5A4BA

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
223
structure length
223
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGTEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords HUMAN ALPHA-ACTININ-2
total genus 92
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a4bA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a4bA01
2VZCA 2QJZA 2WA6A 4TXKA 3REPB 5A37A 4EDNA 1MB8A 3FERA 1WYLA 5BVRA 2JV9A 1BKRA 1AA2A 4B7LA 5L0OA 1RT8A 1QAGA 2D87A 3I6XA 5A4BA 2WFNA 1WYOA 1PXYA 3HOCA 2R0OA 3KMWB 2D88A 2WA5A 2QJXA 4EDMA 2EE7A 5A36A 4TXIA 5J8EA 2VZGB 4EDLA 2L3GA 1H67A 4Q59A 3CO1A 2D86A 1VKAA 2RR8A 1V5KA 2EYIA 3KY9A 2E9KA 3JALM 1P2XA 1P5SA 1WYNA 4Q57B 3HORA 1WIXA 1TJTA 1AOAA 3HOPA 1WYQA 1PA7A 2D85A 2WA7A 1UEGA 2YRNA 1WYMA 2K3SA 1SH5A 1DXXA 1UJOA 3F7PA 1WJOA 3JARM 2DK9A 2VZDA 2K2RA 5A38A 1BHDA 1WYRA 3KMUB 1WKUA 2R8UA 1WYPA 4Q58A 1SH6A 2EYNA 2D89A 2VZIB 3JAKM
chains in the Genus database with same CATH superfamily
2VZCA 2QJZA 4LVPA 2WA6A 4TXKA 5FMTA 3REPB 5A37A 4EDNA 1MB8A 3FERA 1WYLA 5FMUA 5BVRA 2JV9A 1BKRA 1AA2A 4B7LA 4DDPA 5L0OA 1RT8A 1QAGA 2D87A 3VP7A 3I6XA 5A4BA 2WFNA 3EAYA 1WYOA 1PXYA 3HOCA 2HKPA 2R0OA 2WDTA 3KMWB 2D88A 2WA5A 2QJXA 4EDMA 2EE7A 4LVRA 2EQOA 5A36A 4TXIA 5J8EA 2VZGB 4EDLA 2L3GA 1H67A 4Q59A 3CO1A 2D86A 1VKAA 2RR8A 1V5KA 2EYIA 3KY9A 2IGPA 2E9KA 3JALM 1P2XA 1P5SA 1WYNA 4Q57B 3HORA 1WIXA 1TJTA 1AOAA 3HOPA 1WYQA 2VE7C 1PA7A 2D85A 2WA7A 1UEGA 2YRNA 2HL9A 1WYMA 2K3SA 1SH5A 2WE6A 1DXXA 1UJOA 2HL8A 2VE7A 3F7PA 1WJOA 3JARM 2DK9A 2VZDA 1EUVA 2K2RA 5A38A 1BHDA 1WYRA 3KMUB 1WKUA 2R8UA 1WYPA 4Q58A 1SH6A 2EYNA 2D89A 2VZIB 3JAKM
chains in the Genus database with same CATH topology
2VZCA 2QJZA 2WA6A 4TXKA 3REPB 5A37A 4EDNA 1MB8A 3FERA 1WYLA 5BVRA 2JV9A 1BKRA 1AA2A 4B7LA 5L0OA 1RT8A 1QAGA 2D87A 3I6XA 5A4BA 2WFNA 1WYOA 1PXYA 3HOCA 2R0OA 3KMWB 2D88A 2WA5A 2QJXA 4EDMA 2EE7A 5A36A 4TXIA 5J8EA 2VZGB 4EDLA 2L3GA 1H67A 4Q59A 3CO1A 2D86A 1VKAA 2RR8A 1V5KA 2EYIA 3KY9A 2E9KA 3JALM 1P2XA 1P5SA 1WYNA 4Q57B 3HORA 1WIXA 1TJTA 1AOAA 3HOPA 1WYQA 1PA7A 2D85A 2WA7A 1UEGA 2YRNA 1WYMA 2K3SA 1SH5A 1DXXA 1UJOA 3F7PA 1WJOA 3JARM 2DK9A 2VZDA 2K2RA 5A38A 1BHDA 1WYRA 3KMUB 1WKUA 2R8UA 1WYPA 4Q58A 1SH6A 2EYNA 2D89A 2VZIB 3JAKM
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VZC A;  2QJZ A;  2WA6 A;  4TXK A;  3REP B;  5A37 A;  4EDN A;  1MB8 A;  3FER A;  1WYL A;  5BVR A;  2JV9 A;  1BKR A;  1AA2 A;  4B7L A;  5L0O A;  1RT8 A;  1QAG A;  2D87 A;  3I6X A;  5A4B A;  2WFN A;  1WYO A;  1PXY A;  3HOC A;  2R0O A;  3KMW B;  2D88 A;  2WA5 A;  2QJX A;  4EDM A;  2EE7 A;  5A36 A;  4TXI A;  5J8E A;  2VZG B;  4EDL A;  2L3G A;  1H67 A;  4Q59 A;  3CO1 A;  2D86 A;  1VKA A;  2RR8 A;  1V5K A;  2EYI A;  3KY9 A;  2E9K A;  3JAL M;  1P2X A;  1P5S A;  1WYN A;  4Q57 B;  3HOR A;  1WIX A;  1TJT A;  1AOA A;  3HOP A;  1WYQ A;  1PA7 A;  2D85 A;  2WA7 A;  1UEG A;  2YRN A;  1WYM A;  2K3S A;  1SH5 A;  1DXX A;  1UJO A;  3F7P A;  1WJO A;  3JAR M;  2DK9 A;  2VZD A;  2K2R A;  5A38 A;  1BHD A;  1WYR A;  3KMU B;  1WKU A;  2R8U A;  1WYP A;  4Q58 A;  1SH6 A;  2EYN A;  2D89 A;  2VZI B;  3JAK M; 
#chains in the Genus database with same CATH topology
 2VZC A;  2QJZ A;  4LVP A;  2WA6 A;  4TXK A;  5FMT A;  3REP B;  5A37 A;  4EDN A;  1MB8 A;  3FER A;  1WYL A;  5FMU A;  5BVR A;  2JV9 A;  1BKR A;  1AA2 A;  4B7L A;  4DDP A;  5L0O A;  1RT8 A;  1QAG A;  2D87 A;  3VP7 A;  3I6X A;  5A4B A;  2WFN A;  3EAY A;  1WYO A;  1PXY A;  3HOC A;  2HKP A;  2R0O A;  2WDT A;  3KMW B;  2D88 A;  2WA5 A;  2QJX A;  4EDM A;  2EE7 A;  4LVR A;  2EQO A;  5A36 A;  4TXI A;  5J8E A;  2VZG B;  4EDL A;  2L3G A;  1H67 A;  4Q59 A;  3CO1 A;  2D86 A;  1VKA A;  2RR8 A;  1V5K A;  2EYI A;  3KY9 A;  2IGP A;  2E9K A;  3JAL M;  1P2X A;  1P5S A;  1WYN A;  4Q57 B;  3HOR A;  1WIX A;  1TJT A;  1AOA A;  3HOP A;  1WYQ A;  2VE7 C;  1PA7 A;  2D85 A;  2WA7 A;  1UEG A;  2YRN A;  2HL9 A;  1WYM A;  2K3S A;  1SH5 A;  2WE6 A;  1DXX A;  1UJO A;  2HL8 A;  2VE7 A;  3F7P A;  1WJO A;  3JAR M;  2DK9 A;  2VZD A;  1EUV A;  2K2R A;  5A38 A;  1BHD A;  1WYR A;  3KMU B;  1WKU A;  2R8U A;  1WYP A;  4Q58 A;  1SH6 A;  2EYN A;  2D89 A;  2VZI B;  3JAK M; 
#chains in the Genus database with same CATH homology
 2VZC A;  2QJZ A;  2WA6 A;  4TXK A;  3REP B;  5A37 A;  4EDN A;  1MB8 A;  3FER A;  1WYL A;  5BVR A;  2JV9 A;  1BKR A;  1AA2 A;  4B7L A;  5L0O A;  1RT8 A;  1QAG A;  2D87 A;  3I6X A;  5A4B A;  2WFN A;  1WYO A;  1PXY A;  3HOC A;  2R0O A;  3KMW B;  2D88 A;  2WA5 A;  2QJX A;  4EDM A;  2EE7 A;  5A36 A;  4TXI A;  5J8E A;  2VZG B;  4EDL A;  2L3G A;  1H67 A;  4Q59 A;  3CO1 A;  2D86 A;  1VKA A;  2RR8 A;  1V5K A;  2EYI A;  3KY9 A;  2E9K A;  3JAL M;  1P2X A;  1P5S A;  1WYN A;  4Q57 B;  3HOR A;  1WIX A;  1TJT A;  1AOA A;  3HOP A;  1WYQ A;  1PA7 A;  2D85 A;  2WA7 A;  1UEG A;  2YRN A;  1WYM A;  2K3S A;  1SH5 A;  1DXX A;  1UJO A;  3F7P A;  1WJO A;  3JAR M;  2DK9 A;  2VZD A;  2K2R A;  5A38 A;  1BHD A;  1WYR A;  3KMU B;  1WKU A;  2R8U A;  1WYP A;  4Q58 A;  1SH6 A;  2EYN A;  2D89 A;  2VZI B;  3JAK M; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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