2EYNA

Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 angstrom resolution
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
234
structure length
229
Chain Sequence
AGHMEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPKMRVHKISNVNKALDFIASKGVKLIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQEFLEPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the actin-binding domain of alpha-actinin 1: Evaluating two competing actin-binding models.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Alpha-actinin 1
total genus 81
structure length 229
sequence length 234
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2eynA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2eynA01
2R0OA 2L3GA 5A38A 3I6XA 1P2XA 2RR8A 5J8EA 1WYLA 5A4BA 4EDNA 2WA7A 2WA6A 1WYQA 2D86A 1WYPA 4EDMA 1BKRA 1WYOA 5BVRA 3KY9A 2YRNA 3HOCA 3JARM 1WYRA 1DXXA 3KMWB 1WJOA 1WKUA 3REPB 2EE7A 3JAKM 1V5KA 1PXYA 4TXKA 3JALM 2D87A 1H67A 1RT8A 3F7PA 3FERA 2WFNA 4TXIA 2DK9A 2QJXA 1UJOA 5A36A 2VZGB 1PA7A 1BHDA 2VZDA 3CO1A 2K2RA 3KMUB 3HORA 2EYIA 1SH5A 5L0OA 1TJTA 1SH6A 4B7LA 2VZIB 2WA5A 1AOAA 1AA2A 2K3SA 5A37A 1WYMA 2D88A 1WYNA 1P5SA 1VKAA 2JV9A 1WIXA 4EDLA 2QJZA 4Q59A 4Q57B 2D85A 2VZCA 4Q58A 1MB8A 1QAGA 1UEGA 2E9KA 3HOPA 2EYNA 2D89A 2R8UA
chains in the Genus database with same CATH superfamily
2R0OA 3EAYA 2L3GA 5A38A 5FMUA 3I6XA 1P2XA 2RR8A 2EQOA 5J8EA 1WYLA 5A4BA 4EDNA 2WA7A 2WA6A 1WYQA 2D86A 1WYPA 4EDMA 1BKRA 1WYOA 5BVRA 3KY9A 2YRNA 3HOCA 3JARM 2WE6A 1WYRA 2WDTA 1DXXA 3KMWB 1WJOA 1WKUA 3REPB 2EE7A 3JAKM 1V5KA 1PXYA 4TXKA 3JALM 2HL9A 2D87A 4LVRA 1EUVA 1H67A 1RT8A 3F7PA 3FERA 2WFNA 4TXIA 2DK9A 2QJXA 1UJOA 5A36A 2VZGB 1PA7A 1BHDA 2VE7A 2VZDA 3CO1A 2K2RA 3KMUB 3HORA 2EYIA 3VP7A 1SH5A 5L0OA 1TJTA 1SH6A 4B7LA 2VZIB 2IGPA 2WA5A 1AOAA 2VE7C 1AA2A 4LVPA 2K3SA 5A37A 1WYMA 5FMTA 2D88A 2HKPA 1WYNA 1P5SA 1VKAA 2JV9A 4DDPA 1WIXA 4EDLA 2QJZA 4Q59A 4Q57B 2D85A 2VZCA 2HL8A 4Q58A 1MB8A 1QAGA 1UEGA 2E9KA 3HOPA 2EYNA 2D89A 2R8UA
chains in the Genus database with same CATH topology
2R0OA 2L3GA 5A38A 3I6XA 1P2XA 2RR8A 5J8EA 1WYLA 5A4BA 4EDNA 2WA7A 2WA6A 1WYQA 2D86A 1WYPA 4EDMA 1BKRA 1WYOA 5BVRA 3KY9A 2YRNA 3HOCA 3JARM 1WYRA 1DXXA 3KMWB 1WJOA 1WKUA 3REPB 2EE7A 3JAKM 1V5KA 1PXYA 4TXKA 3JALM 2D87A 1H67A 1RT8A 3F7PA 3FERA 2WFNA 4TXIA 2DK9A 2QJXA 1UJOA 5A36A 2VZGB 1PA7A 1BHDA 2VZDA 3CO1A 2K2RA 3KMUB 3HORA 2EYIA 1SH5A 5L0OA 1TJTA 1SH6A 4B7LA 2VZIB 2WA5A 1AOAA 1AA2A 2K3SA 5A37A 1WYMA 2D88A 1WYNA 1P5SA 1VKAA 2JV9A 1WIXA 4EDLA 2QJZA 4Q59A 4Q57B 2D85A 2VZCA 4Q58A 1MB8A 1QAGA 1UEGA 2E9KA 3HOPA 2EYNA 2D89A 2R8UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R0O A;  2L3G A;  5A38 A;  3I6X A;  1P2X A;  2RR8 A;  5J8E A;  1WYL A;  5A4B A;  4EDN A;  2WA7 A;  2WA6 A;  1WYQ A;  2D86 A;  1WYP A;  4EDM A;  1BKR A;  1WYO A;  5BVR A;  3KY9 A;  2YRN A;  3HOC A;  3JAR M;  1WYR A;  1DXX A;  3KMW B;  1WJO A;  1WKU A;  3REP B;  2EE7 A;  3JAK M;  1V5K A;  1PXY A;  4TXK A;  3JAL M;  2D87 A;  1H67 A;  1RT8 A;  3F7P A;  3FER A;  2WFN A;  4TXI A;  2DK9 A;  2QJX A;  1UJO A;  5A36 A;  2VZG B;  1PA7 A;  1BHD A;  2VZD A;  3CO1 A;  2K2R A;  3KMU B;  3HOR A;  2EYI A;  1SH5 A;  5L0O A;  1TJT A;  1SH6 A;  4B7L A;  2VZI B;  2WA5 A;  1AOA A;  1AA2 A;  2K3S A;  5A37 A;  1WYM A;  2D88 A;  1WYN A;  1P5S A;  1VKA A;  2JV9 A;  1WIX A;  4EDL A;  2QJZ A;  4Q59 A;  4Q57 B;  2D85 A;  2VZC A;  4Q58 A;  1MB8 A;  1QAG A;  1UEG A;  2E9K A;  3HOP A;  2EYN A;  2D89 A;  2R8U A; 
#chains in the Genus database with same CATH topology
 2R0O A;  3EAY A;  2L3G A;  5A38 A;  5FMU A;  3I6X A;  1P2X A;  2RR8 A;  2EQO A;  5J8E A;  1WYL A;  5A4B A;  4EDN A;  2WA7 A;  2WA6 A;  1WYQ A;  2D86 A;  1WYP A;  4EDM A;  1BKR A;  1WYO A;  5BVR A;  3KY9 A;  2YRN A;  3HOC A;  3JAR M;  2WE6 A;  1WYR A;  2WDT A;  1DXX A;  3KMW B;  1WJO A;  1WKU A;  3REP B;  2EE7 A;  3JAK M;  1V5K A;  1PXY A;  4TXK A;  3JAL M;  2HL9 A;  2D87 A;  4LVR A;  1EUV A;  1H67 A;  1RT8 A;  3F7P A;  3FER A;  2WFN A;  4TXI A;  2DK9 A;  2QJX A;  1UJO A;  5A36 A;  2VZG B;  1PA7 A;  1BHD A;  2VE7 A;  2VZD A;  3CO1 A;  2K2R A;  3KMU B;  3HOR A;  2EYI A;  3VP7 A;  1SH5 A;  5L0O A;  1TJT A;  1SH6 A;  4B7L A;  2VZI B;  2IGP A;  2WA5 A;  1AOA A;  2VE7 C;  1AA2 A;  4LVP A;  2K3S A;  5A37 A;  1WYM A;  5FMT A;  2D88 A;  2HKP A;  1WYN A;  1P5S A;  1VKA A;  2JV9 A;  4DDP A;  1WIX A;  4EDL A;  2QJZ A;  4Q59 A;  4Q57 B;  2D85 A;  2VZC A;  2HL8 A;  4Q58 A;  1MB8 A;  1QAG A;  1UEG A;  2E9K A;  3HOP A;  2EYN A;  2D89 A;  2R8U A; 
#chains in the Genus database with same CATH homology
 2R0O A;  2L3G A;  5A38 A;  3I6X A;  1P2X A;  2RR8 A;  5J8E A;  1WYL A;  5A4B A;  4EDN A;  2WA7 A;  2WA6 A;  1WYQ A;  2D86 A;  1WYP A;  4EDM A;  1BKR A;  1WYO A;  5BVR A;  3KY9 A;  2YRN A;  3HOC A;  3JAR M;  1WYR A;  1DXX A;  3KMW B;  1WJO A;  1WKU A;  3REP B;  2EE7 A;  3JAK M;  1V5K A;  1PXY A;  4TXK A;  3JAL M;  2D87 A;  1H67 A;  1RT8 A;  3F7P A;  3FER A;  2WFN A;  4TXI A;  2DK9 A;  2QJX A;  1UJO A;  5A36 A;  2VZG B;  1PA7 A;  1BHD A;  2VZD A;  3CO1 A;  2K2R A;  3KMU B;  3HOR A;  2EYI A;  1SH5 A;  5L0O A;  1TJT A;  1SH6 A;  4B7L A;  2VZI B;  2WA5 A;  1AOA A;  1AA2 A;  2K3S A;  5A37 A;  1WYM A;  2D88 A;  1WYN A;  1P5S A;  1VKA A;  2JV9 A;  1WIX A;  4EDL A;  2QJZ A;  4Q59 A;  4Q57 B;  2D85 A;  2VZC A;  4Q58 A;  1MB8 A;  1QAG A;  1UEG A;  2E9K A;  3HOP A;  2EYN A;  2D89 A;  2R8U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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