2WA5A

Crystal structure of human filamin b actin binding domain at 1.9 angstroms resolution
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
243
structure length
237
Chain Sequence
MAPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH2 (13-30)EMPTYAH10 (194-209)AH7 (107-123)TVIII1 (37-40)AH3 (40-44)AH4 (48-58)AH6 (99-104)TI1 (44-47)AH5 (73-90)TIV1 (67-70)AH12 (227-235)TIV3 (123-126)AH8 (141-152)TI2 (153-156)AH9 (169-178)TIV9 (235-238)TIV5 (160-163)TI6 (222-225)TI5 (190-193)3H2 (163-165)TII1 (179-182)TIV7 (181-184)TIV6 (180-183)TI4 (183-186)3H3 (186-188)AH11 (217-221)TVIII2 (213-216)TI3 (165-168)AH1 (5-10)3H1 (31-33)Updating...
connected with : NaN
publication title Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords FILAMIN-B
total genus 82
structure length 237
sequence length 243
ec nomenclature
pdb deposition date 2009-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2wa5A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2wa5A01
4EDNA 2WFNA 2WA5A 1VKAA 1P5SA 5A36A 3JARM 1PXYA 1AA2A 2VZGB 3I6XA 2JV9A 2VZDA 2L3GA 2EE7A 1BHDA 4Q57B 1DXXA 2VZCA 5L0OA 2WA7A 4Q59A 3FERA 1BKRA 1QAGA 1WYMA 1P2XA 1RT8A 3JAKM 2YRNA 3KMWB 2R8UA 1AOAA 3KY9A 2RR8A 2D88A 3HOPA 2DK9A 3HORA 3CO1A 1V5KA 1WKUA 2EYIA 5BVRA 3F7PA 3KMUB 2D89A 1WJOA 2WA6A 2D87A 1MB8A 2D85A 2K3SA 2QJZA 4TXKA 2R0OA 1PA7A 3HOCA 1WYRA 1WYQA 1WYOA 2D86A 1UEGA 4Q58A 1UJOA 4B7LA 1H67A 1WYPA 1SH5A 4EDMA 5A37A 2E9KA 2VZIB 4EDLA 1WIXA 1TJTA 3REPB 5A38A 4TXIA 1SH6A 3JALM 2K2RA 1WYLA 2QJXA 5J8EA 2EYNA 1WYNA 5A4BA
chains in the Genus database with same CATH superfamily
4EDNA 2WFNA 2WA5A 5FMTA 3VP7A 1VKAA 1P5SA 5A36A 3JARM 2HL8A 1PXYA 1AA2A 2VZGB 3I6XA 2JV9A 2VZDA 2IGPA 2L3GA 2EQOA 2EE7A 1BHDA 4Q57B 1DXXA 2VZCA 5L0OA 2WA7A 4Q59A 3FERA 1BKRA 1QAGA 1WYMA 2WE6A 4LVRA 3EAYA 2VE7C 2VE7A 1P2XA 1RT8A 3JAKM 2YRNA 3KMWB 2R8UA 1AOAA 3KY9A 2RR8A 2HKPA 1EUVA 2D88A 3HOPA 2DK9A 3HORA 3CO1A 2HL9A 1V5KA 1WKUA 2EYIA 5BVRA 3F7PA 3KMUB 2D89A 1WJOA 2WA6A 2WDTA 2D87A 1MB8A 2D85A 4LVPA 2K3SA 2QJZA 4TXKA 2R0OA 1PA7A 3HOCA 1WYRA 1WYQA 1WYOA 2D86A 1UEGA 4Q58A 1UJOA 4B7LA 1H67A 1WYPA 1SH5A 4EDMA 5A37A 4DDPA 2E9KA 2VZIB 4EDLA 5FMUA 1WIXA 1TJTA 3REPB 5A38A 1SH6A 4TXIA 3JALM 2K2RA 1WYLA 2QJXA 5J8EA 2EYNA 1WYNA 5A4BA
chains in the Genus database with same CATH topology
4EDNA 2WFNA 2WA5A 1VKAA 1P5SA 5A36A 3JARM 1PXYA 1AA2A 2VZGB 3I6XA 2JV9A 2VZDA 2L3GA 2EE7A 1BHDA 4Q57B 1DXXA 2VZCA 5L0OA 2WA7A 4Q59A 3FERA 1BKRA 1QAGA 1WYMA 1P2XA 1RT8A 3JAKM 2YRNA 3KMWB 2R8UA 1AOAA 3KY9A 2RR8A 2D88A 3HOPA 2DK9A 3HORA 3CO1A 1V5KA 1WKUA 2EYIA 5BVRA 3F7PA 3KMUB 2D89A 1WJOA 2WA6A 2D87A 1MB8A 2D85A 2K3SA 2QJZA 4TXKA 2R0OA 1PA7A 3HOCA 1WYRA 1WYQA 1WYOA 2D86A 1UEGA 4Q58A 1UJOA 4B7LA 1H67A 1WYPA 1SH5A 4EDMA 5A37A 2E9KA 2VZIB 4EDLA 1WIXA 1TJTA 3REPB 5A38A 4TXIA 1SH6A 3JALM 2K2RA 1WYLA 2QJXA 5J8EA 2EYNA 1WYNA 5A4BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EDN A;  2WFN A;  2WA5 A;  1VKA A;  1P5S A;  5A36 A;  3JAR M;  1PXY A;  1AA2 A;  2VZG B;  3I6X A;  2JV9 A;  2VZD A;  2L3G A;  2EE7 A;  1BHD A;  4Q57 B;  1DXX A;  2VZC A;  5L0O A;  2WA7 A;  4Q59 A;  3FER A;  1BKR A;  1QAG A;  1WYM A;  1P2X A;  1RT8 A;  3JAK M;  2YRN A;  3KMW B;  2R8U A;  1AOA A;  3KY9 A;  2RR8 A;  2D88 A;  3HOP A;  2DK9 A;  3HOR A;  3CO1 A;  1V5K A;  1WKU A;  2EYI A;  5BVR A;  3F7P A;  3KMU B;  2D89 A;  1WJO A;  2WA6 A;  2D87 A;  1MB8 A;  2D85 A;  2K3S A;  2QJZ A;  4TXK A;  2R0O A;  1PA7 A;  3HOC A;  1WYR A;  1WYQ A;  1WYO A;  2D86 A;  1UEG A;  4Q58 A;  1UJO A;  4B7L A;  1H67 A;  1WYP A;  1SH5 A;  4EDM A;  5A37 A;  2E9K A;  2VZI B;  4EDL A;  1WIX A;  1TJT A;  3REP B;  5A38 A;  4TXI A;  1SH6 A;  3JAL M;  2K2R A;  1WYL A;  2QJX A;  5J8E A;  2EYN A;  1WYN A;  5A4B A; 
#chains in the Genus database with same CATH topology
 4EDN A;  2WFN A;  2WA5 A;  5FMT A;  3VP7 A;  1VKA A;  1P5S A;  5A36 A;  3JAR M;  2HL8 A;  1PXY A;  1AA2 A;  2VZG B;  3I6X A;  2JV9 A;  2VZD A;  2IGP A;  2L3G A;  2EQO A;  2EE7 A;  1BHD A;  4Q57 B;  1DXX A;  2VZC A;  5L0O A;  2WA7 A;  4Q59 A;  3FER A;  1BKR A;  1QAG A;  1WYM A;  2WE6 A;  4LVR A;  3EAY A;  2VE7 C;  2VE7 A;  1P2X A;  1RT8 A;  3JAK M;  2YRN A;  3KMW B;  2R8U A;  1AOA A;  3KY9 A;  2RR8 A;  2HKP A;  1EUV A;  2D88 A;  3HOP A;  2DK9 A;  3HOR A;  3CO1 A;  2HL9 A;  1V5K A;  1WKU A;  2EYI A;  5BVR A;  3F7P A;  3KMU B;  2D89 A;  1WJO A;  2WA6 A;  2WDT A;  2D87 A;  1MB8 A;  2D85 A;  4LVP A;  2K3S A;  2QJZ A;  4TXK A;  2R0O A;  1PA7 A;  3HOC A;  1WYR A;  1WYQ A;  1WYO A;  2D86 A;  1UEG A;  4Q58 A;  1UJO A;  4B7L A;  1H67 A;  1WYP A;  1SH5 A;  4EDM A;  5A37 A;  4DDP A;  2E9K A;  2VZI B;  4EDL A;  5FMU A;  1WIX A;  1TJT A;  3REP B;  5A38 A;  1SH6 A;  4TXI A;  3JAL M;  2K2R A;  1WYL A;  2QJX A;  5J8E A;  2EYN A;  1WYN A;  5A4B A; 
#chains in the Genus database with same CATH homology
 4EDN A;  2WFN A;  2WA5 A;  1VKA A;  1P5S A;  5A36 A;  3JAR M;  1PXY A;  1AA2 A;  2VZG B;  3I6X A;  2JV9 A;  2VZD A;  2L3G A;  2EE7 A;  1BHD A;  4Q57 B;  1DXX A;  2VZC A;  5L0O A;  2WA7 A;  4Q59 A;  3FER A;  1BKR A;  1QAG A;  1WYM A;  1P2X A;  1RT8 A;  3JAK M;  2YRN A;  3KMW B;  2R8U A;  1AOA A;  3KY9 A;  2RR8 A;  2D88 A;  3HOP A;  2DK9 A;  3HOR A;  3CO1 A;  1V5K A;  1WKU A;  2EYI A;  5BVR A;  3F7P A;  3KMU B;  2D89 A;  1WJO A;  2WA6 A;  2D87 A;  1MB8 A;  2D85 A;  2K3S A;  2QJZ A;  4TXK A;  2R0O A;  1PA7 A;  3HOC A;  1WYR A;  1WYQ A;  1WYO A;  2D86 A;  1UEG A;  4Q58 A;  1UJO A;  4B7L A;  1H67 A;  1WYP A;  1SH5 A;  4EDM A;  5A37 A;  2E9K A;  2VZI B;  4EDL A;  1WIX A;  1TJT A;  3REP B;  5A38 A;  4TXI A;  1SH6 A;  3JAL M;  2K2R A;  1WYL A;  2QJX A;  5J8E A;  2EYN A;  1WYN A;  5A4B A; 
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