5C66A

E. coli alkaline phosphatase in complex with tungstate
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
441
structure length
441
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli (strain k12)
molecule keywords Alkaline phosphatase
total genus 161
structure length 441
sequence length 441
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5c66A00
1E33P 1ALKA 4LQYA 3BDFA 2ANHA 4CXKA 5LRNA 3NVLA 1KHNA 1ZEFA 3A52A 2W5VA 3TG0A 1FSUA 3NKRA 4CXUA 4CYSA 4LR2A 1ALIA 3T00A 3DPCA 5K4PA 1EW9A 3CMRA 5L0EA 2GLQA 3TX0A 3WAYA 2W5WA 3BDGA 5LRMA 1N2KA 3MK1A 5KXAA 2W8DA 4UPHA 4TN0A 4UOOA 1KHLA 3B5QA 3IGZB 4KM4A 1O98A 4LREA 3M8WA 1E2SP 2VQRA 4B56A 4GTZA 3NKQA 4CXSA 5GOVA 4LRFA 1KH9A 3SZZA 4LRAA 1E1ZP 3DYCA 1EW2A 3NKPA 4NWXA 3UO0A 4CYRA 5HRTA 5INHA 4FDJA 1KH7A 2W5QA 4LRDA 3ED4A 5LIAA 1Y7AA 2W8SA 3WAWA 3M7VA 3IDDA 5AJ9A 2W5RA 4MY4A 5EGHA 4MIVA 5GRRA 5L0KA 2IFYA 5L0BA 4LR8A 3M8ZA 1ED8A 4UOPA 3SZYA 4GTYA 3WAVA 3MK0A 2IUCB 4UPIA 1Y6VA 4GTXA 4LR7A 1KH5A 1ANJA 3LXQA 4KAYA 1N2LA 1URBA 4UPKA 2W5XA 2GA3A 1EQJA 4KAVA 1HQAA 3UN5A 3BDGB 4ZG6A 2XR9A 4YR1A 4ZG7A 3UN3A 1AJCA 1EI6A 2G9YA 1AJAA 2W5TA 3OT9A 2XRGA 1EJJA 3IGYB 3WBHA 5IJSA 3MK2A 1HDHA 2D1GA 4KJDA 4UPLA 1ALJA 1O99A 2RH6A 1ED9A 1B8JA 1HJKA 4ZGAA 1ANIA 1K7HA 1SHNA 1ELXA 4GTWA 2GSOA 5DLTA 3T02A 3NKMA 3BDHA 4ZG9A 1P49A 5C66A 5DLWA 1ALHA 3NKOA 4FDIA 5EGEA 2W5SA 1SHQA 4KJGA 4QAXA 2GSNA 4N7TA 1ZEDA 2IUCA 1AUKA 1AJDA 1ELZA 3Q3QA 3UN2A 3NKNA 3UNYA 3WAXA 5LQQA 2ZKTA 3KD8A 2QZUA 4LRCA 4MHXA 1URAA 1EW8A 1ZEBA 2X98A 1KHJA 1ELYA 4LRBA 3E2DA 5TJ3A 3TWZA 1KHKA 4LR9A 1E3CP 1AJBA 3M8YA 5IJQA 3T01A 2GSUA 4NWJA 4UORA 1KH4A 5DLVA
chains in the Genus database with same CATH superfamily
1E33P 1ALKA 4LQYA 3BDFA 2ANHA 4CXKA 5LRNA 3NVLA 1KHNA 1ZEFA 3A52A 2W5VA 3TG0A 1FSUA 3NKRA 4CXUA 4CYSA 4LR2A 1ALIA 3T00A 3DPCA 5K4PA 1EW9A 3CMRA 5L0EA 2GLQA 3TX0A 3WAYA 2W5WA 3BDGA 5LRMA 1N2KA 3MK1A 5KXAA 2W8DA 4UPHA 4TN0A 4UOOA 1KHLA 3B5QA 3IGZB 4KM4A 1O98A 4LREA 3M8WA 1E2SP 2VQRA 4B56A 4GTZA 3NKQA 4CXSA 5GOVA 4LRFA 1KH9A 3SZZA 4LRAA 1E1ZP 3DYCA 1EW2A 3NKPA 4NWXA 3UO0A 4CYRA 5HRTA 5INHA 4FDJA 1KH7A 2W5QA 4LRDA 3ED4A 5LIAA 1Y7AA 2W8SA 3WAWA 3M7VA 3IDDA 5AJ9A 2W5RA 4MY4A 5EGHA 4MIVA 5GRRA 5L0KA 2IFYA 5L0BA 4LR8A 3M8ZA 1ED8A 4UOPA 3SZYA 4GTYA 3WAVA 3MK0A 2IUCB 4UPIA 1Y6VA 4GTXA 4LR7A 1KH5A 1ANJA 3LXQA 4KAYA 1N2LA 1URBA 4UPKA 2W5XA 2GA3A 1EQJA 4KAVA 1HQAA 3UN5A 3BDGB 4ZG6A 2XR9A 4YR1A 4ZG7A 3UN3A 1AJCA 1EI6A 2G9YA 1AJAA 2W5TA 3OT9A 2XRGA 1EJJA 3IGYB 3WBHA 5IJSA 3MK2A 1HDHA 2D1GA 4KJDA 4UPLA 1ALJA 1O99A 2RH6A 1ED9A 1B8JA 1HJKA 4ZGAA 1ANIA 1K7HA 1SHNA 1ELXA 4GTWA 2GSOA 5DLTA 3T02A 3NKMA 3BDHA 4ZG9A 1P49A 5C66A 5DLWA 1ALHA 3NKOA 4FDIA 5EGEA 2W5SA 1SHQA 4KJGA 4QAXA 2GSNA 4N7TA 1ZEDA 2IUCA 1AUKA 1AJDA 1ELZA 3Q3QA 3UN2A 3NKNA 3UNYA 3WAXA 5LQQA 2ZKTA 3KD8A 2QZUA 4LRCA 4MHXA 1URAA 1EW8A 1ZEBA 2X98A 1KHJA 1ELYA 4LRBA 3E2DA 5TJ3A 3TWZA 1KHKA 4LR9A 1E3CP 1AJBA 3M8YA 5IJQA 3T01A 2GSUA 4NWJA 4UORA 1KH4A 5DLVA
chains in the Genus database with same CATH topology
1E33P 1ALKA 4LQYA 3BDFA 2ANHA 4CXKA 5LRNA 3NVLA 1KHNA 1ZEFA 3A52A 2W5VA 3TG0A 1FSUA 3NKRA 4CXUA 4CYSA 4LR2A 1ALIA 3T00A 3DPCA 5K4PA 1EW9A 3CMRA 5L0EA 2GLQA 3TX0A 3WAYA 2W5WA 3BDGA 5LRMA 1N2KA 3MK1A 5KXAA 2W8DA 4UPHA 4TN0A 4UOOA 1KHLA 3B5QA 3IGZB 4KM4A 1O98A 4LREA 3M8WA 1E2SP 2VQRA 4B56A 4GTZA 3NKQA 4CXSA 5GOVA 4LRFA 1KH9A 3SZZA 4LRAA 1E1ZP 3DYCA 1EW2A 3NKPA 4NWXA 3UO0A 4CYRA 5HRTA 5INHA 4FDJA 1KH7A 2W5QA 4LRDA 3ED4A 5LIAA 1Y7AA 2W8SA 3WAWA 3M7VA 3IDDA 5AJ9A 2W5RA 4MY4A 5EGHA 4MIVA 5GRRA 5L0KA 2IFYA 5L0BA 4LR8A 3M8ZA 1ED8A 4UOPA 3SZYA 4GTYA 3WAVA 3MK0A 2IUCB 4UPIA 1Y6VA 4GTXA 4LR7A 1KH5A 1ANJA 3LXQA 4KAYA 1N2LA 1URBA 4UPKA 2W5XA 2GA3A 1EQJA 4KAVA 1HQAA 3UN5A 3BDGB 4ZG6A 2XR9A 4YR1A 4ZG7A 3UN3A 1AJCA 1EI6A 2G9YA 1AJAA 2W5TA 3OT9A 2XRGA 1EJJA 3IGYB 3WBHA 5IJSA 3MK2A 1HDHA 2D1GA 4KJDA 4UPLA 1ALJA 1O99A 2RH6A 1ED9A 1B8JA 1HJKA 4ZGAA 1ANIA 1K7HA 1SHNA 1ELXA 4GTWA 2GSOA 5DLTA 3T02A 3NKMA 3BDHA 4ZG9A 1P49A 5C66A 5DLWA 1ALHA 3NKOA 4FDIA 5EGEA 2W5SA 1SHQA 4KJGA 4QAXA 2GSNA 4N7TA 1ZEDA 2IUCA 1AUKA 1AJDA 1ELZA 3Q3QA 3UN2A 3NKNA 3UNYA 3WAXA 5LQQA 2ZKTA 3KD8A 2QZUA 4LRCA 4MHXA 1URAA 1EW8A 1ZEBA 2X98A 1KHJA 1ELYA 4LRBA 3E2DA 5TJ3A 3TWZA 1KHKA 4LR9A 1E3CP 1AJBA 3M8YA 5IJQA 3T01A 2GSUA 4NWJA 4UORA 1KH4A 5DLVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E33 P;  1ALK A;  4LQY A;  3BDF A;  2ANH A;  4CXK A;  5LRN A;  3NVL A;  1KHN A;  1ZEF A;  3A52 A;  2W5V A;  3TG0 A;  1FSU A;  3NKR A;  4CXU A;  4CYS A;  4LR2 A;  1ALI A;  3T00 A;  3DPC A;  5K4P A;  1EW9 A;  3CMR A;  5L0E A;  2GLQ A;  3TX0 A;  3WAY A;  2W5W A;  3BDG A;  5LRM A;  1N2K A;  3MK1 A;  5KXA A;  2W8D A;  4UPH A;  4TN0 A;  4UOO A;  1KHL A;  3B5Q A;  3IGZ B;  4KM4 A;  1O98 A;  4LRE A;  3M8W A;  1E2S P;  2VQR A;  4B56 A;  4GTZ A;  3NKQ A;  4CXS A;  5GOV A;  4LRF A;  1KH9 A;  3SZZ A;  4LRA A;  1E1Z P;  3DYC A;  1EW2 A;  3NKP A;  4NWX A;  3UO0 A;  4CYR A;  5HRT A;  5INH A;  4FDJ A;  1KH7 A;  2W5Q A;  4LRD A;  3ED4 A;  5LIA A;  1Y7A A;  2W8S A;  3WAW A;  3M7V A;  3IDD A;  5AJ9 A;  2W5R A;  4MY4 A;  5EGH A;  4MIV A;  5GRR A;  5L0K A;  2IFY A;  5L0B A;  4LR8 A;  3M8Z A;  1ED8 A;  4UOP A;  3SZY A;  4GTY A;  3WAV A;  3MK0 A;  2IUC B;  4UPI A;  1Y6V A;  4GTX A;  4LR7 A;  1KH5 A;  1ANJ A;  3LXQ A;  4KAY A;  1N2L A;  1URB A;  4UPK A;  2W5X A;  2GA3 A;  1EQJ A;  4KAV A;  1HQA A;  3UN5 A;  3BDG B;  4ZG6 A;  2XR9 A;  4YR1 A;  4ZG7 A;  3UN3 A;  1AJC A;  1EI6 A;  2G9Y A;  1AJA A;  2W5T A;  3OT9 A;  2XRG A;  1EJJ A;  3IGY B;  3WBH A;  5IJS A;  3MK2 A;  1HDH A;  2D1G A;  4KJD A;  4UPL A;  1ALJ A;  1O99 A;  2RH6 A;  1ED9 A;  1B8J A;  1HJK A;  4ZGA A;  1ANI A;  1K7H A;  1SHN A;  1ELX A;  4GTW A;  2GSO A;  5DLT A;  3T02 A;  3NKM A;  3BDH A;  4ZG9 A;  1P49 A;  5C66 A;  5DLW A;  1ALH A;  3NKO A;  4FDI A;  5EGE A;  2W5S A;  1SHQ A;  4KJG A;  4QAX A;  2GSN A;  4N7T A;  1ZED A;  2IUC A;  1AUK A;  1AJD A;  1ELZ A;  3Q3Q A;  3UN2 A;  3NKN A;  3UNY A;  3WAX A;  5LQQ A;  2ZKT A;  3KD8 A;  2QZU A;  4LRC A;  4MHX A;  1URA A;  1EW8 A;  1ZEB A;  2X98 A;  1KHJ A;  1ELY A;  4LRB A;  3E2D A;  5TJ3 A;  3TWZ A;  1KHK A;  4LR9 A;  1E3C P;  1AJB A;  3M8Y A;  5IJQ A;  3T01 A;  2GSU A;  4NWJ A;  4UOR A;  1KH4 A;  5DLV A; 
#chains in the Genus database with same CATH topology
 1E33 P;  1ALK A;  4LQY A;  3BDF A;  2ANH A;  4CXK A;  5LRN A;  3NVL A;  1KHN A;  1ZEF A;  3A52 A;  2W5V A;  3TG0 A;  1FSU A;  3NKR A;  4CXU A;  4CYS A;  4LR2 A;  1ALI A;  3T00 A;  3DPC A;  5K4P A;  1EW9 A;  3CMR A;  5L0E A;  2GLQ A;  3TX0 A;  3WAY A;  2W5W A;  3BDG A;  5LRM A;  1N2K A;  3MK1 A;  5KXA A;  2W8D A;  4UPH A;  4TN0 A;  4UOO A;  1KHL A;  3B5Q A;  3IGZ B;  4KM4 A;  1O98 A;  4LRE A;  3M8W A;  1E2S P;  2VQR A;  4B56 A;  4GTZ A;  3NKQ A;  4CXS A;  5GOV A;  4LRF A;  1KH9 A;  3SZZ A;  4LRA A;  1E1Z P;  3DYC A;  1EW2 A;  3NKP A;  4NWX A;  3UO0 A;  4CYR A;  5HRT A;  5INH A;  4FDJ A;  1KH7 A;  2W5Q A;  4LRD A;  3ED4 A;  5LIA A;  1Y7A A;  2W8S A;  3WAW A;  3M7V A;  3IDD A;  5AJ9 A;  2W5R A;  4MY4 A;  5EGH A;  4MIV A;  5GRR A;  5L0K A;  2IFY A;  5L0B A;  4LR8 A;  3M8Z A;  1ED8 A;  4UOP A;  3SZY A;  4GTY A;  3WAV A;  3MK0 A;  2IUC B;  4UPI A;  1Y6V A;  4GTX A;  4LR7 A;  1KH5 A;  1ANJ A;  3LXQ A;  4KAY A;  1N2L A;  1URB A;  4UPK A;  2W5X A;  2GA3 A;  1EQJ A;  4KAV A;  1HQA A;  3UN5 A;  3BDG B;  4ZG6 A;  2XR9 A;  4YR1 A;  4ZG7 A;  3UN3 A;  1AJC A;  1EI6 A;  2G9Y A;  1AJA A;  2W5T A;  3OT9 A;  2XRG A;  1EJJ A;  3IGY B;  3WBH A;  5IJS A;  3MK2 A;  1HDH A;  2D1G A;  4KJD A;  4UPL A;  1ALJ A;  1O99 A;  2RH6 A;  1ED9 A;  1B8J A;  1HJK A;  4ZGA A;  1ANI A;  1K7H A;  1SHN A;  1ELX A;  4GTW A;  2GSO A;  5DLT A;  3T02 A;  3NKM A;  3BDH A;  4ZG9 A;  1P49 A;  5C66 A;  5DLW A;  1ALH A;  3NKO A;  4FDI A;  5EGE A;  2W5S A;  1SHQ A;  4KJG A;  4QAX A;  2GSN A;  4N7T A;  1ZED A;  2IUC A;  1AUK A;  1AJD A;  1ELZ A;  3Q3Q A;  3UN2 A;  3NKN A;  3UNY A;  3WAX A;  5LQQ A;  2ZKT A;  3KD8 A;  2QZU A;  4LRC A;  4MHX A;  1URA A;  1EW8 A;  1ZEB A;  2X98 A;  1KHJ A;  1ELY A;  4LRB A;  3E2D A;  5TJ3 A;  3TWZ A;  1KHK A;  4LR9 A;  1E3C P;  1AJB A;  3M8Y A;  5IJQ A;  3T01 A;  2GSU A;  4NWJ A;  4UOR A;  1KH4 A;  5DLV A; 
#chains in the Genus database with same CATH homology
 1E33 P;  1ALK A;  4LQY A;  3BDF A;  2ANH A;  4CXK A;  5LRN A;  3NVL A;  1KHN A;  1ZEF A;  3A52 A;  2W5V A;  3TG0 A;  1FSU A;  3NKR A;  4CXU A;  4CYS A;  4LR2 A;  1ALI A;  3T00 A;  3DPC A;  5K4P A;  1EW9 A;  3CMR A;  5L0E A;  2GLQ A;  3TX0 A;  3WAY A;  2W5W A;  3BDG A;  5LRM A;  1N2K A;  3MK1 A;  5KXA A;  2W8D A;  4UPH A;  4TN0 A;  4UOO A;  1KHL A;  3B5Q A;  3IGZ B;  4KM4 A;  1O98 A;  4LRE A;  3M8W A;  1E2S P;  2VQR A;  4B56 A;  4GTZ A;  3NKQ A;  4CXS A;  5GOV A;  4LRF A;  1KH9 A;  3SZZ A;  4LRA A;  1E1Z P;  3DYC A;  1EW2 A;  3NKP A;  4NWX A;  3UO0 A;  4CYR A;  5HRT A;  5INH A;  4FDJ A;  1KH7 A;  2W5Q A;  4LRD A;  3ED4 A;  5LIA A;  1Y7A A;  2W8S A;  3WAW A;  3M7V A;  3IDD A;  5AJ9 A;  2W5R A;  4MY4 A;  5EGH A;  4MIV A;  5GRR A;  5L0K A;  2IFY A;  5L0B A;  4LR8 A;  3M8Z A;  1ED8 A;  4UOP A;  3SZY A;  4GTY A;  3WAV A;  3MK0 A;  2IUC B;  4UPI A;  1Y6V A;  4GTX A;  4LR7 A;  1KH5 A;  1ANJ A;  3LXQ A;  4KAY A;  1N2L A;  1URB A;  4UPK A;  2W5X A;  2GA3 A;  1EQJ A;  4KAV A;  1HQA A;  3UN5 A;  3BDG B;  4ZG6 A;  2XR9 A;  4YR1 A;  4ZG7 A;  3UN3 A;  1AJC A;  1EI6 A;  2G9Y A;  1AJA A;  2W5T A;  3OT9 A;  2XRG A;  1EJJ A;  3IGY B;  3WBH A;  5IJS A;  3MK2 A;  1HDH A;  2D1G A;  4KJD A;  4UPL A;  1ALJ A;  1O99 A;  2RH6 A;  1ED9 A;  1B8J A;  1HJK A;  4ZGA A;  1ANI A;  1K7H A;  1SHN A;  1ELX A;  4GTW A;  2GSO A;  5DLT A;  3T02 A;  3NKM A;  3BDH A;  4ZG9 A;  1P49 A;  5C66 A;  5DLW A;  1ALH A;  3NKO A;  4FDI A;  5EGE A;  2W5S A;  1SHQ A;  4KJG A;  4QAX A;  2GSN A;  4N7T A;  1ZED A;  2IUC A;  1AUK A;  1AJD A;  1ELZ A;  3Q3Q A;  3UN2 A;  3NKN A;  3UNY A;  3WAX A;  5LQQ A;  2ZKT A;  3KD8 A;  2QZU A;  4LRC A;  4MHX A;  1URA A;  1EW8 A;  1ZEB A;  2X98 A;  1KHJ A;  1ELY A;  4LRB A;  3E2D A;  5TJ3 A;  3TWZ A;  1KHK A;  4LR9 A;  1E3C P;  1AJB A;  3M8Y A;  5IJQ A;  3T01 A;  2GSU A;  4NWJ A;  4UOR A;  1KH4 A;  5DLV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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