2EYIA

Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 angstrom resolution
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
234
structure length
234
Chain Sequence
AGHMEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQEFLEPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the actin-binding domain of alpha-actinin 1: Evaluating two competing actin-binding models.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Alpha-actinin 1
total genus 84
structure length 234
sequence length 234
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2eyiA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2eyiA01
2WA6A 1SH6A 1AOAA 4EDLA 2EE7A 4Q58A 4B7LA 2RR8A 2D87A 5J8EA 1UJOA 1WYLA 4Q59A 1BKRA 2DK9A 3FERA 3CO1A 2WA7A 1WYPA 1VKAA 2D89A 1WYQA 5A36A 1P5SA 1RT8A 2WA5A 2D86A 1DXXA 2R8UA 2VZDA 4Q57B 4EDMA 1WYMA 1WKUA 2VZCA 3KMWB 3REPB 1UEGA 5A37A 1PXYA 2QJZA 1WYOA 3F7PA 2D88A 2R0OA 2EYNA 1V5KA 2VZGB 1WYNA 3KY9A 5A4BA 5BVRA 4EDNA 2L3GA 1WJOA 1WIXA 4TXKA 1BHDA 3I6XA 1PA7A 1MB8A 1AA2A 3JARM 3JALM 3KMUB 1P2XA 3HORA 5A38A 1SH5A 2VZIB 2JV9A 1TJTA 3HOPA 2QJXA 2WFNA 3JAKM 5L0OA 1WYRA 1H67A 4TXIA 2E9KA 2K3SA 1QAGA 2D85A 3HOCA 2K2RA 2YRNA 2EYIA
chains in the Genus database with same CATH superfamily
2WA6A 1SH6A 2HL8A 1AOAA 4EDLA 3VP7A 2EE7A 4Q58A 4B7LA 2RR8A 2D87A 5J8EA 1UJOA 1WYLA 4Q59A 2VE7A 1BKRA 3EAYA 1EUVA 2DK9A 3FERA 3CO1A 2WA7A 1WYPA 1VKAA 2IGPA 2D89A 1WYQA 5A36A 1P5SA 1RT8A 2WA5A 2D86A 1DXXA 2EQOA 4DDPA 2R8UA 2VZDA 4Q57B 4EDMA 1WYMA 1WKUA 2VZCA 3KMWB 3REPB 1UEGA 5A37A 1PXYA 2QJZA 1WYOA 3F7PA 4LVRA 2D88A 2R0OA 2EYNA 5FMTA 1V5KA 5FMUA 2VZGB 1WYNA 3KY9A 5A4BA 5BVRA 4EDNA 2L3GA 1WJOA 1WIXA 4TXKA 1BHDA 3I6XA 1PA7A 1MB8A 2WDTA 1AA2A 2WE6A 3JARM 3JALM 3KMUB 1P2XA 3HORA 5A38A 1SH5A 2HKPA 2VZIB 2JV9A 1TJTA 3HOPA 2QJXA 2WFNA 3JAKM 5L0OA 1WYRA 1H67A 4TXIA 2E9KA 2K3SA 1QAGA 2D85A 3HOCA 2HL9A 2K2RA 2VE7C 2YRNA 4LVPA 2EYIA
chains in the Genus database with same CATH topology
2WA6A 1SH6A 1AOAA 4EDLA 2EE7A 4Q58A 4B7LA 2RR8A 2D87A 5J8EA 1UJOA 1WYLA 4Q59A 1BKRA 2DK9A 3FERA 3CO1A 2WA7A 1WYPA 1VKAA 2D89A 1WYQA 5A36A 1P5SA 1RT8A 2WA5A 2D86A 1DXXA 2R8UA 2VZDA 4Q57B 4EDMA 1WYMA 1WKUA 2VZCA 3KMWB 3REPB 1UEGA 5A37A 1PXYA 2QJZA 1WYOA 3F7PA 2D88A 2R0OA 2EYNA 1V5KA 2VZGB 1WYNA 3KY9A 5A4BA 5BVRA 4EDNA 2L3GA 1WJOA 1WIXA 4TXKA 1BHDA 3I6XA 1PA7A 1MB8A 1AA2A 3JARM 3JALM 3KMUB 1P2XA 3HORA 5A38A 1SH5A 2VZIB 2JV9A 1TJTA 3HOPA 2QJXA 2WFNA 3JAKM 5L0OA 1WYRA 1H67A 4TXIA 2E9KA 2K3SA 1QAGA 2D85A 3HOCA 2K2RA 2YRNA 2EYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WA6 A;  1SH6 A;  1AOA A;  4EDL A;  2EE7 A;  4Q58 A;  4B7L A;  2RR8 A;  2D87 A;  5J8E A;  1UJO A;  1WYL A;  4Q59 A;  1BKR A;  2DK9 A;  3FER A;  3CO1 A;  2WA7 A;  1WYP A;  1VKA A;  2D89 A;  1WYQ A;  5A36 A;  1P5S A;  1RT8 A;  2WA5 A;  2D86 A;  1DXX A;  2R8U A;  2VZD A;  4Q57 B;  4EDM A;  1WYM A;  1WKU A;  2VZC A;  3KMW B;  3REP B;  1UEG A;  5A37 A;  1PXY A;  2QJZ A;  1WYO A;  3F7P A;  2D88 A;  2R0O A;  2EYN A;  1V5K A;  2VZG B;  1WYN A;  3KY9 A;  5A4B A;  5BVR A;  4EDN A;  2L3G A;  1WJO A;  1WIX A;  4TXK A;  1BHD A;  3I6X A;  1PA7 A;  1MB8 A;  1AA2 A;  3JAR M;  3JAL M;  3KMU B;  1P2X A;  3HOR A;  5A38 A;  1SH5 A;  2VZI B;  2JV9 A;  1TJT A;  3HOP A;  2QJX A;  2WFN A;  3JAK M;  5L0O A;  1WYR A;  1H67 A;  4TXI A;  2E9K A;  2K3S A;  1QAG A;  2D85 A;  3HOC A;  2K2R A;  2YRN A;  2EYI A; 
#chains in the Genus database with same CATH topology
 2WA6 A;  1SH6 A;  2HL8 A;  1AOA A;  4EDL A;  3VP7 A;  2EE7 A;  4Q58 A;  4B7L A;  2RR8 A;  2D87 A;  5J8E A;  1UJO A;  1WYL A;  4Q59 A;  2VE7 A;  1BKR A;  3EAY A;  1EUV A;  2DK9 A;  3FER A;  3CO1 A;  2WA7 A;  1WYP A;  1VKA A;  2IGP A;  2D89 A;  1WYQ A;  5A36 A;  1P5S A;  1RT8 A;  2WA5 A;  2D86 A;  1DXX A;  2EQO A;  4DDP A;  2R8U A;  2VZD A;  4Q57 B;  4EDM A;  1WYM A;  1WKU A;  2VZC A;  3KMW B;  3REP B;  1UEG A;  5A37 A;  1PXY A;  2QJZ A;  1WYO A;  3F7P A;  4LVR A;  2D88 A;  2R0O A;  2EYN A;  5FMT A;  1V5K A;  5FMU A;  2VZG B;  1WYN A;  3KY9 A;  5A4B A;  5BVR A;  4EDN A;  2L3G A;  1WJO A;  1WIX A;  4TXK A;  1BHD A;  3I6X A;  1PA7 A;  1MB8 A;  2WDT A;  1AA2 A;  2WE6 A;  3JAR M;  3JAL M;  3KMU B;  1P2X A;  3HOR A;  5A38 A;  1SH5 A;  2HKP A;  2VZI B;  2JV9 A;  1TJT A;  3HOP A;  2QJX A;  2WFN A;  3JAK M;  5L0O A;  1WYR A;  1H67 A;  4TXI A;  2E9K A;  2K3S A;  1QAG A;  2D85 A;  3HOC A;  2HL9 A;  2K2R A;  2VE7 C;  2YRN A;  4LVP A;  2EYI A; 
#chains in the Genus database with same CATH homology
 2WA6 A;  1SH6 A;  1AOA A;  4EDL A;  2EE7 A;  4Q58 A;  4B7L A;  2RR8 A;  2D87 A;  5J8E A;  1UJO A;  1WYL A;  4Q59 A;  1BKR A;  2DK9 A;  3FER A;  3CO1 A;  2WA7 A;  1WYP A;  1VKA A;  2D89 A;  1WYQ A;  5A36 A;  1P5S A;  1RT8 A;  2WA5 A;  2D86 A;  1DXX A;  2R8U A;  2VZD A;  4Q57 B;  4EDM A;  1WYM A;  1WKU A;  2VZC A;  3KMW B;  3REP B;  1UEG A;  5A37 A;  1PXY A;  2QJZ A;  1WYO A;  3F7P A;  2D88 A;  2R0O A;  2EYN A;  1V5K A;  2VZG B;  1WYN A;  3KY9 A;  5A4B A;  5BVR A;  4EDN A;  2L3G A;  1WJO A;  1WIX A;  4TXK A;  1BHD A;  3I6X A;  1PA7 A;  1MB8 A;  1AA2 A;  3JAR M;  3JAL M;  3KMU B;  1P2X A;  3HOR A;  5A38 A;  1SH5 A;  2VZI B;  2JV9 A;  1TJT A;  3HOP A;  2QJX A;  2WFN A;  3JAK M;  5L0O A;  1WYR A;  1H67 A;  4TXI A;  2E9K A;  2K3S A;  1QAG A;  2D85 A;  3HOC A;  2K2R A;  2YRN A;  2EYI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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