5LRMA

Structure of di-zinc mcr-1 in p41212 space group
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
Knots found
sequence length
323
structure length
312
Chain Sequence
TIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
pubmed doi rcsb
molecule tags Transferase
source organism Escherichia coli
molecule keywords phosphatidylethanolamine transferase Mcr-1
total genus 126
structure length 312
sequence length 323
other databases KnotProt 2.0: S +31
ec nomenclature ec 2.7.-.-:
pdb deposition date 2016-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5lrmA00
3WAWA 4UPLA 1AUKA 2D1GA 4ZGAA 2W5TA 3KD8A 1AJDA 4GTZA 1K7HA 4NWXA 1HDHA 4FDJA 3A52A 5GOVA 4LRAA 1ELZA 2RH6A 3WBHA 1FSUA 4CXUA 1O98A 3UN2A 5LQQA 4CXSA 1ED8A 3Q3QA 1E33P 3M8WA 1SHNA 4LRFA 4CYRA 1E2SP 1KH5A 2W5QA 3BDGB 1Y7AA 1Y6VA 2GA3A 1ELXA 1KH4A 3M7VA 3TX0A 3OT9A 5LRMA 1ZEBA 4LRDA 1KH9A 4ZG6A 4UPHA 3SZYA 2IUCB 1ALKA 3NVLA 5C66A 3WAVA 5EGEA 2W5RA 1KHJA 1SHQA 1N2LA 3T00A 5DLVA 3WAYA 5INHA 4GTYA 5DLWA 3T01A 4LR2A 1AJCA 5DLTA 2VQRA 3SZZA 3UO0A 1KH7A 5L0BA 4LRBA 4CYSA 2W8DA 5L0KA 1ANIA 5LRNA 2XRGA 5LIAA 3BDGA 2IFYA 4MY4A 1EW2A 2W5SA 1HJKA 3TWZA 3M8ZA 3T02A 1P49A 2W5WA 3IGYB 1URAA 4KM4A 4MIVA 2IUCA 5IJSA 1ED9A 1URBA 5AJ9A 5EGHA 2X98A 5HRTA 3WAXA 3UN3A 4UOOA 3B5QA 4LR7A 1ZEFA 3UN5A 5KXAA 1E1ZP 1AJBA 2GLQA 3IDDA 4ZG7A 3CMRA 4MHXA 1KHLA 4QAXA 1ALHA 5K4PA 4LREA 2G9YA 2ZKTA 2XR9A 2GSUA 5L0EA 3NKQA 1EI6A 4FDIA 3IGZB 3BDHA 4LRCA 1ELYA 4KJDA 4B56A 3TG0A 1EW8A 2ANHA 4UORA 1ALJA 4ZG9A 3NKMA 4UPIA 4NWJA 4CXKA 4N7TA 4KAYA 1KHNA 1EJJA 2W8SA 3DYCA 3NKPA 3MK2A 4GTXA 1HQAA 3E2DA 3ED4A 1EQJA 4UOPA 2QZUA 4LR9A 1B8JA 3MK0A 1N2KA 5IJQA 3MK1A 4UPKA 3NKRA 4GTWA 3NKNA 1E3CP 3BDFA 1O99A 2W5VA 4KAVA 1ANJA 4TN0A 1KHKA 3UNYA 3M8YA 4LR8A 1ZEDA 1ALIA 2GSNA 3DPCA 4LQYA 1AJAA 3NKOA 4KJGA 2W5XA 5GRRA 2GSOA 1EW9A 3LXQA 4YR1A 5TJ3A
chains in the Genus database with same CATH superfamily
3WAWA 4UPLA 1AUKA 2D1GA 4ZGAA 2W5TA 3KD8A 1AJDA 4GTZA 1K7HA 4NWXA 1HDHA 4FDJA 3A52A 5GOVA 4LRAA 1ELZA 2RH6A 3WBHA 1FSUA 4CXUA 1O98A 3UN2A 5LQQA 4CXSA 1ED8A 3Q3QA 1E33P 3M8WA 1SHNA 4LRFA 4CYRA 1E2SP 1KH5A 2W5QA 3BDGB 1Y7AA 1Y6VA 2GA3A 1ELXA 1KH4A 3M7VA 3TX0A 3OT9A 5LRMA 1ZEBA 4LRDA 1KH9A 4ZG6A 4UPHA 3SZYA 2IUCB 1ALKA 3NVLA 5C66A 3WAVA 5EGEA 2W5RA 1KHJA 1SHQA 1N2LA 3T00A 5DLVA 3WAYA 5INHA 4GTYA 5DLWA 3T01A 4LR2A 1AJCA 5DLTA 2VQRA 3SZZA 3UO0A 1KH7A 5L0BA 4LRBA 4CYSA 2W8DA 5L0KA 1ANIA 5LRNA 2XRGA 5LIAA 3BDGA 2IFYA 4MY4A 1EW2A 2W5SA 1HJKA 3TWZA 3M8ZA 3T02A 1P49A 2W5WA 3IGYB 1URAA 4KM4A 4MIVA 2IUCA 5IJSA 1ED9A 1URBA 5AJ9A 5EGHA 2X98A 5HRTA 3WAXA 3UN3A 4UOOA 3B5QA 4LR7A 1ZEFA 3UN5A 5KXAA 1E1ZP 1AJBA 2GLQA 3IDDA 4ZG7A 3CMRA 4MHXA 1KHLA 4QAXA 1ALHA 5K4PA 4LREA 2G9YA 2ZKTA 2XR9A 2GSUA 5L0EA 3NKQA 1EI6A 4FDIA 3IGZB 3BDHA 4LRCA 1ELYA 4KJDA 4B56A 3TG0A 1EW8A 2ANHA 4UORA 1ALJA 4ZG9A 3NKMA 4UPIA 4NWJA 4CXKA 4N7TA 4KAYA 1KHNA 1EJJA 2W8SA 3DYCA 3NKPA 3MK2A 4GTXA 1HQAA 3E2DA 3ED4A 1EQJA 4UOPA 2QZUA 4LR9A 1B8JA 3MK0A 1N2KA 5IJQA 3MK1A 4UPKA 3NKRA 4GTWA 3NKNA 1E3CP 3BDFA 1O99A 2W5VA 4KAVA 1ANJA 4TN0A 1KHKA 3UNYA 3M8YA 4LR8A 1ZEDA 1ALIA 2GSNA 3DPCA 4LQYA 1AJAA 3NKOA 4KJGA 2W5XA 5GRRA 2GSOA 1EW9A 3LXQA 4YR1A 5TJ3A
chains in the Genus database with same CATH topology
3WAWA 4UPLA 1AUKA 2D1GA 4ZGAA 2W5TA 3KD8A 1AJDA 4GTZA 1K7HA 4NWXA 1HDHA 4FDJA 3A52A 5GOVA 4LRAA 1ELZA 2RH6A 3WBHA 1FSUA 4CXUA 1O98A 3UN2A 5LQQA 4CXSA 1ED8A 3Q3QA 1E33P 3M8WA 1SHNA 4LRFA 4CYRA 1E2SP 1KH5A 2W5QA 3BDGB 1Y7AA 1Y6VA 2GA3A 1ELXA 1KH4A 3M7VA 3TX0A 3OT9A 5LRMA 1ZEBA 4LRDA 1KH9A 4ZG6A 4UPHA 3SZYA 2IUCB 1ALKA 3NVLA 5C66A 3WAVA 5EGEA 2W5RA 1KHJA 1SHQA 1N2LA 3T00A 5DLVA 3WAYA 5INHA 4GTYA 5DLWA 3T01A 4LR2A 1AJCA 5DLTA 2VQRA 3SZZA 3UO0A 1KH7A 5L0BA 4LRBA 4CYSA 2W8DA 5L0KA 1ANIA 5LRNA 2XRGA 5LIAA 3BDGA 2IFYA 4MY4A 1EW2A 2W5SA 1HJKA 3TWZA 3M8ZA 3T02A 1P49A 2W5WA 3IGYB 1URAA 4KM4A 4MIVA 2IUCA 5IJSA 1ED9A 1URBA 5AJ9A 5EGHA 2X98A 5HRTA 3WAXA 3UN3A 4UOOA 3B5QA 4LR7A 1ZEFA 3UN5A 5KXAA 1E1ZP 1AJBA 2GLQA 3IDDA 4ZG7A 3CMRA 4MHXA 1KHLA 4QAXA 1ALHA 5K4PA 4LREA 2G9YA 2ZKTA 2XR9A 2GSUA 5L0EA 3NKQA 1EI6A 4FDIA 3IGZB 3BDHA 4LRCA 1ELYA 4KJDA 4B56A 3TG0A 1EW8A 2ANHA 4UORA 1ALJA 4ZG9A 3NKMA 4UPIA 4NWJA 4CXKA 4N7TA 4KAYA 1KHNA 1EJJA 2W8SA 3DYCA 3NKPA 3MK2A 4GTXA 1HQAA 3E2DA 3ED4A 1EQJA 4UOPA 2QZUA 4LR9A 1B8JA 3MK0A 1N2KA 5IJQA 3MK1A 4UPKA 3NKRA 4GTWA 3NKNA 1E3CP 3BDFA 1O99A 2W5VA 4KAVA 1ANJA 4TN0A 1KHKA 3UNYA 3M8YA 4LR8A 1ZEDA 1ALIA 2GSNA 3DPCA 4LQYA 1AJAA 3NKOA 4KJGA 2W5XA 5GRRA 2GSOA 1EW9A 3LXQA 4YR1A 5TJ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WAW A;  4UPL A;  1AUK A;  2D1G A;  4ZGA A;  2W5T A;  3KD8 A;  1AJD A;  4GTZ A;  1K7H A;  4NWX A;  1HDH A;  4FDJ A;  3A52 A;  5GOV A;  4LRA A;  1ELZ A;  2RH6 A;  3WBH A;  1FSU A;  4CXU A;  1O98 A;  3UN2 A;  5LQQ A;  4CXS A;  1ED8 A;  3Q3Q A;  1E33 P;  3M8W A;  1SHN A;  4LRF A;  4CYR A;  1E2S P;  1KH5 A;  2W5Q A;  3BDG B;  1Y7A A;  1Y6V A;  2GA3 A;  1ELX A;  1KH4 A;  3M7V A;  3TX0 A;  3OT9 A;  5LRM A;  1ZEB A;  4LRD A;  1KH9 A;  4ZG6 A;  4UPH A;  3SZY A;  2IUC B;  1ALK A;  3NVL A;  5C66 A;  3WAV A;  5EGE A;  2W5R A;  1KHJ A;  1SHQ A;  1N2L A;  3T00 A;  5DLV A;  3WAY A;  5INH A;  4GTY A;  5DLW A;  3T01 A;  4LR2 A;  1AJC A;  5DLT A;  2VQR A;  3SZZ A;  3UO0 A;  1KH7 A;  5L0B A;  4LRB A;  4CYS A;  2W8D A;  5L0K A;  1ANI A;  5LRN A;  2XRG A;  5LIA A;  3BDG A;  2IFY A;  4MY4 A;  1EW2 A;  2W5S A;  1HJK A;  3TWZ A;  3M8Z A;  3T02 A;  1P49 A;  2W5W A;  3IGY B;  1URA A;  4KM4 A;  4MIV A;  2IUC A;  5IJS A;  1ED9 A;  1URB A;  5AJ9 A;  5EGH A;  2X98 A;  5HRT A;  3WAX A;  3UN3 A;  4UOO A;  3B5Q A;  4LR7 A;  1ZEF A;  3UN5 A;  5KXA A;  1E1Z P;  1AJB A;  2GLQ A;  3IDD A;  4ZG7 A;  3CMR A;  4MHX A;  1KHL A;  4QAX A;  1ALH A;  5K4P A;  4LRE A;  2G9Y A;  2ZKT A;  2XR9 A;  2GSU A;  5L0E A;  3NKQ A;  1EI6 A;  4FDI A;  3IGZ B;  3BDH A;  4LRC A;  1ELY A;  4KJD A;  4B56 A;  3TG0 A;  1EW8 A;  2ANH A;  4UOR A;  1ALJ A;  4ZG9 A;  3NKM A;  4UPI A;  4NWJ A;  4CXK A;  4N7T A;  4KAY A;  1KHN A;  1EJJ A;  2W8S A;  3DYC A;  3NKP A;  3MK2 A;  4GTX A;  1HQA A;  3E2D A;  3ED4 A;  1EQJ A;  4UOP A;  2QZU A;  4LR9 A;  1B8J A;  3MK0 A;  1N2K A;  5IJQ A;  3MK1 A;  4UPK A;  3NKR A;  4GTW A;  3NKN A;  1E3C P;  3BDF A;  1O99 A;  2W5V A;  4KAV A;  1ANJ A;  4TN0 A;  1KHK A;  3UNY A;  3M8Y A;  4LR8 A;  1ZED A;  1ALI A;  2GSN A;  3DPC A;  4LQY A;  1AJA A;  3NKO A;  4KJG A;  2W5X A;  5GRR A;  2GSO A;  1EW9 A;  3LXQ A;  4YR1 A;  5TJ3 A; 
#chains in the Genus database with same CATH topology
 3WAW A;  4UPL A;  1AUK A;  2D1G A;  4ZGA A;  2W5T A;  3KD8 A;  1AJD A;  4GTZ A;  1K7H A;  4NWX A;  1HDH A;  4FDJ A;  3A52 A;  5GOV A;  4LRA A;  1ELZ A;  2RH6 A;  3WBH A;  1FSU A;  4CXU A;  1O98 A;  3UN2 A;  5LQQ A;  4CXS A;  1ED8 A;  3Q3Q A;  1E33 P;  3M8W A;  1SHN A;  4LRF A;  4CYR A;  1E2S P;  1KH5 A;  2W5Q A;  3BDG B;  1Y7A A;  1Y6V A;  2GA3 A;  1ELX A;  1KH4 A;  3M7V A;  3TX0 A;  3OT9 A;  5LRM A;  1ZEB A;  4LRD A;  1KH9 A;  4ZG6 A;  4UPH A;  3SZY A;  2IUC B;  1ALK A;  3NVL A;  5C66 A;  3WAV A;  5EGE A;  2W5R A;  1KHJ A;  1SHQ A;  1N2L A;  3T00 A;  5DLV A;  3WAY A;  5INH A;  4GTY A;  5DLW A;  3T01 A;  4LR2 A;  1AJC A;  5DLT A;  2VQR A;  3SZZ A;  3UO0 A;  1KH7 A;  5L0B A;  4LRB A;  4CYS A;  2W8D A;  5L0K A;  1ANI A;  5LRN A;  2XRG A;  5LIA A;  3BDG A;  2IFY A;  4MY4 A;  1EW2 A;  2W5S A;  1HJK A;  3TWZ A;  3M8Z A;  3T02 A;  1P49 A;  2W5W A;  3IGY B;  1URA A;  4KM4 A;  4MIV A;  2IUC A;  5IJS A;  1ED9 A;  1URB A;  5AJ9 A;  5EGH A;  2X98 A;  5HRT A;  3WAX A;  3UN3 A;  4UOO A;  3B5Q A;  4LR7 A;  1ZEF A;  3UN5 A;  5KXA A;  1E1Z P;  1AJB A;  2GLQ A;  3IDD A;  4ZG7 A;  3CMR A;  4MHX A;  1KHL A;  4QAX A;  1ALH A;  5K4P A;  4LRE A;  2G9Y A;  2ZKT A;  2XR9 A;  2GSU A;  5L0E A;  3NKQ A;  1EI6 A;  4FDI A;  3IGZ B;  3BDH A;  4LRC A;  1ELY A;  4KJD A;  4B56 A;  3TG0 A;  1EW8 A;  2ANH A;  4UOR A;  1ALJ A;  4ZG9 A;  3NKM A;  4UPI A;  4NWJ A;  4CXK A;  4N7T A;  4KAY A;  1KHN A;  1EJJ A;  2W8S A;  3DYC A;  3NKP A;  3MK2 A;  4GTX A;  1HQA A;  3E2D A;  3ED4 A;  1EQJ A;  4UOP A;  2QZU A;  4LR9 A;  1B8J A;  3MK0 A;  1N2K A;  5IJQ A;  3MK1 A;  4UPK A;  3NKR A;  4GTW A;  3NKN A;  1E3C P;  3BDF A;  1O99 A;  2W5V A;  4KAV A;  1ANJ A;  4TN0 A;  1KHK A;  3UNY A;  3M8Y A;  4LR8 A;  1ZED A;  1ALI A;  2GSN A;  3DPC A;  4LQY A;  1AJA A;  3NKO A;  4KJG A;  2W5X A;  5GRR A;  2GSO A;  1EW9 A;  3LXQ A;  4YR1 A;  5TJ3 A; 
#chains in the Genus database with same CATH homology
 3WAW A;  4UPL A;  1AUK A;  2D1G A;  4ZGA A;  2W5T A;  3KD8 A;  1AJD A;  4GTZ A;  1K7H A;  4NWX A;  1HDH A;  4FDJ A;  3A52 A;  5GOV A;  4LRA A;  1ELZ A;  2RH6 A;  3WBH A;  1FSU A;  4CXU A;  1O98 A;  3UN2 A;  5LQQ A;  4CXS A;  1ED8 A;  3Q3Q A;  1E33 P;  3M8W A;  1SHN A;  4LRF A;  4CYR A;  1E2S P;  1KH5 A;  2W5Q A;  3BDG B;  1Y7A A;  1Y6V A;  2GA3 A;  1ELX A;  1KH4 A;  3M7V A;  3TX0 A;  3OT9 A;  5LRM A;  1ZEB A;  4LRD A;  1KH9 A;  4ZG6 A;  4UPH A;  3SZY A;  2IUC B;  1ALK A;  3NVL A;  5C66 A;  3WAV A;  5EGE A;  2W5R A;  1KHJ A;  1SHQ A;  1N2L A;  3T00 A;  5DLV A;  3WAY A;  5INH A;  4GTY A;  5DLW A;  3T01 A;  4LR2 A;  1AJC A;  5DLT A;  2VQR A;  3SZZ A;  3UO0 A;  1KH7 A;  5L0B A;  4LRB A;  4CYS A;  2W8D A;  5L0K A;  1ANI A;  5LRN A;  2XRG A;  5LIA A;  3BDG A;  2IFY A;  4MY4 A;  1EW2 A;  2W5S A;  1HJK A;  3TWZ A;  3M8Z A;  3T02 A;  1P49 A;  2W5W A;  3IGY B;  1URA A;  4KM4 A;  4MIV A;  2IUC A;  5IJS A;  1ED9 A;  1URB A;  5AJ9 A;  5EGH A;  2X98 A;  5HRT A;  3WAX A;  3UN3 A;  4UOO A;  3B5Q A;  4LR7 A;  1ZEF A;  3UN5 A;  5KXA A;  1E1Z P;  1AJB A;  2GLQ A;  3IDD A;  4ZG7 A;  3CMR A;  4MHX A;  1KHL A;  4QAX A;  1ALH A;  5K4P A;  4LRE A;  2G9Y A;  2ZKT A;  2XR9 A;  2GSU A;  5L0E A;  3NKQ A;  1EI6 A;  4FDI A;  3IGZ B;  3BDH A;  4LRC A;  1ELY A;  4KJD A;  4B56 A;  3TG0 A;  1EW8 A;  2ANH A;  4UOR A;  1ALJ A;  4ZG9 A;  3NKM A;  4UPI A;  4NWJ A;  4CXK A;  4N7T A;  4KAY A;  1KHN A;  1EJJ A;  2W8S A;  3DYC A;  3NKP A;  3MK2 A;  4GTX A;  1HQA A;  3E2D A;  3ED4 A;  1EQJ A;  4UOP A;  2QZU A;  4LR9 A;  1B8J A;  3MK0 A;  1N2K A;  5IJQ A;  3MK1 A;  4UPK A;  3NKR A;  4GTW A;  3NKN A;  1E3C P;  3BDF A;  1O99 A;  2W5V A;  4KAV A;  1ANJ A;  4TN0 A;  1KHK A;  3UNY A;  3M8Y A;  4LR8 A;  1ZED A;  1ALI A;  2GSN A;  3DPC A;  4LQY A;  1AJA A;  3NKO A;  4KJG A;  2W5X A;  5GRR A;  2GSO A;  1EW9 A;  3LXQ A;  4YR1 A;  5TJ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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