3HOC | Genus

Total Genus 76

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	76
sequence length	227
structure length	215
Chain Sequence	APWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDKHSVMTYLSQFP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Structural protein
source organism	Homo sapiens
publication title	Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders pubmed doi rcsb
molecule keywords	Filamin-A
total genus	76
structure length	215
sequence length	227
chains with identical sequence	B
ec nomenclature
pdb deposition date	2009-06-02

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00307	CH	Calponin homology (CH) domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	3hocA01
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	3hocA02

3JAKM 1WIXA 2DK9A 2YRNA 2VZGB 4EDLA 1P5SA 1UJOA 1WYQA 2K3SA 2WA5A 4EDMA 2L3GA 5L0OA 3JARM 1PA7A 2R8UA 1DXXA 1BHDA 2K2RA 2QJXA 3CO1A 5A37A 1BKRA 2D89A 2WFNA 4EDNA 3HOPA 1VKAA 1MB8A 1WYNA 3F7PA 1P2XA 2WA6A 1WKUA 1WJOA 1WYLA 1WYMA 2WA7A 5A4BA 1PXYA 4Q58A 2VZIB 2D85A 4TXKA 2R0OA 2RR8A 4TXIA 2VZDA 1AA2A 5A38A 2JV9A 5A36A 1H67A 4Q57B 2EYNA 1UEGA 2VZCA 3REPB 5BVRA 1QAGA 2D86A 2EYIA 1WYRA 2D87A 2QJZA 1RT8A 3FERA 3KY9A 3KMUB 1TJTA 1WYPA 3JALM 2EE7A 4B7LA 1SH6A 5J8EA 3HOCA 3HORA 1WYOA 4Q59A 1V5KA 2E9KA 3I6XA 3KMWB 2D88A 1AOAA 1SH5A
chains in the Genus database with same CATH superfamily

3JAKM 1WIXA 2DK9A 2YRNA 2VZGB 4EDLA 1P5SA 4LVPA 1UJOA 1WYQA 2K3SA 2WA5A 4EDMA 2L3GA 5L0OA 4LVRA 3JARM 1PA7A 2R8UA 1DXXA 1BHDA 2VE7C 2K2RA 2QJXA 3VP7A 3CO1A 5A37A 1BKRA 5FMTA 2D89A 2WE6A 4DDPA 2WFNA 4EDNA 3HOPA 1VKAA 1MB8A 1WYNA 3F7PA 1P2XA 2WA6A 1WKUA 1WJOA 1WYLA 1WYMA 2WA7A 5A4BA 1PXYA 4Q58A 2VZIB 2D85A 2HL9A 4TXKA 2R0OA 2RR8A 4TXIA 2VZDA 1AA2A 5A38A 2JV9A 5A36A 1H67A 4Q57B 2EYNA 1UEGA 2VZCA 3REPB 5BVRA 2IGPA 1QAGA 2D86A 1EUVA 5FMUA 2EYIA 1WYRA 2D87A 3EAYA 2QJZA 1RT8A 3FERA 2WDTA 2EQOA 3KY9A 3KMUB 1TJTA 1WYPA 2HL8A 3JALM 2EE7A 4B7LA 1SH6A 5J8EA 3HOCA 3HORA 1WYOA 4Q59A 1V5KA 2E9KA 3I6XA 3KMWB 2HKPA 2D88A 1AOAA 2VE7A 1SH5A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3JAK M;  1WIX A;  2DK9 A;  2YRN A;  2VZG B;  4EDL A;  1P5S A;  1UJO A;  1WYQ A;  2K3S A;  2WA5 A;  4EDM A;  2L3G A;  5L0O A;  3JAR M;  1PA7 A;  2R8U A;  1DXX A;  1BHD A;  2K2R A;  2QJX A;  3CO1 A;  5A37 A;  1BKR A;  2D89 A;  2WFN A;  4EDN A;  3HOP A;  1VKA A;  1MB8 A;  1WYN A;  3F7P A;  1P2X A;  2WA6 A;  1WKU A;  1WJO A;  1WYL A;  1WYM A;  2WA7 A;  5A4B A;  1PXY A;  4Q58 A;  2VZI B;  2D85 A;  4TXK A;  2R0O A;  2RR8 A;  4TXI A;  2VZD A;  1AA2 A;  5A38 A;  2JV9 A;  5A36 A;  1H67 A;  4Q57 B;  2EYN A;  1UEG A;  2VZC A;  3REP B;  5BVR A;  1QAG A;  2D86 A;  2EYI A;  1WYR A;  2D87 A;  2QJZ A;  1RT8 A;  3FER A;  3KY9 A;  3KMU B;  1TJT A;  1WYP A;  3JAL M;  2EE7 A;  4B7L A;  1SH6 A;  5J8E A;  3HOC A;  3HOR A;  1WYO A;  4Q59 A;  1V5K A;  2E9K A;  3I6X A;  3KMW B;  2D88 A;  1AOA A;  1SH5 A; 
#chains in the Genus database with same CATH topology
 3JAK M;  1WIX A;  2DK9 A;  2YRN A;  2VZG B;  4EDL A;  1P5S A;  4LVP A;  1UJO A;  1WYQ A;  2K3S A;  2WA5 A;  4EDM A;  2L3G A;  5L0O A;  4LVR A;  3JAR M;  1PA7 A;  2R8U A;  1DXX A;  1BHD A;  2VE7 C;  2K2R A;  2QJX A;  3VP7 A;  3CO1 A;  5A37 A;  1BKR A;  5FMT A;  2D89 A;  2WE6 A;  4DDP A;  2WFN A;  4EDN A;  3HOP A;  1VKA A;  1MB8 A;  1WYN A;  3F7P A;  1P2X A;  2WA6 A;  1WKU A;  1WJO A;  1WYL A;  1WYM A;  2WA7 A;  5A4B A;  1PXY A;  4Q58 A;  2VZI B;  2D85 A;  2HL9 A;  4TXK A;  2R0O A;  2RR8 A;  4TXI A;  2VZD A;  1AA2 A;  5A38 A;  2JV9 A;  5A36 A;  1H67 A;  4Q57 B;  2EYN A;  1UEG A;  2VZC A;  3REP B;  5BVR A;  2IGP A;  1QAG A;  2D86 A;  1EUV A;  5FMU A;  2EYI A;  1WYR A;  2D87 A;  3EAY A;  2QJZ A;  1RT8 A;  3FER A;  2WDT A;  2EQO A;  3KY9 A;  3KMU B;  1TJT A;  1WYP A;  2HL8 A;  3JAL M;  2EE7 A;  4B7L A;  1SH6 A;  5J8E A;  3HOC A;  3HOR A;  1WYO A;  4Q59 A;  1V5K A;  2E9K A;  3I6X A;  3KMW B;  2HKP A;  2D88 A;  1AOA A;  2VE7 A;  1SH5 A; 
#chains in the Genus database with same CATH homology
 3JAK M;  1WIX A;  2DK9 A;  2YRN A;  2VZG B;  4EDL A;  1P5S A;  1UJO A;  1WYQ A;  2K3S A;  2WA5 A;  4EDM A;  2L3G A;  5L0O A;  3JAR M;  1PA7 A;  2R8U A;  1DXX A;  1BHD A;  2K2R A;  2QJX A;  3CO1 A;  5A37 A;  1BKR A;  2D89 A;  2WFN A;  4EDN A;  3HOP A;  1VKA A;  1MB8 A;  1WYN A;  3F7P A;  1P2X A;  2WA6 A;  1WKU A;  1WJO A;  1WYL A;  1WYM A;  2WA7 A;  5A4B A;  1PXY A;  4Q58 A;  2VZI B;  2D85 A;  4TXK A;  2R0O A;  2RR8 A;  4TXI A;  2VZD A;  1AA2 A;  5A38 A;  2JV9 A;  5A36 A;  1H67 A;  4Q57 B;  2EYN A;  1UEG A;  2VZC A;  3REP B;  5BVR A;  1QAG A;  2D86 A;  2EYI A;  1WYR A;  2D87 A;  2QJZ A;  1RT8 A;  3FER A;  3KY9 A;  3KMU B;  1TJT A;  1WYP A;  3JAL M;  2EE7 A;  4B7L A;  1SH6 A;  5J8E A;  3HOC A;  3HOR A;  1WYO A;  4Q59 A;  1V5K A;  2E9K A;  3I6X A;  3KMW B;  2D88 A;  1AOA A;  1SH5 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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3HOCA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations