2WA7A

Structure of the m202v mutant of human filamin b actin binding domain at 1.85 angstrom resolution
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
229
structure length
225
Chain Sequence
APWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAVQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Structural protein
source organism Homo sapiens
publication title Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
pubmed doi rcsb
molecule keywords FILAMIN-B
total genus 80
structure length 225
sequence length 229
ec nomenclature
pdb deposition date 2009-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2wa7A01
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 2wa7A02
1RT8A 3HOCA 1QAGA 5J8EA 3KY9A 2JV9A 2R8UA 4EDMA 1WYQA 3HOPA 1SH6A 2WFNA 1WKUA 3KMUB 2D89A 2D86A 1VKAA 2R0OA 2E9KA 2WA5A 1PA7A 1MB8A 1WYPA 1UJOA 2D88A 2DK9A 1H67A 1WYMA 1UEGA 3JALM 2K2RA 1WJOA 1WYLA 1V5KA 5A36A 1P2XA 2EYIA 5BVRA 1BHDA 2EYNA 2QJZA 2L3GA 1BKRA 4Q58A 2VZCA 1AOAA 5A37A 2YRNA 2WA7A 1P5SA 3JARM 2K3SA 3I6XA 5A4BA 2RR8A 2VZGB 3REPB 2WA6A 1PXYA 1SH5A 1WYRA 3KMWB 2D87A 4B7LA 4Q59A 1DXXA 1WYOA 3JAKM 2QJXA 3HORA 2EE7A 4Q57B 5L0OA 2VZDA 3CO1A 4TXKA 1AA2A 2D85A 5A38A 3FERA 1WIXA 4EDLA 4TXIA 1WYNA 4EDNA 2VZIB 3F7PA 1TJTA
chains in the Genus database with same CATH superfamily
1RT8A 3HOCA 4LVRA 1QAGA 5J8EA 1EUVA 3KY9A 2JV9A 2R8UA 4EDMA 1WYQA 3HOPA 1SH6A 2WFNA 1WKUA 2HKPA 3KMUB 2D89A 2D86A 1VKAA 2WDTA 2R0OA 2E9KA 2VE7C 2WA5A 1PA7A 1MB8A 1WYPA 1UJOA 2D88A 2DK9A 1H67A 1WYMA 2WE6A 1UEGA 3JALM 2K2RA 1WJOA 4LVPA 1WYLA 1V5KA 5A36A 1P2XA 2EYIA 5BVRA 1BHDA 2EYNA 5FMTA 2HL9A 2QJZA 2L3GA 1BKRA 4Q58A 4DDPA 2VZCA 1AOAA 5A37A 2YRNA 2WA7A 1P5SA 3JARM 5FMUA 2K3SA 3I6XA 3VP7A 5A4BA 2RR8A 2VZGB 3REPB 2WA6A 2HL8A 2IGPA 1PXYA 1SH5A 1WYRA 3KMWB 2D87A 4B7LA 4Q59A 1DXXA 1WYOA 3JAKM 2QJXA 3HORA 2EE7A 4Q57B 5L0OA 2VZDA 2VE7A 3CO1A 4TXKA 1AA2A 2D85A 5A38A 3EAYA 3FERA 1WIXA 2EQOA 4TXIA 4EDLA 1WYNA 4EDNA 2VZIB 3F7PA 1TJTA
chains in the Genus database with same CATH topology
1RT8A 3HOCA 1QAGA 5J8EA 3KY9A 2JV9A 2R8UA 4EDMA 1WYQA 3HOPA 1SH6A 2WFNA 1WKUA 3KMUB 2D89A 2D86A 1VKAA 2R0OA 2E9KA 2WA5A 1PA7A 1MB8A 1WYPA 1UJOA 2D88A 2DK9A 1H67A 1WYMA 1UEGA 3JALM 2K2RA 1WJOA 1WYLA 1V5KA 5A36A 1P2XA 2EYIA 5BVRA 1BHDA 2EYNA 2QJZA 2L3GA 1BKRA 4Q58A 2VZCA 1AOAA 5A37A 2YRNA 2WA7A 1P5SA 3JARM 2K3SA 3I6XA 5A4BA 2RR8A 2VZGB 3REPB 2WA6A 1PXYA 1SH5A 1WYRA 3KMWB 2D87A 4B7LA 4Q59A 1DXXA 1WYOA 3JAKM 2QJXA 3HORA 2EE7A 4Q57B 5L0OA 2VZDA 3CO1A 4TXKA 1AA2A 2D85A 5A38A 3FERA 1WIXA 4EDLA 4TXIA 1WYNA 4EDNA 2VZIB 3F7PA 1TJTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RT8 A;  3HOC A;  1QAG A;  5J8E A;  3KY9 A;  2JV9 A;  2R8U A;  4EDM A;  1WYQ A;  3HOP A;  1SH6 A;  2WFN A;  1WKU A;  3KMU B;  2D89 A;  2D86 A;  1VKA A;  2R0O A;  2E9K A;  2WA5 A;  1PA7 A;  1MB8 A;  1WYP A;  1UJO A;  2D88 A;  2DK9 A;  1H67 A;  1WYM A;  1UEG A;  3JAL M;  2K2R A;  1WJO A;  1WYL A;  1V5K A;  5A36 A;  1P2X A;  2EYI A;  5BVR A;  1BHD A;  2EYN A;  2QJZ A;  2L3G A;  1BKR A;  4Q58 A;  2VZC A;  1AOA A;  5A37 A;  2YRN A;  2WA7 A;  1P5S A;  3JAR M;  2K3S A;  3I6X A;  5A4B A;  2RR8 A;  2VZG B;  3REP B;  2WA6 A;  1PXY A;  1SH5 A;  1WYR A;  3KMW B;  2D87 A;  4B7L A;  4Q59 A;  1DXX A;  1WYO A;  3JAK M;  2QJX A;  3HOR A;  2EE7 A;  4Q57 B;  5L0O A;  2VZD A;  3CO1 A;  4TXK A;  1AA2 A;  2D85 A;  5A38 A;  3FER A;  1WIX A;  4EDL A;  4TXI A;  1WYN A;  4EDN A;  2VZI B;  3F7P A;  1TJT A; 
#chains in the Genus database with same CATH topology
 1RT8 A;  3HOC A;  4LVR A;  1QAG A;  5J8E A;  1EUV A;  3KY9 A;  2JV9 A;  2R8U A;  4EDM A;  1WYQ A;  3HOP A;  1SH6 A;  2WFN A;  1WKU A;  2HKP A;  3KMU B;  2D89 A;  2D86 A;  1VKA A;  2WDT A;  2R0O A;  2E9K A;  2VE7 C;  2WA5 A;  1PA7 A;  1MB8 A;  1WYP A;  1UJO A;  2D88 A;  2DK9 A;  1H67 A;  1WYM A;  2WE6 A;  1UEG A;  3JAL M;  2K2R A;  1WJO A;  4LVP A;  1WYL A;  1V5K A;  5A36 A;  1P2X A;  2EYI A;  5BVR A;  1BHD A;  2EYN A;  5FMT A;  2HL9 A;  2QJZ A;  2L3G A;  1BKR A;  4Q58 A;  4DDP A;  2VZC A;  1AOA A;  5A37 A;  2YRN A;  2WA7 A;  1P5S A;  3JAR M;  5FMU A;  2K3S A;  3I6X A;  3VP7 A;  5A4B A;  2RR8 A;  2VZG B;  3REP B;  2WA6 A;  2HL8 A;  2IGP A;  1PXY A;  1SH5 A;  1WYR A;  3KMW B;  2D87 A;  4B7L A;  4Q59 A;  1DXX A;  1WYO A;  3JAK M;  2QJX A;  3HOR A;  2EE7 A;  4Q57 B;  5L0O A;  2VZD A;  2VE7 A;  3CO1 A;  4TXK A;  1AA2 A;  2D85 A;  5A38 A;  3EAY A;  3FER A;  1WIX A;  2EQO A;  4TXI A;  4EDL A;  1WYN A;  4EDN A;  2VZI B;  3F7P A;  1TJT A; 
#chains in the Genus database with same CATH homology
 1RT8 A;  3HOC A;  1QAG A;  5J8E A;  3KY9 A;  2JV9 A;  2R8U A;  4EDM A;  1WYQ A;  3HOP A;  1SH6 A;  2WFN A;  1WKU A;  3KMU B;  2D89 A;  2D86 A;  1VKA A;  2R0O A;  2E9K A;  2WA5 A;  1PA7 A;  1MB8 A;  1WYP A;  1UJO A;  2D88 A;  2DK9 A;  1H67 A;  1WYM A;  1UEG A;  3JAL M;  2K2R A;  1WJO A;  1WYL A;  1V5K A;  5A36 A;  1P2X A;  2EYI A;  5BVR A;  1BHD A;  2EYN A;  2QJZ A;  2L3G A;  1BKR A;  4Q58 A;  2VZC A;  1AOA A;  5A37 A;  2YRN A;  2WA7 A;  1P5S A;  3JAR M;  2K3S A;  3I6X A;  5A4B A;  2RR8 A;  2VZG B;  3REP B;  2WA6 A;  1PXY A;  1SH5 A;  1WYR A;  3KMW B;  2D87 A;  4B7L A;  4Q59 A;  1DXX A;  1WYO A;  3JAK M;  2QJX A;  3HOR A;  2EE7 A;  4Q57 B;  5L0O A;  2VZD A;  3CO1 A;  4TXK A;  1AA2 A;  2D85 A;  5A38 A;  3FER A;  1WIX A;  4EDL A;  4TXI A;  1WYN A;  4EDN A;  2VZI B;  3F7P A;  1TJT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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