1MB8A

Crystal structure of the actin binding domain of plectin
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
243
structure length
243
Chain Sequence
SHMAVIRIADERDRVQKKTFTKWVNKHLIKHWRAEAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Analysis of the Actin Binding Domain of Plectin Suggests Alternative Mechanisms for Binding to F-Actin and Integrin Beta4
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Plectin
total genus 92
structure length 243
sequence length 243
ec nomenclature
pdb deposition date 2002-08-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1mb8A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1mb8A01
1P2XA 1VKAA 3F7PA 1UEGA 4Q57B 1WKUA 5A36A 1WYRA 4EDLA 2RR8A 5A37A 5A38A 2JV9A 2QJXA 2L3GA 2R0OA 4B7LA 3I6XA 5L0OA 2D87A 2VZDA 3JAKM 3KMWB 2E9KA 5A4BA 1PA7A 1WYMA 2K2RA 1SH5A 2D88A 1PXYA 1WYLA 3HORA 4TXIA 2R8UA 3KY9A 1UJOA 3CO1A 3KMUB 1WJOA 3JALM 1RT8A 1H67A 2EYIA 2VZIB 2YRNA 1AOAA 5BVRA 1BKRA 1MB8A 2K3SA 2D85A 1BHDA 2D89A 4EDNA 2DK9A 2WA5A 4Q58A 3REPB 2WFNA 2EYNA 3HOCA 2VZGB 4Q59A 1DXXA 1AA2A 2D86A 3HOPA 1P5SA 2VZCA 1WYOA 4EDMA 1WYQA 1V5KA 1TJTA 3JARM 4TXKA 1QAGA 3FERA 1WIXA 5J8EA 2QJZA 1WYNA 2WA6A 2EE7A 1SH6A 2WA7A 1WYPA
chains in the Genus database with same CATH superfamily
1P2XA 1VKAA 2HL9A 3F7PA 1UEGA 4Q57B 2VE7C 1WKUA 5A36A 1WYRA 1EUVA 4EDLA 2RR8A 5A37A 5A38A 2JV9A 2QJXA 2L3GA 2R0OA 4DDPA 4B7LA 3I6XA 5L0OA 2D87A 5FMUA 2VZDA 3JAKM 3KMWB 2E9KA 5A4BA 3VP7A 1PA7A 1WYMA 2K2RA 1SH5A 2D88A 1PXYA 1WYLA 3HORA 4TXIA 2EQOA 2R8UA 3KY9A 1UJOA 2HKPA 3CO1A 3KMUB 1WJOA 3JALM 3EAYA 1RT8A 5FMTA 1H67A 2EYIA 2VZIB 2YRNA 1AOAA 5BVRA 1BKRA 1MB8A 2K3SA 2D85A 1BHDA 2D89A 2WDTA 4EDNA 2WE6A 2DK9A 2WA5A 4Q58A 3REPB 2WFNA 2EYNA 3HOCA 2VZGB 4Q59A 4LVPA 1DXXA 1AA2A 2D86A 2HL8A 3HOPA 1P5SA 2VZCA 1WYOA 4EDMA 2VE7A 1WYQA 1V5KA 4LVRA 1TJTA 3JARM 4TXKA 1QAGA 3FERA 1WIXA 5J8EA 2QJZA 1WYNA 2WA6A 2EE7A 1SH6A 2IGPA 2WA7A 1WYPA
chains in the Genus database with same CATH topology
1P2XA 1VKAA 3F7PA 1UEGA 4Q57B 1WKUA 5A36A 1WYRA 4EDLA 2RR8A 5A37A 5A38A 2JV9A 2QJXA 2L3GA 2R0OA 4B7LA 3I6XA 5L0OA 2D87A 2VZDA 3JAKM 3KMWB 2E9KA 5A4BA 1PA7A 1WYMA 2K2RA 1SH5A 2D88A 1PXYA 1WYLA 3HORA 4TXIA 2R8UA 3KY9A 1UJOA 3CO1A 3KMUB 1WJOA 3JALM 1RT8A 1H67A 2EYIA 2VZIB 2YRNA 1AOAA 5BVRA 1BKRA 1MB8A 2K3SA 2D85A 1BHDA 2D89A 4EDNA 2DK9A 2WA5A 4Q58A 3REPB 2WFNA 2EYNA 3HOCA 2VZGB 4Q59A 1DXXA 1AA2A 2D86A 3HOPA 1P5SA 2VZCA 1WYOA 4EDMA 1WYQA 1V5KA 1TJTA 3JARM 4TXKA 1QAGA 3FERA 1WIXA 5J8EA 2QJZA 1WYNA 2WA6A 2EE7A 1SH6A 2WA7A 1WYPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P2X A;  1VKA A;  3F7P A;  1UEG A;  4Q57 B;  1WKU A;  5A36 A;  1WYR A;  4EDL A;  2RR8 A;  5A37 A;  5A38 A;  2JV9 A;  2QJX A;  2L3G A;  2R0O A;  4B7L A;  3I6X A;  5L0O A;  2D87 A;  2VZD A;  3JAK M;  3KMW B;  2E9K A;  5A4B A;  1PA7 A;  1WYM A;  2K2R A;  1SH5 A;  2D88 A;  1PXY A;  1WYL A;  3HOR A;  4TXI A;  2R8U A;  3KY9 A;  1UJO A;  3CO1 A;  3KMU B;  1WJO A;  3JAL M;  1RT8 A;  1H67 A;  2EYI A;  2VZI B;  2YRN A;  1AOA A;  5BVR A;  1BKR A;  1MB8 A;  2K3S A;  2D85 A;  1BHD A;  2D89 A;  4EDN A;  2DK9 A;  2WA5 A;  4Q58 A;  3REP B;  2WFN A;  2EYN A;  3HOC A;  2VZG B;  4Q59 A;  1DXX A;  1AA2 A;  2D86 A;  3HOP A;  1P5S A;  2VZC A;  1WYO A;  4EDM A;  1WYQ A;  1V5K A;  1TJT A;  3JAR M;  4TXK A;  1QAG A;  3FER A;  1WIX A;  5J8E A;  2QJZ A;  1WYN A;  2WA6 A;  2EE7 A;  1SH6 A;  2WA7 A;  1WYP A; 
#chains in the Genus database with same CATH topology
 1P2X A;  1VKA A;  2HL9 A;  3F7P A;  1UEG A;  4Q57 B;  2VE7 C;  1WKU A;  5A36 A;  1WYR A;  1EUV A;  4EDL A;  2RR8 A;  5A37 A;  5A38 A;  2JV9 A;  2QJX A;  2L3G A;  2R0O A;  4DDP A;  4B7L A;  3I6X A;  5L0O A;  2D87 A;  5FMU A;  2VZD A;  3JAK M;  3KMW B;  2E9K A;  5A4B A;  3VP7 A;  1PA7 A;  1WYM A;  2K2R A;  1SH5 A;  2D88 A;  1PXY A;  1WYL A;  3HOR A;  4TXI A;  2EQO A;  2R8U A;  3KY9 A;  1UJO A;  2HKP A;  3CO1 A;  3KMU B;  1WJO A;  3JAL M;  3EAY A;  1RT8 A;  5FMT A;  1H67 A;  2EYI A;  2VZI B;  2YRN A;  1AOA A;  5BVR A;  1BKR A;  1MB8 A;  2K3S A;  2D85 A;  1BHD A;  2D89 A;  2WDT A;  4EDN A;  2WE6 A;  2DK9 A;  2WA5 A;  4Q58 A;  3REP B;  2WFN A;  2EYN A;  3HOC A;  2VZG B;  4Q59 A;  4LVP A;  1DXX A;  1AA2 A;  2D86 A;  2HL8 A;  3HOP A;  1P5S A;  2VZC A;  1WYO A;  4EDM A;  2VE7 A;  1WYQ A;  1V5K A;  4LVR A;  1TJT A;  3JAR M;  4TXK A;  1QAG A;  3FER A;  1WIX A;  5J8E A;  2QJZ A;  1WYN A;  2WA6 A;  2EE7 A;  1SH6 A;  2IGP A;  2WA7 A;  1WYP A; 
#chains in the Genus database with same CATH homology
 1P2X A;  1VKA A;  3F7P A;  1UEG A;  4Q57 B;  1WKU A;  5A36 A;  1WYR A;  4EDL A;  2RR8 A;  5A37 A;  5A38 A;  2JV9 A;  2QJX A;  2L3G A;  2R0O A;  4B7L A;  3I6X A;  5L0O A;  2D87 A;  2VZD A;  3JAK M;  3KMW B;  2E9K A;  5A4B A;  1PA7 A;  1WYM A;  2K2R A;  1SH5 A;  2D88 A;  1PXY A;  1WYL A;  3HOR A;  4TXI A;  2R8U A;  3KY9 A;  1UJO A;  3CO1 A;  3KMU B;  1WJO A;  3JAL M;  1RT8 A;  1H67 A;  2EYI A;  2VZI B;  2YRN A;  1AOA A;  5BVR A;  1BKR A;  1MB8 A;  2K3S A;  2D85 A;  1BHD A;  2D89 A;  4EDN A;  2DK9 A;  2WA5 A;  4Q58 A;  3REP B;  2WFN A;  2EYN A;  3HOC A;  2VZG B;  4Q59 A;  1DXX A;  1AA2 A;  2D86 A;  3HOP A;  1P5S A;  2VZC A;  1WYO A;  4EDM A;  1WYQ A;  1V5K A;  1TJT A;  3JAR M;  4TXK A;  1QAG A;  3FER A;  1WIX A;  5J8E A;  2QJZ A;  1WYN A;  2WA6 A;  2EE7 A;  1SH6 A;  2WA7 A;  1WYP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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