3IGYB

Crystal structures of leishmania mexicana phosphoglycerate mutase at high cobalt concentrations
Total Genus 205
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
205
Knots found
sequence length
549
structure length
549
Chain Sequence
LLLKPHKDLPRRTVLIVVMDGLGIGPEDDYDAVHMASTPFMDAHRRDNRHFRCVRAHGTAVGLPTDADMGNSEVGHNALGAGRVALQGASLVDDAIKSGEIYTGEGYRYLHGAFSKEGSTLHLIGLLSDGGVHSRDNQIYSIIEHAVKDGAKRIRVHALYDGRDVPDGSSFRFTDELEAVLAKVRQNGCDAAIASGGGRMFVTMDRYDADWSIVERGWRAQVLGDARHFHSAKEAITTFREEDPKVTDQYYPPFIVVDEQDKPLGTIEDGDAVLCVNFRGDRVIEMTRAFEDEDFNKFDRVRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNIFACSETQKFGHVTYFWNGNRSGKIDEKHETFKEVPSDRVQFNEKPRMQSAAITEAAIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGVEAVDESLAKLKDAVDSVNGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTSHTLSPVPVFIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPEDYEPSLIYVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Cofactor-independent phosphoglycerate mutase
publication title Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
pubmed doi rcsb
source organism Leishmania mexicana
molecule tags Isomerase
total genus 205
structure length 549
sequence length 549
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.1: Transferred entry: 5.4.2.11 and 5.4.2.12.
pdb deposition date 2009-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01676 Metalloenzyme Metalloenzyme superfamily
B PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3igyB01
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 3igyB02
4KAVA 3SZYA 2GLQA 1KH7A 3T02A 3WAXA 5LIAA 3NKQA 1Y7AA 1SHQA 1KHJA 4NWJA 3MK0A 5L0EA 1Y6VA 5GRRA 3NKOA 4LRBA 1SHNA 1O99A 1KHKA 1KH5A 1N2LA 3BDGA 4ZG6A 1AUKA 1AJCA 3M8YA 1ELYA 4LR2A 5GOVA 1N2KA 4LREA 2XRGA 5HRTA 2ANHA 1B8JA 4LRDA 2XR9A 2RH6A 5L0BA 5TJ3A 3TX0A 4NWXA 4UPHA 2W5RA 1URAA 4MHXA 4N7TA 1KHNA 3UNYA 3LXQA 4CYRA 1HJKA 2W5WA 2W5XA 4KJGA 4KM4A 5IJSA 2D1GA 4LRCA 2IFYA 2GSOA 1URBA 2GSUA 2QZUA 1ALIA 4ZGAA 2W5TA 3M8ZA 1AJDA 1O98A 1KH9A 3IGZB 4LQYA 4FDJA 3MK2A 5LRMA 5K4PA 5AJ9A 4GTXA 2GSNA 1KHLA 3NKNA 1ALKA 1HQAA 3UN5A 2W8DA 5IJQA 3NKPA 3UN3A 3WBHA 1EW9A 4CXKA 3MK1A 3DPCA 4MY4A 1HDHA 3IDDA 4UPKA 5DLVA 1E33P 4CXSA 4UPLA 4LR9A 2W8SA 5LRNA 4UPIA 3BDGB 2W5QA 3T00A 3BDFA 4LRFA 1E2SP 4FDIA 3UO0A 5EGEA 4CYSA 4LR7A 3TWZA 1ED8A 1P49A 2GA3A 3T01A 4UOOA 1ELZA 1ALJA 4KJDA 4TN0A 4QAXA 5DLTA 5L0KA 2VQRA 3KD8A 5C66A 1EW2A 2W5SA 1ED9A 2ZKTA 4ZG7A 1ANIA 1FSUA 4GTWA 4MIVA 5LQQA 1EI6A 1AJBA 1E1ZP 3ED4A 4YR1A 3Q3QA 4KAYA 1E3CP 3WAWA 3M7VA 4CXUA 1ZEDA 1KH4A 3DYCA 3UN2A 3WAVA 3WAYA 3OT9A 1ANJA 1AJAA 1ALHA 3M8WA 3CMRA 2G9YA 1EQJA 2IUCA 3BDHA 1ZEBA 3NVLA 4ZG9A 3SZZA 5INHA 2W5VA 5KXAA 4UOPA 4GTYA 2IUCB 3NKMA 1K7HA 4UORA 3IGYB 1ELXA 4LR8A 3E2DA 1ZEFA 1EW8A 1EJJA 2X98A 4GTZA 4B56A 3TG0A 3NKRA 5EGHA 3B5QA 5DLWA 4LRAA 3A52A
chains in the Genus database with same CATH superfamily
4KAVA 3SZYA 2GLQA 1KH7A 3T02A 3WAXA 5LIAA 3NKQA 1Y7AA 1SHQA 1KHJA 4NWJA 3MK0A 5L0EA 1Y6VA 5GRRA 3NKOA 4LRBA 1SHNA 1O99A 1KHKA 1KH5A 1N2LA 3BDGA 4ZG6A 1AUKA 1AJCA 3M8YA 1ELYA 4LR2A 5GOVA 1N2KA 4LREA 2XRGA 5HRTA 2ANHA 1B8JA 4LRDA 2XR9A 2RH6A 5L0BA 5TJ3A 3TX0A 4NWXA 4UPHA 2W5RA 1URAA 4MHXA 4N7TA 1KHNA 3UNYA 3LXQA 4CYRA 1HJKA 2W5WA 2W5XA 4KJGA 4KM4A 5IJSA 2D1GA 4LRCA 2IFYA 2GSOA 1URBA 2GSUA 2QZUA 1ALIA 4ZGAA 2W5TA 3M8ZA 1AJDA 1O98A 1KH9A 3IGZB 4LQYA 4FDJA 3MK2A 5LRMA 5K4PA 5AJ9A 4GTXA 2GSNA 1KHLA 3NKNA 1ALKA 1HQAA 3UN5A 2W8DA 5IJQA 3NKPA 3UN3A 3WBHA 1EW9A 4CXKA 3MK1A 3DPCA 4MY4A 1HDHA 3IDDA 4UPKA 5DLVA 1E33P 4CXSA 4UPLA 4LR9A 2W8SA 5LRNA 4UPIA 3BDGB 2W5QA 3T00A 3BDFA 4LRFA 1E2SP 4FDIA 3UO0A 5EGEA 4CYSA 4LR7A 3TWZA 1ED8A 1P49A 2GA3A 3T01A 4UOOA 1ELZA 1ALJA 4KJDA 4TN0A 4QAXA 5DLTA 5L0KA 2VQRA 3KD8A 5C66A 1EW2A 2W5SA 1ED9A 2ZKTA 4ZG7A 1ANIA 1FSUA 4GTWA 4MIVA 5LQQA 1EI6A 1AJBA 1E1ZP 3ED4A 4YR1A 3Q3QA 4KAYA 1E3CP 3WAWA 3M7VA 4CXUA 1ZEDA 1KH4A 3DYCA 3UN2A 3WAVA 3WAYA 3OT9A 1ANJA 1AJAA 1ALHA 3M8WA 3CMRA 2G9YA 1EQJA 2IUCA 3BDHA 1ZEBA 3NVLA 4ZG9A 3SZZA 5INHA 2W5VA 5KXAA 4UOPA 4GTYA 2IUCB 3NKMA 1K7HA 4UORA 3IGYB 1ELXA 4LR8A 3E2DA 1ZEFA 1EW8A 1EJJA 2X98A 4GTZA 4B56A 3TG0A 3NKRA 5EGHA 3B5QA 5DLWA 4LRAA 3A52A
chains in the Genus database with same CATH topology
4KAVA 3SZYA 2GLQA 1KH7A 3T02A 3WAXA 5LIAA 3NKQA 1Y7AA 1SHQA 1KHJA 4NWJA 3MK0A 5L0EA 1Y6VA 5GRRA 3NKOA 4LRBA 1SHNA 1O99A 1KHKA 1KH5A 1N2LA 3BDGA 4ZG6A 1AUKA 1AJCA 3M8YA 1ELYA 4LR2A 5GOVA 1N2KA 4LREA 2XRGA 5HRTA 2ANHA 1B8JA 4LRDA 2XR9A 2RH6A 5L0BA 5TJ3A 3TX0A 4NWXA 4UPHA 2W5RA 1URAA 4MHXA 4N7TA 1KHNA 3UNYA 3LXQA 4CYRA 1HJKA 2W5WA 2W5XA 4KJGA 4KM4A 5IJSA 2D1GA 4LRCA 2IFYA 2GSOA 1URBA 2GSUA 2QZUA 1ALIA 4ZGAA 2W5TA 3M8ZA 1AJDA 1O98A 1KH9A 3IGZB 4LQYA 4FDJA 3MK2A 5LRMA 5K4PA 5AJ9A 4GTXA 2GSNA 1KHLA 3NKNA 1ALKA 1HQAA 3UN5A 2W8DA 5IJQA 3NKPA 3UN3A 3WBHA 1EW9A 4CXKA 3MK1A 3DPCA 4MY4A 1HDHA 3IDDA 4UPKA 5DLVA 1E33P 4CXSA 4UPLA 4LR9A 2W8SA 5LRNA 4UPIA 3BDGB 2W5QA 3T00A 3BDFA 4LRFA 1E2SP 4FDIA 3UO0A 5EGEA 4CYSA 4LR7A 3TWZA 1ED8A 1P49A 2GA3A 3T01A 4UOOA 1ELZA 1ALJA 4KJDA 4TN0A 4QAXA 5DLTA 5L0KA 2VQRA 3KD8A 5C66A 1EW2A 2W5SA 1ED9A 2ZKTA 4ZG7A 1ANIA 1FSUA 4GTWA 4MIVA 5LQQA 1EI6A 1AJBA 1E1ZP 3ED4A 4YR1A 3Q3QA 4KAYA 1E3CP 3WAWA 3M7VA 4CXUA 1ZEDA 1KH4A 3DYCA 3UN2A 3WAVA 3WAYA 3OT9A 1ANJA 1AJAA 1ALHA 3M8WA 3CMRA 2G9YA 1EQJA 2IUCA 3BDHA 1ZEBA 3NVLA 4ZG9A 3SZZA 5INHA 2W5VA 5KXAA 4UOPA 4GTYA 2IUCB 3NKMA 1K7HA 4UORA 3IGYB 1ELXA 4LR8A 3E2DA 1ZEFA 1EW8A 1EJJA 2X98A 4GTZA 4B56A 3TG0A 3NKRA 5EGHA 3B5QA 5DLWA 4LRAA 3A52A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KAV A;  3SZY A;  2GLQ A;  1KH7 A;  3T02 A;  3WAX A;  5LIA A;  3NKQ A;  1Y7A A;  1SHQ A;  1KHJ A;  4NWJ A;  3MK0 A;  5L0E A;  1Y6V A;  5GRR A;  3NKO A;  4LRB A;  1SHN A;  1O99 A;  1KHK A;  1KH5 A;  1N2L A;  3BDG A;  4ZG6 A;  1AUK A;  1AJC A;  3M8Y A;  1ELY A;  4LR2 A;  5GOV A;  1N2K A;  4LRE A;  2XRG A;  5HRT A;  2ANH A;  1B8J A;  4LRD A;  2XR9 A;  2RH6 A;  5L0B A;  5TJ3 A;  3TX0 A;  4NWX A;  4UPH A;  2W5R A;  1URA A;  4MHX A;  4N7T A;  1KHN A;  3UNY A;  3LXQ A;  4CYR A;  1HJK A;  2W5W A;  2W5X A;  4KJG A;  4KM4 A;  5IJS A;  2D1G A;  4LRC A;  2IFY A;  2GSO A;  1URB A;  2GSU A;  2QZU A;  1ALI A;  4ZGA A;  2W5T A;  3M8Z A;  1AJD A;  1O98 A;  1KH9 A;  3IGZ B;  4LQY A;  4FDJ A;  3MK2 A;  5LRM A;  5K4P A;  5AJ9 A;  4GTX A;  2GSN A;  1KHL A;  3NKN A;  1ALK A;  1HQA A;  3UN5 A;  2W8D A;  5IJQ A;  3NKP A;  3UN3 A;  3WBH A;  1EW9 A;  4CXK A;  3MK1 A;  3DPC A;  4MY4 A;  1HDH A;  3IDD A;  4UPK A;  5DLV A;  1E33 P;  4CXS A;  4UPL A;  4LR9 A;  2W8S A;  5LRN A;  4UPI A;  3BDG B;  2W5Q A;  3T00 A;  3BDF A;  4LRF A;  1E2S P;  4FDI A;  3UO0 A;  5EGE A;  4CYS A;  4LR7 A;  3TWZ A;  1ED8 A;  1P49 A;  2GA3 A;  3T01 A;  4UOO A;  1ELZ A;  1ALJ A;  4KJD A;  4TN0 A;  4QAX A;  5DLT A;  5L0K A;  2VQR A;  3KD8 A;  5C66 A;  1EW2 A;  2W5S A;  1ED9 A;  2ZKT A;  4ZG7 A;  1ANI A;  1FSU A;  4GTW A;  4MIV A;  5LQQ A;  1EI6 A;  1AJB A;  1E1Z P;  3ED4 A;  4YR1 A;  3Q3Q A;  4KAY A;  1E3C P;  3WAW A;  3M7V A;  4CXU A;  1ZED A;  1KH4 A;  3DYC A;  3UN2 A;  3WAV A;  3WAY A;  3OT9 A;  1ANJ A;  1AJA A;  1ALH A;  3M8W A;  3CMR A;  2G9Y A;  1EQJ A;  2IUC A;  3BDH A;  1ZEB A;  3NVL A;  4ZG9 A;  3SZZ A;  5INH A;  2W5V A;  5KXA A;  4UOP A;  4GTY A;  2IUC B;  3NKM A;  1K7H A;  4UOR A;  3IGY B;  1ELX A;  4LR8 A;  3E2D A;  1ZEF A;  1EW8 A;  1EJJ A;  2X98 A;  4GTZ A;  4B56 A;  3TG0 A;  3NKR A;  5EGH A;  3B5Q A;  5DLW A;  4LRA A;  3A52 A; 
#chains in the Genus database with same CATH topology
 4KAV A;  3SZY A;  2GLQ A;  1KH7 A;  3T02 A;  3WAX A;  5LIA A;  3NKQ A;  1Y7A A;  1SHQ A;  1KHJ A;  4NWJ A;  3MK0 A;  5L0E A;  1Y6V A;  5GRR A;  3NKO A;  4LRB A;  1SHN A;  1O99 A;  1KHK A;  1KH5 A;  1N2L A;  3BDG A;  4ZG6 A;  1AUK A;  1AJC A;  3M8Y A;  1ELY A;  4LR2 A;  5GOV A;  1N2K A;  4LRE A;  2XRG A;  5HRT A;  2ANH A;  1B8J A;  4LRD A;  2XR9 A;  2RH6 A;  5L0B A;  5TJ3 A;  3TX0 A;  4NWX A;  4UPH A;  2W5R A;  1URA A;  4MHX A;  4N7T A;  1KHN A;  3UNY A;  3LXQ A;  4CYR A;  1HJK A;  2W5W A;  2W5X A;  4KJG A;  4KM4 A;  5IJS A;  2D1G A;  4LRC A;  2IFY A;  2GSO A;  1URB A;  2GSU A;  2QZU A;  1ALI A;  4ZGA A;  2W5T A;  3M8Z A;  1AJD A;  1O98 A;  1KH9 A;  3IGZ B;  4LQY A;  4FDJ A;  3MK2 A;  5LRM A;  5K4P A;  5AJ9 A;  4GTX A;  2GSN A;  1KHL A;  3NKN A;  1ALK A;  1HQA A;  3UN5 A;  2W8D A;  5IJQ A;  3NKP A;  3UN3 A;  3WBH A;  1EW9 A;  4CXK A;  3MK1 A;  3DPC A;  4MY4 A;  1HDH A;  3IDD A;  4UPK A;  5DLV A;  1E33 P;  4CXS A;  4UPL A;  4LR9 A;  2W8S A;  5LRN A;  4UPI A;  3BDG B;  2W5Q A;  3T00 A;  3BDF A;  4LRF A;  1E2S P;  4FDI A;  3UO0 A;  5EGE A;  4CYS A;  4LR7 A;  3TWZ A;  1ED8 A;  1P49 A;  2GA3 A;  3T01 A;  4UOO A;  1ELZ A;  1ALJ A;  4KJD A;  4TN0 A;  4QAX A;  5DLT A;  5L0K A;  2VQR A;  3KD8 A;  5C66 A;  1EW2 A;  2W5S A;  1ED9 A;  2ZKT A;  4ZG7 A;  1ANI A;  1FSU A;  4GTW A;  4MIV A;  5LQQ A;  1EI6 A;  1AJB A;  1E1Z P;  3ED4 A;  4YR1 A;  3Q3Q A;  4KAY A;  1E3C P;  3WAW A;  3M7V A;  4CXU A;  1ZED A;  1KH4 A;  3DYC A;  3UN2 A;  3WAV A;  3WAY A;  3OT9 A;  1ANJ A;  1AJA A;  1ALH A;  3M8W A;  3CMR A;  2G9Y A;  1EQJ A;  2IUC A;  3BDH A;  1ZEB A;  3NVL A;  4ZG9 A;  3SZZ A;  5INH A;  2W5V A;  5KXA A;  4UOP A;  4GTY A;  2IUC B;  3NKM A;  1K7H A;  4UOR A;  3IGY B;  1ELX A;  4LR8 A;  3E2D A;  1ZEF A;  1EW8 A;  1EJJ A;  2X98 A;  4GTZ A;  4B56 A;  3TG0 A;  3NKR A;  5EGH A;  3B5Q A;  5DLW A;  4LRA A;  3A52 A; 
#chains in the Genus database with same CATH homology
 4KAV A;  3SZY A;  2GLQ A;  1KH7 A;  3T02 A;  3WAX A;  5LIA A;  3NKQ A;  1Y7A A;  1SHQ A;  1KHJ A;  4NWJ A;  3MK0 A;  5L0E A;  1Y6V A;  5GRR A;  3NKO A;  4LRB A;  1SHN A;  1O99 A;  1KHK A;  1KH5 A;  1N2L A;  3BDG A;  4ZG6 A;  1AUK A;  1AJC A;  3M8Y A;  1ELY A;  4LR2 A;  5GOV A;  1N2K A;  4LRE A;  2XRG A;  5HRT A;  2ANH A;  1B8J A;  4LRD A;  2XR9 A;  2RH6 A;  5L0B A;  5TJ3 A;  3TX0 A;  4NWX A;  4UPH A;  2W5R A;  1URA A;  4MHX A;  4N7T A;  1KHN A;  3UNY A;  3LXQ A;  4CYR A;  1HJK A;  2W5W A;  2W5X A;  4KJG A;  4KM4 A;  5IJS A;  2D1G A;  4LRC A;  2IFY A;  2GSO A;  1URB A;  2GSU A;  2QZU A;  1ALI A;  4ZGA A;  2W5T A;  3M8Z A;  1AJD A;  1O98 A;  1KH9 A;  3IGZ B;  4LQY A;  4FDJ A;  3MK2 A;  5LRM A;  5K4P A;  5AJ9 A;  4GTX A;  2GSN A;  1KHL A;  3NKN A;  1ALK A;  1HQA A;  3UN5 A;  2W8D A;  5IJQ A;  3NKP A;  3UN3 A;  3WBH A;  1EW9 A;  4CXK A;  3MK1 A;  3DPC A;  4MY4 A;  1HDH A;  3IDD A;  4UPK A;  5DLV A;  1E33 P;  4CXS A;  4UPL A;  4LR9 A;  2W8S A;  5LRN A;  4UPI A;  3BDG B;  2W5Q A;  3T00 A;  3BDF A;  4LRF A;  1E2S P;  4FDI A;  3UO0 A;  5EGE A;  4CYS A;  4LR7 A;  3TWZ A;  1ED8 A;  1P49 A;  2GA3 A;  3T01 A;  4UOO A;  1ELZ A;  1ALJ A;  4KJD A;  4TN0 A;  4QAX A;  5DLT A;  5L0K A;  2VQR A;  3KD8 A;  5C66 A;  1EW2 A;  2W5S A;  1ED9 A;  2ZKT A;  4ZG7 A;  1ANI A;  1FSU A;  4GTW A;  4MIV A;  5LQQ A;  1EI6 A;  1AJB A;  1E1Z P;  3ED4 A;  4YR1 A;  3Q3Q A;  4KAY A;  1E3C P;  3WAW A;  3M7V A;  4CXU A;  1ZED A;  1KH4 A;  3DYC A;  3UN2 A;  3WAV A;  3WAY A;  3OT9 A;  1ANJ A;  1AJA A;  1ALH A;  3M8W A;  3CMR A;  2G9Y A;  1EQJ A;  2IUC A;  3BDH A;  1ZEB A;  3NVL A;  4ZG9 A;  3SZZ A;  5INH A;  2W5V A;  5KXA A;  4UOP A;  4GTY A;  2IUC B;  3NKM A;  1K7H A;  4UOR A;  3IGY B;  1ELX A;  4LR8 A;  3E2D A;  1ZEF A;  1EW8 A;  1EJJ A;  2X98 A;  4GTZ A;  4B56 A;  3TG0 A;  3NKR A;  5EGH A;  3B5Q A;  5DLW A;  4LRA A;  3A52 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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