5A37 | Genus

Total Genus 84

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	84
sequence length	224
structure length	220
Chain Sequence	PAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKVVIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Actin-binding protein
source organism	Homo sapiens
publication title	Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. pubmed doi rcsb
molecule keywords	HUMAN ALPHA-ACTININ-2
total genus	84
structure length	220
sequence length	224
chains with identical sequence	B
ec nomenclature
pdb deposition date	2015-05-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00307	CH	Calponin homology (CH) domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	5a37A02
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	5a37A01

1BKRA 3HOCA 1WKUA 5A38A 2EYNA 2L3GA 3I6XA 4TXKA 4B7LA 2R0OA 2VZDA 2K2RA 1UJOA 3F7PA 1V5KA 2D86A 1QAGA 1BHDA 5A36A 2QJXA 1P5SA 2E9KA 1WYRA 3KY9A 3HOPA 1WYLA 3KMUB 2EE7A 1MB8A 1TJTA 2D89A 5A37A 3KMWB 2WA5A 2WA6A 3HORA 2EYIA 2D88A 2JV9A 2YRNA 2D85A 4EDLA 4Q58A 3JARM 1WJOA 1H67A 5BVRA 3REPB 1WYPA 1WYOA 1WIXA 2VZGB 4Q57B 1WYMA 1VKAA 3FERA 2D87A 4Q59A 1SH6A 1WYNA 2VZIB 2RR8A 1AOAA 5J8EA 3JAKM 4EDNA 5L0OA 2K3SA 1DXXA 2QJZA 1PA7A 2VZCA 5A4BA 4EDMA 1P2XA 1RT8A 3CO1A 1AA2A 1UEGA 2R8UA 1SH5A 1WYQA 1PXYA 4TXIA 2WFNA 3JALM 2WA7A 2DK9A
chains in the Genus database with same CATH superfamily

1BKRA 3HOCA 5FMUA 1WKUA 5A38A 2EYNA 2L3GA 3I6XA 4TXKA 4B7LA 2R0OA 2VZDA 2K2RA 1UJOA 3F7PA 1V5KA 2D86A 1QAGA 1BHDA 5A36A 2QJXA 1P5SA 2E9KA 1WYRA 4DDPA 3KY9A 3HOPA 1WYLA 3KMUB 2EE7A 1MB8A 1TJTA 2WE6A 2D89A 5A37A 2IGPA 3KMWB 2HL9A 2WA5A 2WA6A 2EQOA 3HORA 2EYIA 2D88A 2JV9A 2YRNA 2D85A 2VE7C 4EDLA 3EAYA 4Q58A 4LVRA 3JARM 1WJOA 1H67A 5BVRA 3REPB 2WDTA 1WYPA 1WYOA 1WIXA 2VZGB 4Q57B 3VP7A 1WYMA 1VKAA 3FERA 2D87A 4Q59A 1SH6A 1WYNA 2VZIB 2RR8A 1AOAA 2HL8A 5FMTA 5J8EA 3JAKM 4EDNA 5L0OA 1EUVA 2K3SA 1DXXA 2QJZA 1PA7A 2VZCA 5A4BA 4EDMA 1P2XA 1RT8A 4LVPA 3CO1A 1AA2A 1UEGA 2R8UA 1SH5A 1WYQA 1PXYA 4TXIA 2WFNA 3JALM 2HKPA 2WA7A 2DK9A 2VE7A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1BKR A;  3HOC A;  1WKU A;  5A38 A;  2EYN A;  2L3G A;  3I6X A;  4TXK A;  4B7L A;  2R0O A;  2VZD A;  2K2R A;  1UJO A;  3F7P A;  1V5K A;  2D86 A;  1QAG A;  1BHD A;  5A36 A;  2QJX A;  1P5S A;  2E9K A;  1WYR A;  3KY9 A;  3HOP A;  1WYL A;  3KMU B;  2EE7 A;  1MB8 A;  1TJT A;  2D89 A;  5A37 A;  3KMW B;  2WA5 A;  2WA6 A;  3HOR A;  2EYI A;  2D88 A;  2JV9 A;  2YRN A;  2D85 A;  4EDL A;  4Q58 A;  3JAR M;  1WJO A;  1H67 A;  5BVR A;  3REP B;  1WYP A;  1WYO A;  1WIX A;  2VZG B;  4Q57 B;  1WYM A;  1VKA A;  3FER A;  2D87 A;  4Q59 A;  1SH6 A;  1WYN A;  2VZI B;  2RR8 A;  1AOA A;  5J8E A;  3JAK M;  4EDN A;  5L0O A;  2K3S A;  1DXX A;  2QJZ A;  1PA7 A;  2VZC A;  5A4B A;  4EDM A;  1P2X A;  1RT8 A;  3CO1 A;  1AA2 A;  1UEG A;  2R8U A;  1SH5 A;  1WYQ A;  1PXY A;  4TXI A;  2WFN A;  3JAL M;  2WA7 A;  2DK9 A; 
#chains in the Genus database with same CATH topology
 1BKR A;  3HOC A;  5FMU A;  1WKU A;  5A38 A;  2EYN A;  2L3G A;  3I6X A;  4TXK A;  4B7L A;  2R0O A;  2VZD A;  2K2R A;  1UJO A;  3F7P A;  1V5K A;  2D86 A;  1QAG A;  1BHD A;  5A36 A;  2QJX A;  1P5S A;  2E9K A;  1WYR A;  4DDP A;  3KY9 A;  3HOP A;  1WYL A;  3KMU B;  2EE7 A;  1MB8 A;  1TJT A;  2WE6 A;  2D89 A;  5A37 A;  2IGP A;  3KMW B;  2HL9 A;  2WA5 A;  2WA6 A;  2EQO A;  3HOR A;  2EYI A;  2D88 A;  2JV9 A;  2YRN A;  2D85 A;  2VE7 C;  4EDL A;  3EAY A;  4Q58 A;  4LVR A;  3JAR M;  1WJO A;  1H67 A;  5BVR A;  3REP B;  2WDT A;  1WYP A;  1WYO A;  1WIX A;  2VZG B;  4Q57 B;  3VP7 A;  1WYM A;  1VKA A;  3FER A;  2D87 A;  4Q59 A;  1SH6 A;  1WYN A;  2VZI B;  2RR8 A;  1AOA A;  2HL8 A;  5FMT A;  5J8E A;  3JAK M;  4EDN A;  5L0O A;  1EUV A;  2K3S A;  1DXX A;  2QJZ A;  1PA7 A;  2VZC A;  5A4B A;  4EDM A;  1P2X A;  1RT8 A;  4LVP A;  3CO1 A;  1AA2 A;  1UEG A;  2R8U A;  1SH5 A;  1WYQ A;  1PXY A;  4TXI A;  2WFN A;  3JAL M;  2HKP A;  2WA7 A;  2DK9 A;  2VE7 A; 
#chains in the Genus database with same CATH homology
 1BKR A;  3HOC A;  1WKU A;  5A38 A;  2EYN A;  2L3G A;  3I6X A;  4TXK A;  4B7L A;  2R0O A;  2VZD A;  2K2R A;  1UJO A;  3F7P A;  1V5K A;  2D86 A;  1QAG A;  1BHD A;  5A36 A;  2QJX A;  1P5S A;  2E9K A;  1WYR A;  3KY9 A;  3HOP A;  1WYL A;  3KMU B;  2EE7 A;  1MB8 A;  1TJT A;  2D89 A;  5A37 A;  3KMW B;  2WA5 A;  2WA6 A;  3HOR A;  2EYI A;  2D88 A;  2JV9 A;  2YRN A;  2D85 A;  4EDL A;  4Q58 A;  3JAR M;  1WJO A;  1H67 A;  5BVR A;  3REP B;  1WYP A;  1WYO A;  1WIX A;  2VZG B;  4Q57 B;  1WYM A;  1VKA A;  3FER A;  2D87 A;  4Q59 A;  1SH6 A;  1WYN A;  2VZI B;  2RR8 A;  1AOA A;  5J8E A;  3JAK M;  4EDN A;  5L0O A;  2K3S A;  1DXX A;  2QJZ A;  1PA7 A;  2VZC A;  5A4B A;  4EDM A;  1P2X A;  1RT8 A;  3CO1 A;  1AA2 A;  1UEG A;  2R8U A;  1SH5 A;  1WYQ A;  1PXY A;  4TXI A;  2WFN A;  3JAL M;  2WA7 A;  2DK9 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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5A37A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations