2R0OA

Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(k255e)
Total Genus 83

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
227
structure length
227
Chain Sequence
FAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEEAIMTYVSSFYHAFSGAL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH7 (196-205)EMPTYTI5 (192-195)AH1 (47-64)TIV2 (74-77)AH2 (82-92)3H1 (65-67)TIV1 (71-74)TI1 (73-76)TIV3 (75-78)AH3 (105-121)AH8 (220-235)AH5 (139-156)TIV5 (126-129)AH4 (131-136)AH6 (165-177)TII1 (180-183)S1 (159-160)TII'1 (160-163)TI4 (177-180)3H4 (212-214)TI6 (216-219)TIV4 (121-124)S2 (163-164)3H3 (207-209)3H2 (190-192)Updating...
connected with : NaN
molecule tags Actin-binding protein
source organism Homo sapiens
publication title Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.
pubmed doi rcsb
molecule keywords Alpha-actinin-4
total genus 83
structure length 227
sequence length 227
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2r0oA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2r0oA01
1DXXA 1WYRA 4B7LA 1P2XA 2QJZA 1SH6A 2EYNA 5A38A 2E9KA 1VKAA 2JV9A 1WJOA 1SH5A 2QJXA 3KMWB 1WYNA 1WYPA 2DK9A 4TXIA 1WYLA 1AOAA 1BHDA 4Q58A 2YRNA 3F7PA 1WYMA 2WA6A 5L0OA 5A37A 2D88A 2WFNA 1TJTA 2RR8A 4Q59A 1UEGA 1QAGA 1H67A 1AA2A 1WYQA 2D85A 5A36A 2EE7A 2WA7A 2D89A 2R8UA 1UJOA 3JAKM 4Q57B 2WA5A 1V5KA 3CO1A 2D86A 2L3GA 3I6XA 3JARM 3KMUB 1BKRA 4EDMA 2D87A 3KY9A 1WIXA 2VZCA 5BVRA 2R0OA 1P5SA 4EDLA 1WYOA 4TXKA 5A4BA 1RT8A 3HORA 3FERA 1PA7A 2VZDA 3HOPA 1PXYA 2K2RA 4EDNA 2EYIA 1MB8A 1WKUA 3REPB 3HOCA 3JALM 5J8EA 2K3SA 2VZIB 2VZGB
chains in the Genus database with same CATH superfamily
1DXXA 1WYRA 4B7LA 1P2XA 2QJZA 1SH6A 2EYNA 5A38A 2E9KA 1VKAA 2JV9A 1WJOA 1SH5A 2QJXA 3VP7A 3KMWB 2HKPA 2HL8A 1WYNA 1EUVA 1WYPA 2VE7C 2DK9A 4LVRA 4TXIA 1WYLA 1AOAA 1BHDA 4Q58A 2YRNA 4DDPA 5FMUA 3F7PA 1WYMA 2WA6A 2HL9A 5L0OA 5A37A 2D88A 2WFNA 1TJTA 2RR8A 4Q59A 1UEGA 1QAGA 1H67A 1AA2A 1WYQA 2D85A 5A36A 2EE7A 2EQOA 2WA7A 5FMTA 2D89A 2R8UA 1UJOA 3JAKM 4Q57B 2WA5A 1V5KA 3CO1A 2D86A 2L3GA 3I6XA 3JARM 2WDTA 3KMUB 1BKRA 4EDMA 2D87A 3KY9A 1WIXA 2VZCA 5BVRA 2VE7A 2R0OA 2WE6A 1P5SA 4EDLA 1WYOA 4TXKA 3EAYA 5A4BA 1RT8A 3HORA 3FERA 1PA7A 2VZDA 3HOPA 1PXYA 2K2RA 4EDNA 2EYIA 1MB8A 4LVPA 1WKUA 2IGPA 3REPB 3HOCA 3JALM 5J8EA 2K3SA 2VZIB 2VZGB
chains in the Genus database with same CATH topology
1DXXA 1WYRA 4B7LA 1P2XA 2QJZA 1SH6A 2EYNA 5A38A 2E9KA 1VKAA 2JV9A 1WJOA 1SH5A 2QJXA 3KMWB 1WYNA 1WYPA 2DK9A 4TXIA 1WYLA 1AOAA 1BHDA 4Q58A 2YRNA 3F7PA 1WYMA 2WA6A 5L0OA 5A37A 2D88A 2WFNA 1TJTA 2RR8A 4Q59A 1UEGA 1QAGA 1H67A 1AA2A 1WYQA 2D85A 5A36A 2EE7A 2WA7A 2D89A 2R8UA 1UJOA 3JAKM 4Q57B 2WA5A 1V5KA 3CO1A 2D86A 2L3GA 3I6XA 3JARM 3KMUB 1BKRA 4EDMA 2D87A 3KY9A 1WIXA 2VZCA 5BVRA 2R0OA 1P5SA 4EDLA 1WYOA 4TXKA 5A4BA 1RT8A 3HORA 3FERA 1PA7A 2VZDA 3HOPA 1PXYA 2K2RA 4EDNA 2EYIA 1MB8A 1WKUA 3REPB 3HOCA 3JALM 5J8EA 2K3SA 2VZIB 2VZGB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DXX A;  1WYR A;  4B7L A;  1P2X A;  2QJZ A;  1SH6 A;  2EYN A;  5A38 A;  2E9K A;  1VKA A;  2JV9 A;  1WJO A;  1SH5 A;  2QJX A;  3KMW B;  1WYN A;  1WYP A;  2DK9 A;  4TXI A;  1WYL A;  1AOA A;  1BHD A;  4Q58 A;  2YRN A;  3F7P A;  1WYM A;  2WA6 A;  5L0O A;  5A37 A;  2D88 A;  2WFN A;  1TJT A;  2RR8 A;  4Q59 A;  1UEG A;  1QAG A;  1H67 A;  1AA2 A;  1WYQ A;  2D85 A;  5A36 A;  2EE7 A;  2WA7 A;  2D89 A;  2R8U A;  1UJO A;  3JAK M;  4Q57 B;  2WA5 A;  1V5K A;  3CO1 A;  2D86 A;  2L3G A;  3I6X A;  3JAR M;  3KMU B;  1BKR A;  4EDM A;  2D87 A;  3KY9 A;  1WIX A;  2VZC A;  5BVR A;  2R0O A;  1P5S A;  4EDL A;  1WYO A;  4TXK A;  5A4B A;  1RT8 A;  3HOR A;  3FER A;  1PA7 A;  2VZD A;  3HOP A;  1PXY A;  2K2R A;  4EDN A;  2EYI A;  1MB8 A;  1WKU A;  3REP B;  3HOC A;  3JAL M;  5J8E A;  2K3S A;  2VZI B;  2VZG B; 
#chains in the Genus database with same CATH topology
 1DXX A;  1WYR A;  4B7L A;  1P2X A;  2QJZ A;  1SH6 A;  2EYN A;  5A38 A;  2E9K A;  1VKA A;  2JV9 A;  1WJO A;  1SH5 A;  2QJX A;  3VP7 A;  3KMW B;  2HKP A;  2HL8 A;  1WYN A;  1EUV A;  1WYP A;  2VE7 C;  2DK9 A;  4LVR A;  4TXI A;  1WYL A;  1AOA A;  1BHD A;  4Q58 A;  2YRN A;  4DDP A;  5FMU A;  3F7P A;  1WYM A;  2WA6 A;  2HL9 A;  5L0O A;  5A37 A;  2D88 A;  2WFN A;  1TJT A;  2RR8 A;  4Q59 A;  1UEG A;  1QAG A;  1H67 A;  1AA2 A;  1WYQ A;  2D85 A;  5A36 A;  2EE7 A;  2EQO A;  2WA7 A;  5FMT A;  2D89 A;  2R8U A;  1UJO A;  3JAK M;  4Q57 B;  2WA5 A;  1V5K A;  3CO1 A;  2D86 A;  2L3G A;  3I6X A;  3JAR M;  2WDT A;  3KMU B;  1BKR A;  4EDM A;  2D87 A;  3KY9 A;  1WIX A;  2VZC A;  5BVR A;  2VE7 A;  2R0O A;  2WE6 A;  1P5S A;  4EDL A;  1WYO A;  4TXK A;  3EAY A;  5A4B A;  1RT8 A;  3HOR A;  3FER A;  1PA7 A;  2VZD A;  3HOP A;  1PXY A;  2K2R A;  4EDN A;  2EYI A;  1MB8 A;  4LVP A;  1WKU A;  2IGP A;  3REP B;  3HOC A;  3JAL M;  5J8E A;  2K3S A;  2VZI B;  2VZG B; 
#chains in the Genus database with same CATH homology
 1DXX A;  1WYR A;  4B7L A;  1P2X A;  2QJZ A;  1SH6 A;  2EYN A;  5A38 A;  2E9K A;  1VKA A;  2JV9 A;  1WJO A;  1SH5 A;  2QJX A;  3KMW B;  1WYN A;  1WYP A;  2DK9 A;  4TXI A;  1WYL A;  1AOA A;  1BHD A;  4Q58 A;  2YRN A;  3F7P A;  1WYM A;  2WA6 A;  5L0O A;  5A37 A;  2D88 A;  2WFN A;  1TJT A;  2RR8 A;  4Q59 A;  1UEG A;  1QAG A;  1H67 A;  1AA2 A;  1WYQ A;  2D85 A;  5A36 A;  2EE7 A;  2WA7 A;  2D89 A;  2R8U A;  1UJO A;  3JAK M;  4Q57 B;  2WA5 A;  1V5K A;  3CO1 A;  2D86 A;  2L3G A;  3I6X A;  3JAR M;  3KMU B;  1BKR A;  4EDM A;  2D87 A;  3KY9 A;  1WIX A;  2VZC A;  5BVR A;  2R0O A;  1P5S A;  4EDL A;  1WYO A;  4TXK A;  5A4B A;  1RT8 A;  3HOR A;  3FER A;  1PA7 A;  2VZD A;  3HOP A;  1PXY A;  2K2R A;  4EDN A;  2EYI A;  1MB8 A;  1WKU A;  3REP B;  3HOC A;  3JAL M;  5J8E A;  2K3S A;  2VZI B;  2VZG B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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