3W8HB

Crystal structure of ccm3 in complex with the c-terminal regulatory domain of stk25
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
66
structure length
66
Chain Sequence
EFSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III.
pubmed doi rcsb
molecule tags Protein binding/transferase
source organism Homo sapiens
molecule keywords Programmed cell death protein 10
total genus 24
structure length 66
sequence length 66
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2013-03-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.12.70 Mainly Alpha Orthogonal Bundle Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 3w8hB00
3RQGA 3L8JA 4GEHB 3L8IA 3RQEA 3W8IB 3W8HB 3AJMA 3RQFA
chains in the Genus database with same CATH superfamily
4I42A 4IZBA 4EMLA 1UX4A 3QXIA 4F47A 4MI2A 5KJPA 4OLQA 3HINA 2IEXA 2DUBA 3KQFA 2FW2A 3L8IA 3O4XE 1DUBA 3AJMA 3T89A 4FJWD 3L8JA 2GTRA 3Q0JA 4U19A 3R9TA 3T88A 2PBPA 1EY3A 1DCIA 4JYLA 3G64A 2VREA 4K2NA 4ELXA 1NZYA 5C9GA 1NZYB 4IZCA 3ADDA 4NEKA 3MOYA 4ELSA 4NNQA 2VX2A 4QIIA 2PPYA 2ZQQA 4GEHB 4JCSA 2HW5A 3A4LA 3OC7A 3SWXA 3H81A 4JOTA 4QIJA 1WZ8A 3RSIA 4WCZA 3R9SA 1Q52A 1UX5A 2FBMA 4ELWA 2F6QA 3T8AA 2QQ3A 4OG1A 1RJMA 2UZFA 1EF8A 3RQEA 1MJ3A 1HZDA 3QK8A 3ADCA 3Q1TA 3I47A 4ZU2A 3RQFA 4IZDA 3FDUA 4I4ZA 4FZWC 4I52A 1Q51A 1UIYA 3MYBA 3QXZA 3AM1A 4JWVA 4KNPA 4U18A 3R0OA 3A4NA 4JFCA 3Q0GA 3SLLA 3P5MA 4FZWA 3RQGA 2P63A 3TRRA 3IRBA 4U1AA 1Y64B 3W8IB 3H02A 5JBXA 1RJNA 3A4MA 4K3WA 3PZKA 2ZQRA 1JXZA 1EF9A 3ADBA 3HRXA 4MOUA 2EJ5A 5JBWA 3W8HB 3TLFA
chains in the Genus database with same CATH topology
3A4NA 1UX5A 1UX4A 3RQGA 2P63A 1RJMA 3L8IA 3ADDA 3O4XE 3RQEA 3IRBA 1Y64B 4NNQA 3W8IB 3AJMA 3A4MA 3L8JA 4GEHB 3A4LA 3ADCA 3RQFA 3ADBA 3AM1A 3W8HB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RQG A;  3L8J A;  4GEH B;  3L8I A;  3RQE A;  3W8I B;  3W8H B;  3AJM A;  3RQF A; 
#chains in the Genus database with same CATH topology
 4I42 A;  4IZB A;  4EML A;  1UX4 A;  3QXI A;  4F47 A;  4MI2 A;  5KJP A;  4OLQ A;  3HIN A;  2IEX A;  2DUB A;  3KQF A;  2FW2 A;  3L8I A;  3O4X E;  1DUB A;  3AJM A;  3T89 A;  4FJW D;  3L8J A;  2GTR A;  3Q0J A;  4U19 A;  3R9T A;  3T88 A;  2PBP A;  1EY3 A;  1DCI A;  4JYL A;  3G64 A;  2VRE A;  4K2N A;  4ELX A;  1NZY A;  5C9G A;  1NZY B;  4IZC A;  3ADD A;  4NEK A;  3MOY A;  4ELS A;  4NNQ A;  2VX2 A;  4QII A;  2PPY A;  2ZQQ A;  4GEH B;  4JCS A;  2HW5 A;  3A4L A;  3OC7 A;  3SWX A;  3H81 A;  4JOT A;  4QIJ A;  1WZ8 A;  3RSI A;  4WCZ A;  3R9S A;  1Q52 A;  1UX5 A;  2FBM A;  4ELW A;  2F6Q A;  3T8A A;  2QQ3 A;  4OG1 A;  1RJM A;  2UZF A;  1EF8 A;  3RQE A;  1MJ3 A;  1HZD A;  3QK8 A;  3ADC A;  3Q1T A;  3I47 A;  4ZU2 A;  3RQF A;  4IZD A;  3FDU A;  4I4Z A;  4FZW C;  4I52 A;  1Q51 A;  1UIY A;  3MYB A;  3QXZ A;  3AM1 A;  4JWV A;  4KNP A;  4U18 A;  3R0O A;  3A4N A;  4JFC A;  3Q0G A;  3SLL A;  3P5M A;  4FZW A;  3RQG A;  2P63 A;  3TRR A;  3IRB A;  4U1A A;  1Y64 B;  3W8I B;  3H02 A;  5JBX A;  1RJN A;  3A4M A;  4K3W A;  3PZK A;  2ZQR A;  1JXZ A;  1EF9 A;  3ADB A;  3HRX A;  4MOU A;  2EJ5 A;  5JBW A;  3W8H B;  3TLF A; 
#chains in the Genus database with same CATH homology
 3A4N A;  1UX5 A;  1UX4 A;  3RQG A;  2P63 A;  1RJM A;  3L8I A;  3ADD A;  3O4X E;  3RQE A;  3IRB A;  1Y64 B;  4NNQ A;  3W8I B;  3AJM A;  3A4M A;  3L8J A;  4GEH B;  3A4L A;  3ADC A;  3RQF A;  3ADB A;  3AM1 A;  3W8H B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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