4TXKA

Construct of mical-1 containing the monooxygenase and calponin homology domains
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
607
structure length
581
Chain Sequence
TNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural insights into modulation of MICAL activity by its Calponin Homology (CH) domain
rcsb
molecule tags Oxidoreductase
source organism Mus musculus
molecule keywords Protein-methionine sulfoxide oxidase MICAL1
total genus 175
structure length 581
sequence length 607
ec nomenclature ec 1.14.13.225: F-actin monooxygenase.
pdb deposition date 2014-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
A PF01494 FAD_binding_3 FAD binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 4txkA03
2WA6A 3I6XA 1SH5A 1WYPA 2WA5A 1WKUA 4EDLA 1RT8A 1WYLA 2K2RA 3HOCA 1WYQA 1AOAA 1DXXA 1WYOA 1H67A 1PXYA 1WYRA 2DK9A 2WA7A 3JARM 4Q58A 3FERA 3REPB 5A38A 1QAGA 2YRNA 5J8EA 2JV9A 1AA2A 2R8UA 2L3GA 4EDNA 2RR8A 3KMUB 2EE7A 1MB8A 3JAKM 3JALM 1V5KA 1VKAA 2EYIA 2VZIB 4TXKA 5A4BA 3CO1A 2VZCA 4TXIA 1BKRA 2D86A 1BHDA 4B7LA 1WYMA 1P2XA 2E9KA 2WFNA 2D85A 3KMWB 2EYNA 3KY9A 4Q57B 5A37A 1UEGA 2QJXA 1TJTA 1WIXA 2D89A 2VZGB 5BVRA 2K3SA 1WJOA 2D87A 1UJOA 3HORA 2D88A 1P5SA 4EDMA 4Q59A 1WYNA 5A36A 2VZDA 3HOPA 2QJZA 3F7PA 1SH6A 2R0OA 1PA7A 5L0OA
chains in the Genus database with same CATH superfamily
2WA6A 2IGPA 3I6XA 1SH5A 1WYPA 2HKPA 2WA5A 1WKUA 4EDLA 1RT8A 5FMUA 1WYLA 2K2RA 3HOCA 1WYQA 1AOAA 1DXXA 2VE7C 1WYOA 2WDTA 1H67A 2EQOA 2VE7A 5FMTA 1PXYA 2HL9A 1WYRA 2DK9A 2WA7A 3EAYA 3JARM 4Q58A 3FERA 2HL8A 2WE6A 3REPB 5A38A 1QAGA 2YRNA 4LVRA 5J8EA 2JV9A 1AA2A 2R8UA 2L3GA 4EDNA 2RR8A 3KMUB 2EE7A 1MB8A 3JAKM 3JALM 1V5KA 1EUVA 1VKAA 4LVPA 2EYIA 2VZIB 4TXKA 5A4BA 3CO1A 2VZCA 4TXIA 1BKRA 2D86A 1BHDA 4B7LA 1WYMA 1P2XA 2E9KA 2WFNA 2D85A 3KMWB 2EYNA 3KY9A 4Q57B 5A37A 1UEGA 2QJXA 1TJTA 1WIXA 2D89A 2VZGB 5BVRA 2K3SA 1WJOA 2D87A 1UJOA 3HORA 4DDPA 2D88A 1P5SA 4EDMA 4Q59A 1WYNA 5A36A 2VZDA 3HOPA 2QJZA 3F7PA 3VP7A 1SH6A 2R0OA 1PA7A 5L0OA
chains in the Genus database with same CATH topology
2WA6A 3I6XA 1SH5A 1WYPA 2WA5A 1WKUA 4EDLA 1RT8A 1WYLA 2K2RA 3HOCA 1WYQA 1AOAA 1DXXA 1WYOA 1H67A 1PXYA 1WYRA 2DK9A 2WA7A 3JARM 4Q58A 3FERA 3REPB 5A38A 1QAGA 2YRNA 5J8EA 2JV9A 1AA2A 2R8UA 2L3GA 4EDNA 2RR8A 3KMUB 2EE7A 1MB8A 3JAKM 3JALM 1V5KA 1VKAA 2EYIA 2VZIB 4TXKA 5A4BA 3CO1A 2VZCA 4TXIA 1BKRA 2D86A 1BHDA 4B7LA 1WYMA 1P2XA 2E9KA 2WFNA 2D85A 3KMWB 2EYNA 3KY9A 4Q57B 5A37A 1UEGA 2QJXA 1TJTA 1WIXA 2D89A 2VZGB 5BVRA 2K3SA 1WJOA 2D87A 1UJOA 3HORA 2D88A 1P5SA 4EDMA 4Q59A 1WYNA 5A36A 2VZDA 3HOPA 2QJZA 3F7PA 1SH6A 2R0OA 1PA7A 5L0OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WA6 A;  3I6X A;  1SH5 A;  1WYP A;  2WA5 A;  1WKU A;  4EDL A;  1RT8 A;  1WYL A;  2K2R A;  3HOC A;  1WYQ A;  1AOA A;  1DXX A;  1WYO A;  1H67 A;  1PXY A;  1WYR A;  2DK9 A;  2WA7 A;  3JAR M;  4Q58 A;  3FER A;  3REP B;  5A38 A;  1QAG A;  2YRN A;  5J8E A;  2JV9 A;  1AA2 A;  2R8U A;  2L3G A;  4EDN A;  2RR8 A;  3KMU B;  2EE7 A;  1MB8 A;  3JAK M;  3JAL M;  1V5K A;  1VKA A;  2EYI A;  2VZI B;  4TXK A;  5A4B A;  3CO1 A;  2VZC A;  4TXI A;  1BKR A;  2D86 A;  1BHD A;  4B7L A;  1WYM A;  1P2X A;  2E9K A;  2WFN A;  2D85 A;  3KMW B;  2EYN A;  3KY9 A;  4Q57 B;  5A37 A;  1UEG A;  2QJX A;  1TJT A;  1WIX A;  2D89 A;  2VZG B;  5BVR A;  2K3S A;  1WJO A;  2D87 A;  1UJO A;  3HOR A;  2D88 A;  1P5S A;  4EDM A;  4Q59 A;  1WYN A;  5A36 A;  2VZD A;  3HOP A;  2QJZ A;  3F7P A;  1SH6 A;  2R0O A;  1PA7 A;  5L0O A; 
#chains in the Genus database with same CATH topology
 2WA6 A;  2IGP A;  3I6X A;  1SH5 A;  1WYP A;  2HKP A;  2WA5 A;  1WKU A;  4EDL A;  1RT8 A;  5FMU A;  1WYL A;  2K2R A;  3HOC A;  1WYQ A;  1AOA A;  1DXX A;  2VE7 C;  1WYO A;  2WDT A;  1H67 A;  2EQO A;  2VE7 A;  5FMT A;  1PXY A;  2HL9 A;  1WYR A;  2DK9 A;  2WA7 A;  3EAY A;  3JAR M;  4Q58 A;  3FER A;  2HL8 A;  2WE6 A;  3REP B;  5A38 A;  1QAG A;  2YRN A;  4LVR A;  5J8E A;  2JV9 A;  1AA2 A;  2R8U A;  2L3G A;  4EDN A;  2RR8 A;  3KMU B;  2EE7 A;  1MB8 A;  3JAK M;  3JAL M;  1V5K A;  1EUV A;  1VKA A;  4LVP A;  2EYI A;  2VZI B;  4TXK A;  5A4B A;  3CO1 A;  2VZC A;  4TXI A;  1BKR A;  2D86 A;  1BHD A;  4B7L A;  1WYM A;  1P2X A;  2E9K A;  2WFN A;  2D85 A;  3KMW B;  2EYN A;  3KY9 A;  4Q57 B;  5A37 A;  1UEG A;  2QJX A;  1TJT A;  1WIX A;  2D89 A;  2VZG B;  5BVR A;  2K3S A;  1WJO A;  2D87 A;  1UJO A;  3HOR A;  4DDP A;  2D88 A;  1P5S A;  4EDM A;  4Q59 A;  1WYN A;  5A36 A;  2VZD A;  3HOP A;  2QJZ A;  3F7P A;  3VP7 A;  1SH6 A;  2R0O A;  1PA7 A;  5L0O A; 
#chains in the Genus database with same CATH homology
 2WA6 A;  3I6X A;  1SH5 A;  1WYP A;  2WA5 A;  1WKU A;  4EDL A;  1RT8 A;  1WYL A;  2K2R A;  3HOC A;  1WYQ A;  1AOA A;  1DXX A;  1WYO A;  1H67 A;  1PXY A;  1WYR A;  2DK9 A;  2WA7 A;  3JAR M;  4Q58 A;  3FER A;  3REP B;  5A38 A;  1QAG A;  2YRN A;  5J8E A;  2JV9 A;  1AA2 A;  2R8U A;  2L3G A;  4EDN A;  2RR8 A;  3KMU B;  2EE7 A;  1MB8 A;  3JAK M;  3JAL M;  1V5K A;  1VKA A;  2EYI A;  2VZI B;  4TXK A;  5A4B A;  3CO1 A;  2VZC A;  4TXI A;  1BKR A;  2D86 A;  1BHD A;  4B7L A;  1WYM A;  1P2X A;  2E9K A;  2WFN A;  2D85 A;  3KMW B;  2EYN A;  3KY9 A;  4Q57 B;  5A37 A;  1UEG A;  2QJX A;  1TJT A;  1WIX A;  2D89 A;  2VZG B;  5BVR A;  2K3S A;  1WJO A;  2D87 A;  1UJO A;  3HOR A;  2D88 A;  1P5S A;  4EDM A;  4Q59 A;  1WYN A;  5A36 A;  2VZD A;  3HOP A;  2QJZ A;  3F7P A;  1SH6 A;  2R0O A;  1PA7 A;  5L0O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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