5A38A

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
223
structure length
223
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
molecule tags Actin-binding protein
source organism Homo sapiens
molecule keywords ALPHA-ACTININ-2
total genus 86
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a38A01
4EDNA 2E9KA 3CO1A 1WYRA 2RR8A 1SH5A 2D89A 3HOCA 5A37A 3FERA 4Q59A 1BHDA 2EYIA 2D88A 1WYPA 2JV9A 4TXKA 2WA5A 4Q57B 3JAKM 2VZGB 5A4BA 3KMWB 1TJTA 4EDMA 2YRNA 3KY9A 4EDLA 2EYNA 1QAGA 3I6XA 1WKUA 2D86A 1UEGA 2R8UA 1DXXA 1WYNA 2VZCA 1WYOA 1BKRA 2QJZA 5L0OA 2R0OA 3HOPA 2WFNA 1WYLA 5A38A 3HORA 1SH6A 2WA6A 5J8EA 2QJXA 2WA7A 3JARM 1P5SA 1V5KA 2VZIB 1MB8A 3REPB 2K3SA 4B7LA 4TXIA 1WYQA 2D87A 1AOAA 2VZDA 1RT8A 2K2RA 1H67A 1WYMA 1P2XA 2L3GA 4Q58A 1WJOA 2D85A 1AA2A 3KMUB 1PA7A 1PXYA 1WIXA 5A36A 5BVRA 1UJOA 3JALM 3F7PA 2DK9A 1VKAA 2EE7A
chains in the Genus database with same CATH superfamily
4EDNA 2WE6A 2E9KA 3VP7A 3CO1A 1WYRA 2RR8A 2VE7C 1SH5A 2D89A 3HOCA 5A37A 3FERA 4Q59A 1BHDA 2EYIA 2D88A 1WYPA 2JV9A 4TXKA 2WA5A 4Q57B 3JAKM 2VZGB 5A4BA 3KMWB 1TJTA 4EDMA 2YRNA 3KY9A 4EDLA 2EQOA 2EYNA 1QAGA 5FMTA 3I6XA 1WKUA 2IGPA 2D86A 1UEGA 1EUVA 2R8UA 1DXXA 1WYNA 2VZCA 5FMUA 1WYOA 1BKRA 2QJZA 5L0OA 2HL9A 2R0OA 3HOPA 2WFNA 2HL8A 1WYLA 5A38A 3HORA 1SH6A 2WA6A 5J8EA 2QJXA 4LVPA 2WA7A 4LVRA 3JARM 1P5SA 1V5KA 2VZIB 1MB8A 2VE7A 3REPB 2K3SA 4B7LA 4TXIA 4DDPA 1WYQA 2D87A 1AOAA 2VZDA 1RT8A 2K2RA 3EAYA 1H67A 2HKPA 1WYMA 1P2XA 2L3GA 4Q58A 1WJOA 2D85A 1AA2A 3KMUB 1PA7A 1PXYA 1WIXA 5A36A 2WDTA 5BVRA 1UJOA 3JALM 3F7PA 2DK9A 1VKAA 2EE7A
chains in the Genus database with same CATH topology
4EDNA 2E9KA 3CO1A 1WYRA 2RR8A 1SH5A 2D89A 3HOCA 5A37A 3FERA 4Q59A 1BHDA 2EYIA 2D88A 1WYPA 2JV9A 4TXKA 2WA5A 4Q57B 3JAKM 2VZGB 5A4BA 3KMWB 1TJTA 4EDMA 2YRNA 3KY9A 4EDLA 2EYNA 1QAGA 3I6XA 1WKUA 2D86A 1UEGA 2R8UA 1DXXA 1WYNA 2VZCA 1WYOA 1BKRA 2QJZA 5L0OA 2R0OA 3HOPA 2WFNA 1WYLA 5A38A 3HORA 1SH6A 2WA6A 5J8EA 2QJXA 2WA7A 3JARM 1P5SA 1V5KA 2VZIB 1MB8A 3REPB 2K3SA 4B7LA 4TXIA 1WYQA 2D87A 1AOAA 2VZDA 1RT8A 2K2RA 1H67A 1WYMA 1P2XA 2L3GA 4Q58A 1WJOA 2D85A 1AA2A 3KMUB 1PA7A 1PXYA 1WIXA 5A36A 5BVRA 1UJOA 3JALM 3F7PA 2DK9A 1VKAA 2EE7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EDN A;  2E9K A;  3CO1 A;  1WYR A;  2RR8 A;  1SH5 A;  2D89 A;  3HOC A;  5A37 A;  3FER A;  4Q59 A;  1BHD A;  2EYI A;  2D88 A;  1WYP A;  2JV9 A;  4TXK A;  2WA5 A;  4Q57 B;  3JAK M;  2VZG B;  5A4B A;  3KMW B;  1TJT A;  4EDM A;  2YRN A;  3KY9 A;  4EDL A;  2EYN A;  1QAG A;  3I6X A;  1WKU A;  2D86 A;  1UEG A;  2R8U A;  1DXX A;  1WYN A;  2VZC A;  1WYO A;  1BKR A;  2QJZ A;  5L0O A;  2R0O A;  3HOP A;  2WFN A;  1WYL A;  5A38 A;  3HOR A;  1SH6 A;  2WA6 A;  5J8E A;  2QJX A;  2WA7 A;  3JAR M;  1P5S A;  1V5K A;  2VZI B;  1MB8 A;  3REP B;  2K3S A;  4B7L A;  4TXI A;  1WYQ A;  2D87 A;  1AOA A;  2VZD A;  1RT8 A;  2K2R A;  1H67 A;  1WYM A;  1P2X A;  2L3G A;  4Q58 A;  1WJO A;  2D85 A;  1AA2 A;  3KMU B;  1PA7 A;  1PXY A;  1WIX A;  5A36 A;  5BVR A;  1UJO A;  3JAL M;  3F7P A;  2DK9 A;  1VKA A;  2EE7 A; 
#chains in the Genus database with same CATH topology
 4EDN A;  2WE6 A;  2E9K A;  3VP7 A;  3CO1 A;  1WYR A;  2RR8 A;  2VE7 C;  1SH5 A;  2D89 A;  3HOC A;  5A37 A;  3FER A;  4Q59 A;  1BHD A;  2EYI A;  2D88 A;  1WYP A;  2JV9 A;  4TXK A;  2WA5 A;  4Q57 B;  3JAK M;  2VZG B;  5A4B A;  3KMW B;  1TJT A;  4EDM A;  2YRN A;  3KY9 A;  4EDL A;  2EQO A;  2EYN A;  1QAG A;  5FMT A;  3I6X A;  1WKU A;  2IGP A;  2D86 A;  1UEG A;  1EUV A;  2R8U A;  1DXX A;  1WYN A;  2VZC A;  5FMU A;  1WYO A;  1BKR A;  2QJZ A;  5L0O A;  2HL9 A;  2R0O A;  3HOP A;  2WFN A;  2HL8 A;  1WYL A;  5A38 A;  3HOR A;  1SH6 A;  2WA6 A;  5J8E A;  2QJX A;  4LVP A;  2WA7 A;  4LVR A;  3JAR M;  1P5S A;  1V5K A;  2VZI B;  1MB8 A;  2VE7 A;  3REP B;  2K3S A;  4B7L A;  4TXI A;  4DDP A;  1WYQ A;  2D87 A;  1AOA A;  2VZD A;  1RT8 A;  2K2R A;  3EAY A;  1H67 A;  2HKP A;  1WYM A;  1P2X A;  2L3G A;  4Q58 A;  1WJO A;  2D85 A;  1AA2 A;  3KMU B;  1PA7 A;  1PXY A;  1WIX A;  5A36 A;  2WDT A;  5BVR A;  1UJO A;  3JAL M;  3F7P A;  2DK9 A;  1VKA A;  2EE7 A; 
#chains in the Genus database with same CATH homology
 4EDN A;  2E9K A;  3CO1 A;  1WYR A;  2RR8 A;  1SH5 A;  2D89 A;  3HOC A;  5A37 A;  3FER A;  4Q59 A;  1BHD A;  2EYI A;  2D88 A;  1WYP A;  2JV9 A;  4TXK A;  2WA5 A;  4Q57 B;  3JAK M;  2VZG B;  5A4B A;  3KMW B;  1TJT A;  4EDM A;  2YRN A;  3KY9 A;  4EDL A;  2EYN A;  1QAG A;  3I6X A;  1WKU A;  2D86 A;  1UEG A;  2R8U A;  1DXX A;  1WYN A;  2VZC A;  1WYO A;  1BKR A;  2QJZ A;  5L0O A;  2R0O A;  3HOP A;  2WFN A;  1WYL A;  5A38 A;  3HOR A;  1SH6 A;  2WA6 A;  5J8E A;  2QJX A;  2WA7 A;  3JAR M;  1P5S A;  1V5K A;  2VZI B;  1MB8 A;  3REP B;  2K3S A;  4B7L A;  4TXI A;  1WYQ A;  2D87 A;  1AOA A;  2VZD A;  1RT8 A;  2K2R A;  1H67 A;  1WYM A;  1P2X A;  2L3G A;  4Q58 A;  1WJO A;  2D85 A;  1AA2 A;  3KMU B;  1PA7 A;  1PXY A;  1WIX A;  5A36 A;  5BVR A;  1UJO A;  3JAL M;  3F7P A;  2DK9 A;  1VKA A;  2EE7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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