4TXKA

Construct of mical-1 containing the monooxygenase and calponin homology domains
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
607
structure length
581
Chain Sequence
TNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural insights into modulation of MICAL activity by its Calponin Homology (CH) domain
rcsb
molecule tags Oxidoreductase
source organism Mus musculus
molecule keywords Protein-methionine sulfoxide oxidase MICAL1
total genus 175
structure length 581
sequence length 607
ec nomenclature ec 1.14.13.225: F-actin monooxygenase.
pdb deposition date 2014-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
A PF01494 FAD_binding_3 FAD binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 4txkA03
1BHDA 1WYLA 1WYNA 1P2XA 2D88A 4TXKA 3FERA 2VZGB 3HOCA 2EE7A 1WJOA 1RT8A 2YRNA 1WYRA 4EDMA 1UJOA 2QJZA 3KMWB 5BVRA 4B7LA 2R8UA 2EYIA 4TXIA 2VZCA 5A37A 3REPB 2D87A 2D86A 2VZDA 1PA7A 5A38A 2K2RA 2L3GA 1WYQA 5J8EA 4EDLA 2DK9A 4Q57B 4EDNA 4Q58A 1QAGA 3HOPA 1WIXA 1TJTA 1H67A 1DXXA 2WA6A 2R0OA 5A4BA 1SH6A 3HORA 2D85A 2RR8A 1MB8A 2QJXA 3F7PA 2VZIB 1V5KA 2K3SA 5A36A 2WA7A 1WKUA 3CO1A 3I6XA 2WFNA 1PXYA 2E9KA 1SH5A 1BKRA 1VKAA 1P5SA 2WA5A 3JARM 3JAKM 3KMUB 1AOAA 3JALM 2EYNA 1WYPA 1WYOA 1WYMA 5L0OA 2D89A 1UEGA 2JV9A 4Q59A 3KY9A 1AA2A
chains in the Genus database with same CATH superfamily
2HKPA 1BHDA 1WYLA 1WYNA 1P2XA 2D88A 4TXKA 3FERA 2VZGB 3HOCA 2EE7A 1WJOA 3VP7A 1RT8A 2YRNA 1WYRA 4EDMA 1UJOA 2QJZA 3KMWB 2WE6A 2WDTA 5BVRA 4B7LA 5FMUA 2R8UA 2EYIA 4TXIA 2VZCA 5A37A 3REPB 2D87A 2D86A 2VZDA 1PA7A 5A38A 2K2RA 2L3GA 1WYQA 5J8EA 4EDLA 2DK9A 4Q57B 4LVPA 2HL8A 4EDNA 4Q58A 1QAGA 3HOPA 1WIXA 1TJTA 1H67A 1DXXA 2WA6A 2IGPA 2R0OA 4DDPA 5A4BA 3EAYA 1SH6A 3HORA 2D85A 2RR8A 1MB8A 2QJXA 3F7PA 2VZIB 1V5KA 2K3SA 5A36A 2WA7A 1WKUA 2VE7A 3CO1A 3I6XA 2HL9A 2WFNA 1PXYA 2E9KA 1SH5A 1BKRA 1VKAA 1P5SA 2WA5A 3JARM 4LVRA 3JAKM 3KMUB 1AOAA 3JALM 2EYNA 2EQOA 5FMTA 1WYPA 1WYOA 1WYMA 5L0OA 2VE7C 1EUVA 2D89A 1UEGA 2JV9A 4Q59A 3KY9A 1AA2A
chains in the Genus database with same CATH topology
1BHDA 1WYLA 1WYNA 1P2XA 2D88A 4TXKA 3FERA 2VZGB 3HOCA 2EE7A 1WJOA 1RT8A 2YRNA 1WYRA 4EDMA 1UJOA 2QJZA 3KMWB 5BVRA 4B7LA 2R8UA 2EYIA 4TXIA 2VZCA 5A37A 3REPB 2D87A 2D86A 2VZDA 1PA7A 5A38A 2K2RA 2L3GA 1WYQA 5J8EA 4EDLA 2DK9A 4Q57B 4EDNA 4Q58A 1QAGA 3HOPA 1WIXA 1TJTA 1H67A 1DXXA 2WA6A 2R0OA 5A4BA 1SH6A 3HORA 2D85A 2RR8A 1MB8A 2QJXA 3F7PA 2VZIB 1V5KA 2K3SA 5A36A 2WA7A 1WKUA 3CO1A 3I6XA 2WFNA 1PXYA 2E9KA 1SH5A 1BKRA 1VKAA 1P5SA 2WA5A 3JARM 3JAKM 3KMUB 1AOAA 3JALM 2EYNA 1WYPA 1WYOA 1WYMA 5L0OA 2D89A 1UEGA 2JV9A 4Q59A 3KY9A 1AA2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BHD A;  1WYL A;  1WYN A;  1P2X A;  2D88 A;  4TXK A;  3FER A;  2VZG B;  3HOC A;  2EE7 A;  1WJO A;  1RT8 A;  2YRN A;  1WYR A;  4EDM A;  1UJO A;  2QJZ A;  3KMW B;  5BVR A;  4B7L A;  2R8U A;  2EYI A;  4TXI A;  2VZC A;  5A37 A;  3REP B;  2D87 A;  2D86 A;  2VZD A;  1PA7 A;  5A38 A;  2K2R A;  2L3G A;  1WYQ A;  5J8E A;  4EDL A;  2DK9 A;  4Q57 B;  4EDN A;  4Q58 A;  1QAG A;  3HOP A;  1WIX A;  1TJT A;  1H67 A;  1DXX A;  2WA6 A;  2R0O A;  5A4B A;  1SH6 A;  3HOR A;  2D85 A;  2RR8 A;  1MB8 A;  2QJX A;  3F7P A;  2VZI B;  1V5K A;  2K3S A;  5A36 A;  2WA7 A;  1WKU A;  3CO1 A;  3I6X A;  2WFN A;  1PXY A;  2E9K A;  1SH5 A;  1BKR A;  1VKA A;  1P5S A;  2WA5 A;  3JAR M;  3JAK M;  3KMU B;  1AOA A;  3JAL M;  2EYN A;  1WYP A;  1WYO A;  1WYM A;  5L0O A;  2D89 A;  1UEG A;  2JV9 A;  4Q59 A;  3KY9 A;  1AA2 A; 
#chains in the Genus database with same CATH topology
 2HKP A;  1BHD A;  1WYL A;  1WYN A;  1P2X A;  2D88 A;  4TXK A;  3FER A;  2VZG B;  3HOC A;  2EE7 A;  1WJO A;  3VP7 A;  1RT8 A;  2YRN A;  1WYR A;  4EDM A;  1UJO A;  2QJZ A;  3KMW B;  2WE6 A;  2WDT A;  5BVR A;  4B7L A;  5FMU A;  2R8U A;  2EYI A;  4TXI A;  2VZC A;  5A37 A;  3REP B;  2D87 A;  2D86 A;  2VZD A;  1PA7 A;  5A38 A;  2K2R A;  2L3G A;  1WYQ A;  5J8E A;  4EDL A;  2DK9 A;  4Q57 B;  4LVP A;  2HL8 A;  4EDN A;  4Q58 A;  1QAG A;  3HOP A;  1WIX A;  1TJT A;  1H67 A;  1DXX A;  2WA6 A;  2IGP A;  2R0O A;  4DDP A;  5A4B A;  3EAY A;  1SH6 A;  3HOR A;  2D85 A;  2RR8 A;  1MB8 A;  2QJX A;  3F7P A;  2VZI B;  1V5K A;  2K3S A;  5A36 A;  2WA7 A;  1WKU A;  2VE7 A;  3CO1 A;  3I6X A;  2HL9 A;  2WFN A;  1PXY A;  2E9K A;  1SH5 A;  1BKR A;  1VKA A;  1P5S A;  2WA5 A;  3JAR M;  4LVR A;  3JAK M;  3KMU B;  1AOA A;  3JAL M;  2EYN A;  2EQO A;  5FMT A;  1WYP A;  1WYO A;  1WYM A;  5L0O A;  2VE7 C;  1EUV A;  2D89 A;  1UEG A;  2JV9 A;  4Q59 A;  3KY9 A;  1AA2 A; 
#chains in the Genus database with same CATH homology
 1BHD A;  1WYL A;  1WYN A;  1P2X A;  2D88 A;  4TXK A;  3FER A;  2VZG B;  3HOC A;  2EE7 A;  1WJO A;  1RT8 A;  2YRN A;  1WYR A;  4EDM A;  1UJO A;  2QJZ A;  3KMW B;  5BVR A;  4B7L A;  2R8U A;  2EYI A;  4TXI A;  2VZC A;  5A37 A;  3REP B;  2D87 A;  2D86 A;  2VZD A;  1PA7 A;  5A38 A;  2K2R A;  2L3G A;  1WYQ A;  5J8E A;  4EDL A;  2DK9 A;  4Q57 B;  4EDN A;  4Q58 A;  1QAG A;  3HOP A;  1WIX A;  1TJT A;  1H67 A;  1DXX A;  2WA6 A;  2R0O A;  5A4B A;  1SH6 A;  3HOR A;  2D85 A;  2RR8 A;  1MB8 A;  2QJX A;  3F7P A;  2VZI B;  1V5K A;  2K3S A;  5A36 A;  2WA7 A;  1WKU A;  3CO1 A;  3I6X A;  2WFN A;  1PXY A;  2E9K A;  1SH5 A;  1BKR A;  1VKA A;  1P5S A;  2WA5 A;  3JAR M;  3JAK M;  3KMU B;  1AOA A;  3JAL M;  2EYN A;  1WYP A;  1WYO A;  1WYM A;  5L0O A;  2D89 A;  1UEG A;  2JV9 A;  4Q59 A;  3KY9 A;  1AA2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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