1DXXA

N-terminal actin-binding domain of human dystrophin
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
238
structure length
238
Chain Sequence
DSYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVSQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of the N-Terminal Actin-Binding Domain of Human Dystrophin and How Mutations in This Domain May Cause Duchenne or Becker Muscular Dystrophy
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords DYSTROPHIN
total genus 91
structure length 238
sequence length 238
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2000-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1dxxA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1dxxA01
1WYRA 3HOPA 3REPB 1P5SA 5BVRA 1WKUA 2WA5A 1BKRA 3FERA 3JALM 2WA7A 1MB8A 2QJXA 1UJOA 2D89A 2DK9A 1PXYA 2D88A 2JV9A 3JARM 4Q58A 1WYPA 2R0OA 3JAKM 3KY9A 1WYQA 1WIXA 5A38A 5A37A 3CO1A 4EDMA 1P2XA 3HORA 1RT8A 1WYLA 1TJTA 2D86A 2EYNA 2VZCA 2WFNA 4B7LA 4Q57B 4Q59A 1SH6A 4EDNA 1QAGA 2VZIB 1WYOA 1AA2A 1AOAA 2RR8A 3HOCA 1WJOA 2R8UA 2K2RA 4TXIA 1PA7A 1SH5A 1DXXA 1V5KA 1UEGA 2L3GA 5L0OA 3F7PA 2VZGB 4TXKA 1WYNA 2VZDA 2EYIA 5A36A 2D87A 2K3SA 3KMWB 1VKAA 1H67A 3KMUB 5A4BA 5J8EA 3I6XA 4EDLA 2QJZA 2D85A 2E9KA 1BHDA 2EE7A 2WA6A 1WYMA 2YRNA
chains in the Genus database with same CATH superfamily
1WYRA 3HOPA 3REPB 1P5SA 5BVRA 2HL9A 1WKUA 2WA5A 4DDPA 1BKRA 3FERA 3JALM 2WA7A 1MB8A 2QJXA 3EAYA 1UJOA 2D89A 2DK9A 1PXYA 2VE7A 2D88A 2JV9A 3JARM 4Q58A 1WYPA 2R0OA 3JAKM 5FMUA 3KY9A 1WYQA 2HKPA 1WIXA 5A38A 5A37A 3CO1A 4EDMA 1P2XA 5FMTA 3HORA 1RT8A 1WYLA 1TJTA 2IGPA 2D86A 2EYNA 2VZCA 4LVPA 2WFNA 4B7LA 4Q57B 4Q59A 1SH6A 4EDNA 1QAGA 2VZIB 2WE6A 1WYOA 1AA2A 1AOAA 2EQOA 2RR8A 3HOCA 1WJOA 2R8UA 2K2RA 4TXIA 1PA7A 4LVRA 1SH5A 1DXXA 1V5KA 1UEGA 2L3GA 5L0OA 2HL8A 3F7PA 2VZGB 1EUVA 4TXKA 3VP7A 1WYNA 2VZDA 2WDTA 2EYIA 5A36A 2D87A 2K3SA 3KMWB 1VKAA 1H67A 3KMUB 5A4BA 5J8EA 3I6XA 4EDLA 2QJZA 2D85A 2E9KA 1BHDA 2EE7A 2WA6A 2VE7C 1WYMA 2YRNA
chains in the Genus database with same CATH topology
1WYRA 3HOPA 3REPB 1P5SA 5BVRA 1WKUA 2WA5A 1BKRA 3FERA 3JALM 2WA7A 1MB8A 2QJXA 1UJOA 2D89A 2DK9A 1PXYA 2D88A 2JV9A 3JARM 4Q58A 1WYPA 2R0OA 3JAKM 3KY9A 1WYQA 1WIXA 5A38A 5A37A 3CO1A 4EDMA 1P2XA 3HORA 1RT8A 1WYLA 1TJTA 2D86A 2EYNA 2VZCA 2WFNA 4B7LA 4Q57B 4Q59A 1SH6A 4EDNA 1QAGA 2VZIB 1WYOA 1AA2A 1AOAA 2RR8A 3HOCA 1WJOA 2R8UA 2K2RA 4TXIA 1PA7A 1SH5A 1DXXA 1V5KA 1UEGA 2L3GA 5L0OA 3F7PA 2VZGB 4TXKA 1WYNA 2VZDA 2EYIA 5A36A 2D87A 2K3SA 3KMWB 1VKAA 1H67A 3KMUB 5A4BA 5J8EA 3I6XA 4EDLA 2QJZA 2D85A 2E9KA 1BHDA 2EE7A 2WA6A 1WYMA 2YRNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WYR A;  3HOP A;  3REP B;  1P5S A;  5BVR A;  1WKU A;  2WA5 A;  1BKR A;  3FER A;  3JAL M;  2WA7 A;  1MB8 A;  2QJX A;  1UJO A;  2D89 A;  2DK9 A;  1PXY A;  2D88 A;  2JV9 A;  3JAR M;  4Q58 A;  1WYP A;  2R0O A;  3JAK M;  3KY9 A;  1WYQ A;  1WIX A;  5A38 A;  5A37 A;  3CO1 A;  4EDM A;  1P2X A;  3HOR A;  1RT8 A;  1WYL A;  1TJT A;  2D86 A;  2EYN A;  2VZC A;  2WFN A;  4B7L A;  4Q57 B;  4Q59 A;  1SH6 A;  4EDN A;  1QAG A;  2VZI B;  1WYO A;  1AA2 A;  1AOA A;  2RR8 A;  3HOC A;  1WJO A;  2R8U A;  2K2R A;  4TXI A;  1PA7 A;  1SH5 A;  1DXX A;  1V5K A;  1UEG A;  2L3G A;  5L0O A;  3F7P A;  2VZG B;  4TXK A;  1WYN A;  2VZD A;  2EYI A;  5A36 A;  2D87 A;  2K3S A;  3KMW B;  1VKA A;  1H67 A;  3KMU B;  5A4B A;  5J8E A;  3I6X A;  4EDL A;  2QJZ A;  2D85 A;  2E9K A;  1BHD A;  2EE7 A;  2WA6 A;  1WYM A;  2YRN A; 
#chains in the Genus database with same CATH topology
 1WYR A;  3HOP A;  3REP B;  1P5S A;  5BVR A;  2HL9 A;  1WKU A;  2WA5 A;  4DDP A;  1BKR A;  3FER A;  3JAL M;  2WA7 A;  1MB8 A;  2QJX A;  3EAY A;  1UJO A;  2D89 A;  2DK9 A;  1PXY A;  2VE7 A;  2D88 A;  2JV9 A;  3JAR M;  4Q58 A;  1WYP A;  2R0O A;  3JAK M;  5FMU A;  3KY9 A;  1WYQ A;  2HKP A;  1WIX A;  5A38 A;  5A37 A;  3CO1 A;  4EDM A;  1P2X A;  5FMT A;  3HOR A;  1RT8 A;  1WYL A;  1TJT A;  2IGP A;  2D86 A;  2EYN A;  2VZC A;  4LVP A;  2WFN A;  4B7L A;  4Q57 B;  4Q59 A;  1SH6 A;  4EDN A;  1QAG A;  2VZI B;  2WE6 A;  1WYO A;  1AA2 A;  1AOA A;  2EQO A;  2RR8 A;  3HOC A;  1WJO A;  2R8U A;  2K2R A;  4TXI A;  1PA7 A;  4LVR A;  1SH5 A;  1DXX A;  1V5K A;  1UEG A;  2L3G A;  5L0O A;  2HL8 A;  3F7P A;  2VZG B;  1EUV A;  4TXK A;  3VP7 A;  1WYN A;  2VZD A;  2WDT A;  2EYI A;  5A36 A;  2D87 A;  2K3S A;  3KMW B;  1VKA A;  1H67 A;  3KMU B;  5A4B A;  5J8E A;  3I6X A;  4EDL A;  2QJZ A;  2D85 A;  2E9K A;  1BHD A;  2EE7 A;  2WA6 A;  2VE7 C;  1WYM A;  2YRN A; 
#chains in the Genus database with same CATH homology
 1WYR A;  3HOP A;  3REP B;  1P5S A;  5BVR A;  1WKU A;  2WA5 A;  1BKR A;  3FER A;  3JAL M;  2WA7 A;  1MB8 A;  2QJX A;  1UJO A;  2D89 A;  2DK9 A;  1PXY A;  2D88 A;  2JV9 A;  3JAR M;  4Q58 A;  1WYP A;  2R0O A;  3JAK M;  3KY9 A;  1WYQ A;  1WIX A;  5A38 A;  5A37 A;  3CO1 A;  4EDM A;  1P2X A;  3HOR A;  1RT8 A;  1WYL A;  1TJT A;  2D86 A;  2EYN A;  2VZC A;  2WFN A;  4B7L A;  4Q57 B;  4Q59 A;  1SH6 A;  4EDN A;  1QAG A;  2VZI B;  1WYO A;  1AA2 A;  1AOA A;  2RR8 A;  3HOC A;  1WJO A;  2R8U A;  2K2R A;  4TXI A;  1PA7 A;  1SH5 A;  1DXX A;  1V5K A;  1UEG A;  2L3G A;  5L0O A;  3F7P A;  2VZG B;  4TXK A;  1WYN A;  2VZD A;  2EYI A;  5A36 A;  2D87 A;  2K3S A;  3KMW B;  1VKA A;  1H67 A;  3KMU B;  5A4B A;  5J8E A;  3I6X A;  4EDL A;  2QJZ A;  2D85 A;  2E9K A;  1BHD A;  2EE7 A;  2WA6 A;  1WYM A;  2YRN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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