3HORA

Structure of the actin-binding domain of human filamin a (reduced)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
222
structure length
210
Chain Sequence
KIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Filamin-A
total genus 70
structure length 210
sequence length 222
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-06-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 3horA01
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 3horA02
2WA7A 5A38A 1SH5A 1PA7A 1WYRA 2QJXA 1PXYA 3I6XA 1VKAA 4TXKA 4EDMA 2RR8A 2E9KA 1BHDA 1P2XA 4EDLA 3JARM 2D89A 1WJOA 2K3SA 2VZCA 3HOCA 2D88A 3KMUB 4Q57B 1RT8A 2VZGB 1WYOA 2EYNA 3HORA 2DK9A 3CO1A 3JAKM 2K2RA 2YRNA 1BKRA 3JALM 3FERA 2VZIB 2D87A 1WYLA 2WA5A 1QAGA 3REPB 2WA6A 4EDNA 1AOAA 4Q58A 1SH6A 2JV9A 5A37A 1WIXA 3HOPA 4B7LA 3KY9A 1UEGA 1WYPA 2R8UA 5J8EA 2WFNA 4Q59A 5L0OA 1MB8A 1TJTA 1WYQA 1WYNA 1P5SA 2L3GA 5BVRA 2QJZA 5A36A 5A4BA 1WYMA 1V5KA 2D86A 1WKUA 1DXXA 1AA2A 2EYIA 2D85A 4TXIA 2R0OA 2VZDA 3KMWB 2EE7A 3F7PA 1H67A 1UJOA
chains in the Genus database with same CATH superfamily
2WA7A 5A38A 1SH5A 1PA7A 2HL8A 1EUVA 1WYRA 2QJXA 1PXYA 3I6XA 1VKAA 2HKPA 4TXKA 4EDMA 2RR8A 4LVRA 2IGPA 2VE7C 2E9KA 1BHDA 1P2XA 2HL9A 4EDLA 2WE6A 3JARM 2D89A 5FMTA 1WJOA 2K3SA 2VZCA 3HOCA 2D88A 3KMUB 4Q57B 1RT8A 2VE7A 2VZGB 1WYOA 2EYNA 3HORA 2DK9A 3CO1A 3JAKM 2K2RA 2YRNA 5FMUA 4DDPA 1BKRA 3JALM 3FERA 2VZIB 2D87A 1WYLA 4LVPA 2WA5A 1QAGA 3REPB 2WA6A 4EDNA 1AOAA 4Q58A 1SH6A 2JV9A 5A37A 1WIXA 3HOPA 4B7LA 2EQOA 3KY9A 1UEGA 1WYPA 2R8UA 5J8EA 2WFNA 4Q59A 5L0OA 1MB8A 1TJTA 1WYQA 1WYNA 2WDTA 1P5SA 2L3GA 5BVRA 2QJZA 5A36A 5A4BA 1WYMA 1V5KA 2D86A 1WKUA 1DXXA 3VP7A 1AA2A 2EYIA 2D85A 4TXIA 2R0OA 2VZDA 3EAYA 3KMWB 2EE7A 3F7PA 1H67A 1UJOA
chains in the Genus database with same CATH topology
2WA7A 5A38A 1SH5A 1PA7A 1WYRA 2QJXA 1PXYA 3I6XA 1VKAA 4TXKA 4EDMA 2RR8A 2E9KA 1BHDA 1P2XA 4EDLA 3JARM 2D89A 1WJOA 2K3SA 2VZCA 3HOCA 2D88A 3KMUB 4Q57B 1RT8A 2VZGB 1WYOA 2EYNA 3HORA 2DK9A 3CO1A 3JAKM 2K2RA 2YRNA 1BKRA 3JALM 3FERA 2VZIB 2D87A 1WYLA 2WA5A 1QAGA 3REPB 2WA6A 4EDNA 1AOAA 4Q58A 1SH6A 2JV9A 5A37A 1WIXA 3HOPA 4B7LA 3KY9A 1UEGA 1WYPA 2R8UA 5J8EA 2WFNA 4Q59A 5L0OA 1MB8A 1TJTA 1WYQA 1WYNA 1P5SA 2L3GA 5BVRA 2QJZA 5A36A 5A4BA 1WYMA 1V5KA 2D86A 1WKUA 1DXXA 1AA2A 2EYIA 2D85A 4TXIA 2R0OA 2VZDA 3KMWB 2EE7A 3F7PA 1H67A 1UJOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WA7 A;  5A38 A;  1SH5 A;  1PA7 A;  1WYR A;  2QJX A;  1PXY A;  3I6X A;  1VKA A;  4TXK A;  4EDM A;  2RR8 A;  2E9K A;  1BHD A;  1P2X A;  4EDL A;  3JAR M;  2D89 A;  1WJO A;  2K3S A;  2VZC A;  3HOC A;  2D88 A;  3KMU B;  4Q57 B;  1RT8 A;  2VZG B;  1WYO A;  2EYN A;  3HOR A;  2DK9 A;  3CO1 A;  3JAK M;  2K2R A;  2YRN A;  1BKR A;  3JAL M;  3FER A;  2VZI B;  2D87 A;  1WYL A;  2WA5 A;  1QAG A;  3REP B;  2WA6 A;  4EDN A;  1AOA A;  4Q58 A;  1SH6 A;  2JV9 A;  5A37 A;  1WIX A;  3HOP A;  4B7L A;  3KY9 A;  1UEG A;  1WYP A;  2R8U A;  5J8E A;  2WFN A;  4Q59 A;  5L0O A;  1MB8 A;  1TJT A;  1WYQ A;  1WYN A;  1P5S A;  2L3G A;  5BVR A;  2QJZ A;  5A36 A;  5A4B A;  1WYM A;  1V5K A;  2D86 A;  1WKU A;  1DXX A;  1AA2 A;  2EYI A;  2D85 A;  4TXI A;  2R0O A;  2VZD A;  3KMW B;  2EE7 A;  3F7P A;  1H67 A;  1UJO A; 
#chains in the Genus database with same CATH topology
 2WA7 A;  5A38 A;  1SH5 A;  1PA7 A;  2HL8 A;  1EUV A;  1WYR A;  2QJX A;  1PXY A;  3I6X A;  1VKA A;  2HKP A;  4TXK A;  4EDM A;  2RR8 A;  4LVR A;  2IGP A;  2VE7 C;  2E9K A;  1BHD A;  1P2X A;  2HL9 A;  4EDL A;  2WE6 A;  3JAR M;  2D89 A;  5FMT A;  1WJO A;  2K3S A;  2VZC A;  3HOC A;  2D88 A;  3KMU B;  4Q57 B;  1RT8 A;  2VE7 A;  2VZG B;  1WYO A;  2EYN A;  3HOR A;  2DK9 A;  3CO1 A;  3JAK M;  2K2R A;  2YRN A;  5FMU A;  4DDP A;  1BKR A;  3JAL M;  3FER A;  2VZI B;  2D87 A;  1WYL A;  4LVP A;  2WA5 A;  1QAG A;  3REP B;  2WA6 A;  4EDN A;  1AOA A;  4Q58 A;  1SH6 A;  2JV9 A;  5A37 A;  1WIX A;  3HOP A;  4B7L A;  2EQO A;  3KY9 A;  1UEG A;  1WYP A;  2R8U A;  5J8E A;  2WFN A;  4Q59 A;  5L0O A;  1MB8 A;  1TJT A;  1WYQ A;  1WYN A;  2WDT A;  1P5S A;  2L3G A;  5BVR A;  2QJZ A;  5A36 A;  5A4B A;  1WYM A;  1V5K A;  2D86 A;  1WKU A;  1DXX A;  3VP7 A;  1AA2 A;  2EYI A;  2D85 A;  4TXI A;  2R0O A;  2VZD A;  3EAY A;  3KMW B;  2EE7 A;  3F7P A;  1H67 A;  1UJO A; 
#chains in the Genus database with same CATH homology
 2WA7 A;  5A38 A;  1SH5 A;  1PA7 A;  1WYR A;  2QJX A;  1PXY A;  3I6X A;  1VKA A;  4TXK A;  4EDM A;  2RR8 A;  2E9K A;  1BHD A;  1P2X A;  4EDL A;  3JAR M;  2D89 A;  1WJO A;  2K3S A;  2VZC A;  3HOC A;  2D88 A;  3KMU B;  4Q57 B;  1RT8 A;  2VZG B;  1WYO A;  2EYN A;  3HOR A;  2DK9 A;  3CO1 A;  3JAK M;  2K2R A;  2YRN A;  1BKR A;  3JAL M;  3FER A;  2VZI B;  2D87 A;  1WYL A;  2WA5 A;  1QAG A;  3REP B;  2WA6 A;  4EDN A;  1AOA A;  4Q58 A;  1SH6 A;  2JV9 A;  5A37 A;  1WIX A;  3HOP A;  4B7L A;  3KY9 A;  1UEG A;  1WYP A;  2R8U A;  5J8E A;  2WFN A;  4Q59 A;  5L0O A;  1MB8 A;  1TJT A;  1WYQ A;  1WYN A;  1P5S A;  2L3G A;  5BVR A;  2QJZ A;  5A36 A;  5A4B A;  1WYM A;  1V5K A;  2D86 A;  1WKU A;  1DXX A;  1AA2 A;  2EYI A;  2D85 A;  4TXI A;  2R0O A;  2VZD A;  3KMW B;  2EE7 A;  3F7P A;  1H67 A;  1UJO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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