5A4B | Genus

Total Genus 92

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	92
sequence length	223
structure length	223
Chain Sequence	AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGTEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 223 atoms

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223 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Structural protein
source organism	Homo sapiens
publication title	Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. pubmed doi rcsb
molecule keywords	HUMAN ALPHA-ACTININ-2
total genus	92
structure length	223
sequence length	223
chains with identical sequence	B
ec nomenclature
pdb deposition date	2015-06-05

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00307	CH	Calponin homology (CH) domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	5a4bA02
1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin; domain 1	Calponin-like domain	5a4bA01

1SH5A 1WYOA 3F7PA 2E9KA 5A36A 5A38A 1PA7A 3HOPA 2WA6A 1UJOA 2R8UA 2D87A 2DK9A 1WYNA 1AOAA 2WA7A 5BVRA 1BKRA 4Q59A 4EDNA 3JALM 3KMWB 4TXKA 3KMUB 5L0OA 2R0OA 1WYPA 4EDLA 1DXXA 2VZGB 1WKUA 2QJZA 1VKAA 1WYLA 3HOCA 5A4BA 4Q58A 4B7LA 3KY9A 2EE7A 2D86A 1BHDA 2EYIA 1PXYA 2EYNA 1H67A 1UEGA 1WYRA 4TXIA 2YRNA 1WYMA 1P2XA 1RT8A 2JV9A 3JAKM 3CO1A 2VZIB 2L3GA 1TJTA 2VZDA 4EDMA 1WYQA 1MB8A 2WFNA 2RR8A 1V5KA 3HORA 2WA5A 1AA2A 2VZCA 2K3SA 2D89A 2D88A 3REPB 1WIXA 3I6XA 2QJXA 1WJOA 1QAGA 5J8EA 4Q57B 1P5SA 5A37A 2D85A 3FERA 1SH6A 3JARM 2K2RA
chains in the Genus database with same CATH superfamily

3EAYA 1SH5A 1WYOA 3F7PA 2E9KA 5A36A 5A38A 1PA7A 2EQOA 3HOPA 2WA6A 2HL8A 1UJOA 2R8UA 1EUVA 2D87A 2DK9A 1WYNA 1AOAA 2WA7A 5BVRA 1BKRA 4Q59A 4EDNA 3JALM 3KMWB 4TXKA 3KMUB 2VE7C 5L0OA 2R0OA 1WYPA 4EDLA 1DXXA 2VZGB 1WKUA 2QJZA 1VKAA 1WYLA 3HOCA 5A4BA 4Q58A 4B7LA 2IGPA 3KY9A 2EE7A 2D86A 4LVPA 1BHDA 2EYIA 1PXYA 2EYNA 1H67A 2HL9A 1UEGA 4DDPA 1WYRA 4TXIA 2YRNA 1WYMA 1P2XA 1RT8A 2JV9A 3JAKM 2WE6A 3CO1A 2VZIB 2L3GA 1TJTA 2VZDA 4EDMA 1WYQA 1MB8A 5FMUA 5FMTA 2VE7A 2WFNA 2RR8A 1V5KA 3HORA 2WA5A 1AA2A 2VZCA 2K3SA 4LVRA 2D89A 2D88A 3REPB 1WIXA 3I6XA 2QJXA 1WJOA 1QAGA 5J8EA 2HKPA 4Q57B 1P5SA 5A37A 2D85A 3FERA 1SH6A 2WDTA 3JARM 2K2RA 3VP7A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1SH5 A;  1WYO A;  3F7P A;  2E9K A;  5A36 A;  5A38 A;  1PA7 A;  3HOP A;  2WA6 A;  1UJO A;  2R8U A;  2D87 A;  2DK9 A;  1WYN A;  1AOA A;  2WA7 A;  5BVR A;  1BKR A;  4Q59 A;  4EDN A;  3JAL M;  3KMW B;  4TXK A;  3KMU B;  5L0O A;  2R0O A;  1WYP A;  4EDL A;  1DXX A;  2VZG B;  1WKU A;  2QJZ A;  1VKA A;  1WYL A;  3HOC A;  5A4B A;  4Q58 A;  4B7L A;  3KY9 A;  2EE7 A;  2D86 A;  1BHD A;  2EYI A;  1PXY A;  2EYN A;  1H67 A;  1UEG A;  1WYR A;  4TXI A;  2YRN A;  1WYM A;  1P2X A;  1RT8 A;  2JV9 A;  3JAK M;  3CO1 A;  2VZI B;  2L3G A;  1TJT A;  2VZD A;  4EDM A;  1WYQ A;  1MB8 A;  2WFN A;  2RR8 A;  1V5K A;  3HOR A;  2WA5 A;  1AA2 A;  2VZC A;  2K3S A;  2D89 A;  2D88 A;  3REP B;  1WIX A;  3I6X A;  2QJX A;  1WJO A;  1QAG A;  5J8E A;  4Q57 B;  1P5S A;  5A37 A;  2D85 A;  3FER A;  1SH6 A;  3JAR M;  2K2R A; 
#chains in the Genus database with same CATH topology
 3EAY A;  1SH5 A;  1WYO A;  3F7P A;  2E9K A;  5A36 A;  5A38 A;  1PA7 A;  2EQO A;  3HOP A;  2WA6 A;  2HL8 A;  1UJO A;  2R8U A;  1EUV A;  2D87 A;  2DK9 A;  1WYN A;  1AOA A;  2WA7 A;  5BVR A;  1BKR A;  4Q59 A;  4EDN A;  3JAL M;  3KMW B;  4TXK A;  3KMU B;  2VE7 C;  5L0O A;  2R0O A;  1WYP A;  4EDL A;  1DXX A;  2VZG B;  1WKU A;  2QJZ A;  1VKA A;  1WYL A;  3HOC A;  5A4B A;  4Q58 A;  4B7L A;  2IGP A;  3KY9 A;  2EE7 A;  2D86 A;  4LVP A;  1BHD A;  2EYI A;  1PXY A;  2EYN A;  1H67 A;  2HL9 A;  1UEG A;  4DDP A;  1WYR A;  4TXI A;  2YRN A;  1WYM A;  1P2X A;  1RT8 A;  2JV9 A;  3JAK M;  2WE6 A;  3CO1 A;  2VZI B;  2L3G A;  1TJT A;  2VZD A;  4EDM A;  1WYQ A;  1MB8 A;  5FMU A;  5FMT A;  2VE7 A;  2WFN A;  2RR8 A;  1V5K A;  3HOR A;  2WA5 A;  1AA2 A;  2VZC A;  2K3S A;  4LVR A;  2D89 A;  2D88 A;  3REP B;  1WIX A;  3I6X A;  2QJX A;  1WJO A;  1QAG A;  5J8E A;  2HKP A;  4Q57 B;  1P5S A;  5A37 A;  2D85 A;  3FER A;  1SH6 A;  2WDT A;  3JAR M;  2K2R A;  3VP7 A; 
#chains in the Genus database with same CATH homology
 1SH5 A;  1WYO A;  3F7P A;  2E9K A;  5A36 A;  5A38 A;  1PA7 A;  3HOP A;  2WA6 A;  1UJO A;  2R8U A;  2D87 A;  2DK9 A;  1WYN A;  1AOA A;  2WA7 A;  5BVR A;  1BKR A;  4Q59 A;  4EDN A;  3JAL M;  3KMW B;  4TXK A;  3KMU B;  5L0O A;  2R0O A;  1WYP A;  4EDL A;  1DXX A;  2VZG B;  1WKU A;  2QJZ A;  1VKA A;  1WYL A;  3HOC A;  5A4B A;  4Q58 A;  4B7L A;  3KY9 A;  2EE7 A;  2D86 A;  1BHD A;  2EYI A;  1PXY A;  2EYN A;  1H67 A;  1UEG A;  1WYR A;  4TXI A;  2YRN A;  1WYM A;  1P2X A;  1RT8 A;  2JV9 A;  3JAK M;  3CO1 A;  2VZI B;  2L3G A;  1TJT A;  2VZD A;  4EDM A;  1WYQ A;  1MB8 A;  2WFN A;  2RR8 A;  1V5K A;  3HOR A;  2WA5 A;  1AA2 A;  2VZC A;  2K3S A;  2D89 A;  2D88 A;  3REP B;  1WIX A;  3I6X A;  2QJX A;  1WJO A;  1QAG A;  5J8E A;  4Q57 B;  1P5S A;  5A37 A;  2D85 A;  3FER A;  1SH6 A;  3JAR M;  2K2R A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5A4BA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations