3MK1A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 180
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk1A00
1O98A 4MHXA 2W5SA 3WAWA 1P49A 4CYSA 1E1ZP 4UOPA 3NKOA 5DLTA 4FDIA 3WAVA 2QZUA 3BDFA 2W5VA 1AJAA 5LQQA 5AJ9A 5DLVA 1ALJA 2X98A 4NWJA 4LRBA 3IGZB 1AJBA 3NKRA 5LRNA 3MK2A 4TN0A 4LRFA 4UPLA 2D1GA 4UORA 3Q3QA 4UPKA 3B5QA 1KH5A 5DLWA 1Y7AA 3SZZA 4QAXA 1ELYA 2GSNA 3WBHA 1ZEFA 3NKMA 4ZG7A 3TWZA 1ZEDA 1URBA 3M8YA 5LRMA 4N7TA 4ZG9A 1ALIA 2W8DA 2W5XA 3A52A 3M7VA 2W5RA 5L0KA 1ELXA 2XR9A 1B8JA 1HDHA 2W8SA 4KAVA 3UN5A 4LREA 1KHNA 3SZYA 4LQYA 3MK1A 1EQJA 3NKQA 3WAXA 3TX0A 5L0BA 1EI6A 5TJ3A 2GSOA 1URAA 2IUCA 4GTWA 1E3CP 3M8ZA 3T00A 5L0EA 4GTZA 3UN3A 3IDDA 5C66A 2GLQA 4ZG6A 5INHA 1AUKA 1ZEBA 1N2KA 4KJDA 3UN2A 4MIVA 4KJGA 4NWXA 3T01A 5LIAA 3IGYB 3LXQA 4UPIA 1KH4A 1AJCA 1EW8A 3NVLA 5K4PA 4CXUA 2XRGA 2W5TA 3E2DA 1SHQA 2IUCB 4MY4A 1Y6VA 4KM4A 1ED9A 1KH7A 2ZKTA 5IJQA 3BDGA 3TG0A 3M8WA 4CXKA 5GOVA 1FSUA 3ED4A 3NKNA 2GA3A 2IFYA 1K7HA 1KHKA 1KH9A 4LR9A 3UO0A 5IJSA 4YR1A 4UOOA 3CMRA 4LRDA 1AJDA 1ELZA 1EJJA 5EGHA 5HRTA 1HQAA 1ALHA 5EGEA 4LRAA 4GTYA 3WAYA 4CXSA 1ALKA 2VQRA 1ANIA 1ANJA 1HJKA 3BDGB 3NKPA 1EW9A 3DPCA 3MK0A 4LR8A 1KHJA 1KHLA 1O99A 3OT9A 1E2SP 4LRCA 4B56A 3UNYA 5KXAA 2G9YA 4LR7A 1EW2A 2RH6A 3T02A 3DYCA 1ED8A 4FDJA 3KD8A 4CYRA 2GSUA 1SHNA 2W5WA 3BDHA 4UPHA 4KAYA 4LR2A 2W5QA 1E33P 1N2LA 4ZGAA 2ANHA 5GRRA 4GTXA
chains in the Genus database with same CATH superfamily
1O98A 4MHXA 2W5SA 3WAWA 1P49A 4CYSA 1E1ZP 4UOPA 3NKOA 5DLTA 4FDIA 3WAVA 2QZUA 3BDFA 2W5VA 1AJAA 5LQQA 5AJ9A 5DLVA 1ALJA 2X98A 4NWJA 4LRBA 3IGZB 1AJBA 3NKRA 5LRNA 3MK2A 4TN0A 4LRFA 4UPLA 2D1GA 4UORA 3Q3QA 4UPKA 3B5QA 1KH5A 5DLWA 1Y7AA 3SZZA 4QAXA 1ELYA 2GSNA 3WBHA 1ZEFA 3NKMA 4ZG7A 3TWZA 1ZEDA 1URBA 3M8YA 5LRMA 4N7TA 4ZG9A 1ALIA 2W8DA 2W5XA 3A52A 3M7VA 2W5RA 5L0KA 1ELXA 2XR9A 1B8JA 1HDHA 2W8SA 4KAVA 3UN5A 4LREA 1KHNA 3SZYA 4LQYA 3MK1A 1EQJA 3NKQA 3WAXA 3TX0A 5L0BA 1EI6A 5TJ3A 2GSOA 1URAA 2IUCA 4GTWA 1E3CP 3M8ZA 3T00A 5L0EA 4GTZA 3UN3A 3IDDA 5C66A 2GLQA 4ZG6A 5INHA 1AUKA 1ZEBA 1N2KA 4KJDA 3UN2A 4MIVA 4KJGA 4NWXA 3T01A 5LIAA 3IGYB 3LXQA 4UPIA 1KH4A 1AJCA 1EW8A 3NVLA 5K4PA 4CXUA 2XRGA 2W5TA 3E2DA 1SHQA 2IUCB 4MY4A 1Y6VA 4KM4A 1ED9A 1KH7A 2ZKTA 5IJQA 3BDGA 3TG0A 3M8WA 4CXKA 5GOVA 1FSUA 3ED4A 3NKNA 2GA3A 2IFYA 1K7HA 1KHKA 1KH9A 4LR9A 3UO0A 5IJSA 4YR1A 4UOOA 3CMRA 4LRDA 1AJDA 1ELZA 1EJJA 5EGHA 5HRTA 1HQAA 1ALHA 5EGEA 4LRAA 4GTYA 3WAYA 4CXSA 1ALKA 2VQRA 1ANIA 1ANJA 1HJKA 3BDGB 3NKPA 1EW9A 3DPCA 3MK0A 4LR8A 1KHJA 1KHLA 1O99A 3OT9A 1E2SP 4LRCA 4B56A 3UNYA 5KXAA 2G9YA 4LR7A 1EW2A 2RH6A 3T02A 3DYCA 1ED8A 4FDJA 3KD8A 4CYRA 2GSUA 1SHNA 2W5WA 3BDHA 4UPHA 4KAYA 4LR2A 2W5QA 1E33P 1N2LA 4ZGAA 2ANHA 5GRRA 4GTXA
chains in the Genus database with same CATH topology
1O98A 4MHXA 2W5SA 3WAWA 1P49A 4CYSA 1E1ZP 4UOPA 3NKOA 5DLTA 4FDIA 3WAVA 2QZUA 3BDFA 2W5VA 1AJAA 5LQQA 5AJ9A 5DLVA 1ALJA 2X98A 4NWJA 4LRBA 3IGZB 1AJBA 3NKRA 5LRNA 3MK2A 4TN0A 4LRFA 4UPLA 2D1GA 4UORA 3Q3QA 4UPKA 3B5QA 1KH5A 5DLWA 1Y7AA 3SZZA 4QAXA 1ELYA 2GSNA 3WBHA 1ZEFA 3NKMA 4ZG7A 3TWZA 1ZEDA 1URBA 3M8YA 5LRMA 4N7TA 4ZG9A 1ALIA 2W8DA 2W5XA 3A52A 3M7VA 2W5RA 5L0KA 1ELXA 2XR9A 1B8JA 1HDHA 2W8SA 4KAVA 3UN5A 4LREA 1KHNA 3SZYA 4LQYA 3MK1A 1EQJA 3NKQA 3WAXA 3TX0A 5L0BA 1EI6A 5TJ3A 2GSOA 1URAA 2IUCA 4GTWA 1E3CP 3M8ZA 3T00A 5L0EA 4GTZA 3UN3A 3IDDA 5C66A 2GLQA 4ZG6A 5INHA 1AUKA 1ZEBA 1N2KA 4KJDA 3UN2A 4MIVA 4KJGA 4NWXA 3T01A 5LIAA 3IGYB 3LXQA 4UPIA 1KH4A 1AJCA 1EW8A 3NVLA 5K4PA 4CXUA 2XRGA 2W5TA 3E2DA 1SHQA 2IUCB 4MY4A 1Y6VA 4KM4A 1ED9A 1KH7A 2ZKTA 5IJQA 3BDGA 3TG0A 3M8WA 4CXKA 5GOVA 1FSUA 3ED4A 3NKNA 2GA3A 2IFYA 1K7HA 1KHKA 1KH9A 4LR9A 3UO0A 5IJSA 4YR1A 4UOOA 3CMRA 4LRDA 1AJDA 1ELZA 1EJJA 5EGHA 5HRTA 1HQAA 1ALHA 5EGEA 4LRAA 4GTYA 3WAYA 4CXSA 1ALKA 2VQRA 1ANIA 1ANJA 1HJKA 3BDGB 3NKPA 1EW9A 3DPCA 3MK0A 4LR8A 1KHJA 1KHLA 1O99A 3OT9A 1E2SP 4LRCA 4B56A 3UNYA 5KXAA 2G9YA 4LR7A 1EW2A 2RH6A 3T02A 3DYCA 1ED8A 4FDJA 3KD8A 4CYRA 2GSUA 1SHNA 2W5WA 3BDHA 4UPHA 4KAYA 4LR2A 2W5QA 1E33P 1N2LA 4ZGAA 2ANHA 5GRRA 4GTXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O98 A;  4MHX A;  2W5S A;  3WAW A;  1P49 A;  4CYS A;  1E1Z P;  4UOP A;  3NKO A;  5DLT A;  4FDI A;  3WAV A;  2QZU A;  3BDF A;  2W5V A;  1AJA A;  5LQQ A;  5AJ9 A;  5DLV A;  1ALJ A;  2X98 A;  4NWJ A;  4LRB A;  3IGZ B;  1AJB A;  3NKR A;  5LRN A;  3MK2 A;  4TN0 A;  4LRF A;  4UPL A;  2D1G A;  4UOR A;  3Q3Q A;  4UPK A;  3B5Q A;  1KH5 A;  5DLW A;  1Y7A A;  3SZZ A;  4QAX A;  1ELY A;  2GSN A;  3WBH A;  1ZEF A;  3NKM A;  4ZG7 A;  3TWZ A;  1ZED A;  1URB A;  3M8Y A;  5LRM A;  4N7T A;  4ZG9 A;  1ALI A;  2W8D A;  2W5X A;  3A52 A;  3M7V A;  2W5R A;  5L0K A;  1ELX A;  2XR9 A;  1B8J A;  1HDH A;  2W8S A;  4KAV A;  3UN5 A;  4LRE A;  1KHN A;  3SZY A;  4LQY A;  3MK1 A;  1EQJ A;  3NKQ A;  3WAX A;  3TX0 A;  5L0B A;  1EI6 A;  5TJ3 A;  2GSO A;  1URA A;  2IUC A;  4GTW A;  1E3C P;  3M8Z A;  3T00 A;  5L0E A;  4GTZ A;  3UN3 A;  3IDD A;  5C66 A;  2GLQ A;  4ZG6 A;  5INH A;  1AUK A;  1ZEB A;  1N2K A;  4KJD A;  3UN2 A;  4MIV A;  4KJG A;  4NWX A;  3T01 A;  5LIA A;  3IGY B;  3LXQ A;  4UPI A;  1KH4 A;  1AJC A;  1EW8 A;  3NVL A;  5K4P A;  4CXU A;  2XRG A;  2W5T A;  3E2D A;  1SHQ A;  2IUC B;  4MY4 A;  1Y6V A;  4KM4 A;  1ED9 A;  1KH7 A;  2ZKT A;  5IJQ A;  3BDG A;  3TG0 A;  3M8W A;  4CXK A;  5GOV A;  1FSU A;  3ED4 A;  3NKN A;  2GA3 A;  2IFY A;  1K7H A;  1KHK A;  1KH9 A;  4LR9 A;  3UO0 A;  5IJS A;  4YR1 A;  4UOO A;  3CMR A;  4LRD A;  1AJD A;  1ELZ A;  1EJJ A;  5EGH A;  5HRT A;  1HQA A;  1ALH A;  5EGE A;  4LRA A;  4GTY A;  3WAY A;  4CXS A;  1ALK A;  2VQR A;  1ANI A;  1ANJ A;  1HJK A;  3BDG B;  3NKP A;  1EW9 A;  3DPC A;  3MK0 A;  4LR8 A;  1KHJ A;  1KHL A;  1O99 A;  3OT9 A;  1E2S P;  4LRC A;  4B56 A;  3UNY A;  5KXA A;  2G9Y A;  4LR7 A;  1EW2 A;  2RH6 A;  3T02 A;  3DYC A;  1ED8 A;  4FDJ A;  3KD8 A;  4CYR A;  2GSU A;  1SHN A;  2W5W A;  3BDH A;  4UPH A;  4KAY A;  4LR2 A;  2W5Q A;  1E33 P;  1N2L A;  4ZGA A;  2ANH A;  5GRR A;  4GTX A; 
#chains in the Genus database with same CATH topology
 1O98 A;  4MHX A;  2W5S A;  3WAW A;  1P49 A;  4CYS A;  1E1Z P;  4UOP A;  3NKO A;  5DLT A;  4FDI A;  3WAV A;  2QZU A;  3BDF A;  2W5V A;  1AJA A;  5LQQ A;  5AJ9 A;  5DLV A;  1ALJ A;  2X98 A;  4NWJ A;  4LRB A;  3IGZ B;  1AJB A;  3NKR A;  5LRN A;  3MK2 A;  4TN0 A;  4LRF A;  4UPL A;  2D1G A;  4UOR A;  3Q3Q A;  4UPK A;  3B5Q A;  1KH5 A;  5DLW A;  1Y7A A;  3SZZ A;  4QAX A;  1ELY A;  2GSN A;  3WBH A;  1ZEF A;  3NKM A;  4ZG7 A;  3TWZ A;  1ZED A;  1URB A;  3M8Y A;  5LRM A;  4N7T A;  4ZG9 A;  1ALI A;  2W8D A;  2W5X A;  3A52 A;  3M7V A;  2W5R A;  5L0K A;  1ELX A;  2XR9 A;  1B8J A;  1HDH A;  2W8S A;  4KAV A;  3UN5 A;  4LRE A;  1KHN A;  3SZY A;  4LQY A;  3MK1 A;  1EQJ A;  3NKQ A;  3WAX A;  3TX0 A;  5L0B A;  1EI6 A;  5TJ3 A;  2GSO A;  1URA A;  2IUC A;  4GTW A;  1E3C P;  3M8Z A;  3T00 A;  5L0E A;  4GTZ A;  3UN3 A;  3IDD A;  5C66 A;  2GLQ A;  4ZG6 A;  5INH A;  1AUK A;  1ZEB A;  1N2K A;  4KJD A;  3UN2 A;  4MIV A;  4KJG A;  4NWX A;  3T01 A;  5LIA A;  3IGY B;  3LXQ A;  4UPI A;  1KH4 A;  1AJC A;  1EW8 A;  3NVL A;  5K4P A;  4CXU A;  2XRG A;  2W5T A;  3E2D A;  1SHQ A;  2IUC B;  4MY4 A;  1Y6V A;  4KM4 A;  1ED9 A;  1KH7 A;  2ZKT A;  5IJQ A;  3BDG A;  3TG0 A;  3M8W A;  4CXK A;  5GOV A;  1FSU A;  3ED4 A;  3NKN A;  2GA3 A;  2IFY A;  1K7H A;  1KHK A;  1KH9 A;  4LR9 A;  3UO0 A;  5IJS A;  4YR1 A;  4UOO A;  3CMR A;  4LRD A;  1AJD A;  1ELZ A;  1EJJ A;  5EGH A;  5HRT A;  1HQA A;  1ALH A;  5EGE A;  4LRA A;  4GTY A;  3WAY A;  4CXS A;  1ALK A;  2VQR A;  1ANI A;  1ANJ A;  1HJK A;  3BDG B;  3NKP A;  1EW9 A;  3DPC A;  3MK0 A;  4LR8 A;  1KHJ A;  1KHL A;  1O99 A;  3OT9 A;  1E2S P;  4LRC A;  4B56 A;  3UNY A;  5KXA A;  2G9Y A;  4LR7 A;  1EW2 A;  2RH6 A;  3T02 A;  3DYC A;  1ED8 A;  4FDJ A;  3KD8 A;  4CYR A;  2GSU A;  1SHN A;  2W5W A;  3BDH A;  4UPH A;  4KAY A;  4LR2 A;  2W5Q A;  1E33 P;  1N2L A;  4ZGA A;  2ANH A;  5GRR A;  4GTX A; 
#chains in the Genus database with same CATH homology
 1O98 A;  4MHX A;  2W5S A;  3WAW A;  1P49 A;  4CYS A;  1E1Z P;  4UOP A;  3NKO A;  5DLT A;  4FDI A;  3WAV A;  2QZU A;  3BDF A;  2W5V A;  1AJA A;  5LQQ A;  5AJ9 A;  5DLV A;  1ALJ A;  2X98 A;  4NWJ A;  4LRB A;  3IGZ B;  1AJB A;  3NKR A;  5LRN A;  3MK2 A;  4TN0 A;  4LRF A;  4UPL A;  2D1G A;  4UOR A;  3Q3Q A;  4UPK A;  3B5Q A;  1KH5 A;  5DLW A;  1Y7A A;  3SZZ A;  4QAX A;  1ELY A;  2GSN A;  3WBH A;  1ZEF A;  3NKM A;  4ZG7 A;  3TWZ A;  1ZED A;  1URB A;  3M8Y A;  5LRM A;  4N7T A;  4ZG9 A;  1ALI A;  2W8D A;  2W5X A;  3A52 A;  3M7V A;  2W5R A;  5L0K A;  1ELX A;  2XR9 A;  1B8J A;  1HDH A;  2W8S A;  4KAV A;  3UN5 A;  4LRE A;  1KHN A;  3SZY A;  4LQY A;  3MK1 A;  1EQJ A;  3NKQ A;  3WAX A;  3TX0 A;  5L0B A;  1EI6 A;  5TJ3 A;  2GSO A;  1URA A;  2IUC A;  4GTW A;  1E3C P;  3M8Z A;  3T00 A;  5L0E A;  4GTZ A;  3UN3 A;  3IDD A;  5C66 A;  2GLQ A;  4ZG6 A;  5INH A;  1AUK A;  1ZEB A;  1N2K A;  4KJD A;  3UN2 A;  4MIV A;  4KJG A;  4NWX A;  3T01 A;  5LIA A;  3IGY B;  3LXQ A;  4UPI A;  1KH4 A;  1AJC A;  1EW8 A;  3NVL A;  5K4P A;  4CXU A;  2XRG A;  2W5T A;  3E2D A;  1SHQ A;  2IUC B;  4MY4 A;  1Y6V A;  4KM4 A;  1ED9 A;  1KH7 A;  2ZKT A;  5IJQ A;  3BDG A;  3TG0 A;  3M8W A;  4CXK A;  5GOV A;  1FSU A;  3ED4 A;  3NKN A;  2GA3 A;  2IFY A;  1K7H A;  1KHK A;  1KH9 A;  4LR9 A;  3UO0 A;  5IJS A;  4YR1 A;  4UOO A;  3CMR A;  4LRD A;  1AJD A;  1ELZ A;  1EJJ A;  5EGH A;  5HRT A;  1HQA A;  1ALH A;  5EGE A;  4LRA A;  4GTY A;  3WAY A;  4CXS A;  1ALK A;  2VQR A;  1ANI A;  1ANJ A;  1HJK A;  3BDG B;  3NKP A;  1EW9 A;  3DPC A;  3MK0 A;  4LR8 A;  1KHJ A;  1KHL A;  1O99 A;  3OT9 A;  1E2S P;  4LRC A;  4B56 A;  3UNY A;  5KXA A;  2G9Y A;  4LR7 A;  1EW2 A;  2RH6 A;  3T02 A;  3DYC A;  1ED8 A;  4FDJ A;  3KD8 A;  4CYR A;  2GSU A;  1SHN A;  2W5W A;  3BDH A;  4UPH A;  4KAY A;  4LR2 A;  2W5Q A;  1E33 P;  1N2L A;  4ZGA A;  2ANH A;  5GRR A;  4GTX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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