5C66A

E. coli alkaline phosphatase in complex with tungstate
Total Genus 161
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
441
structure length
441
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli (strain k12)
molecule keywords Alkaline phosphatase
total genus 161
structure length 441
sequence length 441
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5c66A00
4MHXA 3WAYA 4ZG7A 4FDIA 3WAVA 1P49A 1ALHA 2W8SA 4GTXA 2IUCB 2W8DA 2GSUA 1KH5A 5IJQA 4GTZA 5L0KA 2XR9A 3T00A 3KD8A 3IGZB 4CYSA 5L0EA 4LR9A 4LRCA 4YR1A 3BDFA 4NWJA 1E3CP 1AJAA 3TG0A 5DLVA 2X98A 3A52A 1SHQA 4KJDA 4LRAA 2W5QA 5GRRA 1ALKA 1B8JA 3T01A 3T02A 4ZG9A 3Q3QA 3WAWA 2RH6A 1O98A 3M8YA 3SZYA 4LR8A 3OT9A 1KHKA 5LRNA 5LQQA 3NKNA 2W5SA 1URAA 4LR7A 1EQJA 3NKQA 4N7TA 4FDJA 3M8ZA 4B56A 4UORA 1FSUA 4LRFA 1URBA 2GSNA 4LR2A 1ZEDA 2GSOA 4CXKA 3TX0A 2VQRA 1E2SP 1EJJA 4ZG6A 1ELZA 1ELXA 2IUCA 3UN2A 1ED8A 4CXSA 3E2DA 3SZZA 3IDDA 5KXAA 4KJGA 1KH9A 2GA3A 1KH7A 3NVLA 1K7HA 3IGYB 3MK1A 4LQYA 4ZGAA 1Y7AA 3UNYA 1AJBA 1E1ZP 4UOPA 5AJ9A 3UO0A 1KH4A 4MIVA 3B5QA 3ED4A 3LXQA 3NKOA 2W5RA 1HDHA 4KM4A 4UPHA 1KHJA 3UN5A 1ZEFA 3BDHA 4CXUA 4UOOA 2D1GA 2XRGA 1KHNA 1E33P 3DPCA 4GTYA 1AUKA 4KAYA 1ALJA 5EGEA 3BDGB 4NWXA 3NKMA 4KAVA 2GLQA 2W5WA 4TN0A 3M7VA 1ELYA 1N2KA 5K4PA 1EW2A 4LRBA 3NKRA 4UPIA 3UN3A 5HRTA 5DLTA 1EW9A 1KHLA 5TJ3A 4GTWA 1AJDA 2QZUA 1Y6VA 5EGHA 5DLWA 1EI6A 3MK0A 5IJSA 4QAXA 5INHA 1HQAA 3MK2A 5LRMA 5L0BA 1O99A 4CYRA 1SHNA 4MY4A 2W5XA 4LREA 2ANHA 1N2LA 2ZKTA 4LRDA 3WAXA 4UPLA 2W5VA 2W5TA 1ALIA 3NKPA 1AJCA 1HJKA 3CMRA 5GOVA 3WBHA 1ZEBA 3TWZA 2G9YA 3BDGA 5C66A 1ANIA 1ED9A 2IFYA 4UPKA 1EW8A 3DYCA 3M8WA 5LIAA 1ANJA
chains in the Genus database with same CATH superfamily
4MHXA 3WAYA 4ZG7A 4FDIA 3WAVA 1P49A 1ALHA 2W8SA 4GTXA 2IUCB 2W8DA 2GSUA 1KH5A 5IJQA 4GTZA 5L0KA 2XR9A 3T00A 3KD8A 3IGZB 4CYSA 5L0EA 4LR9A 4LRCA 4YR1A 3BDFA 4NWJA 1E3CP 1AJAA 3TG0A 5DLVA 2X98A 3A52A 1SHQA 4KJDA 4LRAA 2W5QA 5GRRA 1ALKA 1B8JA 3T01A 3T02A 4ZG9A 3Q3QA 3WAWA 2RH6A 1O98A 3M8YA 3SZYA 4LR8A 3OT9A 1KHKA 5LRNA 5LQQA 3NKNA 2W5SA 1URAA 4LR7A 1EQJA 3NKQA 4N7TA 4FDJA 3M8ZA 4B56A 4UORA 1FSUA 4LRFA 1URBA 2GSNA 4LR2A 1ZEDA 2GSOA 4CXKA 3TX0A 2VQRA 1E2SP 1EJJA 4ZG6A 1ELZA 1ELXA 2IUCA 3UN2A 1ED8A 4CXSA 3E2DA 3SZZA 3IDDA 5KXAA 4KJGA 1KH9A 2GA3A 1KH7A 3NVLA 1K7HA 3IGYB 3MK1A 4LQYA 4ZGAA 1Y7AA 3UNYA 1AJBA 1E1ZP 4UOPA 5AJ9A 3UO0A 1KH4A 4MIVA 3B5QA 3ED4A 3LXQA 3NKOA 2W5RA 1HDHA 4KM4A 4UPHA 1KHJA 3UN5A 1ZEFA 3BDHA 4CXUA 4UOOA 2D1GA 2XRGA 1KHNA 1E33P 3DPCA 4GTYA 1AUKA 4KAYA 1ALJA 5EGEA 3BDGB 4NWXA 3NKMA 4KAVA 2GLQA 2W5WA 4TN0A 3M7VA 1ELYA 1N2KA 5K4PA 1EW2A 4LRBA 3NKRA 4UPIA 3UN3A 5HRTA 5DLTA 1EW9A 1KHLA 5TJ3A 4GTWA 1AJDA 2QZUA 1Y6VA 5EGHA 5DLWA 1EI6A 3MK0A 5IJSA 4QAXA 5INHA 1HQAA 3MK2A 5LRMA 5L0BA 1O99A 4CYRA 1SHNA 4MY4A 2W5XA 4LREA 2ANHA 1N2LA 2ZKTA 4LRDA 3WAXA 4UPLA 2W5VA 2W5TA 1ALIA 3NKPA 1AJCA 1HJKA 3CMRA 5GOVA 3WBHA 1ZEBA 3TWZA 2G9YA 3BDGA 5C66A 1ANIA 1ED9A 2IFYA 4UPKA 1EW8A 3DYCA 3M8WA 5LIAA 1ANJA
chains in the Genus database with same CATH topology
4MHXA 3WAYA 4ZG7A 4FDIA 3WAVA 1P49A 1ALHA 2W8SA 4GTXA 2IUCB 2W8DA 2GSUA 1KH5A 5IJQA 4GTZA 5L0KA 2XR9A 3T00A 3KD8A 3IGZB 4CYSA 5L0EA 4LR9A 4LRCA 4YR1A 3BDFA 4NWJA 1E3CP 1AJAA 3TG0A 5DLVA 2X98A 3A52A 1SHQA 4KJDA 4LRAA 2W5QA 5GRRA 1ALKA 1B8JA 3T01A 3T02A 4ZG9A 3Q3QA 3WAWA 2RH6A 1O98A 3M8YA 3SZYA 4LR8A 3OT9A 1KHKA 5LRNA 5LQQA 3NKNA 2W5SA 1URAA 4LR7A 1EQJA 3NKQA 4N7TA 4FDJA 3M8ZA 4B56A 4UORA 1FSUA 4LRFA 1URBA 2GSNA 4LR2A 1ZEDA 2GSOA 4CXKA 3TX0A 2VQRA 1E2SP 1EJJA 4ZG6A 1ELZA 1ELXA 2IUCA 3UN2A 1ED8A 4CXSA 3E2DA 3SZZA 3IDDA 5KXAA 4KJGA 1KH9A 2GA3A 1KH7A 3NVLA 1K7HA 3IGYB 3MK1A 4LQYA 4ZGAA 1Y7AA 3UNYA 1AJBA 1E1ZP 4UOPA 5AJ9A 3UO0A 1KH4A 4MIVA 3B5QA 3ED4A 3LXQA 3NKOA 2W5RA 1HDHA 4KM4A 4UPHA 1KHJA 3UN5A 1ZEFA 3BDHA 4CXUA 4UOOA 2D1GA 2XRGA 1KHNA 1E33P 3DPCA 4GTYA 1AUKA 4KAYA 1ALJA 5EGEA 3BDGB 4NWXA 3NKMA 4KAVA 2GLQA 2W5WA 4TN0A 3M7VA 1ELYA 1N2KA 5K4PA 1EW2A 4LRBA 3NKRA 4UPIA 3UN3A 5HRTA 5DLTA 1EW9A 1KHLA 5TJ3A 4GTWA 1AJDA 2QZUA 1Y6VA 5EGHA 5DLWA 1EI6A 3MK0A 5IJSA 4QAXA 5INHA 1HQAA 3MK2A 5LRMA 5L0BA 1O99A 4CYRA 1SHNA 4MY4A 2W5XA 4LREA 2ANHA 1N2LA 2ZKTA 4LRDA 3WAXA 4UPLA 2W5VA 2W5TA 1ALIA 3NKPA 1AJCA 1HJKA 3CMRA 5GOVA 3WBHA 1ZEBA 3TWZA 2G9YA 3BDGA 5C66A 1ANIA 1ED9A 2IFYA 4UPKA 1EW8A 3DYCA 3M8WA 5LIAA 1ANJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MHX A;  3WAY A;  4ZG7 A;  4FDI A;  3WAV A;  1P49 A;  1ALH A;  2W8S A;  4GTX A;  2IUC B;  2W8D A;  2GSU A;  1KH5 A;  5IJQ A;  4GTZ A;  5L0K A;  2XR9 A;  3T00 A;  3KD8 A;  3IGZ B;  4CYS A;  5L0E A;  4LR9 A;  4LRC A;  4YR1 A;  3BDF A;  4NWJ A;  1E3C P;  1AJA A;  3TG0 A;  5DLV A;  2X98 A;  3A52 A;  1SHQ A;  4KJD A;  4LRA A;  2W5Q A;  5GRR A;  1ALK A;  1B8J A;  3T01 A;  3T02 A;  4ZG9 A;  3Q3Q A;  3WAW A;  2RH6 A;  1O98 A;  3M8Y A;  3SZY A;  4LR8 A;  3OT9 A;  1KHK A;  5LRN A;  5LQQ A;  3NKN A;  2W5S A;  1URA A;  4LR7 A;  1EQJ A;  3NKQ A;  4N7T A;  4FDJ A;  3M8Z A;  4B56 A;  4UOR A;  1FSU A;  4LRF A;  1URB A;  2GSN A;  4LR2 A;  1ZED A;  2GSO A;  4CXK A;  3TX0 A;  2VQR A;  1E2S P;  1EJJ A;  4ZG6 A;  1ELZ A;  1ELX A;  2IUC A;  3UN2 A;  1ED8 A;  4CXS A;  3E2D A;  3SZZ A;  3IDD A;  5KXA A;  4KJG A;  1KH9 A;  2GA3 A;  1KH7 A;  3NVL A;  1K7H A;  3IGY B;  3MK1 A;  4LQY A;  4ZGA A;  1Y7A A;  3UNY A;  1AJB A;  1E1Z P;  4UOP A;  5AJ9 A;  3UO0 A;  1KH4 A;  4MIV A;  3B5Q A;  3ED4 A;  3LXQ A;  3NKO A;  2W5R A;  1HDH A;  4KM4 A;  4UPH A;  1KHJ A;  3UN5 A;  1ZEF A;  3BDH A;  4CXU A;  4UOO A;  2D1G A;  2XRG A;  1KHN A;  1E33 P;  3DPC A;  4GTY A;  1AUK A;  4KAY A;  1ALJ A;  5EGE A;  3BDG B;  4NWX A;  3NKM A;  4KAV A;  2GLQ A;  2W5W A;  4TN0 A;  3M7V A;  1ELY A;  1N2K A;  5K4P A;  1EW2 A;  4LRB A;  3NKR A;  4UPI A;  3UN3 A;  5HRT A;  5DLT A;  1EW9 A;  1KHL A;  5TJ3 A;  4GTW A;  1AJD A;  2QZU A;  1Y6V A;  5EGH A;  5DLW A;  1EI6 A;  3MK0 A;  5IJS A;  4QAX A;  5INH A;  1HQA A;  3MK2 A;  5LRM A;  5L0B A;  1O99 A;  4CYR A;  1SHN A;  4MY4 A;  2W5X A;  4LRE A;  2ANH A;  1N2L A;  2ZKT A;  4LRD A;  3WAX A;  4UPL A;  2W5V A;  2W5T A;  1ALI A;  3NKP A;  1AJC A;  1HJK A;  3CMR A;  5GOV A;  3WBH A;  1ZEB A;  3TWZ A;  2G9Y A;  3BDG A;  5C66 A;  1ANI A;  1ED9 A;  2IFY A;  4UPK A;  1EW8 A;  3DYC A;  3M8W A;  5LIA A;  1ANJ A; 
#chains in the Genus database with same CATH topology
 4MHX A;  3WAY A;  4ZG7 A;  4FDI A;  3WAV A;  1P49 A;  1ALH A;  2W8S A;  4GTX A;  2IUC B;  2W8D A;  2GSU A;  1KH5 A;  5IJQ A;  4GTZ A;  5L0K A;  2XR9 A;  3T00 A;  3KD8 A;  3IGZ B;  4CYS A;  5L0E A;  4LR9 A;  4LRC A;  4YR1 A;  3BDF A;  4NWJ A;  1E3C P;  1AJA A;  3TG0 A;  5DLV A;  2X98 A;  3A52 A;  1SHQ A;  4KJD A;  4LRA A;  2W5Q A;  5GRR A;  1ALK A;  1B8J A;  3T01 A;  3T02 A;  4ZG9 A;  3Q3Q A;  3WAW A;  2RH6 A;  1O98 A;  3M8Y A;  3SZY A;  4LR8 A;  3OT9 A;  1KHK A;  5LRN A;  5LQQ A;  3NKN A;  2W5S A;  1URA A;  4LR7 A;  1EQJ A;  3NKQ A;  4N7T A;  4FDJ A;  3M8Z A;  4B56 A;  4UOR A;  1FSU A;  4LRF A;  1URB A;  2GSN A;  4LR2 A;  1ZED A;  2GSO A;  4CXK A;  3TX0 A;  2VQR A;  1E2S P;  1EJJ A;  4ZG6 A;  1ELZ A;  1ELX A;  2IUC A;  3UN2 A;  1ED8 A;  4CXS A;  3E2D A;  3SZZ A;  3IDD A;  5KXA A;  4KJG A;  1KH9 A;  2GA3 A;  1KH7 A;  3NVL A;  1K7H A;  3IGY B;  3MK1 A;  4LQY A;  4ZGA A;  1Y7A A;  3UNY A;  1AJB A;  1E1Z P;  4UOP A;  5AJ9 A;  3UO0 A;  1KH4 A;  4MIV A;  3B5Q A;  3ED4 A;  3LXQ A;  3NKO A;  2W5R A;  1HDH A;  4KM4 A;  4UPH A;  1KHJ A;  3UN5 A;  1ZEF A;  3BDH A;  4CXU A;  4UOO A;  2D1G A;  2XRG A;  1KHN A;  1E33 P;  3DPC A;  4GTY A;  1AUK A;  4KAY A;  1ALJ A;  5EGE A;  3BDG B;  4NWX A;  3NKM A;  4KAV A;  2GLQ A;  2W5W A;  4TN0 A;  3M7V A;  1ELY A;  1N2K A;  5K4P A;  1EW2 A;  4LRB A;  3NKR A;  4UPI A;  3UN3 A;  5HRT A;  5DLT A;  1EW9 A;  1KHL A;  5TJ3 A;  4GTW A;  1AJD A;  2QZU A;  1Y6V A;  5EGH A;  5DLW A;  1EI6 A;  3MK0 A;  5IJS A;  4QAX A;  5INH A;  1HQA A;  3MK2 A;  5LRM A;  5L0B A;  1O99 A;  4CYR A;  1SHN A;  4MY4 A;  2W5X A;  4LRE A;  2ANH A;  1N2L A;  2ZKT A;  4LRD A;  3WAX A;  4UPL A;  2W5V A;  2W5T A;  1ALI A;  3NKP A;  1AJC A;  1HJK A;  3CMR A;  5GOV A;  3WBH A;  1ZEB A;  3TWZ A;  2G9Y A;  3BDG A;  5C66 A;  1ANI A;  1ED9 A;  2IFY A;  4UPK A;  1EW8 A;  3DYC A;  3M8W A;  5LIA A;  1ANJ A; 
#chains in the Genus database with same CATH homology
 4MHX A;  3WAY A;  4ZG7 A;  4FDI A;  3WAV A;  1P49 A;  1ALH A;  2W8S A;  4GTX A;  2IUC B;  2W8D A;  2GSU A;  1KH5 A;  5IJQ A;  4GTZ A;  5L0K A;  2XR9 A;  3T00 A;  3KD8 A;  3IGZ B;  4CYS A;  5L0E A;  4LR9 A;  4LRC A;  4YR1 A;  3BDF A;  4NWJ A;  1E3C P;  1AJA A;  3TG0 A;  5DLV A;  2X98 A;  3A52 A;  1SHQ A;  4KJD A;  4LRA A;  2W5Q A;  5GRR A;  1ALK A;  1B8J A;  3T01 A;  3T02 A;  4ZG9 A;  3Q3Q A;  3WAW A;  2RH6 A;  1O98 A;  3M8Y A;  3SZY A;  4LR8 A;  3OT9 A;  1KHK A;  5LRN A;  5LQQ A;  3NKN A;  2W5S A;  1URA A;  4LR7 A;  1EQJ A;  3NKQ A;  4N7T A;  4FDJ A;  3M8Z A;  4B56 A;  4UOR A;  1FSU A;  4LRF A;  1URB A;  2GSN A;  4LR2 A;  1ZED A;  2GSO A;  4CXK A;  3TX0 A;  2VQR A;  1E2S P;  1EJJ A;  4ZG6 A;  1ELZ A;  1ELX A;  2IUC A;  3UN2 A;  1ED8 A;  4CXS A;  3E2D A;  3SZZ A;  3IDD A;  5KXA A;  4KJG A;  1KH9 A;  2GA3 A;  1KH7 A;  3NVL A;  1K7H A;  3IGY B;  3MK1 A;  4LQY A;  4ZGA A;  1Y7A A;  3UNY A;  1AJB A;  1E1Z P;  4UOP A;  5AJ9 A;  3UO0 A;  1KH4 A;  4MIV A;  3B5Q A;  3ED4 A;  3LXQ A;  3NKO A;  2W5R A;  1HDH A;  4KM4 A;  4UPH A;  1KHJ A;  3UN5 A;  1ZEF A;  3BDH A;  4CXU A;  4UOO A;  2D1G A;  2XRG A;  1KHN A;  1E33 P;  3DPC A;  4GTY A;  1AUK A;  4KAY A;  1ALJ A;  5EGE A;  3BDG B;  4NWX A;  3NKM A;  4KAV A;  2GLQ A;  2W5W A;  4TN0 A;  3M7V A;  1ELY A;  1N2K A;  5K4P A;  1EW2 A;  4LRB A;  3NKR A;  4UPI A;  3UN3 A;  5HRT A;  5DLT A;  1EW9 A;  1KHL A;  5TJ3 A;  4GTW A;  1AJD A;  2QZU A;  1Y6V A;  5EGH A;  5DLW A;  1EI6 A;  3MK0 A;  5IJS A;  4QAX A;  5INH A;  1HQA A;  3MK2 A;  5LRM A;  5L0B A;  1O99 A;  4CYR A;  1SHN A;  4MY4 A;  2W5X A;  4LRE A;  2ANH A;  1N2L A;  2ZKT A;  4LRD A;  3WAX A;  4UPL A;  2W5V A;  2W5T A;  1ALI A;  3NKP A;  1AJC A;  1HJK A;  3CMR A;  5GOV A;  3WBH A;  1ZEB A;  3TWZ A;  2G9Y A;  3BDG A;  5C66 A;  1ANI A;  1ED9 A;  2IFY A;  4UPK A;  1EW8 A;  3DYC A;  3M8W A;  5LIA A;  1ANJ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...