2WN8A

Structural basis for substrate recognition in the enzymatic component of adp-ribosyltransferase toxin cdta from clostridium difficile
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
396
structure length
389
Chain Sequence
EWERKEAERIEQKLERSEKEALESYKKDSVEISKYSQTRNYFYDYQIEANSREKEYKELRNAISKNKIDKPMYVYYFESPEKFAFNKVIRTENQNEISLEKFNEFKETIQNKLFKQDGFKDISLYEPGKGDEKPTPLLMHLKLPRNTGMLPYTVSTLIEQGYSIKIDKIVRIVIDGKHYIKAEASVVSSLDFKDDVSKGDSWGKANYNDWSNKLTPNELADVNDYMRGGYTAINNYLISNGPVNNPNPELDSKITNIENALKREPIPTNLTVYRRSGPQEFGLTLTSPEYDFNKLENIDAFKSKWEGQALSYPNFISTSIGSVNMSAFAKRKIVLRITIPKGSPGAYLSAIPGEYEVLLNHGSKFKINKIDSYKDGTITKLIVDATLIP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADP-RIBOSYLTRANSFERASE ENZYMATIC COMPONENT
publication title Structural Basis for Substrate Recognition in the Enzymatic Component of Adp-Ribosyltransferase Toxin Cdta from Clostridium Difficile.
pubmed doi rcsb
source organism Clostridium difficile
molecule tags Transferase
total genus 125
structure length 389
sequence length 396
ec nomenclature
pdb deposition date 2009-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03496 ADPrib_exo_Tox ADP-ribosyltransferase exoenzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.176.10 Alpha Beta Alpha-Beta Complex Toxin ADP-ribosyltransferase; Chain A, domain 1 Toxin ADP-ribosyltransferase; Chain A, domain 1 2wn8A02
3.90.176.10 Alpha Beta Alpha-Beta Complex Toxin ADP-ribosyltransferase; Chain A, domain 1 Toxin ADP-ribosyltransferase; Chain A, domain 1 2wn8A01
2J3ZA 1ZXVA 4GF1A 2C8AA 1R4BA 1PWVA 4PKUA 1UZIA 2WN5A 4DV8A 4FMLA 2BOVB 1PWWA 5H03A 1PWUA 2C8HA 4FK7A 1QS2A 4PKVA 1QS1A 2C8GA 1GXYA 3BW8A 4PKWA 4WF6A 1OJQA 4PKSA 5D1UA 1GZFA 1JKYA 5D1TA 2WN8A 4PKQA 1J7NA 2WN7A 2GWMA 2C8FE 1OJZA 1PWPA 5BWMB 4XM7A 1R45A 4H0TA 4ELNA 5H04A 1GIRA 4H0YA 2A78B 2A9KB 1GXZA 2J3XA 4GY2A 2C8CA 1GY0A 2GWLA 4FXQA 1OG4A 2J3VA 3U0JA 2WN4A 5GTTA 1GIQA 1OG1A 4H0VA 4XM6A 4XSGB 4H0XA 2C8BX 2C8EE 4PKTA 4XSHB 1PWQA 1OG3A 4XM8A 1YQYA 3BUZA 2C89A 3NTSA 4PKRA 4TR5A 5D1SA 1GZEA 2WN6A 4H03A 2C8DA 5DZQA 1G24A
chains in the Genus database with same CATH superfamily
2J3ZA 1ZXVA 4GF1A 2C8AA 1R4BA 1PWVA 4PKUA 1UZIA 2WN5A 4DV8A 4FMLA 2BOVB 1PWWA 5H03A 1PWUA 2C8HA 4FK7A 1QS2A 4PKVA 1QS1A 2C8GA 1GXYA 3BW8A 4PKWA 4WF6A 1OJQA 4PKSA 5D1UA 1GZFA 1JKYA 5D1TA 2WN8A 4PKQA 1J7NA 2WN7A 2GWMA 2C8FE 1OJZA 1PWPA 5BWMB 4XM7A 1R45A 4H0TA 4ELNA 5H04A 1GIRA 4H0YA 2A78B 2A9KB 1GXZA 2J3XA 4GY2A 2C8CA 1GY0A 2GWLA 4FXQA 1OG4A 2J3VA 3U0JA 2WN4A 5GTTA 1GIQA 1OG1A 4H0VA 4XM6A 4XSGB 4H0XA 2C8BX 2C8EE 4PKTA 4XSHB 1PWQA 1OG3A 4XM8A 1YQYA 3BUZA 2C89A 3NTSA 4PKRA 4TR5A 5D1SA 1GZEA 2WN6A 4H03A 2C8DA 5DZQA 1G24A
chains in the Genus database with same CATH topology
2J3ZA 1ZXVA 4GF1A 2C8AA 1R4BA 1PWVA 4PKUA 1UZIA 2WN5A 4DV8A 4FMLA 2BOVB 1PWWA 5H03A 1PWUA 2C8HA 4FK7A 1QS2A 4PKVA 1QS1A 2C8GA 1GXYA 3BW8A 4PKWA 4WF6A 1OJQA 4PKSA 5D1UA 1GZFA 1JKYA 5D1TA 2WN8A 4PKQA 1J7NA 2WN7A 2GWMA 2C8FE 1OJZA 1PWPA 5BWMB 4XM7A 1R45A 4H0TA 4ELNA 5H04A 1GIRA 4H0YA 2A78B 2A9KB 1GXZA 2J3XA 4GY2A 2C8CA 1GY0A 2GWLA 4FXQA 1OG4A 2J3VA 3U0JA 2WN4A 5GTTA 1GIQA 1OG1A 4H0VA 4XM6A 4XSGB 4H0XA 2C8BX 2C8EE 4PKTA 4XSHB 1PWQA 1OG3A 4XM8A 1YQYA 3BUZA 2C89A 3NTSA 4PKRA 4TR5A 5D1SA 1GZEA 2WN6A 4H03A 2C8DA 5DZQA 1G24A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J3Z A;  1ZXV A;  4GF1 A;  2C8A A;  1R4B A;  1PWV A;  4PKU A;  1UZI A;  2WN5 A;  4DV8 A;  4FML A;  2BOV B;  1PWW A;  5H03 A;  1PWU A;  2C8H A;  4FK7 A;  1QS2 A;  4PKV A;  1QS1 A;  2C8G A;  1GXY A;  3BW8 A;  4PKW A;  4WF6 A;  1OJQ A;  4PKS A;  5D1U A;  1GZF A;  1JKY A;  5D1T A;  2WN8 A;  4PKQ A;  1J7N A;  2WN7 A;  2GWM A;  2C8F E;  1OJZ A;  1PWP A;  5BWM B;  4XM7 A;  1R45 A;  4H0T A;  4ELN A;  5H04 A;  1GIR A;  4H0Y A;  2A78 B;  2A9K B;  1GXZ A;  2J3X A;  4GY2 A;  2C8C A;  1GY0 A;  2GWL A;  4FXQ A;  1OG4 A;  2J3V A;  3U0J A;  2WN4 A;  5GTT A;  1GIQ A;  1OG1 A;  4H0V A;  4XM6 A;  4XSG B;  4H0X A;  2C8B X;  2C8E E;  4PKT A;  4XSH B;  1PWQ A;  1OG3 A;  4XM8 A;  1YQY A;  3BUZ A;  2C89 A;  3NTS A;  4PKR A;  4TR5 A;  5D1S A;  1GZE A;  2WN6 A;  4H03 A;  2C8D A;  5DZQ A;  1G24 A; 
#chains in the Genus database with same CATH topology
 2J3Z A;  1ZXV A;  4GF1 A;  2C8A A;  1R4B A;  1PWV A;  4PKU A;  1UZI A;  2WN5 A;  4DV8 A;  4FML A;  2BOV B;  1PWW A;  5H03 A;  1PWU A;  2C8H A;  4FK7 A;  1QS2 A;  4PKV A;  1QS1 A;  2C8G A;  1GXY A;  3BW8 A;  4PKW A;  4WF6 A;  1OJQ A;  4PKS A;  5D1U A;  1GZF A;  1JKY A;  5D1T A;  2WN8 A;  4PKQ A;  1J7N A;  2WN7 A;  2GWM A;  2C8F E;  1OJZ A;  1PWP A;  5BWM B;  4XM7 A;  1R45 A;  4H0T A;  4ELN A;  5H04 A;  1GIR A;  4H0Y A;  2A78 B;  2A9K B;  1GXZ A;  2J3X A;  4GY2 A;  2C8C A;  1GY0 A;  2GWL A;  4FXQ A;  1OG4 A;  2J3V A;  3U0J A;  2WN4 A;  5GTT A;  1GIQ A;  1OG1 A;  4H0V A;  4XM6 A;  4XSG B;  4H0X A;  2C8B X;  2C8E E;  4PKT A;  4XSH B;  1PWQ A;  1OG3 A;  4XM8 A;  1YQY A;  3BUZ A;  2C89 A;  3NTS A;  4PKR A;  4TR5 A;  5D1S A;  1GZE A;  2WN6 A;  4H03 A;  2C8D A;  5DZQ A;  1G24 A; 
#chains in the Genus database with same CATH homology
 2J3Z A;  1ZXV A;  4GF1 A;  2C8A A;  1R4B A;  1PWV A;  4PKU A;  1UZI A;  2WN5 A;  4DV8 A;  4FML A;  2BOV B;  1PWW A;  5H03 A;  1PWU A;  2C8H A;  4FK7 A;  1QS2 A;  4PKV A;  1QS1 A;  2C8G A;  1GXY A;  3BW8 A;  4PKW A;  4WF6 A;  1OJQ A;  4PKS A;  5D1U A;  1GZF A;  1JKY A;  5D1T A;  2WN8 A;  4PKQ A;  1J7N A;  2WN7 A;  2GWM A;  2C8F E;  1OJZ A;  1PWP A;  5BWM B;  4XM7 A;  1R45 A;  4H0T A;  4ELN A;  5H04 A;  1GIR A;  4H0Y A;  2A78 B;  2A9K B;  1GXZ A;  2J3X A;  4GY2 A;  2C8C A;  1GY0 A;  2GWL A;  4FXQ A;  1OG4 A;  2J3V A;  3U0J A;  2WN4 A;  5GTT A;  1GIQ A;  1OG1 A;  4H0V A;  4XM6 A;  4XSG B;  4H0X A;  2C8B X;  2C8E E;  4PKT A;  4XSH B;  1PWQ A;  1OG3 A;  4XM8 A;  1YQY A;  3BUZ A;  2C89 A;  3NTS A;  4PKR A;  4TR5 A;  5D1S A;  1GZE A;  2WN6 A;  4H03 A;  2C8D A;  5DZQ A;  1G24 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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