3MK2A

Placental alkaline phosphatase complexed with phe
Total Genus 184
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 184
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk2A00
3WAXA 1EW9A 5GRRA 1SHNA 2G9YA 2IFYA 2GSOA 1URBA 1EI6A 3T02A 3E2DA 1O98A 1ANJA 4LRFA 5KXAA 2D1GA 4GTWA 1N2LA 2QZUA 3T01A 1KHNA 4N7TA 3DPCA 3NKMA 2VQRA 1B8JA 4KJDA 1HQAA 3MK0A 4MIVA 4TN0A 4UPKA 4ZG7A 1ED9A 2W8DA 3IDDA 3BDFA 1K7HA 5K4PA 4LRCA 3CMRA 3NKOA 4YR1A 1O99A 1KHKA 1ED8A 2IUCB 2W5SA 3M8WA 3A52A 3BDHA 4KM4A 4KAYA 4QAXA 5LQQA 5INHA 1E33P 1Y6VA 1AUKA 3M8YA 3UNYA 4LR2A 2W5RA 3B5QA 4UOPA 1KHLA 4GTYA 1Y7AA 5GOVA 4ZGAA 1E1ZP 3NKRA 1AJDA 3UN5A 3IGZB 1ELXA 4B56A 5IJQA 3ED4A 4CXSA 2GA3A 3IGYB 1P49A 1N2KA 5TJ3A 4GTXA 3BDGA 2XRGA 2W5TA 1AJBA 2GSNA 3BDGB 3LXQA 3SZZA 1ELYA 1ALKA 2W8SA 3MK2A 3SZYA 4ZG9A 5C66A 4FDIA 2W5XA 3NVLA 1ALHA 5DLVA 1KH9A 1SHQA 3MK1A 1ZEDA 4LR8A 4LRAA 4NWXA 4UPHA 4UOOA 2W5WA 5L0BA 3M7VA 3TWZA 4KAVA 3UN2A 4UPLA 1EQJA 3NKPA 4CXUA 4LR9A 5EGEA 4LRDA 3Q3QA 1URAA 1EW2A 4KJGA 3NKNA 2X98A 1ZEFA 2W5VA 3WAVA 3KD8A 4CXKA 1ALJA 2XR9A 3TG0A 1AJAA 1KHJA 2RH6A 1HJKA 3TX0A 3OT9A 3M8ZA 4MY4A 4UPIA 4UORA 4FDJA 3UO0A 2ANHA 5DLWA 1KH5A 5HRTA 2GLQA 1EW8A 4GTZA 4LRBA 5EGHA 3T00A 2W5QA 4LR7A 5IJSA 4NWJA 1KH7A 5L0EA 5LRNA 5LIAA 3WBHA 4MHXA 1ELZA 4LREA 5DLTA 1FSUA 1ANIA 4LQYA 3NKQA 5LRMA 5L0KA 1E2SP 1ALIA 1EJJA 1ZEBA 5AJ9A 1KH4A 2GSUA 4ZG6A 4CYSA 3WAWA 1E3CP 2IUCA 3DYCA 3WAYA 3UN3A 2ZKTA 1HDHA 4CYRA 1AJCA
chains in the Genus database with same CATH superfamily
3WAXA 1EW9A 5GRRA 1SHNA 2G9YA 2IFYA 2GSOA 1URBA 1EI6A 3T02A 3E2DA 1O98A 1ANJA 4LRFA 5KXAA 2D1GA 4GTWA 1N2LA 2QZUA 3T01A 1KHNA 4N7TA 3DPCA 3NKMA 2VQRA 1B8JA 4KJDA 1HQAA 3MK0A 4MIVA 4TN0A 4UPKA 4ZG7A 1ED9A 2W8DA 3IDDA 3BDFA 1K7HA 5K4PA 4LRCA 3CMRA 3NKOA 4YR1A 1O99A 1KHKA 1ED8A 2IUCB 2W5SA 3M8WA 3A52A 3BDHA 4KM4A 4KAYA 4QAXA 5LQQA 5INHA 1E33P 1Y6VA 1AUKA 3M8YA 3UNYA 4LR2A 2W5RA 3B5QA 4UOPA 1KHLA 4GTYA 1Y7AA 5GOVA 4ZGAA 1E1ZP 3NKRA 1AJDA 3UN5A 3IGZB 1ELXA 4B56A 5IJQA 3ED4A 4CXSA 2GA3A 3IGYB 1P49A 1N2KA 5TJ3A 4GTXA 3BDGA 2XRGA 2W5TA 1AJBA 2GSNA 3BDGB 3LXQA 3SZZA 1ELYA 1ALKA 2W8SA 3MK2A 3SZYA 4ZG9A 5C66A 4FDIA 2W5XA 3NVLA 1ALHA 5DLVA 1KH9A 1SHQA 3MK1A 1ZEDA 4LR8A 4LRAA 4NWXA 4UPHA 4UOOA 2W5WA 5L0BA 3M7VA 3TWZA 4KAVA 3UN2A 4UPLA 1EQJA 3NKPA 4CXUA 4LR9A 5EGEA 4LRDA 3Q3QA 1URAA 1EW2A 4KJGA 3NKNA 2X98A 1ZEFA 2W5VA 3WAVA 3KD8A 4CXKA 1ALJA 2XR9A 3TG0A 1AJAA 1KHJA 2RH6A 1HJKA 3TX0A 3OT9A 3M8ZA 4MY4A 4UPIA 4UORA 4FDJA 3UO0A 2ANHA 5DLWA 1KH5A 5HRTA 2GLQA 1EW8A 4GTZA 4LRBA 5EGHA 3T00A 2W5QA 4LR7A 5IJSA 4NWJA 1KH7A 5L0EA 5LRNA 5LIAA 3WBHA 4MHXA 1ELZA 4LREA 5DLTA 1FSUA 1ANIA 4LQYA 3NKQA 5LRMA 5L0KA 1E2SP 1ALIA 1EJJA 1ZEBA 5AJ9A 1KH4A 2GSUA 4ZG6A 4CYSA 3WAWA 1E3CP 2IUCA 3DYCA 3WAYA 3UN3A 2ZKTA 1HDHA 4CYRA 1AJCA
chains in the Genus database with same CATH topology
3WAXA 1EW9A 5GRRA 1SHNA 2G9YA 2IFYA 2GSOA 1URBA 1EI6A 3T02A 3E2DA 1O98A 1ANJA 4LRFA 5KXAA 2D1GA 4GTWA 1N2LA 2QZUA 3T01A 1KHNA 4N7TA 3DPCA 3NKMA 2VQRA 1B8JA 4KJDA 1HQAA 3MK0A 4MIVA 4TN0A 4UPKA 4ZG7A 1ED9A 2W8DA 3IDDA 3BDFA 1K7HA 5K4PA 4LRCA 3CMRA 3NKOA 4YR1A 1O99A 1KHKA 1ED8A 2IUCB 2W5SA 3M8WA 3A52A 3BDHA 4KM4A 4KAYA 4QAXA 5LQQA 5INHA 1E33P 1Y6VA 1AUKA 3M8YA 3UNYA 4LR2A 2W5RA 3B5QA 4UOPA 1KHLA 4GTYA 1Y7AA 5GOVA 4ZGAA 1E1ZP 3NKRA 1AJDA 3UN5A 3IGZB 1ELXA 4B56A 5IJQA 3ED4A 4CXSA 2GA3A 3IGYB 1P49A 1N2KA 5TJ3A 4GTXA 3BDGA 2XRGA 2W5TA 1AJBA 2GSNA 3BDGB 3LXQA 3SZZA 1ELYA 1ALKA 2W8SA 3MK2A 3SZYA 4ZG9A 5C66A 4FDIA 2W5XA 3NVLA 1ALHA 5DLVA 1KH9A 1SHQA 3MK1A 1ZEDA 4LR8A 4LRAA 4NWXA 4UPHA 4UOOA 2W5WA 5L0BA 3M7VA 3TWZA 4KAVA 3UN2A 4UPLA 1EQJA 3NKPA 4CXUA 4LR9A 5EGEA 4LRDA 3Q3QA 1URAA 1EW2A 4KJGA 3NKNA 2X98A 1ZEFA 2W5VA 3WAVA 3KD8A 4CXKA 1ALJA 2XR9A 3TG0A 1AJAA 1KHJA 2RH6A 1HJKA 3TX0A 3OT9A 3M8ZA 4MY4A 4UPIA 4UORA 4FDJA 3UO0A 2ANHA 5DLWA 1KH5A 5HRTA 2GLQA 1EW8A 4GTZA 4LRBA 5EGHA 3T00A 2W5QA 4LR7A 5IJSA 4NWJA 1KH7A 5L0EA 5LRNA 5LIAA 3WBHA 4MHXA 1ELZA 4LREA 5DLTA 1FSUA 1ANIA 4LQYA 3NKQA 5LRMA 5L0KA 1E2SP 1ALIA 1EJJA 1ZEBA 5AJ9A 1KH4A 2GSUA 4ZG6A 4CYSA 3WAWA 1E3CP 2IUCA 3DYCA 3WAYA 3UN3A 2ZKTA 1HDHA 4CYRA 1AJCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WAX A;  1EW9 A;  5GRR A;  1SHN A;  2G9Y A;  2IFY A;  2GSO A;  1URB A;  1EI6 A;  3T02 A;  3E2D A;  1O98 A;  1ANJ A;  4LRF A;  5KXA A;  2D1G A;  4GTW A;  1N2L A;  2QZU A;  3T01 A;  1KHN A;  4N7T A;  3DPC A;  3NKM A;  2VQR A;  1B8J A;  4KJD A;  1HQA A;  3MK0 A;  4MIV A;  4TN0 A;  4UPK A;  4ZG7 A;  1ED9 A;  2W8D A;  3IDD A;  3BDF A;  1K7H A;  5K4P A;  4LRC A;  3CMR A;  3NKO A;  4YR1 A;  1O99 A;  1KHK A;  1ED8 A;  2IUC B;  2W5S A;  3M8W A;  3A52 A;  3BDH A;  4KM4 A;  4KAY A;  4QAX A;  5LQQ A;  5INH A;  1E33 P;  1Y6V A;  1AUK A;  3M8Y A;  3UNY A;  4LR2 A;  2W5R A;  3B5Q A;  4UOP A;  1KHL A;  4GTY A;  1Y7A A;  5GOV A;  4ZGA A;  1E1Z P;  3NKR A;  1AJD A;  3UN5 A;  3IGZ B;  1ELX A;  4B56 A;  5IJQ A;  3ED4 A;  4CXS A;  2GA3 A;  3IGY B;  1P49 A;  1N2K A;  5TJ3 A;  4GTX A;  3BDG A;  2XRG A;  2W5T A;  1AJB A;  2GSN A;  3BDG B;  3LXQ A;  3SZZ A;  1ELY A;  1ALK A;  2W8S A;  3MK2 A;  3SZY A;  4ZG9 A;  5C66 A;  4FDI A;  2W5X A;  3NVL A;  1ALH A;  5DLV A;  1KH9 A;  1SHQ A;  3MK1 A;  1ZED A;  4LR8 A;  4LRA A;  4NWX A;  4UPH A;  4UOO A;  2W5W A;  5L0B A;  3M7V A;  3TWZ A;  4KAV A;  3UN2 A;  4UPL A;  1EQJ A;  3NKP A;  4CXU A;  4LR9 A;  5EGE A;  4LRD A;  3Q3Q A;  1URA A;  1EW2 A;  4KJG A;  3NKN A;  2X98 A;  1ZEF A;  2W5V A;  3WAV A;  3KD8 A;  4CXK A;  1ALJ A;  2XR9 A;  3TG0 A;  1AJA A;  1KHJ A;  2RH6 A;  1HJK A;  3TX0 A;  3OT9 A;  3M8Z A;  4MY4 A;  4UPI A;  4UOR A;  4FDJ A;  3UO0 A;  2ANH A;  5DLW A;  1KH5 A;  5HRT A;  2GLQ A;  1EW8 A;  4GTZ A;  4LRB A;  5EGH A;  3T00 A;  2W5Q A;  4LR7 A;  5IJS A;  4NWJ A;  1KH7 A;  5L0E A;  5LRN A;  5LIA A;  3WBH A;  4MHX A;  1ELZ A;  4LRE A;  5DLT A;  1FSU A;  1ANI A;  4LQY A;  3NKQ A;  5LRM A;  5L0K A;  1E2S P;  1ALI A;  1EJJ A;  1ZEB A;  5AJ9 A;  1KH4 A;  2GSU A;  4ZG6 A;  4CYS A;  3WAW A;  1E3C P;  2IUC A;  3DYC A;  3WAY A;  3UN3 A;  2ZKT A;  1HDH A;  4CYR A;  1AJC A; 
#chains in the Genus database with same CATH topology
 3WAX A;  1EW9 A;  5GRR A;  1SHN A;  2G9Y A;  2IFY A;  2GSO A;  1URB A;  1EI6 A;  3T02 A;  3E2D A;  1O98 A;  1ANJ A;  4LRF A;  5KXA A;  2D1G A;  4GTW A;  1N2L A;  2QZU A;  3T01 A;  1KHN A;  4N7T A;  3DPC A;  3NKM A;  2VQR A;  1B8J A;  4KJD A;  1HQA A;  3MK0 A;  4MIV A;  4TN0 A;  4UPK A;  4ZG7 A;  1ED9 A;  2W8D A;  3IDD A;  3BDF A;  1K7H A;  5K4P A;  4LRC A;  3CMR A;  3NKO A;  4YR1 A;  1O99 A;  1KHK A;  1ED8 A;  2IUC B;  2W5S A;  3M8W A;  3A52 A;  3BDH A;  4KM4 A;  4KAY A;  4QAX A;  5LQQ A;  5INH A;  1E33 P;  1Y6V A;  1AUK A;  3M8Y A;  3UNY A;  4LR2 A;  2W5R A;  3B5Q A;  4UOP A;  1KHL A;  4GTY A;  1Y7A A;  5GOV A;  4ZGA A;  1E1Z P;  3NKR A;  1AJD A;  3UN5 A;  3IGZ B;  1ELX A;  4B56 A;  5IJQ A;  3ED4 A;  4CXS A;  2GA3 A;  3IGY B;  1P49 A;  1N2K A;  5TJ3 A;  4GTX A;  3BDG A;  2XRG A;  2W5T A;  1AJB A;  2GSN A;  3BDG B;  3LXQ A;  3SZZ A;  1ELY A;  1ALK A;  2W8S A;  3MK2 A;  3SZY A;  4ZG9 A;  5C66 A;  4FDI A;  2W5X A;  3NVL A;  1ALH A;  5DLV A;  1KH9 A;  1SHQ A;  3MK1 A;  1ZED A;  4LR8 A;  4LRA A;  4NWX A;  4UPH A;  4UOO A;  2W5W A;  5L0B A;  3M7V A;  3TWZ A;  4KAV A;  3UN2 A;  4UPL A;  1EQJ A;  3NKP A;  4CXU A;  4LR9 A;  5EGE A;  4LRD A;  3Q3Q A;  1URA A;  1EW2 A;  4KJG A;  3NKN A;  2X98 A;  1ZEF A;  2W5V A;  3WAV A;  3KD8 A;  4CXK A;  1ALJ A;  2XR9 A;  3TG0 A;  1AJA A;  1KHJ A;  2RH6 A;  1HJK A;  3TX0 A;  3OT9 A;  3M8Z A;  4MY4 A;  4UPI A;  4UOR A;  4FDJ A;  3UO0 A;  2ANH A;  5DLW A;  1KH5 A;  5HRT A;  2GLQ A;  1EW8 A;  4GTZ A;  4LRB A;  5EGH A;  3T00 A;  2W5Q A;  4LR7 A;  5IJS A;  4NWJ A;  1KH7 A;  5L0E A;  5LRN A;  5LIA A;  3WBH A;  4MHX A;  1ELZ A;  4LRE A;  5DLT A;  1FSU A;  1ANI A;  4LQY A;  3NKQ A;  5LRM A;  5L0K A;  1E2S P;  1ALI A;  1EJJ A;  1ZEB A;  5AJ9 A;  1KH4 A;  2GSU A;  4ZG6 A;  4CYS A;  3WAW A;  1E3C P;  2IUC A;  3DYC A;  3WAY A;  3UN3 A;  2ZKT A;  1HDH A;  4CYR A;  1AJC A; 
#chains in the Genus database with same CATH homology
 3WAX A;  1EW9 A;  5GRR A;  1SHN A;  2G9Y A;  2IFY A;  2GSO A;  1URB A;  1EI6 A;  3T02 A;  3E2D A;  1O98 A;  1ANJ A;  4LRF A;  5KXA A;  2D1G A;  4GTW A;  1N2L A;  2QZU A;  3T01 A;  1KHN A;  4N7T A;  3DPC A;  3NKM A;  2VQR A;  1B8J A;  4KJD A;  1HQA A;  3MK0 A;  4MIV A;  4TN0 A;  4UPK A;  4ZG7 A;  1ED9 A;  2W8D A;  3IDD A;  3BDF A;  1K7H A;  5K4P A;  4LRC A;  3CMR A;  3NKO A;  4YR1 A;  1O99 A;  1KHK A;  1ED8 A;  2IUC B;  2W5S A;  3M8W A;  3A52 A;  3BDH A;  4KM4 A;  4KAY A;  4QAX A;  5LQQ A;  5INH A;  1E33 P;  1Y6V A;  1AUK A;  3M8Y A;  3UNY A;  4LR2 A;  2W5R A;  3B5Q A;  4UOP A;  1KHL A;  4GTY A;  1Y7A A;  5GOV A;  4ZGA A;  1E1Z P;  3NKR A;  1AJD A;  3UN5 A;  3IGZ B;  1ELX A;  4B56 A;  5IJQ A;  3ED4 A;  4CXS A;  2GA3 A;  3IGY B;  1P49 A;  1N2K A;  5TJ3 A;  4GTX A;  3BDG A;  2XRG A;  2W5T A;  1AJB A;  2GSN A;  3BDG B;  3LXQ A;  3SZZ A;  1ELY A;  1ALK A;  2W8S A;  3MK2 A;  3SZY A;  4ZG9 A;  5C66 A;  4FDI A;  2W5X A;  3NVL A;  1ALH A;  5DLV A;  1KH9 A;  1SHQ A;  3MK1 A;  1ZED A;  4LR8 A;  4LRA A;  4NWX A;  4UPH A;  4UOO A;  2W5W A;  5L0B A;  3M7V A;  3TWZ A;  4KAV A;  3UN2 A;  4UPL A;  1EQJ A;  3NKP A;  4CXU A;  4LR9 A;  5EGE A;  4LRD A;  3Q3Q A;  1URA A;  1EW2 A;  4KJG A;  3NKN A;  2X98 A;  1ZEF A;  2W5V A;  3WAV A;  3KD8 A;  4CXK A;  1ALJ A;  2XR9 A;  3TG0 A;  1AJA A;  1KHJ A;  2RH6 A;  1HJK A;  3TX0 A;  3OT9 A;  3M8Z A;  4MY4 A;  4UPI A;  4UOR A;  4FDJ A;  3UO0 A;  2ANH A;  5DLW A;  1KH5 A;  5HRT A;  2GLQ A;  1EW8 A;  4GTZ A;  4LRB A;  5EGH A;  3T00 A;  2W5Q A;  4LR7 A;  5IJS A;  4NWJ A;  1KH7 A;  5L0E A;  5LRN A;  5LIA A;  3WBH A;  4MHX A;  1ELZ A;  4LRE A;  5DLT A;  1FSU A;  1ANI A;  4LQY A;  3NKQ A;  5LRM A;  5L0K A;  1E2S P;  1ALI A;  1EJJ A;  1ZEB A;  5AJ9 A;  1KH4 A;  2GSU A;  4ZG6 A;  4CYS A;  3WAW A;  1E3C P;  2IUC A;  3DYC A;  3WAY A;  3UN3 A;  2ZKT A;  1HDH A;  4CYR A;  1AJC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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