5J8EA

Crystal structure of human hook3's conserved hook domain
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
150
structure length
150
Chain Sequence
RAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
pubmed doi rcsb
molecule tags Protein transport
source organism Homo sapiens
molecule keywords Protein Hook homolog 3
total genus 54
structure length 150
sequence length 150
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-04-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5j8eA00
3REPB 2K2RA 2D89A 3KMWB 2D86A 1AA2A 2WFNA 2EE7A 3CO1A 2K3SA 5A36A 1WYLA 3HORA 4B7LA 3HOCA 1PXYA 1WIXA 2R8UA 1WYOA 2QJXA 1WKUA 2VZDA 1V5KA 2QJZA 4Q58A 1SH6A 2VZCA 4EDNA 1QAGA 1H67A 2JV9A 2VZIB 2YRNA 4EDMA 2EYNA 5A37A 1RT8A 5J8EA 3HOPA 1DXXA 3I6XA 1WYPA 1PA7A 3JARM 3JAKM 1BKRA 1SH5A 4TXKA 1BHDA 4TXIA 4Q59A 2DK9A 1UEGA 2EYIA 1WJOA 3KY9A 2WA5A 2VZGB 1TJTA 3JALM 2D88A 2WA6A 5A38A 1AOAA 3FERA 1P5SA 1WYNA 2WA7A 2D87A 3F7PA 1MB8A 2E9KA 5L0OA 2L3GA 1UJOA 4EDLA 5BVRA 4Q57B 1P2XA 1WYQA 2R0OA 1WYRA 1VKAA 2D85A 3KMUB 5A4BA 2RR8A 1WYMA
chains in the Genus database with same CATH superfamily
3REPB 2HL8A 2K2RA 2D89A 3EAYA 3KMWB 2D86A 1AA2A 2WFNA 4LVRA 2EE7A 2VE7C 3CO1A 2EQOA 2K3SA 5A36A 1WYLA 3HORA 4B7LA 4LVPA 5FMUA 3HOCA 1PXYA 2IGPA 2WE6A 2WDTA 1WIXA 2R8UA 1WYOA 2QJXA 1WKUA 3VP7A 2VZDA 1V5KA 2VE7A 2QJZA 4Q58A 1SH6A 2VZCA 4EDNA 1QAGA 1H67A 2JV9A 2VZIB 2YRNA 4EDMA 2EYNA 5A37A 1RT8A 5J8EA 3HOPA 1DXXA 2HL9A 3I6XA 1WYPA 1PA7A 3JARM 3JAKM 1BKRA 1SH5A 4TXKA 1BHDA 4TXIA 1EUVA 4Q59A 2DK9A 1UEGA 2EYIA 1WJOA 3KY9A 2HKPA 2WA5A 2VZGB 1TJTA 3JALM 2D88A 2WA6A 4DDPA 5A38A 1AOAA 3FERA 1P5SA 1WYNA 2WA7A 2D87A 3F7PA 1MB8A 2E9KA 5L0OA 2L3GA 1UJOA 4EDLA 5FMTA 5BVRA 4Q57B 1P2XA 1WYQA 2R0OA 1WYRA 1VKAA 2D85A 3KMUB 5A4BA 2RR8A 1WYMA
chains in the Genus database with same CATH topology
3REPB 2K2RA 2D89A 3KMWB 2D86A 1AA2A 2WFNA 2EE7A 3CO1A 2K3SA 5A36A 1WYLA 3HORA 4B7LA 3HOCA 1PXYA 1WIXA 2R8UA 1WYOA 2QJXA 1WKUA 2VZDA 1V5KA 2QJZA 4Q58A 1SH6A 2VZCA 4EDNA 1QAGA 1H67A 2JV9A 2VZIB 2YRNA 4EDMA 2EYNA 5A37A 1RT8A 5J8EA 3HOPA 1DXXA 3I6XA 1WYPA 1PA7A 3JARM 3JAKM 1BKRA 1SH5A 4TXKA 1BHDA 4TXIA 4Q59A 2DK9A 1UEGA 2EYIA 1WJOA 3KY9A 2WA5A 2VZGB 1TJTA 3JALM 2D88A 2WA6A 5A38A 1AOAA 3FERA 1P5SA 1WYNA 2WA7A 2D87A 3F7PA 1MB8A 2E9KA 5L0OA 2L3GA 1UJOA 4EDLA 5BVRA 4Q57B 1P2XA 1WYQA 2R0OA 1WYRA 1VKAA 2D85A 3KMUB 5A4BA 2RR8A 1WYMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3REP B;  2K2R A;  2D89 A;  3KMW B;  2D86 A;  1AA2 A;  2WFN A;  2EE7 A;  3CO1 A;  2K3S A;  5A36 A;  1WYL A;  3HOR A;  4B7L A;  3HOC A;  1PXY A;  1WIX A;  2R8U A;  1WYO A;  2QJX A;  1WKU A;  2VZD A;  1V5K A;  2QJZ A;  4Q58 A;  1SH6 A;  2VZC A;  4EDN A;  1QAG A;  1H67 A;  2JV9 A;  2VZI B;  2YRN A;  4EDM A;  2EYN A;  5A37 A;  1RT8 A;  5J8E A;  3HOP A;  1DXX A;  3I6X A;  1WYP A;  1PA7 A;  3JAR M;  3JAK M;  1BKR A;  1SH5 A;  4TXK A;  1BHD A;  4TXI A;  4Q59 A;  2DK9 A;  1UEG A;  2EYI A;  1WJO A;  3KY9 A;  2WA5 A;  2VZG B;  1TJT A;  3JAL M;  2D88 A;  2WA6 A;  5A38 A;  1AOA A;  3FER A;  1P5S A;  1WYN A;  2WA7 A;  2D87 A;  3F7P A;  1MB8 A;  2E9K A;  5L0O A;  2L3G A;  1UJO A;  4EDL A;  5BVR A;  4Q57 B;  1P2X A;  1WYQ A;  2R0O A;  1WYR A;  1VKA A;  2D85 A;  3KMU B;  5A4B A;  2RR8 A;  1WYM A; 
#chains in the Genus database with same CATH topology
 3REP B;  2HL8 A;  2K2R A;  2D89 A;  3EAY A;  3KMW B;  2D86 A;  1AA2 A;  2WFN A;  4LVR A;  2EE7 A;  2VE7 C;  3CO1 A;  2EQO A;  2K3S A;  5A36 A;  1WYL A;  3HOR A;  4B7L A;  4LVP A;  5FMU A;  3HOC A;  1PXY A;  2IGP A;  2WE6 A;  2WDT A;  1WIX A;  2R8U A;  1WYO A;  2QJX A;  1WKU A;  3VP7 A;  2VZD A;  1V5K A;  2VE7 A;  2QJZ A;  4Q58 A;  1SH6 A;  2VZC A;  4EDN A;  1QAG A;  1H67 A;  2JV9 A;  2VZI B;  2YRN A;  4EDM A;  2EYN A;  5A37 A;  1RT8 A;  5J8E A;  3HOP A;  1DXX A;  2HL9 A;  3I6X A;  1WYP A;  1PA7 A;  3JAR M;  3JAK M;  1BKR A;  1SH5 A;  4TXK A;  1BHD A;  4TXI A;  1EUV A;  4Q59 A;  2DK9 A;  1UEG A;  2EYI A;  1WJO A;  3KY9 A;  2HKP A;  2WA5 A;  2VZG B;  1TJT A;  3JAL M;  2D88 A;  2WA6 A;  4DDP A;  5A38 A;  1AOA A;  3FER A;  1P5S A;  1WYN A;  2WA7 A;  2D87 A;  3F7P A;  1MB8 A;  2E9K A;  5L0O A;  2L3G A;  1UJO A;  4EDL A;  5FMT A;  5BVR A;  4Q57 B;  1P2X A;  1WYQ A;  2R0O A;  1WYR A;  1VKA A;  2D85 A;  3KMU B;  5A4B A;  2RR8 A;  1WYM A; 
#chains in the Genus database with same CATH homology
 3REP B;  2K2R A;  2D89 A;  3KMW B;  2D86 A;  1AA2 A;  2WFN A;  2EE7 A;  3CO1 A;  2K3S A;  5A36 A;  1WYL A;  3HOR A;  4B7L A;  3HOC A;  1PXY A;  1WIX A;  2R8U A;  1WYO A;  2QJX A;  1WKU A;  2VZD A;  1V5K A;  2QJZ A;  4Q58 A;  1SH6 A;  2VZC A;  4EDN A;  1QAG A;  1H67 A;  2JV9 A;  2VZI B;  2YRN A;  4EDM A;  2EYN A;  5A37 A;  1RT8 A;  5J8E A;  3HOP A;  1DXX A;  3I6X A;  1WYP A;  1PA7 A;  3JAR M;  3JAK M;  1BKR A;  1SH5 A;  4TXK A;  1BHD A;  4TXI A;  4Q59 A;  2DK9 A;  1UEG A;  2EYI A;  1WJO A;  3KY9 A;  2WA5 A;  2VZG B;  1TJT A;  3JAL M;  2D88 A;  2WA6 A;  5A38 A;  1AOA A;  3FER A;  1P5S A;  1WYN A;  2WA7 A;  2D87 A;  3F7P A;  1MB8 A;  2E9K A;  5L0O A;  2L3G A;  1UJO A;  4EDL A;  5BVR A;  4Q57 B;  1P2X A;  1WYQ A;  2R0O A;  1WYR A;  1VKA A;  2D85 A;  3KMU B;  5A4B A;  2RR8 A;  1WYM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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