UPI A;  4CYS A;  3WAY A;  4LRB A;  1O98 A;  1KHL A;  3CMR A;  2VQR A;  3B5Q A;  4QAX A;  1URA A;  4LRC A;  2ANH A;  5L0E A;  3E2D A;  2W5S A;  4UPH A;  1ANJ A;  1ALK A;  5GOV A;  1ZEB A;  4UOP A;  5DLT A;  2W5R A;  4CYR A;  1K7H A;  5DLV A;  1FSU A;  4UPL A;  3SZZ A;  1EW9 A;  1EW8 A;  3NKR A;  2IUC B;  3KD8 A;  4UOO A;  2XR9 A;  5LRM A;  2W5Q A;  2GLQ A;  1HJK A;  3ED4 A;  3UO0 A;  4FDJ A;  2IFY A;  3TWZ A;  4LRE A;  4ZG9 A;  1E1Z P;  4MY4 A;  5LQQ A;  3TX0 A;  1ELX A;  2W8S A;  3TG0 A;  5L0B A;  3NKM A;  1E3C P;  4MHX A;  3LXQ A;  4LQY A;  1AJA A;  1KHJ A;  5DLW A;  5LRN A;  1ZEF A;  2QZU A;  1KH7 A;  4KJG A;  4MIV A;  1ALI A;  1AJC A;  2W5X A;  5L0K A;  4KAY A;  1O99 A;  1ANI A;  1B8J A;  5IJQ A;  3BDH A;  3UNY A;  1KH5 A;  5AJ9 A;  3NKP A;  5KXA A;  4N7T A;  4CXS A;  3NKN A;  3IDD A;  2GSU A;  3IGY B;  1ALJ A;  2GSO A;  3BDG A;  5INH A;  2XRG A;  3MK0 A;  4LR8 A;  5HRT A;  4UOR A;  1EI6 A;  4GTZ A;  1P49 A;  4KM4 A;  1KH4 A;  3T00 A;  2X98 A;  3A52 A;  4KJD A;  1SHN A;  1E2S P;  1HQA A;  3NVL A;  2G9Y A;  2W8D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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