5A36A

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
239
structure length
239
Chain Sequence
YMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords ALPHA-ACTININ-2
total genus 89
structure length 239
sequence length 239
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a36A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a36A01
2R0OA 5A38A 3HOPA 1PXYA 1SH6A 2VZGB 4TXIA 3KY9A 1AOAA 2D86A 3HOCA 1MB8A 5A37A 1V5KA 3HORA 1WYNA 2VZCA 2EYIA 1WKUA 3F7PA 1UJOA 3JALM 2VZIB 4Q57B 2R8UA 1P5SA 2JV9A 4Q59A 2D88A 3JAKM 3FERA 2K2RA 2VZDA 4TXKA 2WA6A 5L0OA 1WYMA 2D89A 1H67A 2K3SA 1VKAA 2EE7A 3I6XA 1WIXA 5A36A 1AA2A 4EDMA 5J8EA 1SH5A 1QAGA 1WYPA 1WJOA 1WYQA 1DXXA 2WA7A 4EDLA 2D87A 1UEGA 2E9KA 2WFNA 4EDNA 1BKRA 2QJZA 1P2XA 2QJXA 2WA5A 2RR8A 3JARM 4Q58A 1TJTA 1WYRA 3KMWB 1BHDA 2EYNA 2D85A 1WYLA 2YRNA 1RT8A 1PA7A 3CO1A 5BVRA 2L3GA 2DK9A 3REPB 5A4BA 3KMUB 1WYOA 4B7LA
chains in the Genus database with same CATH superfamily
2R0OA 5A38A 3HOPA 4DDPA 1PXYA 2HL9A 1SH6A 2VZGB 4TXIA 3KY9A 1AOAA 3VP7A 2D86A 2WDTA 3HOCA 1MB8A 5A37A 1V5KA 3HORA 1WYNA 5FMUA 2VZCA 2EYIA 2VE7A 1WKUA 3F7PA 1UJOA 3JALM 2VZIB 2IGPA 4Q57B 2R8UA 1P5SA 2JV9A 4Q59A 2D88A 3JAKM 2WE6A 3FERA 2K2RA 2VZDA 4TXKA 2WA6A 2EQOA 5L0OA 4LVPA 1EUVA 1WYMA 2D89A 1H67A 2K3SA 1VKAA 2EE7A 3EAYA 3I6XA 1WIXA 5A36A 2VE7C 1AA2A 4EDMA 5J8EA 1SH5A 1QAGA 1WYPA 1WJOA 1WYQA 1DXXA 2WA7A 4EDLA 2D87A 1UEGA 5FMTA 2E9KA 2WFNA 4EDNA 4LVRA 1BKRA 2QJZA 1P2XA 2QJXA 2WA5A 2RR8A 3JARM 4Q58A 1TJTA 1WYRA 3KMWB 1BHDA 2EYNA 2D85A 1WYLA 2YRNA 1RT8A 1PA7A 3CO1A 2HL8A 5BVRA 2L3GA 2DK9A 2HKPA 3REPB 5A4BA 3KMUB 1WYOA 4B7LA
chains in the Genus database with same CATH topology
2R0OA 5A38A 3HOPA 1PXYA 1SH6A 2VZGB 4TXIA 3KY9A 1AOAA 2D86A 3HOCA 1MB8A 5A37A 1V5KA 3HORA 1WYNA 2VZCA 2EYIA 1WKUA 3F7PA 1UJOA 3JALM 2VZIB 4Q57B 2R8UA 1P5SA 2JV9A 4Q59A 2D88A 3JAKM 3FERA 2K2RA 2VZDA 4TXKA 2WA6A 5L0OA 1WYMA 2D89A 1H67A 2K3SA 1VKAA 2EE7A 3I6XA 1WIXA 5A36A 1AA2A 4EDMA 5J8EA 1SH5A 1QAGA 1WYPA 1WJOA 1WYQA 1DXXA 2WA7A 4EDLA 2D87A 1UEGA 2E9KA 2WFNA 4EDNA 1BKRA 2QJZA 1P2XA 2QJXA 2WA5A 2RR8A 3JARM 4Q58A 1TJTA 1WYRA 3KMWB 1BHDA 2EYNA 2D85A 1WYLA 2YRNA 1RT8A 1PA7A 3CO1A 5BVRA 2L3GA 2DK9A 3REPB 5A4BA 3KMUB 1WYOA 4B7LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R0O A;  5A38 A;  3HOP A;  1PXY A;  1SH6 A;  2VZG B;  4TXI A;  3KY9 A;  1AOA A;  2D86 A;  3HOC A;  1MB8 A;  5A37 A;  1V5K A;  3HOR A;  1WYN A;  2VZC A;  2EYI A;  1WKU A;  3F7P A;  1UJO A;  3JAL M;  2VZI B;  4Q57 B;  2R8U A;  1P5S A;  2JV9 A;  4Q59 A;  2D88 A;  3JAK M;  3FER A;  2K2R A;  2VZD A;  4TXK A;  2WA6 A;  5L0O A;  1WYM A;  2D89 A;  1H67 A;  2K3S A;  1VKA A;  2EE7 A;  3I6X A;  1WIX A;  5A36 A;  1AA2 A;  4EDM A;  5J8E A;  1SH5 A;  1QAG A;  1WYP A;  1WJO A;  1WYQ A;  1DXX A;  2WA7 A;  4EDL A;  2D87 A;  1UEG A;  2E9K A;  2WFN A;  4EDN A;  1BKR A;  2QJZ A;  1P2X A;  2QJX A;  2WA5 A;  2RR8 A;  3JAR M;  4Q58 A;  1TJT A;  1WYR A;  3KMW B;  1BHD A;  2EYN A;  2D85 A;  1WYL A;  2YRN A;  1RT8 A;  1PA7 A;  3CO1 A;  5BVR A;  2L3G A;  2DK9 A;  3REP B;  5A4B A;  3KMU B;  1WYO A;  4B7L A; 
#chains in the Genus database with same CATH topology
 2R0O A;  5A38 A;  3HOP A;  4DDP A;  1PXY A;  2HL9 A;  1SH6 A;  2VZG B;  4TXI A;  3KY9 A;  1AOA A;  3VP7 A;  2D86 A;  2WDT A;  3HOC A;  1MB8 A;  5A37 A;  1V5K A;  3HOR A;  1WYN A;  5FMU A;  2VZC A;  2EYI A;  2VE7 A;  1WKU A;  3F7P A;  1UJO A;  3JAL M;  2VZI B;  2IGP A;  4Q57 B;  2R8U A;  1P5S A;  2JV9 A;  4Q59 A;  2D88 A;  3JAK M;  2WE6 A;  3FER A;  2K2R A;  2VZD A;  4TXK A;  2WA6 A;  2EQO A;  5L0O A;  4LVP A;  1EUV A;  1WYM A;  2D89 A;  1H67 A;  2K3S A;  1VKA A;  2EE7 A;  3EAY A;  3I6X A;  1WIX A;  5A36 A;  2VE7 C;  1AA2 A;  4EDM A;  5J8E A;  1SH5 A;  1QAG A;  1WYP A;  1WJO A;  1WYQ A;  1DXX A;  2WA7 A;  4EDL A;  2D87 A;  1UEG A;  5FMT A;  2E9K A;  2WFN A;  4EDN A;  4LVR A;  1BKR A;  2QJZ A;  1P2X A;  2QJX A;  2WA5 A;  2RR8 A;  3JAR M;  4Q58 A;  1TJT A;  1WYR A;  3KMW B;  1BHD A;  2EYN A;  2D85 A;  1WYL A;  2YRN A;  1RT8 A;  1PA7 A;  3CO1 A;  2HL8 A;  5BVR A;  2L3G A;  2DK9 A;  2HKP A;  3REP B;  5A4B A;  3KMU B;  1WYO A;  4B7L A; 
#chains in the Genus database with same CATH homology
 2R0O A;  5A38 A;  3HOP A;  1PXY A;  1SH6 A;  2VZG B;  4TXI A;  3KY9 A;  1AOA A;  2D86 A;  3HOC A;  1MB8 A;  5A37 A;  1V5K A;  3HOR A;  1WYN A;  2VZC A;  2EYI A;  1WKU A;  3F7P A;  1UJO A;  3JAL M;  2VZI B;  4Q57 B;  2R8U A;  1P5S A;  2JV9 A;  4Q59 A;  2D88 A;  3JAK M;  3FER A;  2K2R A;  2VZD A;  4TXK A;  2WA6 A;  5L0O A;  1WYM A;  2D89 A;  1H67 A;  2K3S A;  1VKA A;  2EE7 A;  3I6X A;  1WIX A;  5A36 A;  1AA2 A;  4EDM A;  5J8E A;  1SH5 A;  1QAG A;  1WYP A;  1WJO A;  1WYQ A;  1DXX A;  2WA7 A;  4EDL A;  2D87 A;  1UEG A;  2E9K A;  2WFN A;  4EDN A;  1BKR A;  2QJZ A;  1P2X A;  2QJX A;  2WA5 A;  2RR8 A;  3JAR M;  4Q58 A;  1TJT A;  1WYR A;  3KMW B;  1BHD A;  2EYN A;  2D85 A;  1WYL A;  2YRN A;  1RT8 A;  1PA7 A;  3CO1 A;  5BVR A;  2L3G A;  2DK9 A;  3REP B;  5A4B A;  3KMU B;  1WYO A;  4B7L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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