1TJTA

X-ray structure of the human alpha-actinin isoform 3 at 2.2a resolution
Total Genus 82
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
224
structure length
224
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The crystal structure of the actin binding domain from alpha-actinin in its closed conformation: structural insight into phospholipid regulation of alpha-actinin
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords Alpha-actinin 3
total genus 82
structure length 224
sequence length 224
ec nomenclature
pdb deposition date 2004-06-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1tjtA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1tjtA01
5J8EA 2RR8A 1AOAA 3KMUB 1P2XA 1WYRA 2D86A 2JV9A 3I6XA 2WA7A 5L0OA 2EE7A 2QJXA 1P5SA 1WYQA 1DXXA 3HORA 2R0OA 1SH5A 3HOCA 2E9KA 4EDLA 2D85A 3KMWB 2EYNA 5A36A 1WYNA 5A4BA 1WIXA 1QAGA 1SH6A 2EYIA 1V5KA 1AA2A 1UJOA 2WA6A 2R8UA 4TXIA 3JAKM 3JALM 4EDMA 5A38A 1WYLA 4Q59A 3JARM 3KY9A 2VZIB 2D88A 2WFNA 2VZCA 3CO1A 1WYMA 5BVRA 2DK9A 2VZGB 4Q58A 1BKRA 2L3GA 2D87A 2D89A 2K3SA 2QJZA 2WA5A 5A37A 3FERA 4EDNA 1UEGA 2K2RA 4TXKA 1TJTA 1MB8A 1H67A 1VKAA 1WJOA 1WKUA 3HOPA 1WYPA 2VZDA 1WYOA 1PA7A 1RT8A 4B7LA 1PXYA 1BHDA 2YRNA 4Q57B 3REPB 3F7PA
chains in the Genus database with same CATH superfamily
5J8EA 2RR8A 1AOAA 3KMUB 1P2XA 1WYRA 2D86A 5FMTA 2JV9A 3I6XA 2WA7A 5L0OA 4LVPA 5FMUA 2EE7A 2QJXA 1P5SA 1WYQA 1DXXA 2IGPA 3HORA 2WDTA 2R0OA 1SH5A 3HOCA 2E9KA 4EDLA 2D85A 3KMWB 2EYNA 5A36A 1WYNA 5A4BA 2HKPA 1WIXA 1QAGA 1SH6A 2EYIA 1V5KA 1AA2A 1UJOA 2WA6A 2R8UA 4TXIA 3JAKM 3EAYA 3JALM 4EDMA 5A38A 1WYLA 4Q59A 3JARM 3KY9A 2HL9A 2VZIB 2D88A 2WFNA 2VE7C 2VZCA 3CO1A 1WYMA 5BVRA 2DK9A 3VP7A 2VZGB 4Q58A 1BKRA 2L3GA 2D87A 2D89A 2K3SA 2QJZA 2WA5A 5A37A 3FERA 1EUVA 4EDNA 1UEGA 2K2RA 4TXKA 1TJTA 1MB8A 2EQOA 4LVRA 1H67A 1VKAA 1WJOA 1WKUA 4DDPA 3HOPA 2WE6A 1WYPA 2VZDA 1WYOA 1PA7A 1RT8A 4B7LA 2HL8A 2VE7A 1PXYA 1BHDA 2YRNA 4Q57B 3REPB 3F7PA
chains in the Genus database with same CATH topology
5J8EA 2RR8A 1AOAA 3KMUB 1P2XA 1WYRA 2D86A 2JV9A 3I6XA 2WA7A 5L0OA 2EE7A 2QJXA 1P5SA 1WYQA 1DXXA 3HORA 2R0OA 1SH5A 3HOCA 2E9KA 4EDLA 2D85A 3KMWB 2EYNA 5A36A 1WYNA 5A4BA 1WIXA 1QAGA 1SH6A 2EYIA 1V5KA 1AA2A 1UJOA 2WA6A 2R8UA 4TXIA 3JAKM 3JALM 4EDMA 5A38A 1WYLA 4Q59A 3JARM 3KY9A 2VZIB 2D88A 2WFNA 2VZCA 3CO1A 1WYMA 5BVRA 2DK9A 2VZGB 4Q58A 1BKRA 2L3GA 2D87A 2D89A 2K3SA 2QJZA 2WA5A 5A37A 3FERA 4EDNA 1UEGA 2K2RA 4TXKA 1TJTA 1MB8A 1H67A 1VKAA 1WJOA 1WKUA 3HOPA 1WYPA 2VZDA 1WYOA 1PA7A 1RT8A 4B7LA 1PXYA 1BHDA 2YRNA 4Q57B 3REPB 3F7PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5J8E A;  2RR8 A;  1AOA A;  3KMU B;  1P2X A;  1WYR A;  2D86 A;  2JV9 A;  3I6X A;  2WA7 A;  5L0O A;  2EE7 A;  2QJX A;  1P5S A;  1WYQ A;  1DXX A;  3HOR A;  2R0O A;  1SH5 A;  3HOC A;  2E9K A;  4EDL A;  2D85 A;  3KMW B;  2EYN A;  5A36 A;  1WYN A;  5A4B A;  1WIX A;  1QAG A;  1SH6 A;  2EYI A;  1V5K A;  1AA2 A;  1UJO A;  2WA6 A;  2R8U A;  4TXI A;  3JAK M;  3JAL M;  4EDM A;  5A38 A;  1WYL A;  4Q59 A;  3JAR M;  3KY9 A;  2VZI B;  2D88 A;  2WFN A;  2VZC A;  3CO1 A;  1WYM A;  5BVR A;  2DK9 A;  2VZG B;  4Q58 A;  1BKR A;  2L3G A;  2D87 A;  2D89 A;  2K3S A;  2QJZ A;  2WA5 A;  5A37 A;  3FER A;  4EDN A;  1UEG A;  2K2R A;  4TXK A;  1TJT A;  1MB8 A;  1H67 A;  1VKA A;  1WJO A;  1WKU A;  3HOP A;  1WYP A;  2VZD A;  1WYO A;  1PA7 A;  1RT8 A;  4B7L A;  1PXY A;  1BHD A;  2YRN A;  4Q57 B;  3REP B;  3F7P A; 
#chains in the Genus database with same CATH topology
 5J8E A;  2RR8 A;  1AOA A;  3KMU B;  1P2X A;  1WYR A;  2D86 A;  5FMT A;  2JV9 A;  3I6X A;  2WA7 A;  5L0O A;  4LVP A;  5FMU A;  2EE7 A;  2QJX A;  1P5S A;  1WYQ A;  1DXX A;  2IGP A;  3HOR A;  2WDT A;  2R0O A;  1SH5 A;  3HOC A;  2E9K A;  4EDL A;  2D85 A;  3KMW B;  2EYN A;  5A36 A;  1WYN A;  5A4B A;  2HKP A;  1WIX A;  1QAG A;  1SH6 A;  2EYI A;  1V5K A;  1AA2 A;  1UJO A;  2WA6 A;  2R8U A;  4TXI A;  3JAK M;  3EAY A;  3JAL M;  4EDM A;  5A38 A;  1WYL A;  4Q59 A;  3JAR M;  3KY9 A;  2HL9 A;  2VZI B;  2D88 A;  2WFN A;  2VE7 C;  2VZC A;  3CO1 A;  1WYM A;  5BVR A;  2DK9 A;  3VP7 A;  2VZG B;  4Q58 A;  1BKR A;  2L3G A;  2D87 A;  2D89 A;  2K3S A;  2QJZ A;  2WA5 A;  5A37 A;  3FER A;  1EUV A;  4EDN A;  1UEG A;  2K2R A;  4TXK A;  1TJT A;  1MB8 A;  2EQO A;  4LVR A;  1H67 A;  1VKA A;  1WJO A;  1WKU A;  4DDP A;  3HOP A;  2WE6 A;  1WYP A;  2VZD A;  1WYO A;  1PA7 A;  1RT8 A;  4B7L A;  2HL8 A;  2VE7 A;  1PXY A;  1BHD A;  2YRN A;  4Q57 B;  3REP B;  3F7P A; 
#chains in the Genus database with same CATH homology
 5J8E A;  2RR8 A;  1AOA A;  3KMU B;  1P2X A;  1WYR A;  2D86 A;  2JV9 A;  3I6X A;  2WA7 A;  5L0O A;  2EE7 A;  2QJX A;  1P5S A;  1WYQ A;  1DXX A;  3HOR A;  2R0O A;  1SH5 A;  3HOC A;  2E9K A;  4EDL A;  2D85 A;  3KMW B;  2EYN A;  5A36 A;  1WYN A;  5A4B A;  1WIX A;  1QAG A;  1SH6 A;  2EYI A;  1V5K A;  1AA2 A;  1UJO A;  2WA6 A;  2R8U A;  4TXI A;  3JAK M;  3JAL M;  4EDM A;  5A38 A;  1WYL A;  4Q59 A;  3JAR M;  3KY9 A;  2VZI B;  2D88 A;  2WFN A;  2VZC A;  3CO1 A;  1WYM A;  5BVR A;  2DK9 A;  2VZG B;  4Q58 A;  1BKR A;  2L3G A;  2D87 A;  2D89 A;  2K3S A;  2QJZ A;  2WA5 A;  5A37 A;  3FER A;  4EDN A;  1UEG A;  2K2R A;  4TXK A;  1TJT A;  1MB8 A;  1H67 A;  1VKA A;  1WJO A;  1WKU A;  3HOP A;  1WYP A;  2VZD A;  1WYO A;  1PA7 A;  1RT8 A;  4B7L A;  1PXY A;  1BHD A;  2YRN A;  4Q57 B;  3REP B;  3F7P A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...