3MK1 | Genus

Total Genus 180

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	180
Knots found	KnotProt 2.0: S +3₁
sequence length	481
structure length	480
Chain Sequence	IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
publication title	Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site. pubmed doi rcsb
molecule keywords	Alkaline phosphatase, placental type
total genus	180
structure length	480
sequence length	481
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2010-04-13

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	3mk1A00

1KHKA 2W5XA 1KH5A 2W5RA 4FDIA 3NKNA 4UORA 3M8WA 1ED8A 1HDHA 1URAA 3UN5A 3OT9A 4FDJA 3NKOA 3ED4A 4GTZA 1SHNA 3IGYB 4LRCA 2ANHA 4LR9A 5EGEA 4B56A 4GTYA 1HQAA 2RH6A 1KHNA 2G9YA 3WAYA 1E3CP 4CYSA 2W5TA 3B5QA 5LIAA 1AJBA 1ANJA 2QZUA 3TX0A 1AJDA 4LQYA 4CYRA 4CXUA 4TN0A 3MK2A 1EW9A 3A52A 5K4PA 3T02A 4LRDA 4ZG6A 2ZKTA 2IFYA 4NWXA 2GSUA 2X98A 3BDGA 3NKPA 1E33P 4NWJA 2GSOA 5AJ9A 5HRTA 3LXQA 1ELXA 3UNYA 4ZG9A 5TJ3A 1K7HA 2W5VA 3KD8A 4LRAA 4UOPA 3WAWA 1HJKA 1ZEFA 1AUKA 3NVLA 4UPLA 3UO0A 3NKRA 2GSNA 3TG0A 3DPCA 1KHLA 1EJJA 5DLVA 5L0BA 3SZZA 3UN2A 3Q3QA 3BDGB 3TWZA 1ALHA 5L0EA 2GLQA 1EW8A 4CXSA 2GA3A 1ELYA 3WBHA 1AJCA 3NKQA 4KM4A 5INHA 5GRRA 1KH4A 4N7TA 2IUCA 2XR9A 1ALJA 1FSUA 3MK0A 1ANIA 4LREA 1O98A 4MIVA 3WAXA 5KXAA 4LR7A 3BDHA 5LRMA 5DLWA 2W5WA 3M8ZA 1N2LA 3DYCA 3CMRA 3BDFA 4LR8A 5C66A 3UN3A 1AJAA 1SHQA 2W8SA 3IGZB 1O99A 4UOOA 4MHXA 5LRNA 3WAVA 4UPIA 1EI6A 1E1ZP 2IUCB 4KJGA 1B8JA 4ZGAA 4LR2A 4YR1A 2W8DA 2W5QA 1Y6VA 1ED9A 4KJDA 4CXKA 1KHJA 1KH7A 5IJQA 5L0KA 1P49A 5EGHA 4ZG7A 2XRGA 4KAYA 4KAVA 2D1GA 5DLTA 3SZYA 1ELZA 4UPHA 1ALIA 3T00A 1E2SP 5LQQA 4LRFA 1ALKA 3E2DA 5GOVA 1ZEDA 3M7VA 4GTWA 1EW2A 2VQRA 3IDDA 4LRBA 3M8YA 4QAXA 1ZEBA 1KH9A 5IJSA 4UPKA 2W5SA 1N2KA 1EQJA 3NKMA 1Y7AA 3MK1A 1URBA 3T01A 4MY4A 4GTXA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1KHK A;  2W5X A;  1KH5 A;  2W5R A;  4FDI A;  3NKN A;  4UOR A;  3M8W A;  1ED8 A;  1HDH A;  1URA A;  3UN5 A;  3OT9 A;  4FDJ A;  3NKO A;  3ED4 A;  4GTZ A;  1SHN A;  3IGY B;  4LRC A;  2ANH A;  4LR9 A;  5EGE A;  4B56 A;  4GTY A;  1HQA A;  2RH6 A;  1KHN A;  2G9Y A;  3WAY A;  1E3C P;  4CYS A;  2W5T A;  3B5Q A;  5LIA A;  1AJB A;  1ANJ A;  2QZU A;  3TX0 A;  1AJD A;  4LQY A;  4CYR A;  4CXU A;  4TN0 A;  3MK2 A;  1EW9 A;  3A52 A;  5K4P A;  3T02 A;  4LRD A;  4ZG6 A;  2ZKT A;  2IFY A;  4NWX A;  2GSU A;  2X98 A;  3BDG A;  3NKP A;  1E33 P;  4NWJ A;  2GSO A;  5AJ9 A;  5HRT A;  3LXQ A;  1ELX A;  3UNY A;  4ZG9 A;  5TJ3 A;  1K7H A;  2W5V A;  3KD8 A;  4LRA A;  4UOP A;  3WAW A;  1HJK A;  1ZEF A;  1AUK A;  3NVL A;  4UPL A;  3UO0 A;  3NKR A;  2GSN A;  3TG0 A;  3DPC A;  1KHL A;  1EJJ A;  5DLV A;  5L0B A;  3SZZ A;  3UN2 A;  3Q3Q A;  3BDG B;  3TWZ A;  1ALH A;  5L0E A;  2GLQ A;  1EW8 A;  4CXS A;  2GA3 A;  1ELY A;  3WBH A;  1AJC A;  3NKQ A;  4KM4 A;  5INH A;  5GRR A;  1KH4 A;  4N7T A;  2IUC A;  2XR9 A;  1ALJ A;  1FSU A;  3MK0 A;  1ANI A;  4LRE A;  1O98 A;  4MIV A;  3WAX A;  5KXA A;  4LR7 A;  3BDH A;  5LRM A;  5DLW A;  2W5W A;  3M8Z A;  1N2L A;  3DYC A;  3CMR A;  3BDF A;  4LR8 A;  5C66 A;  3UN3 A;  1AJA A;  1SHQ A;  2W8S A;  3IGZ B;  1O99 A;  4UOO A;  4MHX A;  5LRN A;  3WAV A;  4UPI A;  1EI6 A;  1E1Z P;  2IUC B;  4KJG A;  1B8J A;  4ZGA A;  4LR2 A;  4YR1 A;  2W8D A;  2W5Q A;  1Y6V A;  1ED9 A;  4KJD A;  4CXK A;  1KHJ A;  1KH7 A;  5IJQ A;  5L0K A;  1P49 A;  5EGH A;  4ZG7 A;  2XRG A;  4KAY A;  4KAV A;  2D1G A;  5DLT A;  3SZY A;  1ELZ A;  4UPH A;  1ALI A;  3T00 A;  1E2S P;  5LQQ A;  4LRF A;  1ALK A;  3E2D A;  5GOV A;  1ZED A;  3M7V A;  4GTW A;  1EW2 A;  2VQR A;  3IDD A;  4LRB A;  3M8Y A;  4QAX A;  1ZEB A;  1KH9 A;  5IJS A;  4UPK A;  2W5S A;  1N2K A;  1EQJ A;  3NKM A;  1Y7A A;  3MK1 A;  1URB A;  3T01 A;  4MY4 A;  4GTX A; 
#chains in the Genus database with same CATH topology
 1KHK A;  2W5X A;  1KH5 A;  2W5R A;  4FDI A;  3NKN A;  4UOR A;  3M8W A;  1ED8 A;  1HDH A;  1URA A;  3UN5 A;  3OT9 A;  4FDJ A;  3NKO A;  3ED4 A;  4GTZ A;  1SHN A;  3IGY B;  4LRC A;  2ANH A;  4LR9 A;  5EGE A;  4B56 A;  4GTY A;  1HQA A;  2RH6 A;  1KHN A;  2G9Y A;  3WAY A;  1E3C P;  4CYS A;  2W5T A;  3B5Q A;  5LIA A;  1AJB A;  1ANJ A;  2QZU A;  3TX0 A;  1AJD A;  4LQY A;  4CYR A;  4CXU A;  4TN0 A;  3MK2 A;  1EW9 A;  3A52 A;  5K4P A;  3T02 A;  4LRD A;  4ZG6 A;  2ZKT A;  2IFY A;  4NWX A;  2GSU A;  2X98 A;  3BDG A;  3NKP A;  1E33 P;  4NWJ A;  2GSO A;  5AJ9 A;  5HRT A;  3LXQ A;  1ELX A;  3UNY A;  4ZG9 A;  5TJ3 A;  1K7H A;  2W5V A;  3KD8 A;  4LRA A;  4UOP A;  3WAW A;  1HJK A;  1ZEF A;  1AUK A;  3NVL A;  4UPL A;  3UO0 A;  3NKR A;  2GSN A;  3TG0 A;  3DPC A;  1KHL A;  1EJJ A;  5DLV A;  5L0B A;  3SZZ A;  3UN2 A;  3Q3Q A;  3BDG B;  3TWZ A;  1ALH A;  5L0E A;  2GLQ A;  1EW8 A;  4CXS A;  2GA3 A;  1ELY A;  3WBH A;  1AJC A;  3NKQ A;  4KM4 A;  5INH A;  5GRR A;  1KH4 A;  4N7T A;  2IUC A;  2XR9 A;  1ALJ A;  1FSU A;  3MK0 A;  1ANI A;  4LRE A;  1O98 A;  4MIV A;  3WAX A;  5KXA A;  4LR7 A;  3BDH A;  5LRM A;  5DLW A;  2W5W A;  3M8Z A;  1N2L A;  3DYC A;  3CMR A;  3BDF A;  4LR8 A;  5C66 A;  3UN3 A;  1AJA A;  1SHQ A;  2W8S A;  3IGZ B;  1O99 A;  4UOO A;  4MHX A;  5LRN A;  3WAV A;  4UPI A;  1EI6 A;  1E1Z P;  2IUC B;  4KJG A;  1B8J A;  4ZGA A;  4LR2 A;  4YR1 A;  2W8D A;  2W5Q A;  1Y6V A;  1ED9 A;  4KJD A;  4CXK A;  1KHJ A;  1KH7 A;  5IJQ A;  5L0K A;  1P49 A;  5EGH A;  4ZG7 A;  2XRG A;  4KAY A;  4KAV A;  2D1G A;  5DLT A;  3SZY A;  1ELZ A;  4UPH A;  1ALI A;  3T00 A;  1E2S P;  5LQQ A;  4LRF A;  1ALK A;  3E2D A;  5GOV A;  1ZED A;  3M7V A;  4GTW A;  1EW2 A;  2VQR A;  3IDD A;  4LRB A;  3M8Y A;  4QAX A;  1ZEB A;  1KH9 A;  5IJS A;  4UPK A;  2W5S A;  1N2K A;  1EQJ A;  3NKM A;  1Y7A A;  3MK1 A;  1URB A;  3T01 A;  4MY4 A;  4GTX A; 
#chains in the Genus database with same CATH homology
 1KHK A;  2W5X A;  1KH5 A;  2W5R A;  4FDI A;  3NKN A;  4UOR A;  3M8W A;  1ED8 A;  1HDH A;  1URA A;  3UN5 A;  3OT9 A;  4FDJ A;  3NKO A;  3ED4 A;  4GTZ A;  1SHN A;  3IGY B;  4LRC A;  2ANH A;  4LR9 A;  5EGE A;  4B56 A;  4GTY A;  1HQA A;  2RH6 A;  1KHN A;  2G9Y A;  3WAY A;  1E3C P;  4CYS A;  2W5T A;  3B5Q A;  5LIA A;  1AJB A;  1ANJ A;  2QZU A;  3TX0 A;  1AJD A;  4LQY A;  4CYR A;  4CXU A;  4TN0 A;  3MK2 A;  1EW9 A;  3A52 A;  5K4P A;  3T02 A;  4LRD A;  4ZG6 A;  2ZKT A;  2IFY A;  4NWX A;  2GSU A;  2X98 A;  3BDG A;  3NKP A;  1E33 P;  4NWJ A;  2GSO A;  5AJ9 A;  5HRT A;  3LXQ A;  1ELX A;  3UNY A;  4ZG9 A;  5TJ3 A;  1K7H A;  2W5V A;  3KD8 A;  4LRA A;  4UOP A;  3WAW A;  1HJK A;  1ZEF A;  1AUK A;  3NVL A;  4UPL A;  3UO0 A;  3NKR A;  2GSN A;  3TG0 A;  3DPC A;  1KHL A;  1EJJ A;  5DLV A;  5L0B A;  3SZZ A;  3UN2 A;  3Q3Q A;  3BDG B;  3TWZ A;  1ALH A;  5L0E A;  2GLQ A;  1EW8 A;  4CXS A;  2GA3 A;  1ELY A;  3WBH A;  1AJC A;  3NKQ A;  4KM4 A;  5INH A;  5GRR A;  1KH4 A;  4N7T A;  2IUC A;  2XR9 A;  1ALJ A;  1FSU A;  3MK0 A;  1ANI A;  4LRE A;  1O98 A;  4MIV A;  3WAX A;  5KXA A;  4LR7 A;  3BDH A;  5LRM A;  5DLW A;  2W5W A;  3M8Z A;  1N2L A;  3DYC A;  3CMR A;  3BDF A;  4LR8 A;  5C66 A;  3UN3 A;  1AJA A;  1SHQ A;  2W8S A;  3IGZ B;  1O99 A;  4UOO A;  4MHX A;  5LRN A;  3WAV A;  4UPI A;  1EI6 A;  1E1Z P;  2IUC B;  4KJG A;  1B8J A;  4ZGA A;  4LR2 A;  4YR1 A;  2W8D A;  2W5Q A;  1Y6V A;  1ED9 A;  4KJD A;  4CXK A;  1KHJ A;  1KH7 A;  5IJQ A;  5L0K A;  1P49 A;  5EGH A;  4ZG7 A;  2XRG A;  4KAY A;  4KAV A;  2D1G A;  5DLT A;  3SZY A;  1ELZ A;  4UPH A;  1ALI A;  3T00 A;  1E2S P;  5LQQ A;  4LRF A;  1ALK A;  3E2D A;  5GOV A;  1ZED A;  3M7V A;  4GTW A;  1EW2 A;  2VQR A;  3IDD A;  4LRB A;  3M8Y A;  4QAX A;  1ZEB A;  1KH9 A;  5IJS A;  4UPK A;  2W5S A;  1N2K A;  1EQJ A;  3NKM A;  1Y7A A;  3MK1 A;  1URB A;  3T01 A;  4MY4 A;  4GTX A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3MK1A

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations