5C66A

E. coli alkaline phosphatase in complex with tungstate
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
441
structure length
441
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli (strain k12)
molecule keywords Alkaline phosphatase
total genus 161
structure length 441
sequence length 441
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5c66A00
4LR8A 1HDHA 4UORA 1EQJA 4UPLA 4GTXA 2W5SA 4UOOA 4ZG6A 2GA3A 4LRDA 3WAYA 1AJCA 3TG0A 5GOVA 5IJSA 1EW9A 4UPHA 1Y6VA 3LXQA 3M7VA 1ANJA 1ELYA 3IGZB 1KHNA 1ED9A 2W5TA 1ZEDA 4YR1A 1EW2A 4MY4A 1ELXA 4LR2A 2G9YA 1E1ZP 3NKNA 1KHLA 2ZKTA 4GTZA 1P49A 1E2SP 1ZEBA 3IGYB 3M8ZA 3WBHA 3WAXA 4ZG9A 5DLVA 1KHKA 1SHQA 3BDFA 3DYCA 3BDGA 1ED8A 4LRAA 1ALIA 4GTWA 3UN5A 2XRGA 1KH5A 5GRRA 2W8SA 5L0EA 3A52A 2IUCA 4MHXA 5LRNA 3WAWA 2W5VA 2VQRA 3M8WA 4LRBA 4FDJA 5INHA 1E33P 3NKRA 2GSUA 2GLQA 3TX0A 3B5QA 3WAVA 2GSNA 1HQAA 1N2KA 1ZEFA 5HRTA 1URAA 3KD8A 3OT9A 3MK0A 4UPIA 5TJ3A 3UN2A 1K7HA 4LQYA 5DLWA 2D1GA 2IFYA 3T02A 3M8YA 1B8JA 3UO0A 3E2DA 3BDGB 5EGEA 4UPKA 1E3CP 4CXKA 4MIVA 3Q3QA 1O99A 2IUCB 1HJKA 5KXAA 4QAXA 4KJGA 1ALKA 5C66A 4FDIA 4LRFA 3UNYA 2W5WA 5DLTA 4LR9A 4TN0A 4N7TA 4GTYA 4ZGAA 3NKQA 3SZYA 3BDHA 1SHNA 4NWXA 2RH6A 4KAYA 1ELZA 4KAVA 1KHJA 1KH7A 1AJAA 1ALJA 1O98A 1KH9A 5AJ9A 3TWZA 5K4PA 4CYSA 4ZG7A 1AJDA 4LREA 4CYRA 1FSUA 3DPCA 2W5RA 2W5XA 1AJBA 1AUKA 3NKOA 5EGHA 4NWJA 1EW8A 3MK2A 4LR7A 3T01A 3T00A 5LQQA 5IJQA 1KH4A 1N2LA 1Y7AA 2W5QA 4KJDA 2GSOA 3NKMA 2XR9A 4LRCA 1URBA 5L0BA 3SZZA 4CXSA 3MK1A 1EI6A 2X98A 5LIAA 3IDDA 4UOPA 5L0KA 2W8DA 3UN3A 4CXUA 4B56A 5LRMA 1ANIA 1ALHA 2ANHA 1EJJA 2QZUA 3CMRA 3ED4A 4KM4A 3NVLA 3NKPA
chains in the Genus database with same CATH superfamily
4LR8A 1HDHA 4UORA 1EQJA 4UPLA 4GTXA 2W5SA 4UOOA 4ZG6A 2GA3A 4LRDA 3WAYA 1AJCA 3TG0A 5GOVA 5IJSA 1EW9A 4UPHA 1Y6VA 3LXQA 3M7VA 1ANJA 1ELYA 3IGZB 1KHNA 1ED9A 2W5TA 1ZEDA 4YR1A 1EW2A 4MY4A 1ELXA 4LR2A 2G9YA 1E1ZP 3NKNA 1KHLA 2ZKTA 4GTZA 1P49A 1E2SP 1ZEBA 3IGYB 3M8ZA 3WBHA 3WAXA 4ZG9A 5DLVA 1KHKA 1SHQA 3BDFA 3DYCA 3BDGA 1ED8A 4LRAA 1ALIA 4GTWA 3UN5A 2XRGA 1KH5A 5GRRA 2W8SA 5L0EA 3A52A 2IUCA 4MHXA 5LRNA 3WAWA 2W5VA 2VQRA 3M8WA 4LRBA 4FDJA 5INHA 1E33P 3NKRA 2GSUA 2GLQA 3TX0A 3B5QA 3WAVA 2GSNA 1HQAA 1N2KA 1ZEFA 5HRTA 1URAA 3KD8A 3OT9A 3MK0A 4UPIA 5TJ3A 3UN2A 1K7HA 4LQYA 5DLWA 2D1GA 2IFYA 3T02A 3M8YA 1B8JA 3UO0A 3E2DA 3BDGB 5EGEA 4UPKA 1E3CP 4CXKA 4MIVA 3Q3QA 1O99A 2IUCB 1HJKA 5KXAA 4QAXA 4KJGA 1ALKA 5C66A 4FDIA 4LRFA 3UNYA 2W5WA 5DLTA 4LR9A 4TN0A 4N7TA 4GTYA 4ZGAA 3NKQA 3SZYA 3BDHA 1SHNA 4NWXA 2RH6A 4KAYA 1ELZA 4KAVA 1KHJA 1KH7A 1AJAA 1ALJA 1O98A 1KH9A 5AJ9A 3TWZA 5K4PA 4CYSA 4ZG7A 1AJDA 4LREA 4CYRA 1FSUA 3DPCA 2W5RA 2W5XA 1AJBA 1AUKA 3NKOA 5EGHA 4NWJA 1EW8A 3MK2A 4LR7A 3T01A 3T00A 5LQQA 5IJQA 1KH4A 1N2LA 1Y7AA 2W5QA 4KJDA 2GSOA 3NKMA 2XR9A 4LRCA 1URBA 5L0BA 3SZZA 4CXSA 3MK1A 1EI6A 2X98A 5LIAA 3IDDA 4UOPA 5L0KA 2W8DA 3UN3A 4CXUA 4B56A 5LRMA 1ANIA 1ALHA 2ANHA 1EJJA 2QZUA 3CMRA 3ED4A 4KM4A 3NVLA 3NKPA
chains in the Genus database with same CATH topology
4LR8A 1HDHA 4UORA 1EQJA 4UPLA 4GTXA 2W5SA 4UOOA 4ZG6A 2GA3A 4LRDA 3WAYA 1AJCA 3TG0A 5GOVA 5IJSA 1EW9A 4UPHA 1Y6VA 3LXQA 3M7VA 1ANJA 1ELYA 3IGZB 1KHNA 1ED9A 2W5TA 1ZEDA 4YR1A 1EW2A 4MY4A 1ELXA 4LR2A 2G9YA 1E1ZP 3NKNA 1KHLA 2ZKTA 4GTZA 1P49A 1E2SP 1ZEBA 3IGYB 3M8ZA 3WBHA 3WAXA 4ZG9A 5DLVA 1KHKA 1SHQA 3BDFA 3DYCA 3BDGA 1ED8A 4LRAA 1ALIA 4GTWA 3UN5A 2XRGA 1KH5A 5GRRA 2W8SA 5L0EA 3A52A 2IUCA 4MHXA 5LRNA 3WAWA 2W5VA 2VQRA 3M8WA 4LRBA 4FDJA 5INHA 1E33P 3NKRA 2GSUA 2GLQA 3TX0A 3B5QA 3WAVA 2GSNA 1HQAA 1N2KA 1ZEFA 5HRTA 1URAA 3KD8A 3OT9A 3MK0A 4UPIA 5TJ3A 3UN2A 1K7HA 4LQYA 5DLWA 2D1GA 2IFYA 3T02A 3M8YA 1B8JA 3UO0A 3E2DA 3BDGB 5EGEA 4UPKA 1E3CP 4CXKA 4MIVA 3Q3QA 1O99A 2IUCB 1HJKA 5KXAA 4QAXA 4KJGA 1ALKA 5C66A 4FDIA 4LRFA 3UNYA 2W5WA 5DLTA 4LR9A 4TN0A 4N7TA 4GTYA 4ZGAA 3NKQA 3SZYA 3BDHA 1SHNA 4NWXA 2RH6A 4KAYA 1ELZA 4KAVA 1KHJA 1KH7A 1AJAA 1ALJA 1O98A 1KH9A 5AJ9A 3TWZA 5K4PA 4CYSA 4ZG7A 1AJDA 4LREA 4CYRA 1FSUA 3DPCA 2W5RA 2W5XA 1AJBA 1AUKA 3NKOA 5EGHA 4NWJA 1EW8A 3MK2A 4LR7A 3T01A 3T00A 5LQQA 5IJQA 1KH4A 1N2LA 1Y7AA 2W5QA 4KJDA 2GSOA 3NKMA 2XR9A 4LRCA 1URBA 5L0BA 3SZZA 4CXSA 3MK1A 1EI6A 2X98A 5LIAA 3IDDA 4UOPA 5L0KA 2W8DA 3UN3A 4CXUA 4B56A 5LRMA 1ANIA 1ALHA 2ANHA 1EJJA 2QZUA 3CMRA 3ED4A 4KM4A 3NVLA 3NKPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR8 A;  1HDH A;  4UOR A;  1EQJ A;  4UPL A;  4GTX A;  2W5S A;  4UOO A;  4ZG6 A;  2GA3 A;  4LRD A;  3WAY A;  1AJC A;  3TG0 A;  5GOV A;  5IJS A;  1EW9 A;  4UPH A;  1Y6V A;  3LXQ A;  3M7V A;  1ANJ A;  1ELY A;  3IGZ B;  1KHN A;  1ED9 A;  2W5T A;  1ZED A;  4YR1 A;  1EW2 A;  4MY4 A;  1ELX A;  4LR2 A;  2G9Y A;  1E1Z P;  3NKN A;  1KHL A;  2ZKT A;  4GTZ A;  1P49 A;  1E2S P;  1ZEB A;  3IGY B;  3M8Z A;  3WBH A;  3WAX A;  4ZG9 A;  5DLV A;  1KHK A;  1SHQ A;  3BDF A;  3DYC A;  3BDG A;  1ED8 A;  4LRA A;  1ALI A;  4GTW A;  3UN5 A;  2XRG A;  1KH5 A;  5GRR A;  2W8S A;  5L0E A;  3A52 A;  2IUC A;  4MHX A;  5LRN A;  3WAW A;  2W5V A;  2VQR A;  3M8W A;  4LRB A;  4FDJ A;  5INH A;  1E33 P;  3NKR A;  2GSU A;  2GLQ A;  3TX0 A;  3B5Q A;  3WAV A;  2GSN A;  1HQA A;  1N2K A;  1ZEF A;  5HRT A;  1URA A;  3KD8 A;  3OT9 A;  3MK0 A;  4UPI A;  5TJ3 A;  3UN2 A;  1K7H A;  4LQY A;  5DLW A;  2D1G A;  2IFY A;  3T02 A;  3M8Y A;  1B8J A;  3UO0 A;  3E2D A;  3BDG B;  5EGE A;  4UPK A;  1E3C P;  4CXK A;  4MIV A;  3Q3Q A;  1O99 A;  2IUC B;  1HJK A;  5KXA A;  4QAX A;  4KJG A;  1ALK A;  5C66 A;  4FDI A;  4LRF A;  3UNY A;  2W5W A;  5DLT A;  4LR9 A;  4TN0 A;  4N7T A;  4GTY A;  4ZGA A;  3NKQ A;  3SZY A;  3BDH A;  1SHN A;  4NWX A;  2RH6 A;  4KAY A;  1ELZ A;  4KAV A;  1KHJ A;  1KH7 A;  1AJA A;  1ALJ A;  1O98 A;  1KH9 A;  5AJ9 A;  3TWZ A;  5K4P A;  4CYS A;  4ZG7 A;  1AJD A;  4LRE A;  4CYR A;  1FSU A;  3DPC A;  2W5R A;  2W5X A;  1AJB A;  1AUK A;  3NKO A;  5EGH A;  4NWJ A;  1EW8 A;  3MK2 A;  4LR7 A;  3T01 A;  3T00 A;  5LQQ A;  5IJQ A;  1KH4 A;  1N2L A;  1Y7A A;  2W5Q A;  4KJD A;  2GSO A;  3NKM A;  2XR9 A;  4LRC A;  1URB A;  5L0B A;  3SZZ A;  4CXS A;  3MK1 A;  1EI6 A;  2X98 A;  5LIA A;  3IDD A;  4UOP A;  5L0K A;  2W8D A;  3UN3 A;  4CXU A;  4B56 A;  5LRM A;  1ANI A;  1ALH A;  2ANH A;  1EJJ A;  2QZU A;  3CMR A;  3ED4 A;  4KM4 A;  3NVL A;  3NKP A; 
#chains in the Genus database with same CATH topology
 4LR8 A;  1HDH A;  4UOR A;  1EQJ A;  4UPL A;  4GTX A;  2W5S A;  4UOO A;  4ZG6 A;  2GA3 A;  4LRD A;  3WAY A;  1AJC A;  3TG0 A;  5GOV A;  5IJS A;  1EW9 A;  4UPH A;  1Y6V A;  3LXQ A;  3M7V A;  1ANJ A;  1ELY A;  3IGZ B;  1KHN A;  1ED9 A;  2W5T A;  1ZED A;  4YR1 A;  1EW2 A;  4MY4 A;  1ELX A;  4LR2 A;  2G9Y A;  1E1Z P;  3NKN A;  1KHL A;  2ZKT A;  4GTZ A;  1P49 A;  1E2S P;  1ZEB A;  3IGY B;  3M8Z A;  3WBH A;  3WAX A;  4ZG9 A;  5DLV A;  1KHK A;  1SHQ A;  3BDF A;  3DYC A;  3BDG A;  1ED8 A;  4LRA A;  1ALI A;  4GTW A;  3UN5 A;  2XRG A;  1KH5 A;  5GRR A;  2W8S A;  5L0E A;  3A52 A;  2IUC A;  4MHX A;  5LRN A;  3WAW A;  2W5V A;  2VQR A;  3M8W A;  4LRB A;  4FDJ A;  5INH A;  1E33 P;  3NKR A;  2GSU A;  2GLQ A;  3TX0 A;  3B5Q A;  3WAV A;  2GSN A;  1HQA A;  1N2K A;  1ZEF A;  5HRT A;  1URA A;  3KD8 A;  3OT9 A;  3MK0 A;  4UPI A;  5TJ3 A;  3UN2 A;  1K7H A;  4LQY A;  5DLW A;  2D1G A;  2IFY A;  3T02 A;  3M8Y A;  1B8J A;  3UO0 A;  3E2D A;  3BDG B;  5EGE A;  4UPK A;  1E3C P;  4CXK A;  4MIV A;  3Q3Q A;  1O99 A;  2IUC B;  1HJK A;  5KXA A;  4QAX A;  4KJG A;  1ALK A;  5C66 A;  4FDI A;  4LRF A;  3UNY A;  2W5W A;  5DLT A;  4LR9 A;  4TN0 A;  4N7T A;  4GTY A;  4ZGA A;  3NKQ A;  3SZY A;  3BDH A;  1SHN A;  4NWX A;  2RH6 A;  4KAY A;  1ELZ A;  4KAV A;  1KHJ A;  1KH7 A;  1AJA A;  1ALJ A;  1O98 A;  1KH9 A;  5AJ9 A;  3TWZ A;  5K4P A;  4CYS A;  4ZG7 A;  1AJD A;  4LRE A;  4CYR A;  1FSU A;  3DPC A;  2W5R A;  2W5X A;  1AJB A;  1AUK A;  3NKO A;  5EGH A;  4NWJ A;  1EW8 A;  3MK2 A;  4LR7 A;  3T01 A;  3T00 A;  5LQQ A;  5IJQ A;  1KH4 A;  1N2L A;  1Y7A A;  2W5Q A;  4KJD A;  2GSO A;  3NKM A;  2XR9 A;  4LRC A;  1URB A;  5L0B A;  3SZZ A;  4CXS A;  3MK1 A;  1EI6 A;  2X98 A;  5LIA A;  3IDD A;  4UOP A;  5L0K A;  2W8D A;  3UN3 A;  4CXU A;  4B56 A;  5LRM A;  1ANI A;  1ALH A;  2ANH A;  1EJJ A;  2QZU A;  3CMR A;  3ED4 A;  4KM4 A;  3NVL A;  3NKP A; 
#chains in the Genus database with same CATH homology
 4LR8 A;  1HDH A;  4UOR A;  1EQJ A;  4UPL A;  4GTX A;  2W5S A;  4UOO A;  4ZG6 A;  2GA3 A;  4LRD A;  3WAY A;  1AJC A;  3TG0 A;  5GOV A;  5IJS A;  1EW9 A;  4UPH A;  1Y6V A;  3LXQ A;  3M7V A;  1ANJ A;  1ELY A;  3IGZ B;  1KHN A;  1ED9 A;  2W5T A;  1ZED A;  4YR1 A;  1EW2 A;  4MY4 A;  1ELX A;  4LR2 A;  2G9Y A;  1E1Z P;  3NKN A;  1KHL A;  2ZKT A;  4GTZ A;  1P49 A;  1E2S P;  1ZEB A;  3IGY B;  3M8Z A;  3WBH A;  3WAX A;  4ZG9 A;  5DLV A;  1KHK A;  1SHQ A;  3BDF A;  3DYC A;  3BDG A;  1ED8 A;  4LRA A;  1ALI A;  4GTW A;  3UN5 A;  2XRG A;  1KH5 A;  5GRR A;  2W8S A;  5L0E A;  3A52 A;  2IUC A;  4MHX A;  5LRN A;  3WAW A;  2W5V A;  2VQR A;  3M8W A;  4LRB A;  4FDJ A;  5INH A;  1E33 P;  3NKR A;  2GSU A;  2GLQ A;  3TX0 A;  3B5Q A;  3WAV A;  2GSN A;  1HQA A;  1N2K A;  1ZEF A;  5HRT A;  1URA A;  3KD8 A;  3OT9 A;  3MK0 A;  4UPI A;  5TJ3 A;  3UN2 A;  1K7H A;  4LQY A;  5DLW A;  2D1G A;  2IFY A;  3T02 A;  3M8Y A;  1B8J A;  3UO0 A;  3E2D A;  3BDG B;  5EGE A;  4UPK A;  1E3C P;  4CXK A;  4MIV A;  3Q3Q A;  1O99 A;  2IUC B;  1HJK A;  5KXA A;  4QAX A;  4KJG A;  1ALK A;  5C66 A;  4FDI A;  4LRF A;  3UNY A;  2W5W A;  5DLT A;  4LR9 A;  4TN0 A;  4N7T A;  4GTY A;  4ZGA A;  3NKQ A;  3SZY A;  3BDH A;  1SHN A;  4NWX A;  2RH6 A;  4KAY A;  1ELZ A;  4KAV A;  1KHJ A;  1KH7 A;  1AJA A;  1ALJ A;  1O98 A;  1KH9 A;  5AJ9 A;  3TWZ A;  5K4P A;  4CYS A;  4ZG7 A;  1AJD A;  4LRE A;  4CYR A;  1FSU A;  3DPC A;  2W5R A;  2W5X A;  1AJB A;  1AUK A;  3NKO A;  5EGH A;  4NWJ A;  1EW8 A;  3MK2 A;  4LR7 A;  3T01 A;  3T00 A;  5LQQ A;  5IJQ A;  1KH4 A;  1N2L A;  1Y7A A;  2W5Q A;  4KJD A;  2GSO A;  3NKM A;  2XR9 A;  4LRC A;  1URB A;  5L0B A;  3SZZ A;  4CXS A;  3MK1 A;  1EI6 A;  2X98 A;  5LIA A;  3IDD A;  4UOP A;  5L0K A;  2W8D A;  3UN3 A;  4CXU A;  4B56 A;  5LRM A;  1ANI A;  1ALH A;  2ANH A;  1EJJ A;  2QZU A;  3CMR A;  3ED4 A;  4KM4 A;  3NVL A;  3NKP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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