1DEVA

Crystal structure of smad2 mh2 domain bound to the smad-binding domain of sara
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
194
structure length
194
Chain Sequence
LQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords MAD (mothers against decapentaplegic, Drosophila) homolog 2
total genus 59
structure length 194
sequence length 194
chains with identical sequence C
ec nomenclature
pdb deposition date 1999-11-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03166 MH2 MH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.200.10 Mainly Beta Sandwich Tumour Suppressor Smad4 Tumour Suppressor Smad4 1devA00
1MJSA 1U7FA 4R9PA 1G88A 1YGSA 1DEVA 1KHXA 3A77A 1U7VB 5JELA 1MR1A 5JERA 5JEKA 1U7FB 1J2FA 5BVIA 5JEMA 5C4VA 1QWTA 5JEJA 5JEOA 1ZOQA 3DSHA 1DD1A 1MK2A 1KHUA 3GMJA 1U7VA 3DITA
chains in the Genus database with same CATH superfamily
3V7WA 1J4KA 1YGSA 3HUFA 1J4OA 4JIWD 2LC1A 4D9VA 1WLNA 4A4YA 1KHXA 4A0EA 1LGPA 1WV3A 4HAOA 3V80A 1SUWA 2G1LA 4DY6A 3V7YA 2BRFA 5C4VA 3I6WA 3HUEA 2A0TA 3VA4A 1GXCA 2JGRA 1K3JA 3UNMA 4WERA 1FHQA 1FHRA 2I29A 3UV0A 3PO8A 3GMJA 1Y3IA 3V8RA 1J4QA 2KB3A 3UMZA 4R9PA 1K2NA 2AFFA 1G88A 1J4PA 1DEVA 1K3NA 4H87A 5DHUA 5EJHA 2KB4A 5JEKA 3POAA 2FEZA 5DHQA 1G3GA 3I0NA 3S40A 2XT9B 2JKDA 3ELVA 1YJMA 1LGQA 1K3QA 5JEOA 1U0TA 3UNNA 5DHSA 1KHUA 3VA1A 4V24A 4EJQA 1MZKA 3I0MA 3HX1A 1U7VA 1YT5A 3ELSA 5DHPA 2I2CA 2P1RA 4EGXA 5A8IA 3UOTA 1U7VB 5JERA 2I2AA 2Q5FA 1DMZA 4G2SA 3AFOA 5EJIA 5EJFA 3MDBA 5JEMA 2JQJA 3VZDA 1QWTA 2I1WA 3KT9A 1QU5A 3VZCA 2FF4A 1ZOQA 3DSHA 3VZBA 2XXSA 1Z0UA 5EJGA 1DD1A 1G6GA 1YJ5C 2JQIA 2I2DA 1Z0ZA 1UJXA 3T5PA 4KU0D 2I2FA 1J4LA 2QV7A 1MJSA 1U7FA 2EH0A 3V8NA 3OUNA 3V8QA 1Z0SA 2KKLA 2BONA 4L02A 3V8MA 1R21A 3V7UA 4JIVD 2QVLA 2KFUA 2W3OA 3V8PA 3A77A 2PIEA 5DHRA 1MR1A 3FM8A 3GQSA 5E50A 1U7FB 3UN0A 1J2FA 2JPEA 2I2BA 5BVIA 1UHTA 4WRRA 3VPYA 3PFNA 1K2MA 2AN1A 5DJOA 5JEJA 1Y3HA 2JQLA 5DHTA 1U0RA 4JONA 1MK2A 4QCJA 5JELA 2CSWA 3I6UA 3DITA
chains in the Genus database with same CATH topology
1J4KA 1YGSA 3HUFA 1J4OA 4JIWD 2LC1A 4D9VA 1WLNA 4A4YA 1KHXA 4A0EA 1LGPA 1WV3A 2G1LA 2BRFA 5C4VA 3I6WA 3HUEA 2A0TA 3VA4A 1GXCA 2JGRA 1K3JA 3UNMA 4WERA 1FHQA 1FHRA 3UV0A 3PO8A 3GMJA 1J4QA 2KB3A 3UMZA 4R9PA 1K2NA 2AFFA 1G88A 1J4PA 1DEVA 1K3NA 4H87A 2KB4A 5JEKA 3POAA 2FEZA 1G3GA 3I0NA 3S40A 2XT9B 2JKDA 3ELVA 1YJMA 1LGQA 1K3QA 5JEOA 3UNNA 1KHUA 3VA1A 4V24A 4EJQA 1MZKA 3I0MA 3HX1A 3ELSA 1U7VA 2P1RA 4EGXA 5A8IA 3UOTA 1U7VB 5JERA 1DMZA 4G2SA 3MDBA 5JEMA 2JQJA 3VZDA 1QWTA 3KT9A 1QU5A 3VZCA 2FF4A 1ZOQA 3DSHA 3VZBA 2XXSA 1DD1A 1G6GA 1YJ5C 2JQIA 1UJXA 3T5PA 4KU0D 1J4LA 2QV7A 1MJSA 1U7FA 2EH0A 3OUNA 2KKLA 2BONA 4L02A 1R21A 4JIVD 2QVLA 2KFUA 2W3OA 3A77A 2PIEA 5E50A 1MR1A 3FM8A 3GQSA 5JELA 1U7FB 3UN0A 1J2FA 2JPEA 5BVIA 1UHTA 4WRRA 3VPYA 1K2MA 5DJOA 5JEJA 2JQLA 4JONA 1MK2A 4QCJA 2CSWA 3I6UA 3DITA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MJS A;  1U7F A;  4R9P A;  1G88 A;  1YGS A;  1DEV A;  1KHX A;  3A77 A;  1U7V B;  5JEL A;  1MR1 A;  5JER A;  5JEK A;  1U7F B;  1J2F A;  5BVI A;  5JEM A;  5C4V A;  1QWT A;  5JEJ A;  5JEO A;  1ZOQ A;  3DSH A;  1DD1 A;  1MK2 A;  1KHU A;  3GMJ A;  1U7V A;  3DIT A; 
#chains in the Genus database with same CATH topology
 3V7W A;  1J4K A;  1YGS A;  3HUF A;  1J4O A;  4JIW D;  2LC1 A;  4D9V A;  1WLN A;  4A4Y A;  1KHX A;  4A0E A;  1LGP A;  1WV3 A;  4HAO A;  3V80 A;  1SUW A;  2G1L A;  4DY6 A;  3V7Y A;  2BRF A;  5C4V A;  3I6W A;  3HUE A;  2A0T A;  3VA4 A;  1GXC A;  2JGR A;  1K3J A;  3UNM A;  4WER A;  1FHQ A;  1FHR A;  2I29 A;  3UV0 A;  3PO8 A;  3GMJ A;  1Y3I A;  3V8R A;  1J4Q A;  2KB3 A;  3UMZ A;  4R9P A;  1K2N A;  2AFF A;  1G88 A;  1J4P A;  1DEV A;  1K3N A;  4H87 A;  5DHU A;  5EJH A;  2KB4 A;  5JEK A;  3POA A;  2FEZ A;  5DHQ A;  1G3G A;  3I0N A;  3S40 A;  2XT9 B;  2JKD A;  3ELV A;  1YJM A;  1LGQ A;  1K3Q A;  5JEO A;  1U0T A;  3UNN A;  5DHS A;  1KHU A;  3VA1 A;  4V24 A;  4EJQ A;  1MZK A;  3I0M A;  3HX1 A;  1U7V A;  1YT5 A;  3ELS A;  5DHP A;  2I2C A;  2P1R A;  4EGX A;  5A8I A;  3UOT A;  1U7V B;  5JER A;  2I2A A;  2Q5F A;  1DMZ A;  4G2S A;  3AFO A;  5EJI A;  5EJF A;  3MDB A;  5JEM A;  2JQJ A;  3VZD A;  1QWT A;  2I1W A;  3KT9 A;  1QU5 A;  3VZC A;  2FF4 A;  1ZOQ A;  3DSH A;  3VZB A;  2XXS A;  1Z0U A;  5EJG A;  1DD1 A;  1G6G A;  1YJ5 C;  2JQI A;  2I2D A;  1Z0Z A;  1UJX A;  3T5P A;  4KU0 D;  2I2F A;  1J4L A;  2QV7 A;  1MJS A;  1U7F A;  2EH0 A;  3V8N A;  3OUN A;  3V8Q A;  1Z0S A;  2KKL A;  2BON A;  4L02 A;  3V8M A;  1R21 A;  3V7U A;  4JIV D;  2QVL A;  2KFU A;  2W3O A;  3V8P A;  3A77 A;  2PIE A;  5DHR A;  1MR1 A;  3FM8 A;  3GQS A;  5E50 A;  1U7F B;  3UN0 A;  1J2F A;  2JPE A;  2I2B A;  5BVI A;  1UHT A;  4WRR A;  3VPY A;  3PFN A;  1K2M A;  2AN1 A;  5DJO A;  5JEJ A;  1Y3H A;  2JQL A;  5DHT A;  1U0R A;  4JON A;  1MK2 A;  4QCJ A;  5JEL A;  2CSW A;  3I6U A;  3DIT A; 
#chains in the Genus database with same CATH homology
 1J4K A;  1YGS A;  3HUF A;  1J4O A;  4JIW D;  2LC1 A;  4D9V A;  1WLN A;  4A4Y A;  1KHX A;  4A0E A;  1LGP A;  1WV3 A;  2G1L A;  2BRF A;  5C4V A;  3I6W A;  3HUE A;  2A0T A;  3VA4 A;  1GXC A;  2JGR A;  1K3J A;  3UNM A;  4WER A;  1FHQ A;  1FHR A;  3UV0 A;  3PO8 A;  3GMJ A;  1J4Q A;  2KB3 A;  3UMZ A;  4R9P A;  1K2N A;  2AFF A;  1G88 A;  1J4P A;  1DEV A;  1K3N A;  4H87 A;  2KB4 A;  5JEK A;  3POA A;  2FEZ A;  1G3G A;  3I0N A;  3S40 A;  2XT9 B;  2JKD A;  3ELV A;  1YJM A;  1LGQ A;  1K3Q A;  5JEO A;  3UNN A;  1KHU A;  3VA1 A;  4V24 A;  4EJQ A;  1MZK A;  3I0M A;  3HX1 A;  3ELS A;  1U7V A;  2P1R A;  4EGX A;  5A8I A;  3UOT A;  1U7V B;  5JER A;  1DMZ A;  4G2S A;  3MDB A;  5JEM A;  2JQJ A;  3VZD A;  1QWT A;  3KT9 A;  1QU5 A;  3VZC A;  2FF4 A;  1ZOQ A;  3DSH A;  3VZB A;  2XXS A;  1DD1 A;  1G6G A;  1YJ5 C;  2JQI A;  1UJX A;  3T5P A;  4KU0 D;  1J4L A;  2QV7 A;  1MJS A;  1U7F A;  2EH0 A;  3OUN A;  2KKL A;  2BON A;  4L02 A;  1R21 A;  4JIV D;  2QVL A;  2KFU A;  2W3O A;  3A77 A;  2PIE A;  5E50 A;  1MR1 A;  3FM8 A;  3GQS A;  5JEL A;  1U7F B;  3UN0 A;  1J2F A;  2JPE A;  5BVI A;  1UHT A;  4WRR A;  3VPY A;  1K2M A;  5DJO A;  5JEJ A;  2JQL A;  4JON A;  1MK2 A;  4QCJ A;  2CSW A;  3I6U A;  3DIT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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