5A4BA

Mutations in the calponin homology domain of alpha-actinin-2 affect actin binding and incorporation in muscle.
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
223
structure length
223
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGTEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords HUMAN ALPHA-ACTININ-2
total genus 92
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a4bA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5a4bA01
4Q58A 3F7PA 4Q57B 2VZGB 2YRNA 5L0OA 1WYPA 1VKAA 3CO1A 3FERA 2EYIA 2D85A 2EYNA 4TXKA 1WYNA 1H67A 1UJOA 2EE7A 5A38A 1WJOA 2WA7A 2DK9A 1V5KA 3HOPA 3REPB 1WYOA 1TJTA 2WA5A 1WKUA 4EDLA 2R8UA 2K2RA 4EDMA 5A37A 2JV9A 2VZCA 3HOCA 1WIXA 1PA7A 2QJZA 3KMUB 2WA6A 2E9KA 3JAKM 3KY9A 1BHDA 3KMWB 1MB8A 4Q59A 1WYRA 2VZIB 4TXIA 1WYLA 5A4BA 2VZDA 3JALM 3I6XA 1RT8A 3JARM 5J8EA 1P2XA 2QJXA 1QAGA 2D88A 1WYQA 2D86A 5A36A 4EDNA 2L3GA 2RR8A 1WYMA 1AOAA 2K3SA 3HORA 1UEGA 2D89A 1PXYA 1SH6A 2R0OA 4B7LA 1BKRA 1DXXA 1AA2A 1P5SA 2D87A 5BVRA 1SH5A 2WFNA
chains in the Genus database with same CATH superfamily
4Q58A 2VE7C 3F7PA 4Q57B 2VZGB 2YRNA 5L0OA 1WYPA 1VKAA 2WDTA 3CO1A 3FERA 2EYIA 2VE7A 2D85A 2EYNA 4TXKA 1WYNA 1H67A 1UJOA 2EE7A 5A38A 1WJOA 2WA7A 2DK9A 1V5KA 3HOPA 3REPB 1WYOA 1TJTA 2WA5A 1WKUA 4EDLA 2R8UA 2K2RA 4LVRA 2EQOA 4EDMA 5A37A 2HKPA 5FMTA 2JV9A 2VZCA 3HOCA 1WIXA 4DDPA 1PA7A 2QJZA 3KMUB 4LVPA 2WA6A 2E9KA 3VP7A 3JAKM 3KY9A 1BHDA 3KMWB 1MB8A 4Q59A 1WYRA 2VZIB 4TXIA 2HL9A 1WYLA 5A4BA 2VZDA 2WE6A 3JALM 3I6XA 1RT8A 3JARM 5J8EA 1P2XA 2QJXA 2IGPA 1QAGA 2D88A 1WYQA 2D86A 5A36A 4EDNA 2L3GA 2RR8A 1WYMA 1AOAA 1EUVA 2K3SA 5FMUA 3HORA 1UEGA 2D89A 3EAYA 1PXYA 1SH6A 2R0OA 4B7LA 2HL8A 1BKRA 1DXXA 1AA2A 1P5SA 2D87A 5BVRA 1SH5A 2WFNA
chains in the Genus database with same CATH topology
4Q58A 3F7PA 4Q57B 2VZGB 2YRNA 5L0OA 1WYPA 1VKAA 3CO1A 3FERA 2EYIA 2D85A 2EYNA 4TXKA 1WYNA 1H67A 1UJOA 2EE7A 5A38A 1WJOA 2WA7A 2DK9A 1V5KA 3HOPA 3REPB 1WYOA 1TJTA 2WA5A 1WKUA 4EDLA 2R8UA 2K2RA 4EDMA 5A37A 2JV9A 2VZCA 3HOCA 1WIXA 1PA7A 2QJZA 3KMUB 2WA6A 2E9KA 3JAKM 3KY9A 1BHDA 3KMWB 1MB8A 4Q59A 1WYRA 2VZIB 4TXIA 1WYLA 5A4BA 2VZDA 3JALM 3I6XA 1RT8A 3JARM 5J8EA 1P2XA 2QJXA 1QAGA 2D88A 1WYQA 2D86A 5A36A 4EDNA 2L3GA 2RR8A 1WYMA 1AOAA 2K3SA 3HORA 1UEGA 2D89A 1PXYA 1SH6A 2R0OA 4B7LA 1BKRA 1DXXA 1AA2A 1P5SA 2D87A 5BVRA 1SH5A 2WFNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q58 A;  3F7P A;  4Q57 B;  2VZG B;  2YRN A;  5L0O A;  1WYP A;  1VKA A;  3CO1 A;  3FER A;  2EYI A;  2D85 A;  2EYN A;  4TXK A;  1WYN A;  1H67 A;  1UJO A;  2EE7 A;  5A38 A;  1WJO A;  2WA7 A;  2DK9 A;  1V5K A;  3HOP A;  3REP B;  1WYO A;  1TJT A;  2WA5 A;  1WKU A;  4EDL A;  2R8U A;  2K2R A;  4EDM A;  5A37 A;  2JV9 A;  2VZC A;  3HOC A;  1WIX A;  1PA7 A;  2QJZ A;  3KMU B;  2WA6 A;  2E9K A;  3JAK M;  3KY9 A;  1BHD A;  3KMW B;  1MB8 A;  4Q59 A;  1WYR A;  2VZI B;  4TXI A;  1WYL A;  5A4B A;  2VZD A;  3JAL M;  3I6X A;  1RT8 A;  3JAR M;  5J8E A;  1P2X A;  2QJX A;  1QAG A;  2D88 A;  1WYQ A;  2D86 A;  5A36 A;  4EDN A;  2L3G A;  2RR8 A;  1WYM A;  1AOA A;  2K3S A;  3HOR A;  1UEG A;  2D89 A;  1PXY A;  1SH6 A;  2R0O A;  4B7L A;  1BKR A;  1DXX A;  1AA2 A;  1P5S A;  2D87 A;  5BVR A;  1SH5 A;  2WFN A; 
#chains in the Genus database with same CATH topology
 4Q58 A;  2VE7 C;  3F7P A;  4Q57 B;  2VZG B;  2YRN A;  5L0O A;  1WYP A;  1VKA A;  2WDT A;  3CO1 A;  3FER A;  2EYI A;  2VE7 A;  2D85 A;  2EYN A;  4TXK A;  1WYN A;  1H67 A;  1UJO A;  2EE7 A;  5A38 A;  1WJO A;  2WA7 A;  2DK9 A;  1V5K A;  3HOP A;  3REP B;  1WYO A;  1TJT A;  2WA5 A;  1WKU A;  4EDL A;  2R8U A;  2K2R A;  4LVR A;  2EQO A;  4EDM A;  5A37 A;  2HKP A;  5FMT A;  2JV9 A;  2VZC A;  3HOC A;  1WIX A;  4DDP A;  1PA7 A;  2QJZ A;  3KMU B;  4LVP A;  2WA6 A;  2E9K A;  3VP7 A;  3JAK M;  3KY9 A;  1BHD A;  3KMW B;  1MB8 A;  4Q59 A;  1WYR A;  2VZI B;  4TXI A;  2HL9 A;  1WYL A;  5A4B A;  2VZD A;  2WE6 A;  3JAL M;  3I6X A;  1RT8 A;  3JAR M;  5J8E A;  1P2X A;  2QJX A;  2IGP A;  1QAG A;  2D88 A;  1WYQ A;  2D86 A;  5A36 A;  4EDN A;  2L3G A;  2RR8 A;  1WYM A;  1AOA A;  1EUV A;  2K3S A;  5FMU A;  3HOR A;  1UEG A;  2D89 A;  3EAY A;  1PXY A;  1SH6 A;  2R0O A;  4B7L A;  2HL8 A;  1BKR A;  1DXX A;  1AA2 A;  1P5S A;  2D87 A;  5BVR A;  1SH5 A;  2WFN A; 
#chains in the Genus database with same CATH homology
 4Q58 A;  3F7P A;  4Q57 B;  2VZG B;  2YRN A;  5L0O A;  1WYP A;  1VKA A;  3CO1 A;  3FER A;  2EYI A;  2D85 A;  2EYN A;  4TXK A;  1WYN A;  1H67 A;  1UJO A;  2EE7 A;  5A38 A;  1WJO A;  2WA7 A;  2DK9 A;  1V5K A;  3HOP A;  3REP B;  1WYO A;  1TJT A;  2WA5 A;  1WKU A;  4EDL A;  2R8U A;  2K2R A;  4EDM A;  5A37 A;  2JV9 A;  2VZC A;  3HOC A;  1WIX A;  1PA7 A;  2QJZ A;  3KMU B;  2WA6 A;  2E9K A;  3JAK M;  3KY9 A;  1BHD A;  3KMW B;  1MB8 A;  4Q59 A;  1WYR A;  2VZI B;  4TXI A;  1WYL A;  5A4B A;  2VZD A;  3JAL M;  3I6X A;  1RT8 A;  3JAR M;  5J8E A;  1P2X A;  2QJX A;  1QAG A;  2D88 A;  1WYQ A;  2D86 A;  5A36 A;  4EDN A;  2L3G A;  2RR8 A;  1WYM A;  1AOA A;  2K3S A;  3HOR A;  1UEG A;  2D89 A;  1PXY A;  1SH6 A;  2R0O A;  4B7L A;  1BKR A;  1DXX A;  1AA2 A;  1P5S A;  2D87 A;  5BVR A;  1SH5 A;  2WFN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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