2WA6 | Genus

Total Genus 81

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	81
sequence length	232
structure length	227
Chain Sequence	LAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEKKQTPKQRLLGRIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPK

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Structural protein
source organism	Homo sapiens
publication title	Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains. pubmed doi rcsb
molecule keywords	FILAMIN-B
total genus	81
structure length	227
sequence length	232
ec nomenclature
pdb deposition date	2009-02-03

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00307	CH	Calponin homology (CH) domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	2wa6A01
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	2wa6A02

1PXYA 2D86A 2R0OA 4Q58A 2RR8A 5A38A 5L0OA 1AOAA 3CO1A 1SH5A 1WYPA 3HORA 2WA7A 3KMUB 3JALM 2D88A 1BKRA 1DXXA 2EYIA 1WYQA 2D89A 2QJZA 4EDNA 4EDMA 3JAKM 2K2RA 1QAGA 5A37A 3FERA 1V5KA 2DK9A 2QJXA 5A36A 3I6XA 1AA2A 2WFNA 2L3GA 1WYMA 2VZDA 2K3SA 4B7LA 2D85A 3F7PA 3HOPA 1P5SA 1UEGA 2YRNA 1BHDA 1WYLA 2R8UA 1UJOA 2VZIB 2VZCA 2JV9A 1WJOA 1SH6A 3JARM 2WA5A 1WYNA 2EYNA 5J8EA 1WIXA 1WYOA 4Q59A 4TXIA 4TXKA 1RT8A 1VKAA 3KY9A 5BVRA 1MB8A 4EDLA 1WYRA 3REPB 1WKUA 1H67A 1TJTA 3KMWB 4Q57B 1PA7A 5A4BA 2WA6A 2D87A 2VZGB 2EE7A 2E9KA 1P2XA 3HOCA
chains in the Genus database with same CATH superfamily

1PXYA 2D86A 2R0OA 4Q58A 2RR8A 5A38A 5L0OA 1AOAA 3CO1A 1SH5A 1WYPA 3VP7A 3HORA 2WA7A 3KMUB 3JALM 2D88A 1BKRA 2HL8A 2WE6A 1DXXA 2EYIA 1WYQA 2D89A 2QJZA 4LVPA 4EDNA 3JAKM 4EDMA 4DDPA 2K2RA 1QAGA 2WDTA 5A37A 3FERA 1V5KA 3EAYA 2HKPA 2DK9A 2QJXA 5A36A 3I6XA 1EUVA 1AA2A 2WFNA 2IGPA 2L3GA 2EQOA 1WYMA 2VZDA 2K3SA 4B7LA 2D85A 3F7PA 3HOPA 1P5SA 1UEGA 2YRNA 5FMUA 1BHDA 1WYLA 2R8UA 1UJOA 2VE7A 2VZIB 2VZCA 2JV9A 1WJOA 1SH6A 3JARM 2WA5A 2VE7C 1WYNA 2EYNA 5J8EA 1WIXA 1WYOA 4Q59A 4TXIA 5FMTA 4TXKA 1RT8A 1VKAA 3KY9A 5BVRA 1MB8A 2HL9A 4EDLA 1WYRA 3REPB 1WKUA 1H67A 1TJTA 3KMWB 4Q57B 1PA7A 5A4BA 2WA6A 2D87A 2VZGB 4LVRA 2EE7A 2E9KA 1P2XA 3HOCA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1PXY A;  2D86 A;  2R0O A;  4Q58 A;  2RR8 A;  5A38 A;  5L0O A;  1AOA A;  3CO1 A;  1SH5 A;  1WYP A;  3HOR A;  2WA7 A;  3KMU B;  3JAL M;  2D88 A;  1BKR A;  1DXX A;  2EYI A;  1WYQ A;  2D89 A;  2QJZ A;  4EDN A;  4EDM A;  3JAK M;  2K2R A;  1QAG A;  5A37 A;  3FER A;  1V5K A;  2DK9 A;  2QJX A;  5A36 A;  3I6X A;  1AA2 A;  2WFN A;  2L3G A;  1WYM A;  2VZD A;  2K3S A;  4B7L A;  2D85 A;  3F7P A;  3HOP A;  1P5S A;  1UEG A;  2YRN A;  1BHD A;  1WYL A;  2R8U A;  1UJO A;  2VZI B;  2VZC A;  2JV9 A;  1WJO A;  1SH6 A;  3JAR M;  2WA5 A;  1WYN A;  2EYN A;  5J8E A;  1WIX A;  1WYO A;  4Q59 A;  4TXI A;  4TXK A;  1RT8 A;  1VKA A;  3KY9 A;  5BVR A;  1MB8 A;  4EDL A;  1WYR A;  3REP B;  1WKU A;  1H67 A;  1TJT A;  3KMW B;  4Q57 B;  1PA7 A;  5A4B A;  2WA6 A;  2D87 A;  2VZG B;  2EE7 A;  2E9K A;  1P2X A;  3HOC A; 
#chains in the Genus database with same CATH topology
 1PXY A;  2D86 A;  2R0O A;  4Q58 A;  2RR8 A;  5A38 A;  5L0O A;  1AOA A;  3CO1 A;  1SH5 A;  1WYP A;  3VP7 A;  3HOR A;  2WA7 A;  3KMU B;  3JAL M;  2D88 A;  1BKR A;  2HL8 A;  2WE6 A;  1DXX A;  2EYI A;  1WYQ A;  2D89 A;  2QJZ A;  4LVP A;  4EDN A;  3JAK M;  4EDM A;  4DDP A;  2K2R A;  1QAG A;  2WDT A;  5A37 A;  3FER A;  1V5K A;  3EAY A;  2HKP A;  2DK9 A;  2QJX A;  5A36 A;  3I6X A;  1EUV A;  1AA2 A;  2WFN A;  2IGP A;  2L3G A;  2EQO A;  1WYM A;  2VZD A;  2K3S A;  4B7L A;  2D85 A;  3F7P A;  3HOP A;  1P5S A;  1UEG A;  2YRN A;  5FMU A;  1BHD A;  1WYL A;  2R8U A;  1UJO A;  2VE7 A;  2VZI B;  2VZC A;  2JV9 A;  1WJO A;  1SH6 A;  3JAR M;  2WA5 A;  2VE7 C;  1WYN A;  2EYN A;  5J8E A;  1WIX A;  1WYO A;  4Q59 A;  4TXI A;  5FMT A;  4TXK A;  1RT8 A;  1VKA A;  3KY9 A;  5BVR A;  1MB8 A;  2HL9 A;  4EDL A;  1WYR A;  3REP B;  1WKU A;  1H67 A;  1TJT A;  3KMW B;  4Q57 B;  1PA7 A;  5A4B A;  2WA6 A;  2D87 A;  2VZG B;  4LVR A;  2EE7 A;  2E9K A;  1P2X A;  3HOC A; 
#chains in the Genus database with same CATH homology
 1PXY A;  2D86 A;  2R0O A;  4Q58 A;  2RR8 A;  5A38 A;  5L0O A;  1AOA A;  3CO1 A;  1SH5 A;  1WYP A;  3HOR A;  2WA7 A;  3KMU B;  3JAL M;  2D88 A;  1BKR A;  1DXX A;  2EYI A;  1WYQ A;  2D89 A;  2QJZ A;  4EDN A;  4EDM A;  3JAK M;  2K2R A;  1QAG A;  5A37 A;  3FER A;  1V5K A;  2DK9 A;  2QJX A;  5A36 A;  3I6X A;  1AA2 A;  2WFN A;  2L3G A;  1WYM A;  2VZD A;  2K3S A;  4B7L A;  2D85 A;  3F7P A;  3HOP A;  1P5S A;  1UEG A;  2YRN A;  1BHD A;  1WYL A;  2R8U A;  1UJO A;  2VZI B;  2VZC A;  2JV9 A;  1WJO A;  1SH6 A;  3JAR M;  2WA5 A;  1WYN A;  2EYN A;  5J8E A;  1WIX A;  1WYO A;  4Q59 A;  4TXI A;  4TXK A;  1RT8 A;  1VKA A;  3KY9 A;  5BVR A;  1MB8 A;  4EDL A;  1WYR A;  3REP B;  1WKU A;  1H67 A;  1TJT A;  3KMW B;  4Q57 B;  1PA7 A;  5A4B A;  2WA6 A;  2D87 A;  2VZG B;  2EE7 A;  2E9K A;  1P2X A;  3HOC A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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2WA6A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations