4H0VA

Crystal structure of nad+-ia(e378s)-actin complex
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
413
structure length
413
Chain Sequence
AFIERPEDFLKDKENAIQWEKKEAERVEKNLDTLEKEALELYKKDSEQISNYSQTRQYFYDYQIESNPREKEYKNLRNAISKNKIDKPINVYYFESPEKFAFNKEIRTENQNEISLEKFNELKETIQDKLFKQDGFKDVSLYEPGNGDEKPTPLLIHLKLPKNTGMLPYINSNDVKTLIEQDYSIKIDKIVRIVIEGKQYIKAEASIVNSLDFKDDVSKGDLWGKENYSDWSNKLTPNELADVNDYMRGGYTAINNYLISNGPLNNPNPELDSKVNNIENALKLTPIPSNLIVYRRSGPQEFGLTLTSPEYDFNKIENIDAFKEKWEGKVITYPNFISTSIGSVNMSAFAKRKIILRINIPKDSPGAYLSAIPGYAGSYEVLLNHGSKFKINKVDSYKDGTVTKLILDATLIN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Iota toxin component Ia
publication title Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex
pubmed doi rcsb
source organism Clostridium perfringens
molecule tags Toxin/structural protein
total genus 147
structure length 413
sequence length 413
ec nomenclature ec 2.4.2.31: NAD(+)--protein-arginine ADP-ribosyltransferase.
pdb deposition date 2012-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03496 ADPrib_exo_Tox ADP-ribosyltransferase exoenzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.176.10 Alpha Beta Alpha-Beta Complex Toxin ADP-ribosyltransferase; Chain A, domain 1 Toxin ADP-ribosyltransferase; Chain A, domain 1 4h0vA02
3.90.176.10 Alpha Beta Alpha-Beta Complex Toxin ADP-ribosyltransferase; Chain A, domain 1 Toxin ADP-ribosyltransferase; Chain A, domain 1 4h0vA01
2BOVB 1PWPA 4H0YA 1YQYA 4XSGB 2WN5A 1OG3A 2J3XA 4FMLA 1G24A 2C8HA 3U0JA 5H04A 4PKQA 4FK7A 2C8DA 4H03A 1J7NA 2C8CA 3BUZA 4H0TA 1PWVA 2A78B 1R45A 4ELNA 3NTSA 1PWQA 4PKWA 2C8GA 1GIQA 2WN7A 1JKYA 2WN4A 1QS2A 4PKUA 5H03A 1GXZA 2J3VA 4DV8A 4FXQA 1GZFA 5GTTA 5DZQA 5D1TA 4XM8A 4H0VA 2C8EE 2C8FE 1OJZA 2J3ZA 4XM7A 2WN6A 1OJQA 4GF1A 5D1UA 4WF6A 4PKTA 4XM6A 1OG1A 2GWMA 1OG4A 1R4BA 2C89A 2A9KB 1ZXVA 1PWWA 1UZIA 2C8AA 1GY0A 1GXYA 4PKRA 4H0XA 1QS1A 4XSHB 2C8BX 1GIRA 2GWLA 4TR5A 5BWMB 2WN8A 5D1SA 3BW8A 4PKVA 4GY2A 4PKSA 1GZEA 1PWUA
chains in the Genus database with same CATH superfamily
2BOVB 1PWPA 4H0YA 1YQYA 4XSGB 2WN5A 1OG3A 2J3XA 4FMLA 1G24A 2C8HA 3U0JA 5H04A 4PKQA 4FK7A 2C8DA 4H03A 1J7NA 2C8CA 3BUZA 4H0TA 1PWVA 2A78B 1R45A 4ELNA 3NTSA 1PWQA 4PKWA 2C8GA 1GIQA 2WN7A 1JKYA 2WN4A 1QS2A 4PKUA 5H03A 1GXZA 2J3VA 4DV8A 4FXQA 1GZFA 5GTTA 5DZQA 5D1TA 4XM8A 4H0VA 2C8EE 2C8FE 1OJZA 2J3ZA 4XM7A 2WN6A 1OJQA 4GF1A 5D1UA 4WF6A 4PKTA 4XM6A 1OG1A 2GWMA 1OG4A 1R4BA 2C89A 2A9KB 1ZXVA 1PWWA 1UZIA 2C8AA 1GY0A 1GXYA 4PKRA 4H0XA 1QS1A 4XSHB 2C8BX 1GIRA 2GWLA 4TR5A 5BWMB 2WN8A 5D1SA 3BW8A 4PKVA 4GY2A 4PKSA 1GZEA 1PWUA
chains in the Genus database with same CATH topology
2BOVB 1PWPA 4H0YA 1YQYA 4XSGB 2WN5A 1OG3A 2J3XA 4FMLA 1G24A 2C8HA 3U0JA 5H04A 4PKQA 4FK7A 2C8DA 4H03A 1J7NA 2C8CA 3BUZA 4H0TA 1PWVA 2A78B 1R45A 4ELNA 3NTSA 1PWQA 4PKWA 2C8GA 1GIQA 2WN7A 1JKYA 2WN4A 1QS2A 4PKUA 5H03A 1GXZA 2J3VA 4DV8A 4FXQA 1GZFA 5GTTA 5DZQA 5D1TA 4XM8A 4H0VA 2C8EE 2C8FE 1OJZA 2J3ZA 4XM7A 2WN6A 1OJQA 4GF1A 5D1UA 4WF6A 4PKTA 4XM6A 1OG1A 2GWMA 1OG4A 1R4BA 2C89A 2A9KB 1ZXVA 1PWWA 1UZIA 2C8AA 1GY0A 1GXYA 4PKRA 4H0XA 1QS1A 4XSHB 2C8BX 1GIRA 2GWLA 4TR5A 5BWMB 2WN8A 5D1SA 3BW8A 4PKVA 4GY2A 4PKSA 1GZEA 1PWUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BOV B;  1PWP A;  4H0Y A;  1YQY A;  4XSG B;  2WN5 A;  1OG3 A;  2J3X A;  4FML A;  1G24 A;  2C8H A;  3U0J A;  5H04 A;  4PKQ A;  4FK7 A;  2C8D A;  4H03 A;  1J7N A;  2C8C A;  3BUZ A;  4H0T A;  1PWV A;  2A78 B;  1R45 A;  4ELN A;  3NTS A;  1PWQ A;  4PKW A;  2C8G A;  1GIQ A;  2WN7 A;  1JKY A;  2WN4 A;  1QS2 A;  4PKU A;  5H03 A;  1GXZ A;  2J3V A;  4DV8 A;  4FXQ A;  1GZF A;  5GTT A;  5DZQ A;  5D1T A;  4XM8 A;  4H0V A;  2C8E E;  2C8F E;  1OJZ A;  2J3Z A;  4XM7 A;  2WN6 A;  1OJQ A;  4GF1 A;  5D1U A;  4WF6 A;  4PKT A;  4XM6 A;  1OG1 A;  2GWM A;  1OG4 A;  1R4B A;  2C89 A;  2A9K B;  1ZXV A;  1PWW A;  1UZI A;  2C8A A;  1GY0 A;  1GXY A;  4PKR A;  4H0X A;  1QS1 A;  4XSH B;  2C8B X;  1GIR A;  2GWL A;  4TR5 A;  5BWM B;  2WN8 A;  5D1S A;  3BW8 A;  4PKV A;  4GY2 A;  4PKS A;  1GZE A;  1PWU A; 
#chains in the Genus database with same CATH topology
 2BOV B;  1PWP A;  4H0Y A;  1YQY A;  4XSG B;  2WN5 A;  1OG3 A;  2J3X A;  4FML A;  1G24 A;  2C8H A;  3U0J A;  5H04 A;  4PKQ A;  4FK7 A;  2C8D A;  4H03 A;  1J7N A;  2C8C A;  3BUZ A;  4H0T A;  1PWV A;  2A78 B;  1R45 A;  4ELN A;  3NTS A;  1PWQ A;  4PKW A;  2C8G A;  1GIQ A;  2WN7 A;  1JKY A;  2WN4 A;  1QS2 A;  4PKU A;  5H03 A;  1GXZ A;  2J3V A;  4DV8 A;  4FXQ A;  1GZF A;  5GTT A;  5DZQ A;  5D1T A;  4XM8 A;  4H0V A;  2C8E E;  2C8F E;  1OJZ A;  2J3Z A;  4XM7 A;  2WN6 A;  1OJQ A;  4GF1 A;  5D1U A;  4WF6 A;  4PKT A;  4XM6 A;  1OG1 A;  2GWM A;  1OG4 A;  1R4B A;  2C89 A;  2A9K B;  1ZXV A;  1PWW A;  1UZI A;  2C8A A;  1GY0 A;  1GXY A;  4PKR A;  4H0X A;  1QS1 A;  4XSH B;  2C8B X;  1GIR A;  2GWL A;  4TR5 A;  5BWM B;  2WN8 A;  5D1S A;  3BW8 A;  4PKV A;  4GY2 A;  4PKS A;  1GZE A;  1PWU A; 
#chains in the Genus database with same CATH homology
 2BOV B;  1PWP A;  4H0Y A;  1YQY A;  4XSG B;  2WN5 A;  1OG3 A;  2J3X A;  4FML A;  1G24 A;  2C8H A;  3U0J A;  5H04 A;  4PKQ A;  4FK7 A;  2C8D A;  4H03 A;  1J7N A;  2C8C A;  3BUZ A;  4H0T A;  1PWV A;  2A78 B;  1R45 A;  4ELN A;  3NTS A;  1PWQ A;  4PKW A;  2C8G A;  1GIQ A;  2WN7 A;  1JKY A;  2WN4 A;  1QS2 A;  4PKU A;  5H03 A;  1GXZ A;  2J3V A;  4DV8 A;  4FXQ A;  1GZF A;  5GTT A;  5DZQ A;  5D1T A;  4XM8 A;  4H0V A;  2C8E E;  2C8F E;  1OJZ A;  2J3Z A;  4XM7 A;  2WN6 A;  1OJQ A;  4GF1 A;  5D1U A;  4WF6 A;  4PKT A;  4XM6 A;  1OG1 A;  2GWM A;  1OG4 A;  1R4B A;  2C89 A;  2A9K B;  1ZXV A;  1PWW A;  1UZI A;  2C8A A;  1GY0 A;  1GXY A;  4PKR A;  4H0X A;  1QS1 A;  4XSH B;  2C8B X;  1GIR A;  2GWL A;  4TR5 A;  5BWM B;  2WN8 A;  5D1S A;  3BW8 A;  4PKV A;  4GY2 A;  4PKS A;  1GZE A;  1PWU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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