5K4PA

Catalytic domain of mcr-1 phosphoethanolamine transferase
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
Knots found
sequence length
324
structure length
323
Chain Sequence
DTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the catalytic domain of the colistin resistance enzyme MCR-1.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Probable phosphatidylethanolamine transferase Mcr-1
total genus 125
structure length 323
sequence length 324
other databases KnotProt 2.0: S +31
ec nomenclature ec 2.7.-.-:
pdb deposition date 2016-05-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5k4pA00
3WAVA 4CYRA 4NWJA 3MK1A 1SHQA 1EW8A 4FDJA 1KH7A 2XRGA 4ZG9A 1K7HA 1Y6VA 4ZGAA 1EW2A 3IGZB 1E33P 4GTXA 3A52A 3TX0A 4CXSA 4LR2A 4UORA 5DLWA 1AJDA 1N2LA 1ANIA 2GSOA 5AJ9A 1HDHA 2GLQA 4KJGA 4YR1A 1AJCA 4LQYA 1E2SP 1ED9A 1ED8A 1KHJA 1KH9A 4CXKA 2GA3A 3WBHA 1Y7AA 1P49A 2XR9A 2W5RA 4N7TA 2IUCA 4TN0A 3T02A 1EI6A 3BDGB 1EW9A 3LXQA 3NKNA 5L0EA 2X98A 1AUKA 1AJAA 3ED4A 2ANHA 1KHLA 4KM4A 4UPIA 3NKOA 3IGYB 5IJQA 3UO0A 4CXUA 3UN5A 2W5SA 4GTYA 1ELZA 1ALHA 4UOOA 4ZG7A 1FSUA 3M7VA 3KD8A 2RH6A 1HQAA 4LR9A 5IJSA 5LIAA 4LRDA 1E1ZP 1KHNA 3NKPA 3SZYA 1ZEBA 3NKMA 2W5VA 4NWXA 3CMRA 2W5XA 3DPCA 5C66A 4LRFA 2QZUA 5KXAA 3M8ZA 2W5TA 1KH4A 2GSUA 3BDHA 2W5QA 2ZKTA 4LRAA 4UOPA 3WAYA 3TG0A 4MIVA 5INHA 4CYSA 1ALJA 5DLVA 5LQQA 3T00A 3WAXA 4ZG6A 4LR7A 3OT9A 1ZEFA 2GSNA 1O98A 2D1GA 4GTWA 4MHXA 1AJBA 1N2KA 1URAA 1O99A 2W8SA 4GTZA 1B8JA 2IUCB 3BDFA 1ALIA 4KJDA 4UPKA 5LRNA 1KHKA 3NVLA 4LR8A 4LRBA 1KH5A 3NKRA 3T01A 4B56A 3E2DA 3UN2A 5L0BA 3TWZA 5L0KA 4KAVA 5TJ3A 1ALKA 4UPHA 2G9YA 3MK2A 5GOVA 3IDDA 4FDIA 4QAXA 5K4PA 4MY4A 3SZZA 1ELXA 5HRTA 5GRRA 3DYCA 3BDGA 3MK0A 3M8WA 1SHNA 4LRCA 1ZEDA 3UN3A 1EQJA 3WAWA 3B5QA 1ANJA 4UPLA 5EGHA 5LRMA 1HJKA 3NKQA 1EJJA 2VQRA 1ELYA 5DLTA 3Q3QA 2IFYA 3UNYA 2W5WA 2W8DA 5EGEA 4LREA 1URBA 3M8YA 1E3CP 4KAYA
chains in the Genus database with same CATH superfamily
3WAVA 4CYRA 4NWJA 3MK1A 1SHQA 1EW8A 4FDJA 1KH7A 2XRGA 4ZG9A 1K7HA 1Y6VA 4ZGAA 1EW2A 3IGZB 1E33P 4GTXA 3A52A 3TX0A 4CXSA 4LR2A 4UORA 5DLWA 1AJDA 1N2LA 1ANIA 2GSOA 5AJ9A 1HDHA 2GLQA 4KJGA 4YR1A 1AJCA 4LQYA 1E2SP 1ED9A 1ED8A 1KHJA 1KH9A 4CXKA 2GA3A 3WBHA 1Y7AA 1P49A 2XR9A 2W5RA 4N7TA 2IUCA 4TN0A 3T02A 1EI6A 3BDGB 1EW9A 3LXQA 3NKNA 5L0EA 2X98A 1AUKA 1AJAA 3ED4A 2ANHA 1KHLA 4KM4A 4UPIA 3NKOA 3IGYB 5IJQA 3UO0A 4CXUA 3UN5A 2W5SA 4GTYA 1ELZA 1ALHA 4UOOA 4ZG7A 1FSUA 3M7VA 3KD8A 2RH6A 1HQAA 4LR9A 5IJSA 5LIAA 4LRDA 1E1ZP 1KHNA 3NKPA 3SZYA 1ZEBA 3NKMA 2W5VA 4NWXA 3CMRA 2W5XA 3DPCA 5C66A 4LRFA 2QZUA 5KXAA 3M8ZA 2W5TA 1KH4A 2GSUA 3BDHA 2W5QA 2ZKTA 4LRAA 4UOPA 3WAYA 3TG0A 4MIVA 5INHA 4CYSA 1ALJA 5DLVA 5LQQA 3T00A 3WAXA 4ZG6A 4LR7A 3OT9A 1ZEFA 2GSNA 1O98A 2D1GA 4GTWA 4MHXA 1AJBA 1N2KA 1URAA 1O99A 2W8SA 4GTZA 1B8JA 2IUCB 3BDFA 1ALIA 4KJDA 4UPKA 5LRNA 1KHKA 3NVLA 4LR8A 4LRBA 1KH5A 3NKRA 3T01A 4B56A 3E2DA 3UN2A 5L0BA 3TWZA 5L0KA 4KAVA 5TJ3A 1ALKA 4UPHA 2G9YA 3MK2A 5GOVA 3IDDA 4FDIA 4QAXA 5K4PA 4MY4A 3SZZA 1ELXA 5HRTA 5GRRA 3DYCA 3BDGA 3MK0A 3M8WA 1SHNA 4LRCA 1ZEDA 3UN3A 1EQJA 3WAWA 3B5QA 1ANJA 4UPLA 5EGHA 5LRMA 1HJKA 3NKQA 1EJJA 2VQRA 1ELYA 5DLTA 3Q3QA 2IFYA 3UNYA 2W5WA 2W8DA 5EGEA 4LREA 1URBA 3M8YA 1E3CP 4KAYA
chains in the Genus database with same CATH topology
3WAVA 4CYRA 4NWJA 3MK1A 1SHQA 1EW8A 4FDJA 1KH7A 2XRGA 4ZG9A 1K7HA 1Y6VA 4ZGAA 1EW2A 3IGZB 1E33P 4GTXA 3A52A 3TX0A 4CXSA 4LR2A 4UORA 5DLWA 1AJDA 1N2LA 1ANIA 2GSOA 5AJ9A 1HDHA 2GLQA 4KJGA 4YR1A 1AJCA 4LQYA 1E2SP 1ED9A 1ED8A 1KHJA 1KH9A 4CXKA 2GA3A 3WBHA 1Y7AA 1P49A 2XR9A 2W5RA 4N7TA 2IUCA 4TN0A 3T02A 1EI6A 3BDGB 1EW9A 3LXQA 3NKNA 5L0EA 2X98A 1AUKA 1AJAA 3ED4A 2ANHA 1KHLA 4KM4A 4UPIA 3NKOA 3IGYB 5IJQA 3UO0A 4CXUA 3UN5A 2W5SA 4GTYA 1ELZA 1ALHA 4UOOA 4ZG7A 1FSUA 3M7VA 3KD8A 2RH6A 1HQAA 4LR9A 5IJSA 5LIAA 4LRDA 1E1ZP 1KHNA 3NKPA 3SZYA 1ZEBA 3NKMA 2W5VA 4NWXA 3CMRA 2W5XA 3DPCA 5C66A 4LRFA 2QZUA 5KXAA 3M8ZA 2W5TA 1KH4A 2GSUA 3BDHA 2W5QA 2ZKTA 4LRAA 4UOPA 3WAYA 3TG0A 4MIVA 5INHA 4CYSA 1ALJA 5DLVA 5LQQA 3T00A 3WAXA 4ZG6A 4LR7A 3OT9A 1ZEFA 2GSNA 1O98A 2D1GA 4GTWA 4MHXA 1AJBA 1N2KA 1URAA 1O99A 2W8SA 4GTZA 1B8JA 2IUCB 3BDFA 1ALIA 4KJDA 4UPKA 5LRNA 1KHKA 3NVLA 4LR8A 4LRBA 1KH5A 3NKRA 3T01A 4B56A 3E2DA 3UN2A 5L0BA 3TWZA 5L0KA 4KAVA 5TJ3A 1ALKA 4UPHA 2G9YA 3MK2A 5GOVA 3IDDA 4FDIA 4QAXA 5K4PA 4MY4A 3SZZA 1ELXA 5HRTA 5GRRA 3DYCA 3BDGA 3MK0A 3M8WA 1SHNA 4LRCA 1ZEDA 3UN3A 1EQJA 3WAWA 3B5QA 1ANJA 4UPLA 5EGHA 5LRMA 1HJKA 3NKQA 1EJJA 2VQRA 1ELYA 5DLTA 3Q3QA 2IFYA 3UNYA 2W5WA 2W8DA 5EGEA 4LREA 1URBA 3M8YA 1E3CP 4KAYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WAV A;  4CYR A;  4NWJ A;  3MK1 A;  1SHQ A;  1EW8 A;  4FDJ A;  1KH7 A;  2XRG A;  4ZG9 A;  1K7H A;  1Y6V A;  4ZGA A;  1EW2 A;  3IGZ B;  1E33 P;  4GTX A;  3A52 A;  3TX0 A;  4CXS A;  4LR2 A;  4UOR A;  5DLW A;  1AJD A;  1N2L A;  1ANI A;  2GSO A;  5AJ9 A;  1HDH A;  2GLQ A;  4KJG A;  4YR1 A;  1AJC A;  4LQY A;  1E2S P;  1ED9 A;  1ED8 A;  1KHJ A;  1KH9 A;  4CXK A;  2GA3 A;  3WBH A;  1Y7A A;  1P49 A;  2XR9 A;  2W5R A;  4N7T A;  2IUC A;  4TN0 A;  3T02 A;  1EI6 A;  3BDG B;  1EW9 A;  3LXQ A;  3NKN A;  5L0E A;  2X98 A;  1AUK A;  1AJA A;  3ED4 A;  2ANH A;  1KHL A;  4KM4 A;  4UPI A;  3NKO A;  3IGY B;  5IJQ A;  3UO0 A;  4CXU A;  3UN5 A;  2W5S A;  4GTY A;  1ELZ A;  1ALH A;  4UOO A;  4ZG7 A;  1FSU A;  3M7V A;  3KD8 A;  2RH6 A;  1HQA A;  4LR9 A;  5IJS A;  5LIA A;  4LRD A;  1E1Z P;  1KHN A;  3NKP A;  3SZY A;  1ZEB A;  3NKM A;  2W5V A;  4NWX A;  3CMR A;  2W5X A;  3DPC A;  5C66 A;  4LRF A;  2QZU A;  5KXA A;  3M8Z A;  2W5T A;  1KH4 A;  2GSU A;  3BDH A;  2W5Q A;  2ZKT A;  4LRA A;  4UOP A;  3WAY A;  3TG0 A;  4MIV A;  5INH A;  4CYS A;  1ALJ A;  5DLV A;  5LQQ A;  3T00 A;  3WAX A;  4ZG6 A;  4LR7 A;  3OT9 A;  1ZEF A;  2GSN A;  1O98 A;  2D1G A;  4GTW A;  4MHX A;  1AJB A;  1N2K A;  1URA A;  1O99 A;  2W8S A;  4GTZ A;  1B8J A;  2IUC B;  3BDF A;  1ALI A;  4KJD A;  4UPK A;  5LRN A;  1KHK A;  3NVL A;  4LR8 A;  4LRB A;  1KH5 A;  3NKR A;  3T01 A;  4B56 A;  3E2D A;  3UN2 A;  5L0B A;  3TWZ A;  5L0K A;  4KAV A;  5TJ3 A;  1ALK A;  4UPH A;  2G9Y A;  3MK2 A;  5GOV A;  3IDD A;  4FDI A;  4QAX A;  5K4P A;  4MY4 A;  3SZZ A;  1ELX A;  5HRT A;  5GRR A;  3DYC A;  3BDG A;  3MK0 A;  3M8W A;  1SHN A;  4LRC A;  1ZED A;  3UN3 A;  1EQJ A;  3WAW A;  3B5Q A;  1ANJ A;  4UPL A;  5EGH A;  5LRM A;  1HJK A;  3NKQ A;  1EJJ A;  2VQR A;  1ELY A;  5DLT A;  3Q3Q A;  2IFY A;  3UNY A;  2W5W A;  2W8D A;  5EGE A;  4LRE A;  1URB A;  3M8Y A;  1E3C P;  4KAY A; 
#chains in the Genus database with same CATH topology
 3WAV A;  4CYR A;  4NWJ A;  3MK1 A;  1SHQ A;  1EW8 A;  4FDJ A;  1KH7 A;  2XRG A;  4ZG9 A;  1K7H A;  1Y6V A;  4ZGA A;  1EW2 A;  3IGZ B;  1E33 P;  4GTX A;  3A52 A;  3TX0 A;  4CXS A;  4LR2 A;  4UOR A;  5DLW A;  1AJD A;  1N2L A;  1ANI A;  2GSO A;  5AJ9 A;  1HDH A;  2GLQ A;  4KJG A;  4YR1 A;  1AJC A;  4LQY A;  1E2S P;  1ED9 A;  1ED8 A;  1KHJ A;  1KH9 A;  4CXK A;  2GA3 A;  3WBH A;  1Y7A A;  1P49 A;  2XR9 A;  2W5R A;  4N7T A;  2IUC A;  4TN0 A;  3T02 A;  1EI6 A;  3BDG B;  1EW9 A;  3LXQ A;  3NKN A;  5L0E A;  2X98 A;  1AUK A;  1AJA A;  3ED4 A;  2ANH A;  1KHL A;  4KM4 A;  4UPI A;  3NKO A;  3IGY B;  5IJQ A;  3UO0 A;  4CXU A;  3UN5 A;  2W5S A;  4GTY A;  1ELZ A;  1ALH A;  4UOO A;  4ZG7 A;  1FSU A;  3M7V A;  3KD8 A;  2RH6 A;  1HQA A;  4LR9 A;  5IJS A;  5LIA A;  4LRD A;  1E1Z P;  1KHN A;  3NKP A;  3SZY A;  1ZEB A;  3NKM A;  2W5V A;  4NWX A;  3CMR A;  2W5X A;  3DPC A;  5C66 A;  4LRF A;  2QZU A;  5KXA A;  3M8Z A;  2W5T A;  1KH4 A;  2GSU A;  3BDH A;  2W5Q A;  2ZKT A;  4LRA A;  4UOP A;  3WAY A;  3TG0 A;  4MIV A;  5INH A;  4CYS A;  1ALJ A;  5DLV A;  5LQQ A;  3T00 A;  3WAX A;  4ZG6 A;  4LR7 A;  3OT9 A;  1ZEF A;  2GSN A;  1O98 A;  2D1G A;  4GTW A;  4MHX A;  1AJB A;  1N2K A;  1URA A;  1O99 A;  2W8S A;  4GTZ A;  1B8J A;  2IUC B;  3BDF A;  1ALI A;  4KJD A;  4UPK A;  5LRN A;  1KHK A;  3NVL A;  4LR8 A;  4LRB A;  1KH5 A;  3NKR A;  3T01 A;  4B56 A;  3E2D A;  3UN2 A;  5L0B A;  3TWZ A;  5L0K A;  4KAV A;  5TJ3 A;  1ALK A;  4UPH A;  2G9Y A;  3MK2 A;  5GOV A;  3IDD A;  4FDI A;  4QAX A;  5K4P A;  4MY4 A;  3SZZ A;  1ELX A;  5HRT A;  5GRR A;  3DYC A;  3BDG A;  3MK0 A;  3M8W A;  1SHN A;  4LRC A;  1ZED A;  3UN3 A;  1EQJ A;  3WAW A;  3B5Q A;  1ANJ A;  4UPL A;  5EGH A;  5LRM A;  1HJK A;  3NKQ A;  1EJJ A;  2VQR A;  1ELY A;  5DLT A;  3Q3Q A;  2IFY A;  3UNY A;  2W5W A;  2W8D A;  5EGE A;  4LRE A;  1URB A;  3M8Y A;  1E3C P;  4KAY A; 
#chains in the Genus database with same CATH homology
 3WAV A;  4CYR A;  4NWJ A;  3MK1 A;  1SHQ A;  1EW8 A;  4FDJ A;  1KH7 A;  2XRG A;  4ZG9 A;  1K7H A;  1Y6V A;  4ZGA A;  1EW2 A;  3IGZ B;  1E33 P;  4GTX A;  3A52 A;  3TX0 A;  4CXS A;  4LR2 A;  4UOR A;  5DLW A;  1AJD A;  1N2L A;  1ANI A;  2GSO A;  5AJ9 A;  1HDH A;  2GLQ A;  4KJG A;  4YR1 A;  1AJC A;  4LQY A;  1E2S P;  1ED9 A;  1ED8 A;  1KHJ A;  1KH9 A;  4CXK A;  2GA3 A;  3WBH A;  1Y7A A;  1P49 A;  2XR9 A;  2W5R A;  4N7T A;  2IUC A;  4TN0 A;  3T02 A;  1EI6 A;  3BDG B;  1EW9 A;  3LXQ A;  3NKN A;  5L0E A;  2X98 A;  1AUK A;  1AJA A;  3ED4 A;  2ANH A;  1KHL A;  4KM4 A;  4UPI A;  3NKO A;  3IGY B;  5IJQ A;  3UO0 A;  4CXU A;  3UN5 A;  2W5S A;  4GTY A;  1ELZ A;  1ALH A;  4UOO A;  4ZG7 A;  1FSU A;  3M7V A;  3KD8 A;  2RH6 A;  1HQA A;  4LR9 A;  5IJS A;  5LIA A;  4LRD A;  1E1Z P;  1KHN A;  3NKP A;  3SZY A;  1ZEB A;  3NKM A;  2W5V A;  4NWX A;  3CMR A;  2W5X A;  3DPC A;  5C66 A;  4LRF A;  2QZU A;  5KXA A;  3M8Z A;  2W5T A;  1KH4 A;  2GSU A;  3BDH A;  2W5Q A;  2ZKT A;  4LRA A;  4UOP A;  3WAY A;  3TG0 A;  4MIV A;  5INH A;  4CYS A;  1ALJ A;  5DLV A;  5LQQ A;  3T00 A;  3WAX A;  4ZG6 A;  4LR7 A;  3OT9 A;  1ZEF A;  2GSN A;  1O98 A;  2D1G A;  4GTW A;  4MHX A;  1AJB A;  1N2K A;  1URA A;  1O99 A;  2W8S A;  4GTZ A;  1B8J A;  2IUC B;  3BDF A;  1ALI A;  4KJD A;  4UPK A;  5LRN A;  1KHK A;  3NVL A;  4LR8 A;  4LRB A;  1KH5 A;  3NKR A;  3T01 A;  4B56 A;  3E2D A;  3UN2 A;  5L0B A;  3TWZ A;  5L0K A;  4KAV A;  5TJ3 A;  1ALK A;  4UPH A;  2G9Y A;  3MK2 A;  5GOV A;  3IDD A;  4FDI A;  4QAX A;  5K4P A;  4MY4 A;  3SZZ A;  1ELX A;  5HRT A;  5GRR A;  3DYC A;  3BDG A;  3MK0 A;  3M8W A;  1SHN A;  4LRC A;  1ZED A;  3UN3 A;  1EQJ A;  3WAW A;  3B5Q A;  1ANJ A;  4UPL A;  5EGH A;  5LRM A;  1HJK A;  3NKQ A;  1EJJ A;  2VQR A;  1ELY A;  5DLT A;  3Q3Q A;  2IFY A;  3UNY A;  2W5W A;  2W8D A;  5EGE A;  4LRE A;  1URB A;  3M8Y A;  1E3C P;  4KAY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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