2C8EE

Structure of the artt motif e214n mutant c3bot1 exoenzyme (free state, crystal form iii)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
200
structure length
200
Chain Sequence
TYQEFTNIDQAKAWGNAQYKKYGLSKSEKEAIVSYTKSASEINGKLRQNKGVINGFPSNLIKQVELLDKSFNKMKTPENIMLFRGDDPAYLGTEFQNTLLNSNGTINKTAFEKAKAKFLNKDRLEYGYISTSLMNVSQFAGRPIITKFKVAKGSKAGYIDPISAFAGQLNMLLPRHSTYHIDDMRLSSDGKQIIITATMM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes.
pubmed doi rcsb
molecule tags Transferase
source organism Clostridium botulinum
molecule keywords MONO-ADP-RIBOSYLTRANSFERASE C3
total genus 71
structure length 200
sequence length 200
chains with identical sequence F, G
ec nomenclature ec 2.4.2.-:
pdb deposition date 2005-12-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.176.10 Alpha Beta Alpha-Beta Complex Toxin ADP-ribosyltransferase; Chain A, domain 1 Toxin ADP-ribosyltransferase; Chain A, domain 1 2c8eE00
2C8AA 3BUZA 1GIRA 2J3XA 4XM6A 4PKVA 1PWPA 1R4BA 4GF1A 2C8EE 2A9KB 2GWLA 4FMLA 4XSGB 1GXYA 2C8CA 4H03A 4H0YA 2GWMA 4XM8A 4PKWA 2WN7A 1GXZA 1ZXVA 4PKUA 1GIQA 2J3ZA 4TR5A 5BWMB 4XSHB 5H03A 1OG4A 1QS1A 3U0JA 4PKQA 1JKYA 4PKRA 4FXQA 4H0VA 1J7NA 1OG1A 1R45A 2WN8A 5D1UA 4FK7A 1PWUA 1YQYA 4PKSA 1OJQA 2C8BX 2C8HA 1GY0A 2C8DA 1QS2A 2J3VA 5D1SA 5D1TA 1GZEA 1GZFA 3NTSA 1PWWA 2BOVB 5GTTA 1OG3A 1UZIA 2C8GA 5DZQA 4ELNA 3BW8A 2WN5A 4DV8A 2C89A 4WF6A 2WN6A 2C8FE 4PKTA 4GY2A 1PWVA 1OJZA 5H04A 1G24A 4XM7A 1PWQA 2WN4A 4H0XA 4H0TA 2A78B
chains in the Genus database with same CATH superfamily
2C8AA 3BUZA 1GIRA 2J3XA 4XM6A 4PKVA 1PWPA 1R4BA 4GF1A 2C8EE 2A9KB 2GWLA 4FMLA 4XSGB 1GXYA 2C8CA 4H03A 4H0YA 2GWMA 4XM8A 4PKWA 2WN7A 1GXZA 1ZXVA 4PKUA 1GIQA 2J3ZA 4TR5A 5BWMB 4XSHB 5H03A 1OG4A 1QS1A 3U0JA 4PKQA 1JKYA 4PKRA 4FXQA 4H0VA 1J7NA 1OG1A 1R45A 2WN8A 5D1UA 4FK7A 1PWUA 1YQYA 4PKSA 1OJQA 2C8BX 2C8HA 1GY0A 2C8DA 1QS2A 2J3VA 5D1SA 5D1TA 1GZEA 1GZFA 3NTSA 1PWWA 2BOVB 5GTTA 1OG3A 1UZIA 2C8GA 5DZQA 4ELNA 3BW8A 2WN5A 4DV8A 2C89A 4WF6A 2WN6A 2C8FE 4PKTA 4GY2A 1PWVA 1OJZA 5H04A 1G24A 4XM7A 1PWQA 2WN4A 4H0XA 4H0TA 2A78B
chains in the Genus database with same CATH topology
2C8AA 3BUZA 1GIRA 2J3XA 4XM6A 4PKVA 1PWPA 1R4BA 4GF1A 2C8EE 2A9KB 2GWLA 4FMLA 4XSGB 1GXYA 2C8CA 4H03A 4H0YA 2GWMA 4XM8A 4PKWA 2WN7A 1GXZA 1ZXVA 4PKUA 1GIQA 2J3ZA 4TR5A 5BWMB 4XSHB 5H03A 1OG4A 1QS1A 3U0JA 4PKQA 1JKYA 4PKRA 4FXQA 4H0VA 1J7NA 1OG1A 1R45A 2WN8A 5D1UA 4FK7A 1PWUA 1YQYA 4PKSA 1OJQA 2C8BX 2C8HA 1GY0A 2C8DA 1QS2A 2J3VA 5D1SA 5D1TA 1GZEA 1GZFA 3NTSA 1PWWA 2BOVB 5GTTA 1OG3A 1UZIA 2C8GA 5DZQA 4ELNA 3BW8A 2WN5A 4DV8A 2C89A 4WF6A 2WN6A 2C8FE 4PKTA 4GY2A 1PWVA 1OJZA 5H04A 1G24A 4XM7A 1PWQA 2WN4A 4H0XA 4H0TA 2A78B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C8A A;  3BUZ A;  1GIR A;  2J3X A;  4XM6 A;  4PKV A;  1PWP A;  1R4B A;  4GF1 A;  2C8E E;  2A9K B;  2GWL A;  4FML A;  4XSG B;  1GXY A;  2C8C A;  4H03 A;  4H0Y A;  2GWM A;  4XM8 A;  4PKW A;  2WN7 A;  1GXZ A;  1ZXV A;  4PKU A;  1GIQ A;  2J3Z A;  4TR5 A;  5BWM B;  4XSH B;  5H03 A;  1OG4 A;  1QS1 A;  3U0J A;  4PKQ A;  1JKY A;  4PKR A;  4FXQ A;  4H0V A;  1J7N A;  1OG1 A;  1R45 A;  2WN8 A;  5D1U A;  4FK7 A;  1PWU A;  1YQY A;  4PKS A;  1OJQ A;  2C8B X;  2C8H A;  1GY0 A;  2C8D A;  1QS2 A;  2J3V A;  5D1S A;  5D1T A;  1GZE A;  1GZF A;  3NTS A;  1PWW A;  2BOV B;  5GTT A;  1OG3 A;  1UZI A;  2C8G A;  5DZQ A;  4ELN A;  3BW8 A;  2WN5 A;  4DV8 A;  2C89 A;  4WF6 A;  2WN6 A;  2C8F E;  4PKT A;  4GY2 A;  1PWV A;  1OJZ A;  5H04 A;  1G24 A;  4XM7 A;  1PWQ A;  2WN4 A;  4H0X A;  4H0T A;  2A78 B; 
#chains in the Genus database with same CATH topology
 2C8A A;  3BUZ A;  1GIR A;  2J3X A;  4XM6 A;  4PKV A;  1PWP A;  1R4B A;  4GF1 A;  2C8E E;  2A9K B;  2GWL A;  4FML A;  4XSG B;  1GXY A;  2C8C A;  4H03 A;  4H0Y A;  2GWM A;  4XM8 A;  4PKW A;  2WN7 A;  1GXZ A;  1ZXV A;  4PKU A;  1GIQ A;  2J3Z A;  4TR5 A;  5BWM B;  4XSH B;  5H03 A;  1OG4 A;  1QS1 A;  3U0J A;  4PKQ A;  1JKY A;  4PKR A;  4FXQ A;  4H0V A;  1J7N A;  1OG1 A;  1R45 A;  2WN8 A;  5D1U A;  4FK7 A;  1PWU A;  1YQY A;  4PKS A;  1OJQ A;  2C8B X;  2C8H A;  1GY0 A;  2C8D A;  1QS2 A;  2J3V A;  5D1S A;  5D1T A;  1GZE A;  1GZF A;  3NTS A;  1PWW A;  2BOV B;  5GTT A;  1OG3 A;  1UZI A;  2C8G A;  5DZQ A;  4ELN A;  3BW8 A;  2WN5 A;  4DV8 A;  2C89 A;  4WF6 A;  2WN6 A;  2C8F E;  4PKT A;  4GY2 A;  1PWV A;  1OJZ A;  5H04 A;  1G24 A;  4XM7 A;  1PWQ A;  2WN4 A;  4H0X A;  4H0T A;  2A78 B; 
#chains in the Genus database with same CATH homology
 2C8A A;  3BUZ A;  1GIR A;  2J3X A;  4XM6 A;  4PKV A;  1PWP A;  1R4B A;  4GF1 A;  2C8E E;  2A9K B;  2GWL A;  4FML A;  4XSG B;  1GXY A;  2C8C A;  4H03 A;  4H0Y A;  2GWM A;  4XM8 A;  4PKW A;  2WN7 A;  1GXZ A;  1ZXV A;  4PKU A;  1GIQ A;  2J3Z A;  4TR5 A;  5BWM B;  4XSH B;  5H03 A;  1OG4 A;  1QS1 A;  3U0J A;  4PKQ A;  1JKY A;  4PKR A;  4FXQ A;  4H0V A;  1J7N A;  1OG1 A;  1R45 A;  2WN8 A;  5D1U A;  4FK7 A;  1PWU A;  1YQY A;  4PKS A;  1OJQ A;  2C8B X;  2C8H A;  1GY0 A;  2C8D A;  1QS2 A;  2J3V A;  5D1S A;  5D1T A;  1GZE A;  1GZF A;  3NTS A;  1PWW A;  2BOV B;  5GTT A;  1OG3 A;  1UZI A;  2C8G A;  5DZQ A;  4ELN A;  3BW8 A;  2WN5 A;  4DV8 A;  2C89 A;  4WF6 A;  2WN6 A;  2C8F E;  4PKT A;  4GY2 A;  1PWV A;  1OJZ A;  5H04 A;  1G24 A;  4XM7 A;  1PWQ A;  2WN4 A;  4H0X A;  4H0T A;  2A78 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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