1J2FA

X-ray crystal structure of irf-3 and its functional implications
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
233
structure length
226
Chain Sequence
NPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystal structure of IRF-3 and its functional implications.
pubmed doi rcsb
molecule tags Dna binding protein
source organism Homo sapiens
molecule keywords Interferon regulatory factor 3
total genus 61
structure length 226
sequence length 233
chains with identical sequence B
ec nomenclature
pdb deposition date 2003-01-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF10401 IRF-3 Interferon-regulatory factor 3
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.200.10 Mainly Beta Sandwich Tumour Suppressor Smad4 Tumour Suppressor Smad4 1j2fA00
1G88A 1MK2A 5JELA 1U7FB 3GMJA 3DSHA 1J2FA 5JEOA 5JEJA 1ZOQA 1KHXA 5BVIA 1U7FA 1U7VB 1DD1A 3A77A 5C4VA 3DITA 1KHUA 5JERA 1U7VA 4R9PA 1MR1A 1YGSA 5JEMA 1DEVA 1QWTA 1MJSA 5JEKA
chains in the Genus database with same CATH superfamily
4D9VA 5DHRA 5EJGA 2LC1A 2JQLA 3V8MA 5JELA 1U7FB 3GMJA 2XT9B 3DSHA 3V8PA 1UHTA 3AFOA 4A4YA 5JEOA 3VPYA 2I2FA 1K2MA 1U0TA 1U7VB 2I2AA 1Z0UA 1DD1A 2BONA 3UNMA 3PO8A 5JERA 1YJ5C 2A0TA 1U0RA 3VZBA 1K3JA 2Q5FA 1YJMA 1Y3IA 2JGRA 2KB3A 3MDBA 1DMZA 4KU0D 1YT5A 2BRFA 4EJQA 2JKDA 3PFNA 2P1RA 3UNNA 5EJFA 5DJOA 1KHXA 2JQJA 1U7FA 2KB4A 3VA1A 3A77A 3UN0A 2I29A 2JQIA 4EGXA 3DITA 1GXCA 1J4QA 2QVLA 1KHUA 3UV0A 1K3QA 1U7VA 4R9PA 1J4LA 3UMZA 1WV3A 1YGSA 3T5PA 2FF4A 1FHQA 1SUWA 3I0MA 4HAOA 3I6UA 1QWTA 1Z0SA 1J4PA 2JPEA 1WLNA 3V7UA 1J4OA 3I6WA 2I2BA 5A8IA 1R21A 4JIVD 3S40A 1K3NA 3POAA 2I2CA 4JIWD 5EJHA 3HUFA 1Y3HA 2G1LA 4G2SA 5E50A 1ZOQA 5JEJA 4V24A 5DHPA 5BVIA 1FHRA 5C4VA 2W3OA 1G3GA 3VZDA 1G6GA 2I2DA 4L02A 1MR1A 4H87A 2FEZA 5DHTA 5JEMA 1DEVA 2KFUA 1MJSA 3I0NA 5JEKA 2AN1A 5DHSA 3FM8A 3V8QA 5EJIA 3UOTA 2AFFA 1G88A 4DY6A 3VZCA 1QU5A 2I1WA 3OUNA 1MK2A 3V7YA 2QV7A 3KT9A 1K2NA 1J2FA 4QCJA 2KKLA 3HUEA 5DHQA 5DHUA 3ELSA 1J4KA 3HX1A 2XXSA 1Z0ZA 4A0EA 4WERA 1LGPA 3ELVA 3V8RA 3VA4A 4WRRA 2EH0A 1LGQA 4JONA 1MZKA 3V7WA 3V80A 3V8NA 2CSWA 3GQSA 2PIEA 1UJXA
chains in the Genus database with same CATH topology
4D9VA 2LC1A 2JQLA 5JELA 1U7FB 3GMJA 2XT9B 3DSHA 1UHTA 4A4YA 5JEOA 3VPYA 1K2MA 1U7VB 1DD1A 2BONA 3UNMA 3PO8A 5JERA 1YJ5C 2A0TA 3VZBA 1K3JA 1YJMA 2JGRA 2KB3A 3MDBA 1DMZA 4KU0D 2BRFA 4EJQA 2JKDA 3UNNA 2P1RA 5DJOA 1KHXA 2JQJA 1U7FA 2KB4A 3VA1A 3A77A 3UN0A 2JQIA 4EGXA 3DITA 1GXCA 1J4QA 2QVLA 1KHUA 3UV0A 1K3QA 1U7VA 4R9PA 1J4LA 3UMZA 1WV3A 1YGSA 3T5PA 2FF4A 1FHQA 3I0MA 3I6UA 1QWTA 1J4PA 2JPEA 1WLNA 1J4OA 3I6WA 5A8IA 1R21A 4JIVD 3S40A 1K3NA 3POAA 4JIWD 3HUFA 2G1LA 5JEJA 4G2SA 5E50A 1ZOQA 4V24A 5BVIA 1FHRA 5C4VA 2W3OA 1G3GA 3VZDA 1G6GA 4L02A 1MR1A 4H87A 2FEZA 5JEMA 1DEVA 2KFUA 1MJSA 3I0NA 5JEKA 3FM8A 3UOTA 2AFFA 1G88A 3VZCA 1QU5A 3OUNA 1MK2A 2QV7A 3KT9A 1K2NA 1J2FA 4QCJA 2KKLA 3HUEA 3ELSA 1J4KA 3HX1A 2XXSA 4A0EA 4WERA 1LGPA 3ELVA 3VA4A 4WRRA 2EH0A 1LGQA 4JONA 1MZKA 2CSWA 3GQSA 2PIEA 1UJXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1G88 A;  1MK2 A;  5JEL A;  1U7F B;  3GMJ A;  3DSH A;  1J2F A;  5JEO A;  5JEJ A;  1ZOQ A;  1KHX A;  5BVI A;  1U7F A;  1U7V B;  1DD1 A;  3A77 A;  5C4V A;  3DIT A;  1KHU A;  5JER A;  1U7V A;  4R9P A;  1MR1 A;  1YGS A;  5JEM A;  1DEV A;  1QWT A;  1MJS A;  5JEK A; 
#chains in the Genus database with same CATH topology
 4D9V A;  5DHR A;  5EJG A;  2LC1 A;  2JQL A;  3V8M A;  5JEL A;  1U7F B;  3GMJ A;  2XT9 B;  3DSH A;  3V8P A;  1UHT A;  3AFO A;  4A4Y A;  5JEO A;  3VPY A;  2I2F A;  1K2M A;  1U0T A;  1U7V B;  2I2A A;  1Z0U A;  1DD1 A;  2BON A;  3UNM A;  3PO8 A;  5JER A;  1YJ5 C;  2A0T A;  1U0R A;  3VZB A;  1K3J A;  2Q5F A;  1YJM A;  1Y3I A;  2JGR A;  2KB3 A;  3MDB A;  1DMZ A;  4KU0 D;  1YT5 A;  2BRF A;  4EJQ A;  2JKD A;  3PFN A;  2P1R A;  3UNN A;  5EJF A;  5DJO A;  1KHX A;  2JQJ A;  1U7F A;  2KB4 A;  3VA1 A;  3A77 A;  3UN0 A;  2I29 A;  2JQI A;  4EGX A;  3DIT A;  1GXC A;  1J4Q A;  2QVL A;  1KHU A;  3UV0 A;  1K3Q A;  1U7V A;  4R9P A;  1J4L A;  3UMZ A;  1WV3 A;  1YGS A;  3T5P A;  2FF4 A;  1FHQ A;  1SUW A;  3I0M A;  4HAO A;  3I6U A;  1QWT A;  1Z0S A;  1J4P A;  2JPE A;  1WLN A;  3V7U A;  1J4O A;  3I6W A;  2I2B A;  5A8I A;  1R21 A;  4JIV D;  3S40 A;  1K3N A;  3POA A;  2I2C A;  4JIW D;  5EJH A;  3HUF A;  1Y3H A;  2G1L A;  4G2S A;  5E50 A;  1ZOQ A;  5JEJ A;  4V24 A;  5DHP A;  5BVI A;  1FHR A;  5C4V A;  2W3O A;  1G3G A;  3VZD A;  1G6G A;  2I2D A;  4L02 A;  1MR1 A;  4H87 A;  2FEZ A;  5DHT A;  5JEM A;  1DEV A;  2KFU A;  1MJS A;  3I0N A;  5JEK A;  2AN1 A;  5DHS A;  3FM8 A;  3V8Q A;  5EJI A;  3UOT A;  2AFF A;  1G88 A;  4DY6 A;  3VZC A;  1QU5 A;  2I1W A;  3OUN A;  1MK2 A;  3V7Y A;  2QV7 A;  3KT9 A;  1K2N A;  1J2F A;  4QCJ A;  2KKL A;  3HUE A;  5DHQ A;  5DHU A;  3ELS A;  1J4K A;  3HX1 A;  2XXS A;  1Z0Z A;  4A0E A;  4WER A;  1LGP A;  3ELV A;  3V8R A;  3VA4 A;  4WRR A;  2EH0 A;  1LGQ A;  4JON A;  1MZK A;  3V7W A;  3V80 A;  3V8N A;  2CSW A;  3GQS A;  2PIE A;  1UJX A; 
#chains in the Genus database with same CATH homology
 4D9V A;  2LC1 A;  2JQL A;  5JEL A;  1U7F B;  3GMJ A;  2XT9 B;  3DSH A;  1UHT A;  4A4Y A;  5JEO A;  3VPY A;  1K2M A;  1U7V B;  1DD1 A;  2BON A;  3UNM A;  3PO8 A;  5JER A;  1YJ5 C;  2A0T A;  3VZB A;  1K3J A;  1YJM A;  2JGR A;  2KB3 A;  3MDB A;  1DMZ A;  4KU0 D;  2BRF A;  4EJQ A;  2JKD A;  3UNN A;  2P1R A;  5DJO A;  1KHX A;  2JQJ A;  1U7F A;  2KB4 A;  3VA1 A;  3A77 A;  3UN0 A;  2JQI A;  4EGX A;  3DIT A;  1GXC A;  1J4Q A;  2QVL A;  1KHU A;  3UV0 A;  1K3Q A;  1U7V A;  4R9P A;  1J4L A;  3UMZ A;  1WV3 A;  1YGS A;  3T5P A;  2FF4 A;  1FHQ A;  3I0M A;  3I6U A;  1QWT A;  1J4P A;  2JPE A;  1WLN A;  1J4O A;  3I6W A;  5A8I A;  1R21 A;  4JIV D;  3S40 A;  1K3N A;  3POA A;  4JIW D;  3HUF A;  2G1L A;  5JEJ A;  4G2S A;  5E50 A;  1ZOQ A;  4V24 A;  5BVI A;  1FHR A;  5C4V A;  2W3O A;  1G3G A;  3VZD A;  1G6G A;  4L02 A;  1MR1 A;  4H87 A;  2FEZ A;  5JEM A;  1DEV A;  2KFU A;  1MJS A;  3I0N A;  5JEK A;  3FM8 A;  3UOT A;  2AFF A;  1G88 A;  3VZC A;  1QU5 A;  3OUN A;  1MK2 A;  2QV7 A;  3KT9 A;  1K2N A;  1J2F A;  4QCJ A;  2KKL A;  3HUE A;  3ELS A;  1J4K A;  3HX1 A;  2XXS A;  4A0E A;  4WER A;  1LGP A;  3ELV A;  3VA4 A;  4WRR A;  2EH0 A;  1LGQ A;  4JON A;  1MZK A;  2CSW A;  3GQS A;  2PIE A;  1UJX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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