3MK2A

Placental alkaline phosphatase complexed with phe
Total Genus 184
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 184
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk2A00
4LQYA 3M8WA 3Q3QA 1SHNA 1O98A 4QAXA 5EGEA 4YR1A 3SZYA 4GTWA 5L0EA 4UOOA 2ANHA 3CMRA 5TJ3A 5KXAA 2GSNA 3NKMA 1ZEFA 2W8SA 2VQRA 3NKPA 4NWXA 4ZG7A 3T00A 3WAXA 3A52A 1KHKA 2W5QA 5INHA 3NKOA 3OT9A 5IJSA 5C66A 4TN0A 4UPLA 3IGZB 3MK0A 1KHLA 1E1ZP 5LIAA 1HJKA 2W8DA 2QZUA 2W5WA 1ZEDA 4LRDA 1KHJA 5K4PA 4ZGAA 1AJCA 2IFYA 3IDDA 5DLVA 1ALHA 1O99A 3UNYA 4KAVA 3ED4A 4UPKA 3M8YA 4LRFA 5GOVA 4UORA 3TX0A 3NVLA 3WAVA 3WBHA 1EW8A 3BDFA 1N2LA 1KH9A 1KH4A 4UPIA 3SZZA 4KM4A 1ELXA 1EJJA 2ZKTA 1AJAA 1ZEBA 5L0KA 3BDHA 4LRBA 5GRRA 1ANJA 2X98A 3NKRA 5DLWA 2W5SA 1KH7A 4KAYA 4LREA 1HDHA 1N2KA 3BDGB 3WAWA 1ED8A 5LRMA 4KJGA 5LQQA 4GTYA 1E33P 4LRCA 1ANIA 2W5TA 3UN2A 4CXKA 2IUCA 4UPHA 3NKQA 2XRGA 3T01A 2D1GA 3TG0A 1URAA 4FDIA 2GLQA 4ZG6A 3MK2A 3M7VA 1Y7AA 3WAYA 4B56A 4UOPA 4MHXA 3UO0A 1KHNA 4FDJA 4LR9A 4LR2A 5IJQA 2W5XA 3UN5A 5HRTA 1HQAA 3IGYB 3NKNA 4LR7A 4MY4A 2W5RA 4CYRA 1ALKA 3UN3A 4CXSA 2W5VA 1KH5A 4N7TA 2IUCB 1P49A 1ELYA 2GSUA 4GTZA 4MIVA 5EGHA 1E2SP 1EQJA 3T02A 5L0BA 5LRNA 2RH6A 2G9YA 4CYSA 3B5QA 1SHQA 1K7HA 4CXUA 1ELZA 3DPCA 1E3CP 2GA3A 3M8ZA 1AJDA 3MK1A 2GSOA 4NWJA 3KD8A 3E2DA 1URBA 1ALIA 4LR8A 1ED9A 4LRAA 3TWZA 1B8JA 1ALJA 4KJDA 4ZG9A 1EW9A 1Y6VA 1AJBA 5AJ9A 3DYCA 3LXQA 1EW2A 1AUKA 4GTXA 2XR9A 3BDGA 5DLTA 1EI6A 1FSUA
chains in the Genus database with same CATH superfamily
4LQYA 3M8WA 3Q3QA 1SHNA 1O98A 4QAXA 5EGEA 4YR1A 3SZYA 4GTWA 5L0EA 4UOOA 2ANHA 3CMRA 5TJ3A 5KXAA 2GSNA 3NKMA 1ZEFA 2W8SA 2VQRA 3NKPA 4NWXA 4ZG7A 3T00A 3WAXA 3A52A 1KHKA 2W5QA 5INHA 3NKOA 3OT9A 5IJSA 5C66A 4TN0A 4UPLA 3IGZB 3MK0A 1KHLA 1E1ZP 5LIAA 1HJKA 2W8DA 2QZUA 2W5WA 1ZEDA 4LRDA 1KHJA 5K4PA 4ZGAA 1AJCA 2IFYA 3IDDA 5DLVA 1ALHA 1O99A 3UNYA 4KAVA 3ED4A 4UPKA 3M8YA 4LRFA 5GOVA 4UORA 3TX0A 3NVLA 3WAVA 3WBHA 1EW8A 3BDFA 1N2LA 1KH9A 1KH4A 4UPIA 3SZZA 4KM4A 1ELXA 1EJJA 2ZKTA 1AJAA 1ZEBA 5L0KA 3BDHA 4LRBA 5GRRA 1ANJA 2X98A 3NKRA 5DLWA 2W5SA 1KH7A 4KAYA 4LREA 1HDHA 1N2KA 3BDGB 3WAWA 1ED8A 5LRMA 4KJGA 5LQQA 4GTYA 1E33P 4LRCA 1ANIA 2W5TA 3UN2A 4CXKA 2IUCA 4UPHA 3NKQA 2XRGA 3T01A 2D1GA 3TG0A 1URAA 4FDIA 2GLQA 4ZG6A 3MK2A 3M7VA 1Y7AA 3WAYA 4B56A 4UOPA 4MHXA 3UO0A 1KHNA 4FDJA 4LR9A 4LR2A 5IJQA 2W5XA 3UN5A 5HRTA 1HQAA 3IGYB 3NKNA 4LR7A 4MY4A 2W5RA 4CYRA 1ALKA 3UN3A 4CXSA 2W5VA 1KH5A 4N7TA 2IUCB 1P49A 1ELYA 2GSUA 4GTZA 4MIVA 5EGHA 1E2SP 1EQJA 3T02A 5L0BA 5LRNA 2RH6A 2G9YA 4CYSA 3B5QA 1SHQA 1K7HA 4CXUA 1ELZA 3DPCA 1E3CP 2GA3A 3M8ZA 1AJDA 3MK1A 2GSOA 4NWJA 3KD8A 3E2DA 1URBA 1ALIA 4LR8A 1ED9A 4LRAA 3TWZA 1B8JA 1ALJA 4KJDA 4ZG9A 1EW9A 1Y6VA 1AJBA 5AJ9A 3DYCA 3LXQA 1EW2A 1AUKA 4GTXA 2XR9A 3BDGA 5DLTA 1EI6A 1FSUA
chains in the Genus database with same CATH topology
4LQYA 3M8WA 3Q3QA 1SHNA 1O98A 4QAXA 5EGEA 4YR1A 3SZYA 4GTWA 5L0EA 4UOOA 2ANHA 3CMRA 5TJ3A 5KXAA 2GSNA 3NKMA 1ZEFA 2W8SA 2VQRA 3NKPA 4NWXA 4ZG7A 3T00A 3WAXA 3A52A 1KHKA 2W5QA 5INHA 3NKOA 3OT9A 5IJSA 5C66A 4TN0A 4UPLA 3IGZB 3MK0A 1KHLA 1E1ZP 5LIAA 1HJKA 2W8DA 2QZUA 2W5WA 1ZEDA 4LRDA 1KHJA 5K4PA 4ZGAA 1AJCA 2IFYA 3IDDA 5DLVA 1ALHA 1O99A 3UNYA 4KAVA 3ED4A 4UPKA 3M8YA 4LRFA 5GOVA 4UORA 3TX0A 3NVLA 3WAVA 3WBHA 1EW8A 3BDFA 1N2LA 1KH9A 1KH4A 4UPIA 3SZZA 4KM4A 1ELXA 1EJJA 2ZKTA 1AJAA 1ZEBA 5L0KA 3BDHA 4LRBA 5GRRA 1ANJA 2X98A 3NKRA 5DLWA 2W5SA 1KH7A 4KAYA 4LREA 1HDHA 1N2KA 3BDGB 3WAWA 1ED8A 5LRMA 4KJGA 5LQQA 4GTYA 1E33P 4LRCA 1ANIA 2W5TA 3UN2A 4CXKA 2IUCA 4UPHA 3NKQA 2XRGA 3T01A 2D1GA 3TG0A 1URAA 4FDIA 2GLQA 4ZG6A 3MK2A 3M7VA 1Y7AA 3WAYA 4B56A 4UOPA 4MHXA 3UO0A 1KHNA 4FDJA 4LR9A 4LR2A 5IJQA 2W5XA 3UN5A 5HRTA 1HQAA 3IGYB 3NKNA 4LR7A 4MY4A 2W5RA 4CYRA 1ALKA 3UN3A 4CXSA 2W5VA 1KH5A 4N7TA 2IUCB 1P49A 1ELYA 2GSUA 4GTZA 4MIVA 5EGHA 1E2SP 1EQJA 3T02A 5L0BA 5LRNA 2RH6A 2G9YA 4CYSA 3B5QA 1SHQA 1K7HA 4CXUA 1ELZA 3DPCA 1E3CP 2GA3A 3M8ZA 1AJDA 3MK1A 2GSOA 4NWJA 3KD8A 3E2DA 1URBA 1ALIA 4LR8A 1ED9A 4LRAA 3TWZA 1B8JA 1ALJA 4KJDA 4ZG9A 1EW9A 1Y6VA 1AJBA 5AJ9A 3DYCA 3LXQA 1EW2A 1AUKA 4GTXA 2XR9A 3BDGA 5DLTA 1EI6A 1FSUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LQY A;  3M8W A;  3Q3Q A;  1SHN A;  1O98 A;  4QAX A;  5EGE A;  4YR1 A;  3SZY A;  4GTW A;  5L0E A;  4UOO A;  2ANH A;  3CMR A;  5TJ3 A;  5KXA A;  2GSN A;  3NKM A;  1ZEF A;  2W8S A;  2VQR A;  3NKP A;  4NWX A;  4ZG7 A;  3T00 A;  3WAX A;  3A52 A;  1KHK A;  2W5Q A;  5INH A;  3NKO A;  3OT9 A;  5IJS A;  5C66 A;  4TN0 A;  4UPL A;  3IGZ B;  3MK0 A;  1KHL A;  1E1Z P;  5LIA A;  1HJK A;  2W8D A;  2QZU A;  2W5W A;  1ZED A;  4LRD A;  1KHJ A;  5K4P A;  4ZGA A;  1AJC A;  2IFY A;  3IDD A;  5DLV A;  1ALH A;  1O99 A;  3UNY A;  4KAV A;  3ED4 A;  4UPK A;  3M8Y A;  4LRF A;  5GOV A;  4UOR A;  3TX0 A;  3NVL A;  3WAV A;  3WBH A;  1EW8 A;  3BDF A;  1N2L A;  1KH9 A;  1KH4 A;  4UPI A;  3SZZ A;  4KM4 A;  1ELX A;  1EJJ A;  2ZKT A;  1AJA A;  1ZEB A;  5L0K A;  3BDH A;  4LRB A;  5GRR A;  1ANJ A;  2X98 A;  3NKR A;  5DLW A;  2W5S A;  1KH7 A;  4KAY A;  4LRE A;  1HDH A;  1N2K A;  3BDG B;  3WAW A;  1ED8 A;  5LRM A;  4KJG A;  5LQQ A;  4GTY A;  1E33 P;  4LRC A;  1ANI A;  2W5T A;  3UN2 A;  4CXK A;  2IUC A;  4UPH A;  3NKQ A;  2XRG A;  3T01 A;  2D1G A;  3TG0 A;  1URA A;  4FDI A;  2GLQ A;  4ZG6 A;  3MK2 A;  3M7V A;  1Y7A A;  3WAY A;  4B56 A;  4UOP A;  4MHX A;  3UO0 A;  1KHN A;  4FDJ A;  4LR9 A;  4LR2 A;  5IJQ A;  2W5X A;  3UN5 A;  5HRT A;  1HQA A;  3IGY B;  3NKN A;  4LR7 A;  4MY4 A;  2W5R A;  4CYR A;  1ALK A;  3UN3 A;  4CXS A;  2W5V A;  1KH5 A;  4N7T A;  2IUC B;  1P49 A;  1ELY A;  2GSU A;  4GTZ A;  4MIV A;  5EGH A;  1E2S P;  1EQJ A;  3T02 A;  5L0B A;  5LRN A;  2RH6 A;  2G9Y A;  4CYS A;  3B5Q A;  1SHQ A;  1K7H A;  4CXU A;  1ELZ A;  3DPC A;  1E3C P;  2GA3 A;  3M8Z A;  1AJD A;  3MK1 A;  2GSO A;  4NWJ A;  3KD8 A;  3E2D A;  1URB A;  1ALI A;  4LR8 A;  1ED9 A;  4LRA A;  3TWZ A;  1B8J A;  1ALJ A;  4KJD A;  4ZG9 A;  1EW9 A;  1Y6V A;  1AJB A;  5AJ9 A;  3DYC A;  3LXQ A;  1EW2 A;  1AUK A;  4GTX A;  2XR9 A;  3BDG A;  5DLT A;  1EI6 A;  1FSU A; 
#chains in the Genus database with same CATH topology
 4LQY A;  3M8W A;  3Q3Q A;  1SHN A;  1O98 A;  4QAX A;  5EGE A;  4YR1 A;  3SZY A;  4GTW A;  5L0E A;  4UOO A;  2ANH A;  3CMR A;  5TJ3 A;  5KXA A;  2GSN A;  3NKM A;  1ZEF A;  2W8S A;  2VQR A;  3NKP A;  4NWX A;  4ZG7 A;  3T00 A;  3WAX A;  3A52 A;  1KHK A;  2W5Q A;  5INH A;  3NKO A;  3OT9 A;  5IJS A;  5C66 A;  4TN0 A;  4UPL A;  3IGZ B;  3MK0 A;  1KHL A;  1E1Z P;  5LIA A;  1HJK A;  2W8D A;  2QZU A;  2W5W A;  1ZED A;  4LRD A;  1KHJ A;  5K4P A;  4ZGA A;  1AJC A;  2IFY A;  3IDD A;  5DLV A;  1ALH A;  1O99 A;  3UNY A;  4KAV A;  3ED4 A;  4UPK A;  3M8Y A;  4LRF A;  5GOV A;  4UOR A;  3TX0 A;  3NVL A;  3WAV A;  3WBH A;  1EW8 A;  3BDF A;  1N2L A;  1KH9 A;  1KH4 A;  4UPI A;  3SZZ A;  4KM4 A;  1ELX A;  1EJJ A;  2ZKT A;  1AJA A;  1ZEB A;  5L0K A;  3BDH A;  4LRB A;  5GRR A;  1ANJ A;  2X98 A;  3NKR A;  5DLW A;  2W5S A;  1KH7 A;  4KAY A;  4LRE A;  1HDH A;  1N2K A;  3BDG B;  3WAW A;  1ED8 A;  5LRM A;  4KJG A;  5LQQ A;  4GTY A;  1E33 P;  4LRC A;  1ANI A;  2W5T A;  3UN2 A;  4CXK A;  2IUC A;  4UPH A;  3NKQ A;  2XRG A;  3T01 A;  2D1G A;  3TG0 A;  1URA A;  4FDI A;  2GLQ A;  4ZG6 A;  3MK2 A;  3M7V A;  1Y7A A;  3WAY A;  4B56 A;  4UOP A;  4MHX A;  3UO0 A;  1KHN A;  4FDJ A;  4LR9 A;  4LR2 A;  5IJQ A;  2W5X A;  3UN5 A;  5HRT A;  1HQA A;  3IGY B;  3NKN A;  4LR7 A;  4MY4 A;  2W5R A;  4CYR A;  1ALK A;  3UN3 A;  4CXS A;  2W5V A;  1KH5 A;  4N7T A;  2IUC B;  1P49 A;  1ELY A;  2GSU A;  4GTZ A;  4MIV A;  5EGH A;  1E2S P;  1EQJ A;  3T02 A;  5L0B A;  5LRN A;  2RH6 A;  2G9Y A;  4CYS A;  3B5Q A;  1SHQ A;  1K7H A;  4CXU A;  1ELZ A;  3DPC A;  1E3C P;  2GA3 A;  3M8Z A;  1AJD A;  3MK1 A;  2GSO A;  4NWJ A;  3KD8 A;  3E2D A;  1URB A;  1ALI A;  4LR8 A;  1ED9 A;  4LRA A;  3TWZ A;  1B8J A;  1ALJ A;  4KJD A;  4ZG9 A;  1EW9 A;  1Y6V A;  1AJB A;  5AJ9 A;  3DYC A;  3LXQ A;  1EW2 A;  1AUK A;  4GTX A;  2XR9 A;  3BDG A;  5DLT A;  1EI6 A;  1FSU A; 
#chains in the Genus database with same CATH homology
 4LQY A;  3M8W A;  3Q3Q A;  1SHN A;  1O98 A;  4QAX A;  5EGE A;  4YR1 A;  3SZY A;  4GTW A;  5L0E A;  4UOO A;  2ANH A;  3CMR A;  5TJ3 A;  5KXA A;  2GSN A;  3NKM A;  1ZEF A;  2W8S A;  2VQR A;  3NKP A;  4NWX A;  4ZG7 A;  3T00 A;  3WAX A;  3A52 A;  1KHK A;  2W5Q A;  5INH A;  3NKO A;  3OT9 A;  5IJS A;  5C66 A;  4TN0 A;  4UPL A;  3IGZ B;  3MK0 A;  1KHL A;  1E1Z P;  5LIA A;  1HJK A;  2W8D A;  2QZU A;  2W5W A;  1ZED A;  4LRD A;  1KHJ A;  5K4P A;  4ZGA A;  1AJC A;  2IFY A;  3IDD A;  5DLV A;  1ALH A;  1O99 A;  3UNY A;  4KAV A;  3ED4 A;  4UPK A;  3M8Y A;  4LRF A;  5GOV A;  4UOR A;  3TX0 A;  3NVL A;  3WAV A;  3WBH A;  1EW8 A;  3BDF A;  1N2L A;  1KH9 A;  1KH4 A;  4UPI A;  3SZZ A;  4KM4 A;  1ELX A;  1EJJ A;  2ZKT A;  1AJA A;  1ZEB A;  5L0K A;  3BDH A;  4LRB A;  5GRR A;  1ANJ A;  2X98 A;  3NKR A;  5DLW A;  2W5S A;  1KH7 A;  4KAY A;  4LRE A;  1HDH A;  1N2K A;  3BDG B;  3WAW A;  1ED8 A;  5LRM A;  4KJG A;  5LQQ A;  4GTY A;  1E33 P;  4LRC A;  1ANI A;  2W5T A;  3UN2 A;  4CXK A;  2IUC A;  4UPH A;  3NKQ A;  2XRG A;  3T01 A;  2D1G A;  3TG0 A;  1URA A;  4FDI A;  2GLQ A;  4ZG6 A;  3MK2 A;  3M7V A;  1Y7A A;  3WAY A;  4B56 A;  4UOP A;  4MHX A;  3UO0 A;  1KHN A;  4FDJ A;  4LR9 A;  4LR2 A;  5IJQ A;  2W5X A;  3UN5 A;  5HRT A;  1HQA A;  3IGY B;  3NKN A;  4LR7 A;  4MY4 A;  2W5R A;  4CYR A;  1ALK A;  3UN3 A;  4CXS A;  2W5V A;  1KH5 A;  4N7T A;  2IUC B;  1P49 A;  1ELY A;  2GSU A;  4GTZ A;  4MIV A;  5EGH A;  1E2S P;  1EQJ A;  3T02 A;  5L0B A;  5LRN A;  2RH6 A;  2G9Y A;  4CYS A;  3B5Q A;  1SHQ A;  1K7H A;  4CXU A;  1ELZ A;  3DPC A;  1E3C P;  2GA3 A;  3M8Z A;  1AJD A;  3MK1 A;  2GSO A;  4NWJ A;  3KD8 A;  3E2D A;  1URB A;  1ALI A;  4LR8 A;  1ED9 A;  4LRA A;  3TWZ A;  1B8J A;  1ALJ A;  4KJD A;  4ZG9 A;  1EW9 A;  1Y6V A;  1AJB A;  5AJ9 A;  3DYC A;  3LXQ A;  1EW2 A;  1AUK A;  4GTX A;  2XR9 A;  3BDG A;  5DLT A;  1EI6 A;  1FSU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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