5K4PA

Catalytic domain of mcr-1 phosphoethanolamine transferase
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
Knots found
sequence length
324
structure length
323
Chain Sequence
DTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the catalytic domain of the colistin resistance enzyme MCR-1.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Probable phosphatidylethanolamine transferase Mcr-1
total genus 125
structure length 323
sequence length 324
other databases KnotProt 2.0: S +31
ec nomenclature ec 2.7.-.-:
pdb deposition date 2016-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5k4pA00
4LR2A 5AJ9A 3IGYB 3NKMA 3KD8A 4LRCA 1E3CP 2D1GA 4GTYA 1ALJA 5L0KA 3UN5A 4LR9A 4NWJA 3UN2A 3A52A 3OT9A 2G9YA 2GSOA 2IUCB 4CYSA 1EW9A 1ELYA 3NKOA 1URBA 3TWZA 3T01A 4CXUA 3M8YA 4LR7A 4LR8A 3B5QA 4KAVA 4GTXA 3M8ZA 1HDHA 1ALIA 1ZEDA 3Q3QA 1HJKA 4NWXA 1KHNA 1SHNA 3WAXA 2ZKTA 4LREA 4CYRA 1ANJA 3BDFA 1Y7AA 4YR1A 4B56A 1O99A 2ANHA 4ZGAA 3LXQA 1B8JA 5LIAA 5DLVA 3MK1A 4UPHA 5LRMA 1AJAA 4CXKA 2GLQA 4LRBA 4UOOA 4UOPA 1ELZA 1HQAA 5INHA 1KHKA 3BDGB 3CMRA 1KHLA 2IUCA 4ZG7A 3UNYA 1ANIA 1Y6VA 4ZG6A 5KXAA 3MK2A 2W5SA 3E2DA 3TG0A 2GSNA 2W5RA 2W8DA 1EW2A 5DLTA 1K7HA 4TN0A 1AJCA 3ED4A 5L0BA 1N2LA 3IGZB 2XR9A 2RH6A 5GOVA 4KAYA 4KJDA 4MIVA 2W5TA 3NVLA 5GRRA 1AUKA 1KH4A 1KHJA 2X98A 4GTZA 1AJDA 4GTWA 3DPCA 5C66A 3BDGA 1E2SP 3T00A 1P49A 3UN3A 1O98A 4LRDA 1EI6A 4LRFA 4LRAA 4FDIA 4N7TA 3NKNA 5L0EA 1E33P 4LQYA 3NKPA 3TX0A 4UPLA 5LQQA 5IJSA 2W8SA 2XRGA 1ALKA 1KH7A 3T02A 2W5VA 3BDHA 4KJGA 5LRNA 4KM4A 3WAWA 3M7VA 1KH9A 3WBHA 1ALHA 1E1ZP 3UO0A 1ED9A 2IFYA 2W5QA 4QAXA 1ZEFA 1KH5A 1ZEBA 4MHXA 3WAVA 3NKQA 5EGHA 1EW8A 5K4PA 5EGEA 5TJ3A 3SZZA 3SZYA 1FSUA 4UPKA 5DLWA 5IJQA 1N2KA 3IDDA 5HRTA 4UORA 4UPIA 2W5WA 4CXSA 2W5XA 4ZG9A 4FDJA 3NKRA 2VQRA 1AJBA 4MY4A 1URAA 3MK0A 1EQJA 3M8WA 3WAYA 1EJJA 2GSUA 2QZUA 1SHQA 1ELXA 1ED8A 2GA3A 3DYCA
chains in the Genus database with same CATH superfamily
4LR2A 5AJ9A 3IGYB 3NKMA 3KD8A 4LRCA 1E3CP 2D1GA 4GTYA 1ALJA 5L0KA 3UN5A 4LR9A 4NWJA 3UN2A 3A52A 3OT9A 2G9YA 2GSOA 2IUCB 4CYSA 1EW9A 1ELYA 3NKOA 1URBA 3TWZA 3T01A 4CXUA 3M8YA 4LR7A 4LR8A 3B5QA 4KAVA 4GTXA 3M8ZA 1HDHA 1ALIA 1ZEDA 3Q3QA 1HJKA 4NWXA 1KHNA 1SHNA 3WAXA 2ZKTA 4LREA 4CYRA 1ANJA 3BDFA 1Y7AA 4YR1A 4B56A 1O99A 2ANHA 4ZGAA 3LXQA 1B8JA 5LIAA 5DLVA 3MK1A 4UPHA 5LRMA 1AJAA 4CXKA 2GLQA 4LRBA 4UOOA 4UOPA 1ELZA 1HQAA 5INHA 1KHKA 3BDGB 3CMRA 1KHLA 2IUCA 4ZG7A 3UNYA 1ANIA 1Y6VA 4ZG6A 5KXAA 3MK2A 2W5SA 3E2DA 3TG0A 2GSNA 2W5RA 2W8DA 1EW2A 5DLTA 1K7HA 4TN0A 1AJCA 3ED4A 5L0BA 1N2LA 3IGZB 2XR9A 2RH6A 5GOVA 4KAYA 4KJDA 4MIVA 2W5TA 3NVLA 5GRRA 1AUKA 1KH4A 1KHJA 2X98A 4GTZA 1AJDA 4GTWA 3DPCA 5C66A 3BDGA 1E2SP 3T00A 1P49A 3UN3A 1O98A 4LRDA 1EI6A 4LRFA 4LRAA 4FDIA 4N7TA 3NKNA 5L0EA 1E33P 4LQYA 3NKPA 3TX0A 4UPLA 5LQQA 5IJSA 2W8SA 2XRGA 1ALKA 1KH7A 3T02A 2W5VA 3BDHA 4KJGA 5LRNA 4KM4A 3WAWA 3M7VA 1KH9A 3WBHA 1ALHA 1E1ZP 3UO0A 1ED9A 2IFYA 2W5QA 4QAXA 1ZEFA 1KH5A 1ZEBA 4MHXA 3WAVA 3NKQA 5EGHA 1EW8A 5K4PA 5EGEA 5TJ3A 3SZZA 3SZYA 1FSUA 4UPKA 5DLWA 5IJQA 1N2KA 3IDDA 5HRTA 4UORA 4UPIA 2W5WA 4CXSA 2W5XA 4ZG9A 4FDJA 3NKRA 2VQRA 1AJBA 4MY4A 1URAA 3MK0A 1EQJA 3M8WA 3WAYA 1EJJA 2GSUA 2QZUA 1SHQA 1ELXA 1ED8A 2GA3A 3DYCA
chains in the Genus database with same CATH topology
4LR2A 5AJ9A 3IGYB 3NKMA 3KD8A 4LRCA 1E3CP 2D1GA 4GTYA 1ALJA 5L0KA 3UN5A 4LR9A 4NWJA 3UN2A 3A52A 3OT9A 2G9YA 2GSOA 2IUCB 4CYSA 1EW9A 1ELYA 3NKOA 1URBA 3TWZA 3T01A 4CXUA 3M8YA 4LR7A 4LR8A 3B5QA 4KAVA 4GTXA 3M8ZA 1HDHA 1ALIA 1ZEDA 3Q3QA 1HJKA 4NWXA 1KHNA 1SHNA 3WAXA 2ZKTA 4LREA 4CYRA 1ANJA 3BDFA 1Y7AA 4YR1A 4B56A 1O99A 2ANHA 4ZGAA 3LXQA 1B8JA 5LIAA 5DLVA 3MK1A 4UPHA 5LRMA 1AJAA 4CXKA 2GLQA 4LRBA 4UOOA 4UOPA 1ELZA 1HQAA 5INHA 1KHKA 3BDGB 3CMRA 1KHLA 2IUCA 4ZG7A 3UNYA 1ANIA 1Y6VA 4ZG6A 5KXAA 3MK2A 2W5SA 3E2DA 3TG0A 2GSNA 2W5RA 2W8DA 1EW2A 5DLTA 1K7HA 4TN0A 1AJCA 3ED4A 5L0BA 1N2LA 3IGZB 2XR9A 2RH6A 5GOVA 4KAYA 4KJDA 4MIVA 2W5TA 3NVLA 5GRRA 1AUKA 1KH4A 1KHJA 2X98A 4GTZA 1AJDA 4GTWA 3DPCA 5C66A 3BDGA 1E2SP 3T00A 1P49A 3UN3A 1O98A 4LRDA 1EI6A 4LRFA 4LRAA 4FDIA 4N7TA 3NKNA 5L0EA 1E33P 4LQYA 3NKPA 3TX0A 4UPLA 5LQQA 5IJSA 2W8SA 2XRGA 1ALKA 1KH7A 3T02A 2W5VA 3BDHA 4KJGA 5LRNA 4KM4A 3WAWA 3M7VA 1KH9A 3WBHA 1ALHA 1E1ZP 3UO0A 1ED9A 2IFYA 2W5QA 4QAXA 1ZEFA 1KH5A 1ZEBA 4MHXA 3WAVA 3NKQA 5EGHA 1EW8A 5K4PA 5EGEA 5TJ3A 3SZZA 3SZYA 1FSUA 4UPKA 5DLWA 5IJQA 1N2KA 3IDDA 5HRTA 4UORA 4UPIA 2W5WA 4CXSA 2W5XA 4ZG9A 4FDJA 3NKRA 2VQRA 1AJBA 4MY4A 1URAA 3MK0A 1EQJA 3M8WA 3WAYA 1EJJA 2GSUA 2QZUA 1SHQA 1ELXA 1ED8A 2GA3A 3DYCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR2 A;  5AJ9 A;  3IGY B;  3NKM A;  3KD8 A;  4LRC A;  1E3C P;  2D1G A;  4GTY A;  1ALJ A;  5L0K A;  3UN5 A;  4LR9 A;  4NWJ A;  3UN2 A;  3A52 A;  3OT9 A;  2G9Y A;  2GSO A;  2IUC B;  4CYS A;  1EW9 A;  1ELY A;  3NKO A;  1URB A;  3TWZ A;  3T01 A;  4CXU A;  3M8Y A;  4LR7 A;  4LR8 A;  3B5Q A;  4KAV A;  4GTX A;  3M8Z A;  1HDH A;  1ALI A;  1ZED A;  3Q3Q A;  1HJK A;  4NWX A;  1KHN A;  1SHN A;  3WAX A;  2ZKT A;  4LRE A;  4CYR A;  1ANJ A;  3BDF A;  1Y7A A;  4YR1 A;  4B56 A;  1O99 A;  2ANH A;  4ZGA A;  3LXQ A;  1B8J A;  5LIA A;  5DLV A;  3MK1 A;  4UPH A;  5LRM A;  1AJA A;  4CXK A;  2GLQ A;  4LRB A;  4UOO A;  4UOP A;  1ELZ A;  1HQA A;  5INH A;  1KHK A;  3BDG B;  3CMR A;  1KHL A;  2IUC A;  4ZG7 A;  3UNY A;  1ANI A;  1Y6V A;  4ZG6 A;  5KXA A;  3MK2 A;  2W5S A;  3E2D A;  3TG0 A;  2GSN A;  2W5R A;  2W8D A;  1EW2 A;  5DLT A;  1K7H A;  4TN0 A;  1AJC A;  3ED4 A;  5L0B A;  1N2L A;  3IGZ B;  2XR9 A;  2RH6 A;  5GOV A;  4KAY A;  4KJD A;  4MIV A;  2W5T A;  3NVL A;  5GRR A;  1AUK A;  1KH4 A;  1KHJ A;  2X98 A;  4GTZ A;  1AJD A;  4GTW A;  3DPC A;  5C66 A;  3BDG A;  1E2S P;  3T00 A;  1P49 A;  3UN3 A;  1O98 A;  4LRD A;  1EI6 A;  4LRF A;  4LRA A;  4FDI A;  4N7T A;  3NKN A;  5L0E A;  1E33 P;  4LQY A;  3NKP A;  3TX0 A;  4UPL A;  5LQQ A;  5IJS A;  2W8S A;  2XRG A;  1ALK A;  1KH7 A;  3T02 A;  2W5V A;  3BDH A;  4KJG A;  5LRN A;  4KM4 A;  3WAW A;  3M7V A;  1KH9 A;  3WBH A;  1ALH A;  1E1Z P;  3UO0 A;  1ED9 A;  2IFY A;  2W5Q A;  4QAX A;  1ZEF A;  1KH5 A;  1ZEB A;  4MHX A;  3WAV A;  3NKQ A;  5EGH A;  1EW8 A;  5K4P A;  5EGE A;  5TJ3 A;  3SZZ A;  3SZY A;  1FSU A;  4UPK A;  5DLW A;  5IJQ A;  1N2K A;  3IDD A;  5HRT A;  4UOR A;  4UPI A;  2W5W A;  4CXS A;  2W5X A;  4ZG9 A;  4FDJ A;  3NKR A;  2VQR A;  1AJB A;  4MY4 A;  1URA A;  3MK0 A;  1EQJ A;  3M8W A;  3WAY A;  1EJJ A;  2GSU A;  2QZU A;  1SHQ A;  1ELX A;  1ED8 A;  2GA3 A;  3DYC A; 
#chains in the Genus database with same CATH topology
 4LR2 A;  5AJ9 A;  3IGY B;  3NKM A;  3KD8 A;  4LRC A;  1E3C P;  2D1G A;  4GTY A;  1ALJ A;  5L0K A;  3UN5 A;  4LR9 A;  4NWJ A;  3UN2 A;  3A52 A;  3OT9 A;  2G9Y A;  2GSO A;  2IUC B;  4CYS A;  1EW9 A;  1ELY A;  3NKO A;  1URB A;  3TWZ A;  3T01 A;  4CXU A;  3M8Y A;  4LR7 A;  4LR8 A;  3B5Q A;  4KAV A;  4GTX A;  3M8Z A;  1HDH A;  1ALI A;  1ZED A;  3Q3Q A;  1HJK A;  4NWX A;  1KHN A;  1SHN A;  3WAX A;  2ZKT A;  4LRE A;  4CYR A;  1ANJ A;  3BDF A;  1Y7A A;  4YR1 A;  4B56 A;  1O99 A;  2ANH A;  4ZGA A;  3LXQ A;  1B8J A;  5LIA A;  5DLV A;  3MK1 A;  4UPH A;  5LRM A;  1AJA A;  4CXK A;  2GLQ A;  4LRB A;  4UOO A;  4UOP A;  1ELZ A;  1HQA A;  5INH A;  1KHK A;  3BDG B;  3CMR A;  1KHL A;  2IUC A;  4ZG7 A;  3UNY A;  1ANI A;  1Y6V A;  4ZG6 A;  5KXA A;  3MK2 A;  2W5S A;  3E2D A;  3TG0 A;  2GSN A;  2W5R A;  2W8D A;  1EW2 A;  5DLT A;  1K7H A;  4TN0 A;  1AJC A;  3ED4 A;  5L0B A;  1N2L A;  3IGZ B;  2XR9 A;  2RH6 A;  5GOV A;  4KAY A;  4KJD A;  4MIV A;  2W5T A;  3NVL A;  5GRR A;  1AUK A;  1KH4 A;  1KHJ A;  2X98 A;  4GTZ A;  1AJD A;  4GTW A;  3DPC A;  5C66 A;  3BDG A;  1E2S P;  3T00 A;  1P49 A;  3UN3 A;  1O98 A;  4LRD A;  1EI6 A;  4LRF A;  4LRA A;  4FDI A;  4N7T A;  3NKN A;  5L0E A;  1E33 P;  4LQY A;  3NKP A;  3TX0 A;  4UPL A;  5LQQ A;  5IJS A;  2W8S A;  2XRG A;  1ALK A;  1KH7 A;  3T02 A;  2W5V A;  3BDH A;  4KJG A;  5LRN A;  4KM4 A;  3WAW A;  3M7V A;  1KH9 A;  3WBH A;  1ALH A;  1E1Z P;  3UO0 A;  1ED9 A;  2IFY A;  2W5Q A;  4QAX A;  1ZEF A;  1KH5 A;  1ZEB A;  4MHX A;  3WAV A;  3NKQ A;  5EGH A;  1EW8 A;  5K4P A;  5EGE A;  5TJ3 A;  3SZZ A;  3SZY A;  1FSU A;  4UPK A;  5DLW A;  5IJQ A;  1N2K A;  3IDD A;  5HRT A;  4UOR A;  4UPI A;  2W5W A;  4CXS A;  2W5X A;  4ZG9 A;  4FDJ A;  3NKR A;  2VQR A;  1AJB A;  4MY4 A;  1URA A;  3MK0 A;  1EQJ A;  3M8W A;  3WAY A;  1EJJ A;  2GSU A;  2QZU A;  1SHQ A;  1ELX A;  1ED8 A;  2GA3 A;  3DYC A; 
#chains in the Genus database with same CATH homology
 4LR2 A;  5AJ9 A;  3IGY B;  3NKM A;  3KD8 A;  4LRC A;  1E3C P;  2D1G A;  4GTY A;  1ALJ A;  5L0K A;  3UN5 A;  4LR9 A;  4NWJ A;  3UN2 A;  3A52 A;  3OT9 A;  2G9Y A;  2GSO A;  2IUC B;  4CYS A;  1EW9 A;  1ELY A;  3NKO A;  1URB A;  3TWZ A;  3T01 A;  4CXU A;  3M8Y A;  4LR7 A;  4LR8 A;  3B5Q A;  4KAV A;  4GTX A;  3M8Z A;  1HDH A;  1ALI A;  1ZED A;  3Q3Q A;  1HJK A;  4NWX A;  1KHN A;  1SHN A;  3WAX A;  2ZKT A;  4LRE A;  4CYR A;  1ANJ A;  3BDF A;  1Y7A A;  4YR1 A;  4B56 A;  1O99 A;  2ANH A;  4ZGA A;  3LXQ A;  1B8J A;  5LIA A;  5DLV A;  3MK1 A;  4UPH A;  5LRM A;  1AJA A;  4CXK A;  2GLQ A;  4LRB A;  4UOO A;  4UOP A;  1ELZ A;  1HQA A;  5INH A;  1KHK A;  3BDG B;  3CMR A;  1KHL A;  2IUC A;  4ZG7 A;  3UNY A;  1ANI A;  1Y6V A;  4ZG6 A;  5KXA A;  3MK2 A;  2W5S A;  3E2D A;  3TG0 A;  2GSN A;  2W5R A;  2W8D A;  1EW2 A;  5DLT A;  1K7H A;  4TN0 A;  1AJC A;  3ED4 A;  5L0B A;  1N2L A;  3IGZ B;  2XR9 A;  2RH6 A;  5GOV A;  4KAY A;  4KJD A;  4MIV A;  2W5T A;  3NVL A;  5GRR A;  1AUK A;  1KH4 A;  1KHJ A;  2X98 A;  4GTZ A;  1AJD A;  4GTW A;  3DPC A;  5C66 A;  3BDG A;  1E2S P;  3T00 A;  1P49 A;  3UN3 A;  1O98 A;  4LRD A;  1EI6 A;  4LRF A;  4LRA A;  4FDI A;  4N7T A;  3NKN A;  5L0E A;  1E33 P;  4LQY A;  3NKP A;  3TX0 A;  4UPL A;  5LQQ A;  5IJS A;  2W8S A;  2XRG A;  1ALK A;  1KH7 A;  3T02 A;  2W5V A;  3BDH A;  4KJG A;  5LRN A;  4KM4 A;  3WAW A;  3M7V A;  1KH9 A;  3WBH A;  1ALH A;  1E1Z P;  3UO0 A;  1ED9 A;  2IFY A;  2W5Q A;  4QAX A;  1ZEF A;  1KH5 A;  1ZEB A;  4MHX A;  3WAV A;  3NKQ A;  5EGH A;  1EW8 A;  5K4P A;  5EGE A;  5TJ3 A;  3SZZ A;  3SZY A;  1FSU A;  4UPK A;  5DLW A;  5IJQ A;  1N2K A;  3IDD A;  5HRT A;  4UOR A;  4UPI A;  2W5W A;  4CXS A;  2W5X A;  4ZG9 A;  4FDJ A;  3NKR A;  2VQR A;  1AJB A;  4MY4 A;  1URA A;  3MK0 A;  1EQJ A;  3M8W A;  3WAY A;  1EJJ A;  2GSU A;  2QZU A;  1SHQ A;  1ELX A;  1ED8 A;  2GA3 A;  3DYC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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