2WA6A

Structure of the w148r mutant of human filamin b actin binding domain at 1.95 angstrom resolution
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
232
structure length
227
Chain Sequence
LAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEKKQTPKQRLLGRIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Structural protein
source organism Homo sapiens
publication title Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
pubmed doi rcsb
molecule keywords FILAMIN-B
total genus 81
structure length 227
sequence length 232
ec nomenclature
pdb deposition date 2009-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2wa6A01
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2wa6A02
4EDNA 3JALM 3KMUB 3CO1A 1WKUA 2RR8A 5A4BA 4EDMA 2K3SA 2WA6A 2VZCA 5A36A 1MB8A 5A37A 2QJXA 1QAGA 3HORA 2VZDA 1AA2A 1WJOA 2R8UA 2D86A 3I6XA 3HOPA 5BVRA 1WYQA 2K2RA 1RT8A 1H67A 1P5SA 2D88A 2EE7A 2VZIB 3F7PA 1WYRA 1PA7A 1VKAA 1DXXA 4EDLA 1WYPA 4Q58A 2EYNA 2YRNA 1WIXA 4Q59A 1AOAA 1UJOA 1PXYA 4TXKA 2QJZA 2D89A 3JAKM 1UEGA 1BHDA 5L0OA 2WA5A 4TXIA 2L3GA 1SH5A 1WYOA 2E9KA 5A38A 2WA7A 1TJTA 2JV9A 2DK9A 1WYLA 1WYMA 3REPB 3KMWB 1V5KA 1SH6A 5J8EA 2D87A 2WFNA 4Q57B 2VZGB 1WYNA 3JARM 2D85A 3KY9A 3HOCA 3FERA 1BKRA 2R0OA 1P2XA 2EYIA 4B7LA
chains in the Genus database with same CATH superfamily
4EDNA 3JALM 3KMUB 2IGPA 3CO1A 1WKUA 2RR8A 5A4BA 2VE7C 4EDMA 2VE7A 2K3SA 2WA6A 2HKPA 2VZCA 5A36A 1MB8A 5A37A 2QJXA 1QAGA 2HL8A 3HORA 4DDPA 2VZDA 1AA2A 1WJOA 2R8UA 2D86A 3I6XA 3HOPA 5BVRA 1WYQA 2K2RA 1RT8A 1H67A 1P5SA 2D88A 2EE7A 2VZIB 2WDTA 3F7PA 1WYRA 1PA7A 1VKAA 1DXXA 4EDLA 1WYPA 3VP7A 4Q58A 2EYNA 2YRNA 1WIXA 4Q59A 5FMUA 1AOAA 1UJOA 1PXYA 4TXKA 2QJZA 3EAYA 2D89A 3JAKM 1UEGA 1BHDA 5L0OA 2WA5A 4TXIA 2L3GA 1SH5A 1WYOA 2E9KA 5A38A 1EUVA 2WA7A 1TJTA 2JV9A 2DK9A 1WYLA 1WYMA 3REPB 3KMWB 1V5KA 1SH6A 5FMTA 2HL9A 5J8EA 2D87A 4LVPA 2WFNA 2EQOA 4Q57B 2VZGB 1WYNA 3JARM 2D85A 3KY9A 2WE6A 3HOCA 3FERA 1BKRA 2R0OA 1P2XA 2EYIA 4B7LA 4LVRA
chains in the Genus database with same CATH topology
4EDNA 3JALM 3KMUB 3CO1A 1WKUA 2RR8A 5A4BA 4EDMA 2K3SA 2WA6A 2VZCA 5A36A 1MB8A 5A37A 2QJXA 1QAGA 3HORA 2VZDA 1AA2A 1WJOA 2R8UA 2D86A 3I6XA 3HOPA 5BVRA 1WYQA 2K2RA 1RT8A 1H67A 1P5SA 2D88A 2EE7A 2VZIB 3F7PA 1WYRA 1PA7A 1VKAA 1DXXA 4EDLA 1WYPA 4Q58A 2EYNA 2YRNA 1WIXA 4Q59A 1AOAA 1UJOA 1PXYA 4TXKA 2QJZA 2D89A 3JAKM 1UEGA 1BHDA 5L0OA 2WA5A 4TXIA 2L3GA 1SH5A 1WYOA 2E9KA 5A38A 2WA7A 1TJTA 2JV9A 2DK9A 1WYLA 1WYMA 3REPB 3KMWB 1V5KA 1SH6A 5J8EA 2D87A 2WFNA 4Q57B 2VZGB 1WYNA 3JARM 2D85A 3KY9A 3HOCA 3FERA 1BKRA 2R0OA 1P2XA 2EYIA 4B7LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EDN A;  3JAL M;  3KMU B;  3CO1 A;  1WKU A;  2RR8 A;  5A4B A;  4EDM A;  2K3S A;  2WA6 A;  2VZC A;  5A36 A;  1MB8 A;  5A37 A;  2QJX A;  1QAG A;  3HOR A;  2VZD A;  1AA2 A;  1WJO A;  2R8U A;  2D86 A;  3I6X A;  3HOP A;  5BVR A;  1WYQ A;  2K2R A;  1RT8 A;  1H67 A;  1P5S A;  2D88 A;  2EE7 A;  2VZI B;  3F7P A;  1WYR A;  1PA7 A;  1VKA A;  1DXX A;  4EDL A;  1WYP A;  4Q58 A;  2EYN A;  2YRN A;  1WIX A;  4Q59 A;  1AOA A;  1UJO A;  1PXY A;  4TXK A;  2QJZ A;  2D89 A;  3JAK M;  1UEG A;  1BHD A;  5L0O A;  2WA5 A;  4TXI A;  2L3G A;  1SH5 A;  1WYO A;  2E9K A;  5A38 A;  2WA7 A;  1TJT A;  2JV9 A;  2DK9 A;  1WYL A;  1WYM A;  3REP B;  3KMW B;  1V5K A;  1SH6 A;  5J8E A;  2D87 A;  2WFN A;  4Q57 B;  2VZG B;  1WYN A;  3JAR M;  2D85 A;  3KY9 A;  3HOC A;  3FER A;  1BKR A;  2R0O A;  1P2X A;  2EYI A;  4B7L A; 
#chains in the Genus database with same CATH topology
 4EDN A;  3JAL M;  3KMU B;  2IGP A;  3CO1 A;  1WKU A;  2RR8 A;  5A4B A;  2VE7 C;  4EDM A;  2VE7 A;  2K3S A;  2WA6 A;  2HKP A;  2VZC A;  5A36 A;  1MB8 A;  5A37 A;  2QJX A;  1QAG A;  2HL8 A;  3HOR A;  4DDP A;  2VZD A;  1AA2 A;  1WJO A;  2R8U A;  2D86 A;  3I6X A;  3HOP A;  5BVR A;  1WYQ A;  2K2R A;  1RT8 A;  1H67 A;  1P5S A;  2D88 A;  2EE7 A;  2VZI B;  2WDT A;  3F7P A;  1WYR A;  1PA7 A;  1VKA A;  1DXX A;  4EDL A;  1WYP A;  3VP7 A;  4Q58 A;  2EYN A;  2YRN A;  1WIX A;  4Q59 A;  5FMU A;  1AOA A;  1UJO A;  1PXY A;  4TXK A;  2QJZ A;  3EAY A;  2D89 A;  3JAK M;  1UEG A;  1BHD A;  5L0O A;  2WA5 A;  4TXI A;  2L3G A;  1SH5 A;  1WYO A;  2E9K A;  5A38 A;  1EUV A;  2WA7 A;  1TJT A;  2JV9 A;  2DK9 A;  1WYL A;  1WYM A;  3REP B;  3KMW B;  1V5K A;  1SH6 A;  5FMT A;  2HL9 A;  5J8E A;  2D87 A;  4LVP A;  2WFN A;  2EQO A;  4Q57 B;  2VZG B;  1WYN A;  3JAR M;  2D85 A;  3KY9 A;  2WE6 A;  3HOC A;  3FER A;  1BKR A;  2R0O A;  1P2X A;  2EYI A;  4B7L A;  4LVR A; 
#chains in the Genus database with same CATH homology
 4EDN A;  3JAL M;  3KMU B;  3CO1 A;  1WKU A;  2RR8 A;  5A4B A;  4EDM A;  2K3S A;  2WA6 A;  2VZC A;  5A36 A;  1MB8 A;  5A37 A;  2QJX A;  1QAG A;  3HOR A;  2VZD A;  1AA2 A;  1WJO A;  2R8U A;  2D86 A;  3I6X A;  3HOP A;  5BVR A;  1WYQ A;  2K2R A;  1RT8 A;  1H67 A;  1P5S A;  2D88 A;  2EE7 A;  2VZI B;  3F7P A;  1WYR A;  1PA7 A;  1VKA A;  1DXX A;  4EDL A;  1WYP A;  4Q58 A;  2EYN A;  2YRN A;  1WIX A;  4Q59 A;  1AOA A;  1UJO A;  1PXY A;  4TXK A;  2QJZ A;  2D89 A;  3JAK M;  1UEG A;  1BHD A;  5L0O A;  2WA5 A;  4TXI A;  2L3G A;  1SH5 A;  1WYO A;  2E9K A;  5A38 A;  2WA7 A;  1TJT A;  2JV9 A;  2DK9 A;  1WYL A;  1WYM A;  3REP B;  3KMW B;  1V5K A;  1SH6 A;  5J8E A;  2D87 A;  2WFN A;  4Q57 B;  2VZG B;  1WYN A;  3JAR M;  2D85 A;  3KY9 A;  3HOC A;  3FER A;  1BKR A;  2R0O A;  1P2X A;  2EYI A;  4B7L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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