3I6XA

Crystal structure of the calponin homology domain of iqgap1
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
164
structure length
164
Chain Sequence
AEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The IQGAP1 N-terminus Forms Dimers and the Dimer Interface is Required for Binding F-actin and Ca2+/calmodulin.
pubmed doi rcsb
molecule tags Calmodulin-binding, membrane protein
source organism Homo sapiens
molecule keywords Ras GTPase-activating-like protein IQGAP1
total genus 66
structure length 164
sequence length 164
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2009-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 3i6xA00
1WJOA 2EYNA 1WKUA 2D87A 2VZGB 2DK9A 1WYOA 4TXIA 3JAKM 2WA7A 2K3SA 3KMWB 2JV9A 1RT8A 2D85A 2EYIA 5A38A 1UJOA 1WYQA 1P2XA 4EDLA 2K2RA 1VKAA 4Q57B 1WYRA 3KMUB 5J8EA 1H67A 1DXXA 4EDMA 3F7PA 3I6XA 3HOPA 1BKRA 2D89A 1P5SA 3FERA 1AA2A 2VZDA 4Q58A 2EE7A 3HORA 2QJZA 1SH6A 2D88A 1WYMA 1WYNA 2E9KA 1UEGA 4Q59A 1BHDA 3HOCA 5A4BA 1WYLA 4TXKA 1PXYA 1WIXA 3REPB 2VZIB 3CO1A 2R8UA 2D86A 5L0OA 4B7LA 5A37A 1PA7A 1SH5A 5BVRA 1WYPA 2VZCA 3JALM 3JARM 2RR8A 1QAGA 2WFNA 1V5KA 2L3GA 2WA5A 2WA6A 4EDNA 2YRNA 1MB8A 2R0OA 1TJTA 5A36A 1AOAA 3KY9A 2QJXA
chains in the Genus database with same CATH superfamily
1WJOA 4LVRA 2EYNA 1WKUA 2D87A 2VZGB 2DK9A 1WYOA 4TXIA 3JAKM 2WA7A 2K3SA 3KMWB 2JV9A 1RT8A 2D85A 2EYIA 5FMUA 5A38A 2WE6A 1UJOA 1WYQA 2HL9A 1P2XA 4EDLA 2K2RA 1VKAA 4Q57B 1WYRA 3KMUB 5J8EA 1H67A 1DXXA 2WDTA 4EDMA 3F7PA 3I6XA 3HOPA 1BKRA 2D89A 1P5SA 2EQOA 3FERA 4LVPA 1AA2A 2VZDA 4Q58A 2EE7A 3HORA 2QJZA 1SH6A 2D88A 1WYMA 5FMTA 1WYNA 2E9KA 1UEGA 4Q59A 1BHDA 3HOCA 5A4BA 1WYLA 4TXKA 1PXYA 1WIXA 3REPB 2VZIB 3CO1A 2HL8A 2R8UA 2D86A 5L0OA 3VP7A 4B7LA 5A37A 1PA7A 3EAYA 2VE7C 1SH5A 5BVRA 1WYPA 2HKPA 2VZCA 3JALM 3JARM 2RR8A 4DDPA 1QAGA 2WFNA 1V5KA 2L3GA 2WA5A 2VE7A 2WA6A 1EUVA 4EDNA 2YRNA 1MB8A 2R0OA 1TJTA 5A36A 1AOAA 3KY9A 2QJXA 2IGPA
chains in the Genus database with same CATH topology
1WJOA 2EYNA 1WKUA 2D87A 2VZGB 2DK9A 1WYOA 4TXIA 3JAKM 2WA7A 2K3SA 3KMWB 2JV9A 1RT8A 2D85A 2EYIA 5A38A 1UJOA 1WYQA 1P2XA 4EDLA 2K2RA 1VKAA 4Q57B 1WYRA 3KMUB 5J8EA 1H67A 1DXXA 4EDMA 3F7PA 3I6XA 3HOPA 1BKRA 2D89A 1P5SA 3FERA 1AA2A 2VZDA 4Q58A 2EE7A 3HORA 2QJZA 1SH6A 2D88A 1WYMA 1WYNA 2E9KA 1UEGA 4Q59A 1BHDA 3HOCA 5A4BA 1WYLA 4TXKA 1PXYA 1WIXA 3REPB 2VZIB 3CO1A 2R8UA 2D86A 5L0OA 4B7LA 5A37A 1PA7A 1SH5A 5BVRA 1WYPA 2VZCA 3JALM 3JARM 2RR8A 1QAGA 2WFNA 1V5KA 2L3GA 2WA5A 2WA6A 4EDNA 2YRNA 1MB8A 2R0OA 1TJTA 5A36A 1AOAA 3KY9A 2QJXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WJO A;  2EYN A;  1WKU A;  2D87 A;  2VZG B;  2DK9 A;  1WYO A;  4TXI A;  3JAK M;  2WA7 A;  2K3S A;  3KMW B;  2JV9 A;  1RT8 A;  2D85 A;  2EYI A;  5A38 A;  1UJO A;  1WYQ A;  1P2X A;  4EDL A;  2K2R A;  1VKA A;  4Q57 B;  1WYR A;  3KMU B;  5J8E A;  1H67 A;  1DXX A;  4EDM A;  3F7P A;  3I6X A;  3HOP A;  1BKR A;  2D89 A;  1P5S A;  3FER A;  1AA2 A;  2VZD A;  4Q58 A;  2EE7 A;  3HOR A;  2QJZ A;  1SH6 A;  2D88 A;  1WYM A;  1WYN A;  2E9K A;  1UEG A;  4Q59 A;  1BHD A;  3HOC A;  5A4B A;  1WYL A;  4TXK A;  1PXY A;  1WIX A;  3REP B;  2VZI B;  3CO1 A;  2R8U A;  2D86 A;  5L0O A;  4B7L A;  5A37 A;  1PA7 A;  1SH5 A;  5BVR A;  1WYP A;  2VZC A;  3JAL M;  3JAR M;  2RR8 A;  1QAG A;  2WFN A;  1V5K A;  2L3G A;  2WA5 A;  2WA6 A;  4EDN A;  2YRN A;  1MB8 A;  2R0O A;  1TJT A;  5A36 A;  1AOA A;  3KY9 A;  2QJX A; 
#chains in the Genus database with same CATH topology
 1WJO A;  4LVR A;  2EYN A;  1WKU A;  2D87 A;  2VZG B;  2DK9 A;  1WYO A;  4TXI A;  3JAK M;  2WA7 A;  2K3S A;  3KMW B;  2JV9 A;  1RT8 A;  2D85 A;  2EYI A;  5FMU A;  5A38 A;  2WE6 A;  1UJO A;  1WYQ A;  2HL9 A;  1P2X A;  4EDL A;  2K2R A;  1VKA A;  4Q57 B;  1WYR A;  3KMU B;  5J8E A;  1H67 A;  1DXX A;  2WDT A;  4EDM A;  3F7P A;  3I6X A;  3HOP A;  1BKR A;  2D89 A;  1P5S A;  2EQO A;  3FER A;  4LVP A;  1AA2 A;  2VZD A;  4Q58 A;  2EE7 A;  3HOR A;  2QJZ A;  1SH6 A;  2D88 A;  1WYM A;  5FMT A;  1WYN A;  2E9K A;  1UEG A;  4Q59 A;  1BHD A;  3HOC A;  5A4B A;  1WYL A;  4TXK A;  1PXY A;  1WIX A;  3REP B;  2VZI B;  3CO1 A;  2HL8 A;  2R8U A;  2D86 A;  5L0O A;  3VP7 A;  4B7L A;  5A37 A;  1PA7 A;  3EAY A;  2VE7 C;  1SH5 A;  5BVR A;  1WYP A;  2HKP A;  2VZC A;  3JAL M;  3JAR M;  2RR8 A;  4DDP A;  1QAG A;  2WFN A;  1V5K A;  2L3G A;  2WA5 A;  2VE7 A;  2WA6 A;  1EUV A;  4EDN A;  2YRN A;  1MB8 A;  2R0O A;  1TJT A;  5A36 A;  1AOA A;  3KY9 A;  2QJX A;  2IGP A; 
#chains in the Genus database with same CATH homology
 1WJO A;  2EYN A;  1WKU A;  2D87 A;  2VZG B;  2DK9 A;  1WYO A;  4TXI A;  3JAK M;  2WA7 A;  2K3S A;  3KMW B;  2JV9 A;  1RT8 A;  2D85 A;  2EYI A;  5A38 A;  1UJO A;  1WYQ A;  1P2X A;  4EDL A;  2K2R A;  1VKA A;  4Q57 B;  1WYR A;  3KMU B;  5J8E A;  1H67 A;  1DXX A;  4EDM A;  3F7P A;  3I6X A;  3HOP A;  1BKR A;  2D89 A;  1P5S A;  3FER A;  1AA2 A;  2VZD A;  4Q58 A;  2EE7 A;  3HOR A;  2QJZ A;  1SH6 A;  2D88 A;  1WYM A;  1WYN A;  2E9K A;  1UEG A;  4Q59 A;  1BHD A;  3HOC A;  5A4B A;  1WYL A;  4TXK A;  1PXY A;  1WIX A;  3REP B;  2VZI B;  3CO1 A;  2R8U A;  2D86 A;  5L0O A;  4B7L A;  5A37 A;  1PA7 A;  1SH5 A;  5BVR A;  1WYP A;  2VZC A;  3JAL M;  3JAR M;  2RR8 A;  1QAG A;  2WFN A;  1V5K A;  2L3G A;  2WA5 A;  2WA6 A;  4EDN A;  2YRN A;  1MB8 A;  2R0O A;  1TJT A;  5A36 A;  1AOA A;  3KY9 A;  2QJX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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