3W8HB

Crystal structure of ccm3 in complex with the c-terminal regulatory domain of stk25
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
66
structure length
66
Chain Sequence
EFSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III.
pubmed doi rcsb
molecule tags Protein binding/transferase
source organism Homo sapiens
molecule keywords Programmed cell death protein 10
total genus 24
structure length 66
sequence length 66
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2013-03-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.12.70 Mainly Alpha Orthogonal Bundle Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 3w8hB00
3RQEA 3W8HB 4GEHB 3W8IB 3L8JA 3RQFA 3AJMA 3L8IA 3RQGA
chains in the Genus database with same CATH superfamily
3QXIA 1DCIA 1UX4A 3Q1TA 5JBWA 4JCSA 4FZWA 3OC7A 3TLFA 3L8JA 3R0OA 2EJ5A 1RJNA 4FZWC 2ZQQA 3QK8A 4OG1A 3T89A 4F47A 3T88A 1WZ8A 3Q0JA 3A4MA 2PPYA 3O4XE 1NZYB 1UIYA 2VX2A 4I4ZA 4U1AA 3MOYA 3FDUA 1NZYA 2DUBA 2FW2A 1Q51A 3H02A 5JBXA 3SLLA 2PBPA 3KQFA 1JXZA 5KJPA 2P63A 3RQEA 3Q0GA 4GEHB 4ELXA 1EY3A 4KNPA 4EMLA 1EF9A 3RSIA 1DUBA 4I52A 3W8IB 2F6QA 4K2NA 3ADCA 4NNQA 4MOUA 3AM1A 3HINA 4OLQA 3RQFA 3I47A 4NEKA 3AJMA 1EF8A 3ADDA 4K3WA 4IZDA 2VREA 4WCZA 4ELSA 4FJWD 4IZCA 4JFCA 4U19A 4JYLA 4IZBA 3T8AA 3R9SA 2UZFA 1HZDA 2HW5A 4I42A 4QIIA 4ELWA 4QIJA 4JOTA 3L8IA 3RQGA 3P5MA 3IRBA 3R9TA 4JWVA 3H81A 2IEXA 3A4NA 4ZU2A 3A4LA 4U18A 3ADBA 2GTRA 1RJMA 1UX5A 1Y64B 2QQ3A 3HRXA 3TRRA 2FBMA 1MJ3A 3PZKA 3W8HB 4MI2A 5C9GA 1Q52A 3QXZA 3G64A 2ZQRA 3SWXA 3MYBA
chains in the Genus database with same CATH topology
1UX4A 3W8IB 3ADCA 3RQGA 3L8IA 4NNQA 3IRBA 3AM1A 3L8JA 3A4NA 3RQFA 3A4LA 3ADBA 3AJMA 3ADDA 1UX5A 1RJMA 1Y64B 3A4MA 3O4XE 2P63A 3RQEA 3W8HB 4GEHB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RQE A;  3W8H B;  4GEH B;  3W8I B;  3L8J A;  3RQF A;  3AJM A;  3L8I A;  3RQG A; 
#chains in the Genus database with same CATH topology
 3QXI A;  1DCI A;  1UX4 A;  3Q1T A;  5JBW A;  4JCS A;  4FZW A;  3OC7 A;  3TLF A;  3L8J A;  3R0O A;  2EJ5 A;  1RJN A;  4FZW C;  2ZQQ A;  3QK8 A;  4OG1 A;  3T89 A;  4F47 A;  3T88 A;  1WZ8 A;  3Q0J A;  3A4M A;  2PPY A;  3O4X E;  1NZY B;  1UIY A;  2VX2 A;  4I4Z A;  4U1A A;  3MOY A;  3FDU A;  1NZY A;  2DUB A;  2FW2 A;  1Q51 A;  3H02 A;  5JBX A;  3SLL A;  2PBP A;  3KQF A;  1JXZ A;  5KJP A;  2P63 A;  3RQE A;  3Q0G A;  4GEH B;  4ELX A;  1EY3 A;  4KNP A;  4EML A;  1EF9 A;  3RSI A;  1DUB A;  4I52 A;  3W8I B;  2F6Q A;  4K2N A;  3ADC A;  4NNQ A;  4MOU A;  3AM1 A;  3HIN A;  4OLQ A;  3RQF A;  3I47 A;  4NEK A;  3AJM A;  1EF8 A;  3ADD A;  4K3W A;  4IZD A;  2VRE A;  4WCZ A;  4ELS A;  4FJW D;  4IZC A;  4JFC A;  4U19 A;  4JYL A;  4IZB A;  3T8A A;  3R9S A;  2UZF A;  1HZD A;  2HW5 A;  4I42 A;  4QII A;  4ELW A;  4QIJ A;  4JOT A;  3L8I A;  3RQG A;  3P5M A;  3IRB A;  3R9T A;  4JWV A;  3H81 A;  2IEX A;  3A4N A;  4ZU2 A;  3A4L A;  4U18 A;  3ADB A;  2GTR A;  1RJM A;  1UX5 A;  1Y64 B;  2QQ3 A;  3HRX A;  3TRR A;  2FBM A;  1MJ3 A;  3PZK A;  3W8H B;  4MI2 A;  5C9G A;  1Q52 A;  3QXZ A;  3G64 A;  2ZQR A;  3SWX A;  3MYB A; 
#chains in the Genus database with same CATH homology
 1UX4 A;  3W8I B;  3ADC A;  3RQG A;  3L8I A;  4NNQ A;  3IRB A;  3AM1 A;  3L8J A;  3A4N A;  3RQF A;  3A4L A;  3ADB A;  3AJM A;  3ADD A;  1UX5 A;  1RJM A;  1Y64 B;  3A4M A;  3O4X E;  2P63 A;  3RQE A;  3W8H B;  4GEH B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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