3HOPA

Structure of the actin-binding domain of human filamin a
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
233
structure length
226
Chain Sequence
EDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Filamin-A
total genus 82
structure length 226
sequence length 233
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-06-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 3hopA01
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 3hopA02
3F7PA 1QAGA 4Q57B 5L0OA 2D87A 1SH5A 2L3GA 1WYOA 2WA5A 4B7LA 2R8UA 2EE7A 1P2XA 3CO1A 1UEGA 1WYNA 5J8EA 1WYPA 3KMUB 3HOCA 1AA2A 3JAKM 2WFNA 2VZCA 2D88A 1AOAA 4EDMA 1WJOA 2EYIA 2D86A 4TXKA 4EDLA 2WA7A 3JARM 2D85A 1SH6A 2QJZA 1TJTA 1UJOA 5A4BA 1DXXA 2DK9A 1VKAA 1H67A 2JV9A 3HORA 1PA7A 1V5KA 1WYMA 2EYNA 3KY9A 3I6XA 1PXYA 3REPB 2E9KA 2YRNA 3FERA 4EDNA 1BHDA 1WKUA 1WYRA 2WA6A 2RR8A 2R0OA 1P5SA 4TXIA 2D89A 4Q58A 1MB8A 5A38A 5A36A 1BKRA 3JALM 3KMWB 1WIXA 2VZDA 3HOPA 2VZIB 2VZGB 1RT8A 1WYLA 2K3SA 5BVRA 4Q59A 5A37A 1WYQA 2QJXA 2K2RA
chains in the Genus database with same CATH superfamily
3F7PA 4DDPA 1QAGA 4Q57B 2VE7C 5L0OA 5FMTA 2D87A 1SH5A 2L3GA 4LVRA 1WYOA 2WA5A 4B7LA 2R8UA 2EE7A 3VP7A 1P2XA 3CO1A 2HL9A 1UEGA 1WYNA 5J8EA 1WYPA 2VE7A 3KMUB 3HOCA 1AA2A 3JAKM 2WFNA 2VZCA 2D88A 1AOAA 4EDMA 1WJOA 2EQOA 2EYIA 2D86A 4TXKA 4EDLA 2WA7A 3JARM 2D85A 1SH6A 2QJZA 1TJTA 2HL8A 2HKPA 1EUVA 1UJOA 1DXXA 5A4BA 2DK9A 1VKAA 1H67A 2JV9A 3EAYA 3HORA 1PA7A 1V5KA 2WDTA 1WYMA 2EYNA 3KY9A 3I6XA 1PXYA 3REPB 2E9KA 2YRNA 2WE6A 3FERA 4EDNA 1BHDA 1WKUA 1WYRA 2WA6A 2RR8A 5FMUA 2IGPA 2R0OA 1P5SA 4TXIA 2D89A 4Q58A 1MB8A 5A38A 5A36A 1BKRA 3JALM 3KMWB 1WIXA 2VZDA 3HOPA 2VZIB 2VZGB 1RT8A 1WYLA 2K3SA 5BVRA 4Q59A 4LVPA 5A37A 1WYQA 2QJXA 2K2RA
chains in the Genus database with same CATH topology
3F7PA 1QAGA 4Q57B 5L0OA 2D87A 1SH5A 2L3GA 1WYOA 2WA5A 4B7LA 2R8UA 2EE7A 1P2XA 3CO1A 1UEGA 1WYNA 5J8EA 1WYPA 3KMUB 3HOCA 1AA2A 3JAKM 2WFNA 2VZCA 2D88A 1AOAA 4EDMA 1WJOA 2EYIA 2D86A 4TXKA 4EDLA 2WA7A 3JARM 2D85A 1SH6A 2QJZA 1TJTA 1UJOA 5A4BA 1DXXA 2DK9A 1VKAA 1H67A 2JV9A 3HORA 1PA7A 1V5KA 1WYMA 2EYNA 3KY9A 3I6XA 1PXYA 3REPB 2E9KA 2YRNA 3FERA 4EDNA 1BHDA 1WKUA 1WYRA 2WA6A 2RR8A 2R0OA 1P5SA 4TXIA 2D89A 4Q58A 1MB8A 5A38A 5A36A 1BKRA 3JALM 3KMWB 1WIXA 2VZDA 3HOPA 2VZIB 2VZGB 1RT8A 1WYLA 2K3SA 5BVRA 4Q59A 5A37A 1WYQA 2QJXA 2K2RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F7P A;  1QAG A;  4Q57 B;  5L0O A;  2D87 A;  1SH5 A;  2L3G A;  1WYO A;  2WA5 A;  4B7L A;  2R8U A;  2EE7 A;  1P2X A;  3CO1 A;  1UEG A;  1WYN A;  5J8E A;  1WYP A;  3KMU B;  3HOC A;  1AA2 A;  3JAK M;  2WFN A;  2VZC A;  2D88 A;  1AOA A;  4EDM A;  1WJO A;  2EYI A;  2D86 A;  4TXK A;  4EDL A;  2WA7 A;  3JAR M;  2D85 A;  1SH6 A;  2QJZ A;  1TJT A;  1UJO A;  5A4B A;  1DXX A;  2DK9 A;  1VKA A;  1H67 A;  2JV9 A;  3HOR A;  1PA7 A;  1V5K A;  1WYM A;  2EYN A;  3KY9 A;  3I6X A;  1PXY A;  3REP B;  2E9K A;  2YRN A;  3FER A;  4EDN A;  1BHD A;  1WKU A;  1WYR A;  2WA6 A;  2RR8 A;  2R0O A;  1P5S A;  4TXI A;  2D89 A;  4Q58 A;  1MB8 A;  5A38 A;  5A36 A;  1BKR A;  3JAL M;  3KMW B;  1WIX A;  2VZD A;  3HOP A;  2VZI B;  2VZG B;  1RT8 A;  1WYL A;  2K3S A;  5BVR A;  4Q59 A;  5A37 A;  1WYQ A;  2QJX A;  2K2R A; 
#chains in the Genus database with same CATH topology
 3F7P A;  4DDP A;  1QAG A;  4Q57 B;  2VE7 C;  5L0O A;  5FMT A;  2D87 A;  1SH5 A;  2L3G A;  4LVR A;  1WYO A;  2WA5 A;  4B7L A;  2R8U A;  2EE7 A;  3VP7 A;  1P2X A;  3CO1 A;  2HL9 A;  1UEG A;  1WYN A;  5J8E A;  1WYP A;  2VE7 A;  3KMU B;  3HOC A;  1AA2 A;  3JAK M;  2WFN A;  2VZC A;  2D88 A;  1AOA A;  4EDM A;  1WJO A;  2EQO A;  2EYI A;  2D86 A;  4TXK A;  4EDL A;  2WA7 A;  3JAR M;  2D85 A;  1SH6 A;  2QJZ A;  1TJT A;  2HL8 A;  2HKP A;  1EUV A;  1UJO A;  1DXX A;  5A4B A;  2DK9 A;  1VKA A;  1H67 A;  2JV9 A;  3EAY A;  3HOR A;  1PA7 A;  1V5K A;  2WDT A;  1WYM A;  2EYN A;  3KY9 A;  3I6X A;  1PXY A;  3REP B;  2E9K A;  2YRN A;  2WE6 A;  3FER A;  4EDN A;  1BHD A;  1WKU A;  1WYR A;  2WA6 A;  2RR8 A;  5FMU A;  2IGP A;  2R0O A;  1P5S A;  4TXI A;  2D89 A;  4Q58 A;  1MB8 A;  5A38 A;  5A36 A;  1BKR A;  3JAL M;  3KMW B;  1WIX A;  2VZD A;  3HOP A;  2VZI B;  2VZG B;  1RT8 A;  1WYL A;  2K3S A;  5BVR A;  4Q59 A;  4LVP A;  5A37 A;  1WYQ A;  2QJX A;  2K2R A; 
#chains in the Genus database with same CATH homology
 3F7P A;  1QAG A;  4Q57 B;  5L0O A;  2D87 A;  1SH5 A;  2L3G A;  1WYO A;  2WA5 A;  4B7L A;  2R8U A;  2EE7 A;  1P2X A;  3CO1 A;  1UEG A;  1WYN A;  5J8E A;  1WYP A;  3KMU B;  3HOC A;  1AA2 A;  3JAK M;  2WFN A;  2VZC A;  2D88 A;  1AOA A;  4EDM A;  1WJO A;  2EYI A;  2D86 A;  4TXK A;  4EDL A;  2WA7 A;  3JAR M;  2D85 A;  1SH6 A;  2QJZ A;  1TJT A;  1UJO A;  5A4B A;  1DXX A;  2DK9 A;  1VKA A;  1H67 A;  2JV9 A;  3HOR A;  1PA7 A;  1V5K A;  1WYM A;  2EYN A;  3KY9 A;  3I6X A;  1PXY A;  3REP B;  2E9K A;  2YRN A;  3FER A;  4EDN A;  1BHD A;  1WKU A;  1WYR A;  2WA6 A;  2RR8 A;  2R0O A;  1P5S A;  4TXI A;  2D89 A;  4Q58 A;  1MB8 A;  5A38 A;  5A36 A;  1BKR A;  3JAL M;  3KMW B;  1WIX A;  2VZD A;  3HOP A;  2VZI B;  2VZG B;  1RT8 A;  1WYL A;  2K3S A;  5BVR A;  4Q59 A;  5A37 A;  1WYQ A;  2QJX A;  2K2R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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