1WKUA

High resolution structure of the human alpha-actinin isoform 3
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
225
structure length
225
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of the actin binding domain from alpha-actinin in its closed conformation: structural insight into phospholipid regulation of alpha-actinin
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords Alpha-actinin 3
total genus 83
structure length 225
sequence length 225
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-06-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1wkuA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1wkuA01
2VZDA 2WFNA 2QJXA 1V5KA 1PA7A 3JAKM 3HOPA 5A38A 2WA7A 1RT8A 5L0OA 1UEGA 2D88A 2R8UA 5BVRA 4B7LA 1VKAA 1P5SA 1AOAA 1WYMA 1WYRA 2EYNA 2JV9A 1QAGA 1TJTA 1PXYA 1BKRA 1H67A 2WA6A 4EDNA 3KMUB 5A4BA 5A36A 3REPB 1WYPA 2DK9A 4EDMA 1BHDA 2D85A 1MB8A 1SH6A 2EE7A 3FERA 2RR8A 2E9KA 1WKUA 3HORA 3F7PA 3JARM 2YRNA 1WIXA 4EDLA 1P2XA 3HOCA 2WA5A 2D87A 1WYLA 1WYNA 2K2RA 3I6XA 1DXXA 4Q59A 2D86A 2QJZA 1WYOA 2VZCA 5J8EA 1AA2A 2VZGB 1SH5A 1UJOA 2D89A 3KY9A 4Q57B 1WJOA 4TXIA 2EYIA 1WYQA 5A37A 3CO1A 4Q58A 2L3GA 3JALM 2R0OA 3KMWB 2VZIB 4TXKA 2K3SA
chains in the Genus database with same CATH superfamily
2VZDA 2WFNA 2HL8A 2QJXA 1V5KA 1PA7A 3JAKM 3HOPA 5A38A 2WA7A 1RT8A 5L0OA 1UEGA 2D88A 5FMTA 2R8UA 5BVRA 4B7LA 4LVPA 5FMUA 1VKAA 1P5SA 2VE7C 1AOAA 2IGPA 1WYMA 1WYRA 2HKPA 2EYNA 2JV9A 1QAGA 3VP7A 1TJTA 1PXYA 1BKRA 1H67A 2WA6A 4EDNA 3KMUB 5A4BA 5A36A 3REPB 1WYPA 2DK9A 4EDMA 1BHDA 2D85A 1MB8A 1SH6A 2EE7A 3FERA 2RR8A 2E9KA 1WKUA 3HORA 3F7PA 3JARM 4DDPA 2YRNA 1WIXA 4EDLA 1P2XA 2HL9A 3HOCA 2WA5A 2D87A 1WYLA 1WYNA 2K2RA 3I6XA 1DXXA 2WE6A 4Q59A 2D86A 2QJZA 2VE7A 1WYOA 2VZCA 5J8EA 1AA2A 2EQOA 2VZGB 1SH5A 1UJOA 2D89A 3KY9A 4Q57B 1WJOA 4LVRA 4TXIA 2EYIA 1WYQA 5A37A 3CO1A 4Q58A 2L3GA 3EAYA 3JALM 2R0OA 3KMWB 2VZIB 4TXKA 2K3SA 2WDTA 1EUVA
chains in the Genus database with same CATH topology
2VZDA 2WFNA 2QJXA 1V5KA 1PA7A 3JAKM 3HOPA 5A38A 2WA7A 1RT8A 5L0OA 1UEGA 2D88A 2R8UA 5BVRA 4B7LA 1VKAA 1P5SA 1AOAA 1WYMA 1WYRA 2EYNA 2JV9A 1QAGA 1TJTA 1PXYA 1BKRA 1H67A 2WA6A 4EDNA 3KMUB 5A4BA 5A36A 3REPB 1WYPA 2DK9A 4EDMA 1BHDA 2D85A 1MB8A 1SH6A 2EE7A 3FERA 2RR8A 2E9KA 1WKUA 3HORA 3F7PA 3JARM 2YRNA 1WIXA 4EDLA 1P2XA 3HOCA 2WA5A 2D87A 1WYLA 1WYNA 2K2RA 3I6XA 1DXXA 4Q59A 2D86A 2QJZA 1WYOA 2VZCA 5J8EA 1AA2A 2VZGB 1SH5A 1UJOA 2D89A 3KY9A 4Q57B 1WJOA 4TXIA 2EYIA 1WYQA 5A37A 3CO1A 4Q58A 2L3GA 3JALM 2R0OA 3KMWB 2VZIB 4TXKA 2K3SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VZD A;  2WFN A;  2QJX A;  1V5K A;  1PA7 A;  3JAK M;  3HOP A;  5A38 A;  2WA7 A;  1RT8 A;  5L0O A;  1UEG A;  2D88 A;  2R8U A;  5BVR A;  4B7L A;  1VKA A;  1P5S A;  1AOA A;  1WYM A;  1WYR A;  2EYN A;  2JV9 A;  1QAG A;  1TJT A;  1PXY A;  1BKR A;  1H67 A;  2WA6 A;  4EDN A;  3KMU B;  5A4B A;  5A36 A;  3REP B;  1WYP A;  2DK9 A;  4EDM A;  1BHD A;  2D85 A;  1MB8 A;  1SH6 A;  2EE7 A;  3FER A;  2RR8 A;  2E9K A;  1WKU A;  3HOR A;  3F7P A;  3JAR M;  2YRN A;  1WIX A;  4EDL A;  1P2X A;  3HOC A;  2WA5 A;  2D87 A;  1WYL A;  1WYN A;  2K2R A;  3I6X A;  1DXX A;  4Q59 A;  2D86 A;  2QJZ A;  1WYO A;  2VZC A;  5J8E A;  1AA2 A;  2VZG B;  1SH5 A;  1UJO A;  2D89 A;  3KY9 A;  4Q57 B;  1WJO A;  4TXI A;  2EYI A;  1WYQ A;  5A37 A;  3CO1 A;  4Q58 A;  2L3G A;  3JAL M;  2R0O A;  3KMW B;  2VZI B;  4TXK A;  2K3S A; 
#chains in the Genus database with same CATH topology
 2VZD A;  2WFN A;  2HL8 A;  2QJX A;  1V5K A;  1PA7 A;  3JAK M;  3HOP A;  5A38 A;  2WA7 A;  1RT8 A;  5L0O A;  1UEG A;  2D88 A;  5FMT A;  2R8U A;  5BVR A;  4B7L A;  4LVP A;  5FMU A;  1VKA A;  1P5S A;  2VE7 C;  1AOA A;  2IGP A;  1WYM A;  1WYR A;  2HKP A;  2EYN A;  2JV9 A;  1QAG A;  3VP7 A;  1TJT A;  1PXY A;  1BKR A;  1H67 A;  2WA6 A;  4EDN A;  3KMU B;  5A4B A;  5A36 A;  3REP B;  1WYP A;  2DK9 A;  4EDM A;  1BHD A;  2D85 A;  1MB8 A;  1SH6 A;  2EE7 A;  3FER A;  2RR8 A;  2E9K A;  1WKU A;  3HOR A;  3F7P A;  3JAR M;  4DDP A;  2YRN A;  1WIX A;  4EDL A;  1P2X A;  2HL9 A;  3HOC A;  2WA5 A;  2D87 A;  1WYL A;  1WYN A;  2K2R A;  3I6X A;  1DXX A;  2WE6 A;  4Q59 A;  2D86 A;  2QJZ A;  2VE7 A;  1WYO A;  2VZC A;  5J8E A;  1AA2 A;  2EQO A;  2VZG B;  1SH5 A;  1UJO A;  2D89 A;  3KY9 A;  4Q57 B;  1WJO A;  4LVR A;  4TXI A;  2EYI A;  1WYQ A;  5A37 A;  3CO1 A;  4Q58 A;  2L3G A;  3EAY A;  3JAL M;  2R0O A;  3KMW B;  2VZI B;  4TXK A;  2K3S A;  2WDT A;  1EUV A; 
#chains in the Genus database with same CATH homology
 2VZD A;  2WFN A;  2QJX A;  1V5K A;  1PA7 A;  3JAK M;  3HOP A;  5A38 A;  2WA7 A;  1RT8 A;  5L0O A;  1UEG A;  2D88 A;  2R8U A;  5BVR A;  4B7L A;  1VKA A;  1P5S A;  1AOA A;  1WYM A;  1WYR A;  2EYN A;  2JV9 A;  1QAG A;  1TJT A;  1PXY A;  1BKR A;  1H67 A;  2WA6 A;  4EDN A;  3KMU B;  5A4B A;  5A36 A;  3REP B;  1WYP A;  2DK9 A;  4EDM A;  1BHD A;  2D85 A;  1MB8 A;  1SH6 A;  2EE7 A;  3FER A;  2RR8 A;  2E9K A;  1WKU A;  3HOR A;  3F7P A;  3JAR M;  2YRN A;  1WIX A;  4EDL A;  1P2X A;  3HOC A;  2WA5 A;  2D87 A;  1WYL A;  1WYN A;  2K2R A;  3I6X A;  1DXX A;  4Q59 A;  2D86 A;  2QJZ A;  1WYO A;  2VZC A;  5J8E A;  1AA2 A;  2VZG B;  1SH5 A;  1UJO A;  2D89 A;  3KY9 A;  4Q57 B;  1WJO A;  4TXI A;  2EYI A;  1WYQ A;  5A37 A;  3CO1 A;  4Q58 A;  2L3G A;  3JAL M;  2R0O A;  3KMW B;  2VZI B;  4TXK A;  2K3S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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