5A36A

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
239
structure length
239
Chain Sequence
YMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords ALPHA-ACTININ-2
total genus 89
structure length 239
sequence length 239
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a36A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a36A01
2EYNA 2WA7A 3CO1A 3JAKM 1WJOA 1WYLA 2D85A 1PXYA 2YRNA 2VZGB 3FERA 4Q58A 1QAGA 2R8UA 1AOAA 1WYNA 2K3SA 2VZIB 2EE7A 2L3GA 2VZDA 1PA7A 2VZCA 2R0OA 1P5SA 2D89A 3JALM 3HOPA 1SH5A 2E9KA 1WYPA 1UJOA 1WYRA 2WFNA 4Q57B 4B7LA 1BHDA 1P2XA 1DXXA 1BKRA 4Q59A 5A4BA 4EDMA 2D86A 2D87A 1AA2A 1SH6A 2D88A 1TJTA 1WIXA 1WYMA 3JARM 2QJZA 3KY9A 1WKUA 2RR8A 2WA6A 1UEGA 3KMWB 1WYQA 1RT8A 3HOCA 1VKAA 2WA5A 3F7PA 1H67A 2DK9A 1WYOA 2QJXA 4TXIA 5L0OA 5J8EA 5BVRA 1V5KA 3REPB 1MB8A 4EDLA 5A36A 2EYIA 3HORA 3I6XA 2JV9A 2K2RA 4EDNA 5A37A 4TXKA 5A38A 3KMUB
chains in the Genus database with same CATH superfamily
2EYNA 2WA7A 3CO1A 3JAKM 2HKPA 1WJOA 1WYLA 2D85A 1PXYA 2YRNA 2VZGB 3FERA 4Q58A 1QAGA 2R8UA 1AOAA 3EAYA 1WYNA 2K3SA 2VZIB 4LVRA 2EE7A 2L3GA 2VZDA 5FMTA 1PA7A 2VZCA 2R0OA 1P5SA 2D89A 3JALM 3HOPA 1SH5A 3VP7A 2E9KA 1WYPA 1UJOA 1WYRA 2WFNA 1EUVA 4Q57B 4B7LA 1BHDA 1P2XA 1DXXA 1BKRA 4Q59A 5A4BA 4LVPA 2WE6A 4EDMA 2D86A 2D87A 1AA2A 1SH6A 4DDPA 2D88A 1TJTA 1WIXA 1WYMA 3JARM 2HL9A 2QJZA 2VE7A 3KY9A 1WKUA 2RR8A 2WA6A 1UEGA 3KMWB 1WYQA 2VE7C 1RT8A 3HOCA 1VKAA 2WA5A 2EQOA 3F7PA 1H67A 2DK9A 2WDTA 5FMUA 1WYOA 2QJXA 4TXIA 5L0OA 5J8EA 2HL8A 5BVRA 1V5KA 3REPB 1MB8A 4EDLA 5A36A 2EYIA 3HORA 3I6XA 2JV9A 2K2RA 4EDNA 5A37A 4TXKA 5A38A 2IGPA 3KMUB
chains in the Genus database with same CATH topology
2EYNA 2WA7A 3CO1A 3JAKM 1WJOA 1WYLA 2D85A 1PXYA 2YRNA 2VZGB 3FERA 4Q58A 1QAGA 2R8UA 1AOAA 1WYNA 2K3SA 2VZIB 2EE7A 2L3GA 2VZDA 1PA7A 2VZCA 2R0OA 1P5SA 2D89A 3JALM 3HOPA 1SH5A 2E9KA 1WYPA 1UJOA 1WYRA 2WFNA 4Q57B 4B7LA 1BHDA 1P2XA 1DXXA 1BKRA 4Q59A 5A4BA 4EDMA 2D86A 2D87A 1AA2A 1SH6A 2D88A 1TJTA 1WIXA 1WYMA 3JARM 2QJZA 3KY9A 1WKUA 2RR8A 2WA6A 1UEGA 3KMWB 1WYQA 1RT8A 3HOCA 1VKAA 2WA5A 3F7PA 1H67A 2DK9A 1WYOA 2QJXA 4TXIA 5L0OA 5J8EA 5BVRA 1V5KA 3REPB 1MB8A 4EDLA 5A36A 2EYIA 3HORA 3I6XA 2JV9A 2K2RA 4EDNA 5A37A 4TXKA 5A38A 3KMUB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EYN A;  2WA7 A;  3CO1 A;  3JAK M;  1WJO A;  1WYL A;  2D85 A;  1PXY A;  2YRN A;  2VZG B;  3FER A;  4Q58 A;  1QAG A;  2R8U A;  1AOA A;  1WYN A;  2K3S A;  2VZI B;  2EE7 A;  2L3G A;  2VZD A;  1PA7 A;  2VZC A;  2R0O A;  1P5S A;  2D89 A;  3JAL M;  3HOP A;  1SH5 A;  2E9K A;  1WYP A;  1UJO A;  1WYR A;  2WFN A;  4Q57 B;  4B7L A;  1BHD A;  1P2X A;  1DXX A;  1BKR A;  4Q59 A;  5A4B A;  4EDM A;  2D86 A;  2D87 A;  1AA2 A;  1SH6 A;  2D88 A;  1TJT A;  1WIX A;  1WYM A;  3JAR M;  2QJZ A;  3KY9 A;  1WKU A;  2RR8 A;  2WA6 A;  1UEG A;  3KMW B;  1WYQ A;  1RT8 A;  3HOC A;  1VKA A;  2WA5 A;  3F7P A;  1H67 A;  2DK9 A;  1WYO A;  2QJX A;  4TXI A;  5L0O A;  5J8E A;  5BVR A;  1V5K A;  3REP B;  1MB8 A;  4EDL A;  5A36 A;  2EYI A;  3HOR A;  3I6X A;  2JV9 A;  2K2R A;  4EDN A;  5A37 A;  4TXK A;  5A38 A;  3KMU B; 
#chains in the Genus database with same CATH topology
 2EYN A;  2WA7 A;  3CO1 A;  3JAK M;  2HKP A;  1WJO A;  1WYL A;  2D85 A;  1PXY A;  2YRN A;  2VZG B;  3FER A;  4Q58 A;  1QAG A;  2R8U A;  1AOA A;  3EAY A;  1WYN A;  2K3S A;  2VZI B;  4LVR A;  2EE7 A;  2L3G A;  2VZD A;  5FMT A;  1PA7 A;  2VZC A;  2R0O A;  1P5S A;  2D89 A;  3JAL M;  3HOP A;  1SH5 A;  3VP7 A;  2E9K A;  1WYP A;  1UJO A;  1WYR A;  2WFN A;  1EUV A;  4Q57 B;  4B7L A;  1BHD A;  1P2X A;  1DXX A;  1BKR A;  4Q59 A;  5A4B A;  4LVP A;  2WE6 A;  4EDM A;  2D86 A;  2D87 A;  1AA2 A;  1SH6 A;  4DDP A;  2D88 A;  1TJT A;  1WIX A;  1WYM A;  3JAR M;  2HL9 A;  2QJZ A;  2VE7 A;  3KY9 A;  1WKU A;  2RR8 A;  2WA6 A;  1UEG A;  3KMW B;  1WYQ A;  2VE7 C;  1RT8 A;  3HOC A;  1VKA A;  2WA5 A;  2EQO A;  3F7P A;  1H67 A;  2DK9 A;  2WDT A;  5FMU A;  1WYO A;  2QJX A;  4TXI A;  5L0O A;  5J8E A;  2HL8 A;  5BVR A;  1V5K A;  3REP B;  1MB8 A;  4EDL A;  5A36 A;  2EYI A;  3HOR A;  3I6X A;  2JV9 A;  2K2R A;  4EDN A;  5A37 A;  4TXK A;  5A38 A;  2IGP A;  3KMU B; 
#chains in the Genus database with same CATH homology
 2EYN A;  2WA7 A;  3CO1 A;  3JAK M;  1WJO A;  1WYL A;  2D85 A;  1PXY A;  2YRN A;  2VZG B;  3FER A;  4Q58 A;  1QAG A;  2R8U A;  1AOA A;  1WYN A;  2K3S A;  2VZI B;  2EE7 A;  2L3G A;  2VZD A;  1PA7 A;  2VZC A;  2R0O A;  1P5S A;  2D89 A;  3JAL M;  3HOP A;  1SH5 A;  2E9K A;  1WYP A;  1UJO A;  1WYR A;  2WFN A;  4Q57 B;  4B7L A;  1BHD A;  1P2X A;  1DXX A;  1BKR A;  4Q59 A;  5A4B A;  4EDM A;  2D86 A;  2D87 A;  1AA2 A;  1SH6 A;  2D88 A;  1TJT A;  1WIX A;  1WYM A;  3JAR M;  2QJZ A;  3KY9 A;  1WKU A;  2RR8 A;  2WA6 A;  1UEG A;  3KMW B;  1WYQ A;  1RT8 A;  3HOC A;  1VKA A;  2WA5 A;  3F7P A;  1H67 A;  2DK9 A;  1WYO A;  2QJX A;  4TXI A;  5L0O A;  5J8E A;  5BVR A;  1V5K A;  3REP B;  1MB8 A;  4EDL A;  5A36 A;  2EYI A;  3HOR A;  3I6X A;  2JV9 A;  2K2R A;  4EDN A;  5A37 A;  4TXK A;  5A38 A;  3KMU B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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