2EYIA

Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 angstrom resolution
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
234
structure length
234
Chain Sequence
AGHMEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQEFLEPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the actin-binding domain of alpha-actinin 1: Evaluating two competing actin-binding models.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Alpha-actinin 1
total genus 84
structure length 234
sequence length 234
ec nomenclature
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2eyiA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2eyiA01
5A37A 1SH6A 1TJTA 5J8EA 3CO1A 1P2XA 4EDMA 1WKUA 1RT8A 2K2RA 1UJOA 2K3SA 1WYRA 4TXIA 4Q59A 2D86A 4EDLA 2WA6A 5A38A 2L3GA 3KMUB 1QAGA 2D85A 3I6XA 2RR8A 2VZCA 2D89A 2QJZA 4TXKA 2EE7A 3KMWB 4EDNA 3FERA 1WYOA 1V5KA 2R0OA 5BVRA 3F7PA 1VKAA 2JV9A 2WA7A 5L0OA 2QJXA 2VZGB 2VZDA 4B7LA 1PXYA 1WYQA 2D88A 1WJOA 1AA2A 2EYIA 2D87A 2DK9A 3JALM 1P5SA 1WYPA 1BKRA 1PA7A 3KY9A 1UEGA 3JAKM 1WYMA 1WIXA 5A36A 1MB8A 4Q57B 2E9KA 3JARM 3HOCA 3REPB 1AOAA 2VZIB 2YRNA 1H67A 1DXXA 5A4BA 2WFNA 2WA5A 3HOPA 1WYLA 2EYNA 1WYNA 2R8UA 1BHDA 4Q58A 3HORA 1SH5A
chains in the Genus database with same CATH superfamily
5A37A 1SH6A 1TJTA 5J8EA 3CO1A 1P2XA 4EDMA 2WE6A 5FMTA 1WKUA 1RT8A 2K2RA 1UJOA 2K3SA 4LVRA 1WYRA 4TXIA 4Q59A 3VP7A 2D86A 4EDLA 2WA6A 5A38A 2L3GA 3KMUB 1QAGA 2D85A 3I6XA 2RR8A 2VZCA 2D89A 2QJZA 4TXKA 2HKPA 2EE7A 5FMUA 3KMWB 4EDNA 3FERA 1WYOA 3EAYA 1V5KA 2R0OA 5BVRA 3F7PA 1VKAA 2JV9A 2WA7A 5L0OA 2QJXA 1EUVA 2VZGB 2VZDA 4DDPA 4B7LA 1PXYA 1WYQA 2D88A 1WJOA 1AA2A 2EQOA 2VE7A 2EYIA 2D87A 2DK9A 3JALM 1P5SA 1WYPA 1BKRA 1PA7A 3KY9A 1UEGA 2HL9A 3JAKM 1WYMA 1WIXA 4LVPA 5A36A 1MB8A 4Q57B 2E9KA 3JARM 3HOCA 3REPB 1AOAA 2VE7C 2VZIB 2YRNA 1H67A 1DXXA 2WDTA 5A4BA 2IGPA 2HL8A 2WFNA 2WA5A 3HOPA 1WYLA 2EYNA 1WYNA 2R8UA 1BHDA 4Q58A 3HORA 1SH5A
chains in the Genus database with same CATH topology
5A37A 1SH6A 1TJTA 5J8EA 3CO1A 1P2XA 4EDMA 1WKUA 1RT8A 2K2RA 1UJOA 2K3SA 1WYRA 4TXIA 4Q59A 2D86A 4EDLA 2WA6A 5A38A 2L3GA 3KMUB 1QAGA 2D85A 3I6XA 2RR8A 2VZCA 2D89A 2QJZA 4TXKA 2EE7A 3KMWB 4EDNA 3FERA 1WYOA 1V5KA 2R0OA 5BVRA 3F7PA 1VKAA 2JV9A 2WA7A 5L0OA 2QJXA 2VZGB 2VZDA 4B7LA 1PXYA 1WYQA 2D88A 1WJOA 1AA2A 2EYIA 2D87A 2DK9A 3JALM 1P5SA 1WYPA 1BKRA 1PA7A 3KY9A 1UEGA 3JAKM 1WYMA 1WIXA 5A36A 1MB8A 4Q57B 2E9KA 3JARM 3HOCA 3REPB 1AOAA 2VZIB 2YRNA 1H67A 1DXXA 5A4BA 2WFNA 2WA5A 3HOPA 1WYLA 2EYNA 1WYNA 2R8UA 1BHDA 4Q58A 3HORA 1SH5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5A37 A;  1SH6 A;  1TJT A;  5J8E A;  3CO1 A;  1P2X A;  4EDM A;  1WKU A;  1RT8 A;  2K2R A;  1UJO A;  2K3S A;  1WYR A;  4TXI A;  4Q59 A;  2D86 A;  4EDL A;  2WA6 A;  5A38 A;  2L3G A;  3KMU B;  1QAG A;  2D85 A;  3I6X A;  2RR8 A;  2VZC A;  2D89 A;  2QJZ A;  4TXK A;  2EE7 A;  3KMW B;  4EDN A;  3FER A;  1WYO A;  1V5K A;  2R0O A;  5BVR A;  3F7P A;  1VKA A;  2JV9 A;  2WA7 A;  5L0O A;  2QJX A;  2VZG B;  2VZD A;  4B7L A;  1PXY A;  1WYQ A;  2D88 A;  1WJO A;  1AA2 A;  2EYI A;  2D87 A;  2DK9 A;  3JAL M;  1P5S A;  1WYP A;  1BKR A;  1PA7 A;  3KY9 A;  1UEG A;  3JAK M;  1WYM A;  1WIX A;  5A36 A;  1MB8 A;  4Q57 B;  2E9K A;  3JAR M;  3HOC A;  3REP B;  1AOA A;  2VZI B;  2YRN A;  1H67 A;  1DXX A;  5A4B A;  2WFN A;  2WA5 A;  3HOP A;  1WYL A;  2EYN A;  1WYN A;  2R8U A;  1BHD A;  4Q58 A;  3HOR A;  1SH5 A; 
#chains in the Genus database with same CATH topology
 5A37 A;  1SH6 A;  1TJT A;  5J8E A;  3CO1 A;  1P2X A;  4EDM A;  2WE6 A;  5FMT A;  1WKU A;  1RT8 A;  2K2R A;  1UJO A;  2K3S A;  4LVR A;  1WYR A;  4TXI A;  4Q59 A;  3VP7 A;  2D86 A;  4EDL A;  2WA6 A;  5A38 A;  2L3G A;  3KMU B;  1QAG A;  2D85 A;  3I6X A;  2RR8 A;  2VZC A;  2D89 A;  2QJZ A;  4TXK A;  2HKP A;  2EE7 A;  5FMU A;  3KMW B;  4EDN A;  3FER A;  1WYO A;  3EAY A;  1V5K A;  2R0O A;  5BVR A;  3F7P A;  1VKA A;  2JV9 A;  2WA7 A;  5L0O A;  2QJX A;  1EUV A;  2VZG B;  2VZD A;  4DDP A;  4B7L A;  1PXY A;  1WYQ A;  2D88 A;  1WJO A;  1AA2 A;  2EQO A;  2VE7 A;  2EYI A;  2D87 A;  2DK9 A;  3JAL M;  1P5S A;  1WYP A;  1BKR A;  1PA7 A;  3KY9 A;  1UEG A;  2HL9 A;  3JAK M;  1WYM A;  1WIX A;  4LVP A;  5A36 A;  1MB8 A;  4Q57 B;  2E9K A;  3JAR M;  3HOC A;  3REP B;  1AOA A;  2VE7 C;  2VZI B;  2YRN A;  1H67 A;  1DXX A;  2WDT A;  5A4B A;  2IGP A;  2HL8 A;  2WFN A;  2WA5 A;  3HOP A;  1WYL A;  2EYN A;  1WYN A;  2R8U A;  1BHD A;  4Q58 A;  3HOR A;  1SH5 A; 
#chains in the Genus database with same CATH homology
 5A37 A;  1SH6 A;  1TJT A;  5J8E A;  3CO1 A;  1P2X A;  4EDM A;  1WKU A;  1RT8 A;  2K2R A;  1UJO A;  2K3S A;  1WYR A;  4TXI A;  4Q59 A;  2D86 A;  4EDL A;  2WA6 A;  5A38 A;  2L3G A;  3KMU B;  1QAG A;  2D85 A;  3I6X A;  2RR8 A;  2VZC A;  2D89 A;  2QJZ A;  4TXK A;  2EE7 A;  3KMW B;  4EDN A;  3FER A;  1WYO A;  1V5K A;  2R0O A;  5BVR A;  3F7P A;  1VKA A;  2JV9 A;  2WA7 A;  5L0O A;  2QJX A;  2VZG B;  2VZD A;  4B7L A;  1PXY A;  1WYQ A;  2D88 A;  1WJO A;  1AA2 A;  2EYI A;  2D87 A;  2DK9 A;  3JAL M;  1P5S A;  1WYP A;  1BKR A;  1PA7 A;  3KY9 A;  1UEG A;  3JAK M;  1WYM A;  1WIX A;  5A36 A;  1MB8 A;  4Q57 B;  2E9K A;  3JAR M;  3HOC A;  3REP B;  1AOA A;  2VZI B;  2YRN A;  1H67 A;  1DXX A;  5A4B A;  2WFN A;  2WA5 A;  3HOP A;  1WYL A;  2EYN A;  1WYN A;  2R8U A;  1BHD A;  4Q58 A;  3HOR A;  1SH5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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